[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

TNSN07398A1 - Anticorps contre la p-cadherine - Google Patents

Anticorps contre la p-cadherine

Info

Publication number
TNSN07398A1
TNSN07398A1 TNP2007000398A TNSN07398A TNSN07398A1 TN SN07398 A1 TNSN07398 A1 TN SN07398A1 TN P2007000398 A TNP2007000398 A TN P2007000398A TN SN07398 A TNSN07398 A TN SN07398A TN SN07398 A1 TNSN07398 A1 TN SN07398A1
Authority
TN
Tunisia
Prior art keywords
present
cadherin
antibodies
relates
human antibodies
Prior art date
Application number
TNP2007000398A
Other languages
English (en)
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of TNSN07398A1 publication Critical patent/TNSN07398A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des anticorps, comprenant des anticorps humains et leurs portions de liaison d'antigène, qui se lient à la P- cadhérine et qui agissent en inhibant la P-cadhérine. La présente invention concerne également des immunoglobulines à chaînes lourdes et chaînes légères dérivées d'anticorps humains contre la P-cadhérine, et des molécules d'acides nucléiques codant pour ces immunoglobulines. La présente invention concerne également des procédés pour la préparation d'anticorps humains contre la P-cadhérine, des compositions comprenant ces anticorps et des méthodes d'utilisation des anticorps et compositions. La présente invention concerne également des animaux transgéniques ou des plantes transgéniques comprenant les molécules d'acides nucléiques de la présente invention.
TNP2007000398A 2005-04-26 2007-10-25 Anticorps contre la p-cadherine TNSN07398A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67531105P 2005-04-26 2005-04-26
PCT/IB2006/001053 WO2006114704A2 (fr) 2005-04-26 2006-04-13 Anticorps de la p-cadherine

Publications (1)

Publication Number Publication Date
TNSN07398A1 true TNSN07398A1 (fr) 2009-03-17

Family

ID=36722281

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2007000398A TNSN07398A1 (fr) 2005-04-26 2007-10-25 Anticorps contre la p-cadherine

Country Status (32)

Country Link
US (3) US7452537B2 (fr)
EP (4) EP2444419A1 (fr)
JP (2) JP4253037B2 (fr)
KR (3) KR100990027B1 (fr)
CN (1) CN101184778B (fr)
AP (1) AP2552A (fr)
AR (2) AR053456A1 (fr)
AU (1) AU2006238930B2 (fr)
BR (1) BRPI0608096A2 (fr)
CA (2) CA2604357C (fr)
CR (1) CR9471A (fr)
CU (1) CU23764A3 (fr)
DO (1) DOP2006000098A (fr)
EA (1) EA012970B1 (fr)
GE (1) GEP20115226B (fr)
GT (1) GT200600176A (fr)
HK (1) HK1117172A1 (fr)
HN (1) HN2006015949A (fr)
IL (2) IL186413A (fr)
MA (1) MA29991B1 (fr)
MX (1) MX2007013304A (fr)
MY (1) MY146773A (fr)
NO (2) NO20074916L (fr)
NZ (1) NZ562234A (fr)
PE (1) PE20061376A1 (fr)
PH (1) PH12014501872A1 (fr)
TN (1) TNSN07398A1 (fr)
TW (2) TW201035110A (fr)
UA (1) UA95775C2 (fr)
UY (1) UY37223A (fr)
WO (1) WO2006114704A2 (fr)
ZA (1) ZA200708548B (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009528257A (ja) * 2006-02-28 2009-08-06 オンコセラピー・サイエンス株式会社 抗ｃｄｈ３抗体のエフェクター機能を用いて細胞を障害する方法
NL1031818C2 (nl) * 2006-05-15 2007-11-23 Pfizer P-Cadherineantilichamen.
JP2010517570A (ja) * 2007-02-08 2010-05-27 メルク・シャープ・エンド・ドーム・コーポレイション Ｄｋｋ−１に特異的な抗体
US20130136689A1 (en) * 2007-06-05 2013-05-30 Christian Rohlff Proteins
UA100127C2 (ru) 2007-08-20 2012-11-26 Онкотерапи Саенс, Инк. Пептид cdh3 и лекарственное средство, содержащее его
RU2011103199A (ru) 2008-06-30 2012-08-10 Онкотерапи Сайенс, Инк. (Jp) Антитела против cdh3, меченные радиоизотопной меткой, и их применение
US9017669B2 (en) 2009-12-28 2015-04-28 Oncotherapy Science, Inc. Anti-CDH3 antibodies and uses thereof
KR101900110B1 (ko) 2010-02-10 2018-09-18 후지필름 알아이 파르마 가부시키가이샤 방사성 금속 표지 항카드헤린 항체
JP2014015396A (ja) * 2010-10-29 2014-01-30 Perseus Proteomics Inc 高い親和性を有する抗ｃｄｈ３抗体
ES2690469T3 (es) * 2010-10-29 2018-11-21 Perseus Proteomics Inc. Anticuerpo anti-CDH3 que tiene alta capacidad de internalización
DK2699598T3 (en) * 2011-04-19 2019-04-23 Pfizer COMBINATIONS OF ANTI-4-1BB ANTIBODIES AND ADCC-INducing ANTIBODIES FOR TREATMENT OF CANCER
LT2809681T (lt) 2012-01-31 2019-02-11 Regeneron Pharmaceuticals, Inc. Antikūnai prieš asic1 ir jų panaudojimas
US9534058B2 (en) 2012-02-08 2017-01-03 Abbvie Stemcentrx Llc Anti-CD324 monoclonal antibodies and uses thereof
WO2015154064A2 (fr) 2014-04-04 2015-10-08 Del Mar Pharmaceuticals Utilisation de dianhydrogalactitol et de leurs analogues ou dérivés dans le traitement du carcinome non à petites cellules des poumons et du cancer des ovaires
SG11201609707WA (en) 2014-07-01 2017-01-27 Pfizer Bispecific heterodimeric diabodies and uses thereof
TN2017000173A1 (en) 2014-11-14 2018-10-19 Novartis Ag Antibody drug conjugates
EA201792193A1 (ru) 2015-04-17 2018-05-31 Эмджен Рисерч (Мьюник) Гмбх Конструкции биспецифического антитела для cdh3 и cd3
EP3844181A1 (fr) 2018-08-30 2021-07-07 HCW Biologics, Inc. Polypeptides chimères à chaînes multiples et leurs utilisations
CA3109361A1 (fr) 2018-08-30 2020-03-05 HCW Biologics, Inc. Polypeptides chimeres a chaine unique et a chaines multiples et leurs utilisations
AU2019328313A1 (en) 2018-08-30 2021-02-25 Immunitybio, Inc. Single-chain chimeric polypeptides and uses thereof
CA3143035A1 (fr) 2019-06-21 2020-12-24 HCW Biologics, Inc. Polypeptides chimeriques a chaines multiples et leurs utilisations
WO2021163298A1 (fr) 2020-02-11 2021-08-19 HCW Biologics, Inc. Méthodes d'activation de lymphocytes t régulateurs
CA3169231A1 (fr) 2020-02-11 2021-08-19 HCW Biologics, Inc. Methodes de traitement de maladies liees a l'age et inflammatoires
KR20220140535A (ko) 2020-02-11 2022-10-18 에이치씨더블유 바이올로직스, 인크. 크로마토그래피 수지 및 이의 용도
US20230174666A1 (en) 2020-04-29 2023-06-08 HCW Biologics, Inc. Anti-cd26 proteins and uses thereof
JP2023527869A (ja) 2020-06-01 2023-06-30 エイチシーダブリュー バイオロジックス インコーポレイテッド 加齢関連障害の治療法
US12024545B2 (en) 2020-06-01 2024-07-02 HCW Biologics, Inc. Methods of treating aging-related disorders
WO2021247003A1 (fr) 2020-06-01 2021-12-09 HCW Biologics, Inc. Méthodes de traitement de troubles liés au vieillissement
WO2022237874A1 (fr) * 2021-05-13 2022-11-17 Wuxi Biologics (Shanghai) Co., Ltd. Conjugué d'anticorps comprenant un anticorps anti-p-cadhérine et ses utilisations
AU2023228683A1 (en) 2022-03-02 2024-09-19 Immunitybio, Inc. Method of treating pancreatic cancer

Family Cites Families (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4510245A (en) 1982-11-18 1985-04-09 Chiron Corporation Adenovirus promoter system
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4740461A (en) 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
CA1319120C (fr) 1985-04-01 1993-06-15 John Henry Kenten Lignee cellulaire myelomateuse transformee et expression d'un gene codant pour un polypeptide d'eucaryote a l'aide de cette lignee
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
GB8607683D0 (en) 1986-03-27 1986-04-30 Ici Plc Anti-tumor agents
US4959455A (en) 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
US5750172A (en) 1987-06-23 1998-05-12 Pharming B.V. Transgenic non human mammal milk
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
GB8809129D0 (en) 1988-04-18 1988-05-18 Celltech Ltd Recombinant dna methods vectors and host cells
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
EP0494175A4 (en) 1989-09-27 1993-05-05 Athena Neurosciences, Inc. Compositions for cell adhesion inhibition and methods of use
US5959177A (en) 1989-10-27 1999-09-28 The Scripps Research Institute Transgenic plants expressing assembled secretory antibodies
US5633076A (en) 1989-12-01 1997-05-27 Pharming Bv Method of producing a transgenic bovine or transgenic bovine embryo
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
DE69120146T2 (de) 1990-01-12 1996-12-12 Cell Genesys Inc Erzeugung xenogener antikörper
US5151510A (en) 1990-04-20 1992-09-29 Applied Biosystems, Inc. Method of synethesizing sulfurized oligonucleotide analogs
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
DK0585287T3 (da) 1990-07-10 2000-04-17 Cambridge Antibody Tech Fremgangsmåde til fremstilling af specifikke bindingsparelementer
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5165424A (en) 1990-08-09 1992-11-24 Silverman Harvey N Method and system for whitening teeth
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
DK0546073T3 (da) 1990-08-29 1998-02-02 Genpharm Int Frembringelse og anvendelse af transgene, ikke-humane dyr, der er i stand til at danne heterologe antistoffer
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
DE69133557D1 (de) 1990-08-29 2007-03-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
AU669474B2 (en) * 1990-10-30 1996-06-13 La Jolla Cancer Research Foundation T-cadherin adhesion molecule
WO1992009690A2 (fr) 1990-12-03 1992-06-11 Genentech, Inc. Methode d'enrichissement pour des variantes de l'hormone de croissance avec des proprietes de liaison modifiees
EP1820858B1 (fr) 1991-03-01 2009-08-12 Dyax Corporation Protéine chimère comprenant des micro-protéines dotées de deux liaisons disulfure ou plus et ses modes de réalisation
DE4110405A1 (de) 1991-03-28 1992-10-01 Birchmeier Walter Prof Dr Verfahren zum nachweis der differenzierung und der invasivitaet von karzinomzellen
AU662148B2 (en) 1991-04-10 1995-08-24 Scripps Research Institute, The Heterodimeric receptor libraries using phagemids
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
WO1993004169A1 (fr) 1991-08-20 1993-03-04 Genpharm International, Inc. Ciblage de genes dans des cellules animales au moyen de produits de synthese d'adn isogeniques
JP3540315B2 (ja) 1991-09-23 2004-07-07 メディカル リサーチ カウンシル キメラ抗体の製造−組合せアプローチ
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
US5777085A (en) 1991-12-20 1998-07-07 Protein Design Labs, Inc. Humanized antibodies reactive with GPIIB/IIIA
ATE295420T1 (de) 1992-02-06 2005-05-15 Chiron Corp Marker für krebs und biosynthetisches bindeprotein dafür
DE69331089T2 (de) 1992-02-18 2002-07-18 Otsuka Kagaku K.K., Osaka Beta-Laktam und Cepham Verbindungen und Ihre Herstellung
US5714350A (en) 1992-03-09 1998-02-03 Protein Design Labs, Inc. Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
US5646250A (en) * 1992-04-17 1997-07-08 Doheny Eye Institute Cadherin polypeptides
EP0604603A4 (fr) 1992-04-17 1996-09-25 Doheny Eye Inst Elements et procedes permettant la production de cadherines.
US5597725A (en) * 1992-04-17 1997-01-28 Doheny Eye Institute Cadherin-specific antibodies and hybridoma cell lines
SG48760A1 (en) 1992-07-24 2003-03-18 Abgenix Inc Generation of xenogenetic antibodies
US6177401B1 (en) 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
AU5669494A (en) 1992-11-17 1994-06-08 Yale University Human homolog of the e-cadherin gene and methods based thereon
ATE193301T1 (de) 1993-03-09 2000-06-15 Genzyme Corp Verfahren zur isolierung von proteinen aus milch
GB9323884D0 (en) * 1993-11-19 1994-01-05 Eisai London Res Lab Ltd Physiological modulation
US5466823A (en) 1993-11-30 1995-11-14 G.D. Searle & Co. Substituted pyrazolyl benzenesulfonamides
US5827690A (en) 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
IL112248A0 (en) 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
US5610281A (en) * 1994-05-03 1997-03-11 Brigham & Women's Hospital, Inc. Antibodies for modulating heterotypic E-cadherin interactions with human T lymphocytes
US5608082A (en) 1994-07-28 1997-03-04 Agouron Pharmaceuticals, Inc. Compounds useful as antiproliferative agents and GARFT inhibitors
US5643763A (en) 1994-11-04 1997-07-01 Genpharm International, Inc. Method for making recombinant yeast artificial chromosomes by minimizing diploid doubling during mating
US6046037A (en) 1994-12-30 2000-04-04 Hiatt; Andrew C. Method for producing immunoglobulins containing protection proteins in plants and their use
US5633272A (en) 1995-02-13 1997-05-27 Talley; John J. Substituted isoxazoles for the treatment of inflammation
US6091001A (en) 1995-03-29 2000-07-18 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
US6130364A (en) 1995-03-29 2000-10-10 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
JPH11503914A (ja) 1995-04-21 1999-04-06 セル ジェネシス，インコーポレイテッド 大ゲノムｄｎａ欠失の生成
AU5632296A (en) 1995-04-27 1996-11-18 Abgenix, Inc. Human antibodies derived from immunized xenomice
AU2466895A (en) 1995-04-28 1996-11-18 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
GB9520822D0 (en) 1995-10-11 1995-12-13 Wellcome Found Therapeutically active compounds
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
CA2244897C (fr) 1996-03-05 2006-04-11 Zeneca Limited Derives de 4-anilinoquinazoline
US5714352A (en) 1996-03-20 1998-02-03 Xenotech Incorporated Directed switch-mediated DNA recombination
US5994619A (en) 1996-04-01 1999-11-30 University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus Production of chimeric bovine or porcine animals using cultured inner cell mass cells
US6180651B1 (en) 1996-04-04 2001-01-30 Bristol-Myers Squibb Diarylmethylidenefuran derivatives, processes for their preparation and their uses in therapeutics
EE03685B1 (et) 1996-04-12 2002-04-15 G.D. Searle & Co. Asendatud benseensulfoonamiidi derivaadid kui COX-2 inhibiitorite eelravimid
US6280739B1 (en) * 1996-04-18 2001-08-28 Genetics Institute, Inc. Method of inhibiting angiogenesis using secreted proteins
US6169071B1 (en) * 1996-07-12 2001-01-02 Mcgill University Compounds and methods for modulating cell adhesion
AU722985B2 (en) 1996-07-12 2000-08-17 Mcgill University Compounds and methods for modulating cell adhesion
US6346512B1 (en) * 1996-07-12 2002-02-12 Mcgill University Compounds and methods for modulating cell adhesion
US6207639B1 (en) * 1996-07-12 2001-03-27 Mcgill University Compounds and methods for modulating neurite outgrowth
US6333307B1 (en) * 1996-07-12 2001-12-25 Mcgill University Compounds and method for modulating neurite outgrowth
HRP970371A2 (en) 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
ATE227283T1 (de) 1996-07-13 2002-11-15 Glaxo Group Ltd Kondensierte heterozyklische verbindungen als protein kinase inhibitoren
WO1998002437A1 (fr) 1996-07-13 1998-01-22 Glaxo Group Limited Composes heteroaromatiques bicycliques en tant qu'inhibiteurs de la proteine tyrosine kinase
EA001444B1 (ru) 1996-07-18 2001-04-23 Мерк Фросст Кэнада Энд Ко./Мерк Фросст Кэнада Э Си Замещенные пиридины в качестве избирательных ингибиторов циклооксигеназы-2
US6312921B1 (en) * 1996-07-26 2001-11-06 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
WO1998016241A1 (fr) 1996-10-15 1998-04-23 Vanderbilt University Procede servant a perturber l'adhesion cellulaire
US5895748A (en) * 1996-11-27 1999-04-20 Johnson; Keith R. Panel of antibodies for detecting cadherins and catenins in tissues and method of using the panel of antibodies
ATE387495T1 (de) 1996-12-03 2008-03-15 Amgen Fremont Inc Vollkommen humane antikörper die egfr binden
SE9604731D0 (sv) 1996-12-20 1996-12-20 Tamas Bartfai Konsulting Ab A component of intercellular junctions in the endothelium
JP3128203B2 (ja) * 1997-02-10 2001-01-29 一男 坪田 分泌腺細胞とリンパ球との接着阻害剤
WO2002024719A1 (fr) 2000-09-20 2002-03-28 Human Genome Sciences, Inc. 21 proteines humaines secretees
US6034256A (en) 1997-04-21 2000-03-07 G.D. Searle & Co. Substituted benzopyran derivatives for the treatment of inflammation
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
CA2289102A1 (fr) 1997-05-07 1998-11-12 Sugen, Inc. Derives de 2-indolinone utilises en tant que modulateurs de l'activite de la proteine kinase
GB2339430A (en) 1997-05-21 2000-01-26 Biovation Ltd Method for the production of non-immunogenic proteins
EP0984692A4 (fr) 1997-05-30 2001-02-21 Merck & Co Inc Nouveaux inhibiteurs d'angiogenese
US6121027A (en) 1997-08-15 2000-09-19 Surmodics, Inc. Polybifunctional reagent having a polymeric backbone and photoreactive moieties and bioactive groups
DE69838172T2 (de) 1997-08-22 2008-04-10 Astrazeneca Ab Oxindolylchinazolinderivate als angiogenesehemmer
CO4960662A1 (es) 1997-08-28 2000-09-25 Novartis Ag Ciertos acidos 5-alquil-2-arilaminofenilaceticos y sus derivados
CA2303830A1 (fr) 1997-09-26 1999-04-08 Merck & Co., Inc. Nouveaux inhibiteurs de l'angiogenese
US6203788B1 (en) 1997-09-29 2001-03-20 Adherex Inc. Compounds and methods for regulating cell adhesion
CN1280580A (zh) 1997-11-11 2001-01-17 辉瑞产品公司 用作抗癌药的噻吩并嘧啶和噻吩并吡啶衍生物
US6248864B1 (en) * 1997-12-31 2001-06-19 Adherex Technologies, Inc. Compounds and methods and modulating tissue permeability
GB9800575D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
GB9800569D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
JPH11292900A (ja) 1998-01-20 1999-10-26 Gsf Forschungszentrum Fuer Umwelt & Gesundheit Gmbh ヒト悪性腫瘍の診断および治療の基礎としてのｅ−カドヘリンの突然変異体
KR20010034554A (ko) 1998-03-03 2001-04-25 레이몬드, 엠. 위티 치료제로서의 ｃｄ147 결합 분자
US20020029391A1 (en) 1998-04-15 2002-03-07 Claude Geoffrey Davis Epitope-driven human antibody production and gene expression profiling
KR100743287B1 (ko) 1998-05-29 2007-07-26 수젠, 인크. 피롤기로 치환된 2-인돌리논 단백질 인산화 효소 억제제
UA60365C2 (uk) 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
US6277824B1 (en) * 1998-07-10 2001-08-21 Adherex Technologies Compounds and methods for modulating adhesion molecule function
AU770555B2 (en) 1998-08-17 2004-02-26 Abgenix, Inc. Generation of modified molecules with increased serum half-lives
AU1316200A (en) * 1998-10-15 2000-05-01 Chiron Corporation Metastatic breast and colon cancer regulated genes
WO2000034317A2 (fr) 1998-12-08 2000-06-15 Biovation Limited Modification de l'immunogenicite de proteines
CN1328571B (zh) 1998-12-23 2016-08-31 辉瑞大药厂 抗ctla-4的人单克隆抗体
US6682736B1 (en) 1998-12-23 2004-01-27 Abgenix, Inc. Human monoclonal antibodies to CTLA-4
UA71945C2 (en) 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
JP3270834B2 (ja) 1999-01-27 2002-04-02 ファイザー・プロダクツ・インク 抗がん剤として有用なヘテロ芳香族二環式誘導体
DE60044087D1 (de) 1999-06-23 2010-05-12 Univ Vermont Verfahren und mittels zur manipulierung der expression des uncoupling proteins
TWI262914B (en) 1999-07-02 2006-10-01 Agouron Pharma Compounds and pharmaceutical compositions for inhibiting protein kinases
US6794132B2 (en) * 1999-10-02 2004-09-21 Biosite, Inc. Human antibodies
US6517529B1 (en) 1999-11-24 2003-02-11 Radius International Limited Partnership Hemodialysis catheter
UA75055C2 (uk) 1999-11-30 2006-03-15 Пфайзер Продактс Інк. Похідні бензоімідазолу, що використовуються як антипроліферативний засіб, фармацевтична композиція на їх основі
BRPI0108394B8 (pt) 2000-02-15 2021-05-25 Upjohn Co inibidores de proteína de quinase de 2-indolinona de pirrol substituído, seus sais e composições farmacêuticas compreendendo os mesmos
CN101348467A (zh) 2000-06-22 2009-01-21 辉瑞产品公司 用于治疗异常细胞生长的取代的双环衍生物
WO2002008261A2 (fr) 2000-07-26 2002-01-31 Stanford University Proteine bstp-trans et reactifs apparentes, et methodes d'utilisation s'y rapportant
WO2002059264A2 (fr) 2000-12-29 2002-08-01 Bio-Technology General Corp. Anticorps humains specifiques pour la therapie selective du cancer
AU2002231368C1 (en) 2001-01-05 2018-08-16 Amgen Fremont Inc. Antibodies to insulin-like growth factor I receptor
AR042586A1 (es) 2001-02-15 2005-06-29 Sugen Inc 3-(4-amidopirrol-2-ilmetiliden)-2-indolinona como inhibidores de la protein quinasa; sus composiciones farmaceuticas; un metodo para la modulacion de la actividad catalitica de la proteinquinasa; un metodo para tratar o prevenir una afeccion relacionada con la proteinquinasa
CA2445611A1 (fr) 2001-05-31 2002-12-05 Chiron Corporation Utilisation de p-cadherine comme cible dans la therapie anticancereuse
AR039067A1 (es) 2001-11-09 2005-02-09 Pfizer Prod Inc Anticuerpos para cd40
US7771951B2 (en) 2001-12-03 2010-08-10 Amgen Fremont Inc. Antibody categorization based on binding characteristics
EP2135879A3 (fr) * 2002-06-28 2010-06-23 Domantis Limited Ligand
CA2496781A1 (fr) 2002-08-26 2004-03-04 Case Western Reserve University Methodes de traitement de patients et d'identification de therapeutique
PA8580301A1 (es) 2002-08-28 2005-05-24 Pfizer Prod Inc Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos
AU2003304203A1 (en) 2002-10-29 2005-01-04 Pharmacia Corporation Differentially expressed genes involved in cancer, the polypeptides encoded thereby, and methods of using the same
AU2003283155A1 (en) 2002-11-14 2004-06-03 Adherex Technologies Inc. Compounds and methods for modulating functions of classical cadherins
WO2004072117A2 (fr) 2003-02-13 2004-08-26 Pharmacia Corporation Anticorps contre c-met dans le traitement de cancers
JP6943759B2 (ja) 2017-12-28 2021-10-06 株式会社東海理化電機製作所 シフト装置

Also Published As

Publication number Publication date
HK1117172A1 (en) 2009-01-09
AR085624A2 (es) 2013-10-16
CR9471A (es) 2007-12-04
CN101184778B (zh) 2012-05-30
WO2006114704A3 (fr) 2007-03-22
US8974781B2 (en) 2015-03-10
GEP20115226B (en) 2011-06-10
US20110182884A1 (en) 2011-07-28
TW201035110A (en) 2010-10-01
KR20100038467A (ko) 2010-04-14
KR101193797B1 (ko) 2012-10-23
CA2763671A1 (fr) 2006-11-02
NZ562234A (en) 2009-09-25
PH12014501872A1 (en) 2016-08-31
MX2007013304A (es) 2007-12-13
EP1877444A2 (fr) 2008-01-16
TWI379838B (en) 2012-12-21
CA2604357A1 (fr) 2006-11-02
PE20061376A1 (es) 2006-12-19
KR20110113785A (ko) 2011-10-18
KR101203328B1 (ko) 2012-11-20
GT200600176A (es) 2006-11-28
AP2552A (en) 2013-01-08
US20060240001A1 (en) 2006-10-26
CU23764A3 (es) 2012-02-15
TW200718712A (en) 2007-05-16
AR053456A1 (es) 2007-05-09
EP2444421A1 (fr) 2012-04-25
IL186413A0 (en) 2008-01-20
EP2444420A1 (fr) 2012-04-25
AU2006238930A1 (en) 2006-11-02
AP2007004191A0 (en) 2007-10-31
EP2444419A1 (fr) 2012-04-25
KR100990027B1 (ko) 2010-10-26
KR20070116155A (ko) 2007-12-06
US20090118487A1 (en) 2009-05-07
IL186413A (en) 2016-09-29
BRPI0608096A2 (pt) 2009-11-10
MA29991B1 (fr) 2008-12-01
NO20181306A1 (no) 2007-10-25
UA95775C2 (uk) 2011-09-12
NO20074916L (no) 2007-10-25
US7452537B2 (en) 2008-11-18
IL234657A0 (en) 2014-11-30
JP2008538909A (ja) 2008-11-13
HN2006015949A (es) 2011-01-17
US7928214B2 (en) 2011-04-19
MY146773A (en) 2012-09-28
ZA200708548B (en) 2008-11-26
CN101184778A (zh) 2008-05-21
JP2009106287A (ja) 2009-05-21
EA200702087A1 (ru) 2008-02-28
WO2006114704A2 (fr) 2006-11-02
UY37223A (es) 2018-11-30
CA2604357C (fr) 2012-01-17
JP4253037B2 (ja) 2009-04-08
JP5086974B2 (ja) 2012-11-28
EA012970B1 (ru) 2010-02-26
AU2006238930B2 (en) 2010-12-23
DOP2006000098A (es) 2006-10-31

Similar Documents

Publication Publication Date Title
TNSN07398A1 (fr) Anticorps contre la p-cadherine
MA28092A1 (fr) Anticorps diriges contre un m-csf
MA28430B1 (fr) Anticorps a madcam.
MA30337B1 (fr) Anticorps
MY164457A (en) Human monoclonal antibodies to activin receptor-like kinase-1
MA33402B1 (fr) Compositions et procédés de ciblage de la proteine c3b de complément par des anticorps
MX2009006891A (es) Anticuerpos cd44.
MA31821B1 (fr) Anticorps anti-cxcr5 humanises, leurs derives et leurs utilisations
MA29524B1 (fr) Anticorps diriges contre la myostatine
TNSN04078A1 (fr) Antibodies to cd40
MA30653B1 (fr) Anticorps monoclonaux anti-il-6 et leurs utilisations
WO2008060331A3 (fr) Anticorps au coronavirus sras
MA35345B1 (fr) Proteines de liaisons a un antigene ayant une liaison accrue a fcrn
MA30531B1 (fr) Anticorps anti-dll4 et leurs procedes d'utilisation
MA33387B1 (fr) Polypeptides et procede de traitement
MA48241A1 (fr) Anticorps dirigés contre madcam
TNSN02089A1 (fr) Anticorps a cd40