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SK281701B6 - Spôsob asymetrickej syntézy fluórfenikolu, tiamfenikolu, chloramfenikolu a oxazolínu - Google Patents

Spôsob asymetrickej syntézy fluórfenikolu, tiamfenikolu, chloramfenikolu a oxazolínu Download PDF

Info

Publication number
SK281701B6
SK281701B6 SK777-95A SK77795A SK281701B6 SK 281701 B6 SK281701 B6 SK 281701B6 SK 77795 A SK77795 A SK 77795A SK 281701 B6 SK281701 B6 SK 281701B6
Authority
SK
Slovakia
Prior art keywords
oxazoline
acid
epoxide
chloride
formula
Prior art date
Application number
SK777-95A
Other languages
English (en)
Slovak (sk)
Other versions
SK77795A3 (en
Inventor
Guang-Zhong Wu
Wanda I. Tormos
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of SK77795A3 publication Critical patent/SK77795A3/sk
Publication of SK281701B6 publication Critical patent/SK281701B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Epoxy Compounds (AREA)
SK777-95A 1992-12-18 1993-12-15 Spôsob asymetrickej syntézy fluórfenikolu, tiamfenikolu, chloramfenikolu a oxazolínu SK281701B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/993,932 US5352832A (en) 1992-12-18 1992-12-18 Asymmetric process for preparing florfenicol, thiamphenicol chloramphenicol and oxazoline intermediates
PCT/US1993/012071 WO1994014764A1 (fr) 1992-12-18 1993-12-15 Procede asymetrique de preparation de florfenicol, thiamphenicol, chloramphenicol et d'intermediaires d'oxazoline

Publications (2)

Publication Number Publication Date
SK77795A3 SK77795A3 (en) 1995-12-06
SK281701B6 true SK281701B6 (sk) 2001-07-10

Family

ID=25540089

Family Applications (1)

Application Number Title Priority Date Filing Date
SK777-95A SK281701B6 (sk) 1992-12-18 1993-12-15 Spôsob asymetrickej syntézy fluórfenikolu, tiamfenikolu, chloramfenikolu a oxazolínu

Country Status (20)

Country Link
US (1) US5352832A (fr)
EP (1) EP0674618B1 (fr)
JP (1) JP3428016B2 (fr)
KR (1) KR100284216B1 (fr)
AT (1) ATE170835T1 (fr)
AU (1) AU676003B2 (fr)
CA (1) CA2152089C (fr)
CZ (1) CZ287461B6 (fr)
DE (1) DE69320986T2 (fr)
DK (1) DK0674618T3 (fr)
ES (1) ES2120605T3 (fr)
FI (1) FI109295B (fr)
HU (1) HU225110B1 (fr)
NO (1) NO303575B1 (fr)
NZ (1) NZ259239A (fr)
PL (1) PL177891B1 (fr)
RU (1) RU2126383C1 (fr)
SK (1) SK281701B6 (fr)
UA (1) UA43331C2 (fr)
WO (1) WO1994014764A1 (fr)

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US7126005B2 (en) * 2003-10-06 2006-10-24 Aurobindo Pharma Limited Process for preparing florfenicol
MXPA06007215A (es) * 2003-12-23 2006-08-18 Schering Plough Ltd Profarmaco florfenicol con mejor solubilidad en agua.
WO2005066119A2 (fr) * 2003-12-31 2005-07-21 Schering-Plough Ltd. 1-(4-mono-and di-halomethylsulphonylphenyl)-2-acylamino-3-fluoropropanols antibacteriens et procede de preparation de ces derniers
AU2005272925B2 (en) 2004-08-13 2011-02-10 Intervet International B.V. Pharmaceutical formulation comprising an antibiotic, a triazole and a corticosteroid
US7312248B2 (en) 2004-09-23 2007-12-25 Schering-Plough Animal Health Corporation Control of parasites in animals by the use of novel trifluoromethanesulfonanilide oxime ether derivatives
EP1811841B1 (fr) * 2004-11-19 2009-10-28 Schering-Plough Ltd. Lutte contre des parasites chez les animaux au moyen de derives parasiticides de 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile
DE602005010479D1 (de) * 2004-12-21 2008-11-27 Intervet Int Bv Injizierbare veterinärmedizinische zusammensetzung enthaltend florfenicol
US20060281695A1 (en) * 2005-06-09 2006-12-14 Schering-Plough Animal Health Corporation Control of parasites in animals by N-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and N-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US8119667B2 (en) * 2005-12-29 2012-02-21 Schering-Plough Animal Health Corporation Carbonates of fenicol antibiotics
US7518017B2 (en) 2006-02-17 2009-04-14 Idexx Laboratories Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
EP2102154A1 (fr) * 2006-12-13 2009-09-23 Schering-Plough Ltd. Promédicaments solubles dans l'eau de chloramphénicol, thiamphénicol et analogues de ceux-ci
CA2672586A1 (fr) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Promedicaments de florfenicol solubles dans l'eau et analogues
CN101686956A (zh) * 2007-04-27 2010-03-31 谢尔英·普劳有限公司 用环糊精增加氟苯尼考及结构相关的抗生素的溶解度的化合物和方法
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
CN105640952A (zh) 2007-06-27 2016-06-08 杜邦公司 动物虫害控制方法
US7550625B2 (en) * 2007-10-19 2009-06-23 Idexx Laboratories Esters of florfenicol
CA2705063C (fr) 2007-11-09 2013-02-05 Intervet International B.V. Formulation solide a liberation rapide, sa preparation et son utilisation
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
US8314252B2 (en) 2008-07-30 2012-11-20 Intervet Inc. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
CN101337916B (zh) * 2008-08-12 2011-02-16 张家港市恒盛药用化学有限公司 氟苯尼考磺酸酯及其盐以及它们的制备方法
MX2012001651A (es) 2009-08-05 2012-03-16 Du Pont Pesticidas mesoionicos.
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
CN102574815A (zh) 2009-08-05 2012-07-11 杜邦公司 介离子杀虫剂
BRPI1002023A2 (pt) 2010-03-01 2011-10-25 Nanocore Biotecnologia S A forma farmacêutica sólida de dissolução rápida para tratamento de infecções bacterianas
UY33397A (es) 2010-05-27 2011-12-01 Du Pont Forma sólida de un naftaleno carboxamida
CN101921214B (zh) * 2010-08-03 2013-04-10 复旦大学 反式对甲砜基肉桂醇的合成方法
WO2012087630A1 (fr) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Composés de pyridine et de pyrimidine utilisés pour lutter contre des nuisibles invertébrés
WO2012105574A1 (fr) * 2011-01-31 2012-08-09 国立大学法人長崎大学 Procédé de fabrication d'un composé optiquement actif ou d'un sel de celui-ci
CN102417472B (zh) * 2011-12-12 2013-11-13 齐鲁动物保健品有限公司 一种氟苯尼考的制备方法
WO2013158422A1 (fr) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Composés hétérocycliques pour la lutte contre des animaux nuisibles invertébrés
CN102827042B (zh) * 2012-09-17 2013-11-06 湖北美天生物科技有限公司 氟苯尼考的手性合成方法
CN102863361B (zh) * 2012-10-17 2014-03-12 湖北美天生物科技有限公司 甲砜霉素的手性催化合成方法
CN102911133B (zh) * 2012-10-31 2014-07-02 绍兴民生医药有限公司 (4r,5r)-2-二氯甲基-4,5-二氢-5-(4-甲砜基苯基)-4-恶唑甲醇的纯化方法
CN103336072A (zh) * 2013-06-19 2013-10-02 湖北龙翔药业有限公司 一种测定氟苯尼考中手性活性成分含量的方法
CN103880719A (zh) * 2014-03-27 2014-06-25 张家港威胜生物医药有限公司 一种制备氟苯尼考琥珀酸酯的方法
EP3133061B1 (fr) * 2014-04-16 2024-03-20 Masteam Bio-tech Co. Ltd. Procédé de synthèse de florfénicol
CN103980167B (zh) * 2014-04-17 2016-06-08 天津大学 一种无定形氟苯尼考及其制备方法
CN106349130B (zh) * 2016-08-25 2018-01-23 潍坊大有生物化工有限公司 一种新的氟苯尼考的合成方法
CN111153838B (zh) * 2020-01-19 2021-08-24 浙江大学宁波理工学院 一种氟苯尼考的合成方法
CN113185473B (zh) * 2021-06-30 2021-10-08 山东国邦药业有限公司 一种氟苯尼考中间体氟甲砜噁唑的制备方法

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US4235892A (en) * 1979-02-05 1980-11-25 Schering Corporation, Patent Dept. 1-Aryl-2-acylamido-3-fluoro-1-propanols, methods for their use as antibacterial agents and compositions useful therefor
ES488154A0 (es) * 1979-02-05 1981-04-16 Schering Corp Un procedimiento para la preparacion de un compuesto d-(treo-1-aril-2-acilamido-3-fluor-1-propanol
US4361557A (en) * 1980-01-28 1982-11-30 Schering Corporation 1-Aryl-2-acylamido-3-fluoro-1-propanol acylates, methods for their use as anti-bacterial agents and compositions useful therefor
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Also Published As

Publication number Publication date
FI952872A0 (fi) 1995-06-12
HUT72669A (en) 1996-05-28
AU676003B2 (en) 1997-02-27
FI109295B (fi) 2002-06-28
KR100284216B1 (ko) 2001-04-02
WO1994014764A1 (fr) 1994-07-07
US5352832A (en) 1994-10-04
CA2152089C (fr) 2006-10-24
JPH08504819A (ja) 1996-05-28
NZ259239A (en) 1996-04-26
UA43331C2 (uk) 2001-12-17
DE69320986D1 (de) 1998-10-15
SK77795A3 (en) 1995-12-06
KR950704244A (ko) 1995-11-17
PL309393A1 (en) 1995-10-02
HU9501776D0 (en) 1995-08-28
EP0674618A1 (fr) 1995-10-04
EP0674618B1 (fr) 1998-09-09
NO303575B1 (no) 1998-08-03
RU2126383C1 (ru) 1999-02-20
FI952872A (fi) 1995-06-12
PL177891B1 (pl) 2000-01-31
ES2120605T3 (es) 1998-11-01
CZ159895A3 (en) 1996-01-17
NO952425L (no) 1995-06-16
JP3428016B2 (ja) 2003-07-22
DE69320986T2 (de) 1999-03-04
AU5748494A (en) 1994-07-19
ATE170835T1 (de) 1998-09-15
CA2152089A1 (fr) 1994-07-07
NO952425D0 (no) 1995-06-16
DK0674618T3 (da) 1999-02-22
CZ287461B6 (en) 2000-11-15
HU225110B1 (en) 2006-06-28

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Legal Events

Date Code Title Description
TC4A Change of owner's name

Owner name: MERCK SHARP & DOHME CORP., RAHWAY, NJ, US

Effective date: 20121108

MK4A Patent expired

Expiry date: 20131215