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EE03685B1 - Asendatud benseensulfoonamiidi derivaadid kui COX-2 inhibiitorite eelravimid - Google Patents

Asendatud benseensulfoonamiidi derivaadid kui COX-2 inhibiitorite eelravimid

Info

Publication number
EE03685B1
EE03685B1 EE9800351A EE9800351A EE03685B1 EE 03685 B1 EE03685 B1 EE 03685B1 EE 9800351 A EE9800351 A EE 9800351A EE 9800351 A EE9800351 A EE 9800351A EE 03685 B1 EE03685 B1 EE 03685B1
Authority
EE
Estonia
Prior art keywords
cox
prodrugs
inhibitors
benzenesulfonamide derivatives
substituted benzenesulfonamide
Prior art date
Application number
EE9800351A
Other languages
English (en)
Other versions
EE9800351A (et
Inventor
L. Brown David
J. Talley John
W. Malecha James
R. Bertenshaw Stephen
J. Graneto Matthew
S. Carter Jeffery
Li Jinglin
R. Nagarajan Srinivasan
J. Rogier Donald Jr.
D. Penning Thomas
K. Khanna Ish
Xu Xiangdong
M. Weier Richard
Original Assignee
G.D. Searle & Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by G.D. Searle & Co. filed Critical G.D. Searle & Co.
Publication of EE9800351A publication Critical patent/EE9800351A/et
Publication of EE03685B1 publication Critical patent/EE03685B1/et

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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