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SI2598503T1 - Derivati cis-tetrahidro-spiro(cikloheksan-1,1'-pirido(3,4-b)indol)-4-amina - Google Patents

Derivati cis-tetrahidro-spiro(cikloheksan-1,1'-pirido(3,4-b)indol)-4-amina

Info

Publication number
SI2598503T1
SI2598503T1 SI201130137T SI201130137T SI2598503T1 SI 2598503 T1 SI2598503 T1 SI 2598503T1 SI 201130137 T SI201130137 T SI 201130137T SI 201130137 T SI201130137 T SI 201130137T SI 2598503 T1 SI2598503 T1 SI 2598503T1
Authority
SI
Slovenia
Prior art keywords
pyridoš3
bćindol
cyclohexan
spiro
tetrahydro
Prior art date
Application number
SI201130137T
Other languages
English (en)
Inventor
Klaus Linz
Saskia Zemolka
Bert Nolte
Stefan Schunk
Hans Schick
Original Assignee
Grunenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44315152&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2598503(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Grunenthal Gmbh filed Critical Grunenthal Gmbh
Publication of SI2598503T1 publication Critical patent/SI2598503T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI201130137T 2010-07-28 2011-07-27 Derivati cis-tetrahidro-spiro(cikloheksan-1,1'-pirido(3,4-b)indol)-4-amina SI2598503T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10007822 2010-07-28
PCT/EP2011/003771 WO2012013343A1 (de) 2010-07-28 2011-07-27 Cis-tetrahydro-spiro(cyclohexan-1,1'-pyrido[3,4-b]indol)-4-amin-derivate
EP11737904.0A EP2598503B1 (de) 2010-07-28 2011-07-27 Cis-tetrahydro-spiro(cyclohexan-1,1'-pyrido[3,4-b]indol)-4-amin-derivate

Publications (1)

Publication Number Publication Date
SI2598503T1 true SI2598503T1 (sl) 2014-05-30

Family

ID=44315152

Family Applications (2)

Application Number Title Priority Date Filing Date
SI201131631T SI2740476T1 (sl) 2010-07-28 2011-07-27 Derivati cis-tetrahidro-spiro(cikloheksan-1,1'-pirido(3,4-b)indol)-4-amina
SI201130137T SI2598503T1 (sl) 2010-07-28 2011-07-27 Derivati cis-tetrahidro-spiro(cikloheksan-1,1'-pirido(3,4-b)indol)-4-amina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SI201131631T SI2740476T1 (sl) 2010-07-28 2011-07-27 Derivati cis-tetrahidro-spiro(cikloheksan-1,1'-pirido(3,4-b)indol)-4-amina

Country Status (32)

Country Link
US (3) US20120029006A1 (sl)
EP (2) EP2740476B1 (sl)
JP (1) JP5898193B2 (sl)
KR (1) KR101927054B1 (sl)
CN (1) CN103025732B (sl)
AR (1) AR082393A1 (sl)
AU (1) AU2011285217B8 (sl)
BR (1) BR112013003642A2 (sl)
CA (1) CA2806633C (sl)
CL (1) CL2013000266A1 (sl)
CO (1) CO6650378A2 (sl)
CY (2) CY1115186T1 (sl)
DK (2) DK2598503T3 (sl)
EC (1) ECSP13012409A (sl)
ES (2) ES2708930T3 (sl)
HK (1) HK1183660A1 (sl)
HR (2) HRP20140569T1 (sl)
HU (1) HUE042732T2 (sl)
IL (1) IL223756A (sl)
LT (1) LT2740476T (sl)
MX (1) MX2013000751A (sl)
NZ (1) NZ607529A (sl)
PE (1) PE20130808A1 (sl)
PL (2) PL2598503T3 (sl)
PT (2) PT2598503E (sl)
RS (2) RS53341B (sl)
RU (1) RU2592283C2 (sl)
SI (2) SI2740476T1 (sl)
TR (1) TR201821273T4 (sl)
TW (1) TWI582092B (sl)
WO (1) WO2012013343A1 (sl)
ZA (1) ZA201301505B (sl)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2970284T1 (sl) 2013-03-15 2018-02-28 Gruenenthal Gmbh Kristalinični cis-(E)-4-(3-fluorofenil)-2',3',4',9'-tetrahidro-N,N-dimetil-2'-(1-okso- 3-fenil-2-propenil)-spiro(cikloheksan-1,1'(1H)-pirido(3,4-b)indol)-4- amin
US9907786B2 (en) 2014-10-21 2018-03-06 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof
US10092550B2 (en) 2014-10-21 2018-10-09 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof
PT3402781T (pt) 2016-01-13 2020-07-07 Gruenenthal Gmbh Derivados de 3-((hetero-)aril)-8-amino-2-oxo-1,3-diazaespiro[ 4.5]decano
WO2017121649A1 (en) 2016-01-13 2017-07-20 Grünenthal GmbH 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
US20170197947A1 (en) 2016-01-13 2017-07-13 Gruenenthal Gmbh 3-((Hetero-)Aryl)-Alkyl-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives
PT3402783T (pt) 2016-01-13 2020-07-03 Gruenenthal Gmbh Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diazaespiro- [4,5]-decano
PT3402782T (pt) 2016-01-13 2020-10-01 Gruenenthal Gmbh Derivados de 8-amino-2-oxo-1,3-diaza-spiro-[4,5]-decano
RU2743513C2 (ru) 2016-01-26 2021-02-19 Интра-Селлулар Терапиз, Инк. Органические соединения
TW201832765A (zh) 2017-02-24 2018-09-16 德商歌林達有限公司 膀胱內投藥用於治療膀胱痛之組合物
TW201908295A (zh) 2017-07-12 2019-03-01 德商歌林達有限公司 １，３－二氮雜－螺－［３．４］－辛烷衍生物
JP2019073493A (ja) * 2017-10-17 2019-05-16 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ヴルヴォディニアの治療
WO2020030777A1 (en) 2018-08-10 2020-02-13 Grünenthal GmbH Composition for treating urinary frequency and/or urinary urgency
AU2020254812A1 (en) * 2019-04-04 2021-11-11 Intra-Cellular Therapies, Inc. Methods of treating neuropathic pain
IL294202A (en) 2019-12-26 2022-08-01 Gilgamesh Pharmaceuticals Inc History of arylcyclohexylamine and their use in the treatment of psychiatric disorders
RU2725197C1 (ru) * 2020-02-12 2020-06-30 федеральное государственное бюджетное образовательное учреждение высшего образования «Ижевская государственная медицинская академия» Министерства здравоохранения Российской Федерации Метод оценки висцеральной гиперчувствительности
EP4084791A1 (en) 2020-02-18 2022-11-09 Gilgamesh Pharmaceuticals, Inc. Specific tryptamines for use in the treatment of mood disorders
US12129265B2 (en) 2020-07-21 2024-10-29 Ankh Life Sciences Limited Therapeutic agents and uses thereof
US12129234B1 (en) 2023-08-03 2024-10-29 Gilgamesh Pharmaceuticals, Inc. Crystalline salts of N-ethyl-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10323172A1 (de) 2003-05-22 2004-12-09 Ina-Schaeffler Kg Treiberstufe für ein Solenoidventil
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360793A1 (de) 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102004019502A1 (de) 2004-04-22 2005-11-17 Rheinmetall Landsysteme Gmbh Munitionsmagazin
DE102004039382A1 (de) 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
US8425881B2 (en) 2005-03-18 2013-04-23 Colgate-Palmolive Company Antibacterial 3′,5-disubstituted 2,4′-dihydroxybiphenyl compounds, derivatives and related methods
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
JP4819878B2 (ja) 2005-04-12 2011-11-24 ジ・オハイオ・ステート・ユニバーシティ 全輪駆動用の電気的に可変なトランスミッション
WO2007112490A1 (en) 2006-03-30 2007-10-11 Innovative Dairy Products Pty Ltd As Trustee For The Participants Of The Cooperative Research Centre For Innovative Dairy Products Chromosomal blocks as markers for traits
WO2007117173A1 (en) 2006-04-07 2007-10-18 Closed Joint Stock Company 'biocad' Fluid dispensing system, methods and products
DE102006019597A1 (de) * 2006-04-27 2007-10-31 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006033114A1 (de) 2006-07-18 2008-01-24 Grünenthal GmbH Spirocyclische Azaindol-Derivate
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
US20080201095A1 (en) 2007-02-12 2008-08-21 Yip Ping F Method for Calibrating an Analytical Instrument
ATE525379T1 (de) * 2008-03-27 2011-10-15 Gruenenthal Gmbh Substituierte spirocyclische cyclohexan-derivate
SI2970284T1 (sl) * 2013-03-15 2018-02-28 Gruenenthal Gmbh Kristalinični cis-(E)-4-(3-fluorofenil)-2',3',4',9'-tetrahidro-N,N-dimetil-2'-(1-okso- 3-fenil-2-propenil)-spiro(cikloheksan-1,1'(1H)-pirido(3,4-b)indol)-4- amin

Also Published As

Publication number Publication date
AU2011285217B2 (en) 2014-04-10
HK1183660A1 (en) 2014-01-03
US20160159787A1 (en) 2016-06-09
CA2806633C (en) 2019-08-20
SI2740476T1 (sl) 2019-02-28
DK2598503T3 (da) 2014-04-14
PT2740476T (pt) 2019-03-18
ECSP13012409A (es) 2013-06-28
HRP20182078T1 (hr) 2019-02-08
CO6650378A2 (es) 2013-04-15
PT2598503E (pt) 2014-05-06
EP2740476B1 (de) 2018-12-05
HRP20140569T1 (hr) 2014-08-15
CL2013000266A1 (es) 2013-05-24
WO2012013343A1 (de) 2012-02-02
KR101927054B1 (ko) 2018-12-10
CY1120993T1 (el) 2019-12-11
JP5898193B2 (ja) 2016-04-06
IL223756A (en) 2015-06-30
PL2740476T3 (pl) 2019-06-28
RU2013108696A (ru) 2014-09-10
CA2806633A1 (en) 2012-02-02
TWI582092B (zh) 2017-05-11
DK2740476T3 (en) 2019-01-14
US20170313703A1 (en) 2017-11-02
AU2011285217A8 (en) 2014-04-24
EP2740476A1 (de) 2014-06-11
NZ607529A (en) 2014-05-30
PL2598503T3 (pl) 2014-08-29
ES2474644T3 (es) 2014-07-09
RS53341B (en) 2014-10-31
JP2013532669A (ja) 2013-08-19
CN103025732B (zh) 2016-06-01
RU2592283C2 (ru) 2016-07-20
AU2011285217B8 (en) 2014-04-24
EP2598503A1 (de) 2013-06-05
PE20130808A1 (es) 2013-07-06
ES2708930T3 (es) 2019-04-12
KR20130098315A (ko) 2013-09-04
TW201204724A (en) 2012-02-01
EP2598503B1 (de) 2014-03-26
BR112013003642A2 (pt) 2016-09-06
AR082393A1 (es) 2012-12-05
LT2740476T (lt) 2018-12-27
TR201821273T4 (tr) 2019-01-21
CY1115186T1 (el) 2017-01-04
US20120029006A1 (en) 2012-02-02
AU2011285217A1 (en) 2013-03-14
HUE042732T2 (hu) 2019-07-29
ZA201301505B (en) 2014-08-27
MX2013000751A (es) 2013-01-29
RS58036B1 (sr) 2019-02-28
CN103025732A (zh) 2013-04-03

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