ECSP13012409A - Derivados de amina cis-tetrahidro-espiro(ciclohexan-1,1'-pirido[3,4-b]indol)-4 - Google Patents
Derivados de amina cis-tetrahidro-espiro(ciclohexan-1,1'-pirido[3,4-b]indol)-4Info
- Publication number
- ECSP13012409A ECSP13012409A ECSP13012409A ECSP13012409A EC SP13012409 A ECSP13012409 A EC SP13012409A EC SP13012409 A ECSP13012409 A EC SP13012409A EC SP13012409 A ECSP13012409 A EC SP13012409A
- Authority
- EC
- Ecuador
- Prior art keywords
- pain
- cis
- derivatives
- ciclohexan
- espiro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invención se refiere a los derivados de amina cis-tetrahidro-espiro(ciclohexan-1,1'-pirido[3,4-b]indol)-4, los cuales tienen efecto sobre el sistema de nociceptina/ receptor ORL-1 y también sobre el sistema receptor opioide µ, y que se presentan de manera más específica, por medio de una eficacia selectiva en el tratamiento del dolor crónico (entre otros, el dolor inflamatorio, el dolor visceral, el dolor de tumores, de preferencia, el dolor neuropático), sin mostrar al mismo tiempo una eficacia pronunciada en el dolor nociceptivo agudo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10007822 | 2010-07-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP13012409A true ECSP13012409A (es) | 2013-06-28 |
Family
ID=44315152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP13012409 ECSP13012409A (es) | 2010-07-28 | 2013-01-28 | Derivados de amina cis-tetrahidro-espiro(ciclohexan-1,1'-pirido[3,4-b]indol)-4 |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US20120029006A1 (es) |
| EP (2) | EP2740476B1 (es) |
| JP (1) | JP5898193B2 (es) |
| KR (1) | KR101927054B1 (es) |
| CN (1) | CN103025732B (es) |
| AR (1) | AR082393A1 (es) |
| AU (1) | AU2011285217B8 (es) |
| BR (1) | BR112013003642A2 (es) |
| CA (1) | CA2806633C (es) |
| CL (1) | CL2013000266A1 (es) |
| CO (1) | CO6650378A2 (es) |
| CY (2) | CY1115186T1 (es) |
| DK (2) | DK2598503T3 (es) |
| EC (1) | ECSP13012409A (es) |
| ES (2) | ES2708930T3 (es) |
| HK (1) | HK1183660A1 (es) |
| HR (2) | HRP20140569T1 (es) |
| HU (1) | HUE042732T2 (es) |
| IL (1) | IL223756A (es) |
| LT (1) | LT2740476T (es) |
| MX (1) | MX2013000751A (es) |
| NZ (1) | NZ607529A (es) |
| PE (1) | PE20130808A1 (es) |
| PL (2) | PL2598503T3 (es) |
| PT (2) | PT2598503E (es) |
| RS (2) | RS53341B (es) |
| RU (1) | RU2592283C2 (es) |
| SI (2) | SI2740476T1 (es) |
| TR (1) | TR201821273T4 (es) |
| TW (1) | TWI582092B (es) |
| WO (1) | WO2012013343A1 (es) |
| ZA (1) | ZA201301505B (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2970284T1 (en) | 2013-03-15 | 2018-02-28 | Gruenenthal Gmbh | Crystalline cis- (E) -4- (3-fluorophenyl) -2 ', 3', 4 ', 9'-tetrahydro-N, N-dimethyl-2' - (1-oxo-3-phenyl-2-propenyl ) -spiro (cyclohexane-1,1 '(1H) -pyrido (3,4-b) indol) -4-amine |
| US9907786B2 (en) | 2014-10-21 | 2018-03-06 | Ions Pharmaceutical S.À R.L. | Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof |
| US10092550B2 (en) | 2014-10-21 | 2018-10-09 | Ions Pharmaceutical S.À R.L. | Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof |
| PT3402781T (pt) | 2016-01-13 | 2020-07-07 | Gruenenthal Gmbh | Derivados de 3-((hetero-)aril)-8-amino-2-oxo-1,3-diazaespiro[ 4.5]decano |
| WO2017121649A1 (en) | 2016-01-13 | 2017-07-20 | Grünenthal GmbH | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| US20170197947A1 (en) | 2016-01-13 | 2017-07-13 | Gruenenthal Gmbh | 3-((Hetero-)Aryl)-Alkyl-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives |
| PT3402783T (pt) | 2016-01-13 | 2020-07-03 | Gruenenthal Gmbh | Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diazaespiro- [4,5]-decano |
| PT3402782T (pt) | 2016-01-13 | 2020-10-01 | Gruenenthal Gmbh | Derivados de 8-amino-2-oxo-1,3-diaza-spiro-[4,5]-decano |
| RU2743513C2 (ru) | 2016-01-26 | 2021-02-19 | Интра-Селлулар Терапиз, Инк. | Органические соединения |
| TW201832765A (zh) | 2017-02-24 | 2018-09-16 | 德商歌林達有限公司 | 膀胱內投藥用於治療膀胱痛之組合物 |
| TW201908295A (zh) | 2017-07-12 | 2019-03-01 | 德商歌林達有限公司 | １，３－二氮雜－螺－［３．４］－辛烷衍生物 |
| JP2019073493A (ja) * | 2017-10-17 | 2019-05-16 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ヴルヴォディニアの治療 |
| WO2020030777A1 (en) | 2018-08-10 | 2020-02-13 | Grünenthal GmbH | Composition for treating urinary frequency and/or urinary urgency |
| AU2020254812A1 (en) * | 2019-04-04 | 2021-11-11 | Intra-Cellular Therapies, Inc. | Methods of treating neuropathic pain |
| IL294202A (en) | 2019-12-26 | 2022-08-01 | Gilgamesh Pharmaceuticals Inc | History of arylcyclohexylamine and their use in the treatment of psychiatric disorders |
| RU2725197C1 (ru) * | 2020-02-12 | 2020-06-30 | федеральное государственное бюджетное образовательное учреждение высшего образования «Ижевская государственная медицинская академия» Министерства здравоохранения Российской Федерации | Метод оценки висцеральной гиперчувствительности |
| EP4084791A1 (en) | 2020-02-18 | 2022-11-09 | Gilgamesh Pharmaceuticals, Inc. | Specific tryptamines for use in the treatment of mood disorders |
| US12129265B2 (en) | 2020-07-21 | 2024-10-29 | Ankh Life Sciences Limited | Therapeutic agents and uses thereof |
| US12129234B1 (en) | 2023-08-03 | 2024-10-29 | Gilgamesh Pharmaceuticals, Inc. | Crystalline salts of N-ethyl-(5-fluoro-1H-indol-3-yl)-N-methylethan-1-amine |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10323172A1 (de) | 2003-05-22 | 2004-12-09 | Ina-Schaeffler Kg | Treiberstufe für ein Solenoidventil |
| DE10360792A1 (de) * | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE10360793A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102004019502A1 (de) | 2004-04-22 | 2005-11-17 | Rheinmetall Landsysteme Gmbh | Munitionsmagazin |
| DE102004039382A1 (de) | 2004-08-13 | 2006-02-23 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| US8425881B2 (en) | 2005-03-18 | 2013-04-23 | Colgate-Palmolive Company | Antibacterial 3′,5-disubstituted 2,4′-dihydroxybiphenyl compounds, derivatives and related methods |
| DE102005016460A1 (de) * | 2005-04-11 | 2006-10-19 | Grünenthal GmbH | Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit |
| JP4819878B2 (ja) | 2005-04-12 | 2011-11-24 | ジ・オハイオ・ステート・ユニバーシティ | 全輪駆動用の電気的に可変なトランスミッション |
| WO2007112490A1 (en) | 2006-03-30 | 2007-10-11 | Innovative Dairy Products Pty Ltd As Trustee For The Participants Of The Cooperative Research Centre For Innovative Dairy Products | Chromosomal blocks as markers for traits |
| WO2007117173A1 (en) | 2006-04-07 | 2007-10-18 | Closed Joint Stock Company 'biocad' | Fluid dispensing system, methods and products |
| DE102006019597A1 (de) * | 2006-04-27 | 2007-10-31 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| DE102006033114A1 (de) | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
| DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
| US20080201095A1 (en) | 2007-02-12 | 2008-08-21 | Yip Ping F | Method for Calibrating an Analytical Instrument |
| ATE525379T1 (de) * | 2008-03-27 | 2011-10-15 | Gruenenthal Gmbh | Substituierte spirocyclische cyclohexan-derivate |
| SI2970284T1 (en) * | 2013-03-15 | 2018-02-28 | Gruenenthal Gmbh | Crystalline cis- (E) -4- (3-fluorophenyl) -2 ', 3', 4 ', 9'-tetrahydro-N, N-dimethyl-2' - (1-oxo-3-phenyl-2-propenyl ) -spiro (cyclohexane-1,1 '(1H) -pyrido (3,4-b) indol) -4-amine |
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2011
- 2011-06-22 TW TW100121735A patent/TWI582092B/zh not_active IP Right Cessation
- 2011-07-27 AR ARP110102711A patent/AR082393A1/es not_active Application Discontinuation
- 2011-07-27 ES ES14000496T patent/ES2708930T3/es active Active
- 2011-07-27 CA CA2806633A patent/CA2806633C/en not_active Expired - Fee Related
- 2011-07-27 RU RU2013108696/04A patent/RU2592283C2/ru active
- 2011-07-27 DK DK11737904.0T patent/DK2598503T3/da active
- 2011-07-27 DK DK14000496.1T patent/DK2740476T3/en active
- 2011-07-27 PL PL11737904T patent/PL2598503T3/pl unknown
- 2011-07-27 PT PT117379040T patent/PT2598503E/pt unknown
- 2011-07-27 CN CN201180038485.8A patent/CN103025732B/zh not_active Expired - Fee Related
- 2011-07-27 MX MX2013000751A patent/MX2013000751A/es active IP Right Grant
- 2011-07-27 RS RS20140312A patent/RS53341B/en unknown
- 2011-07-27 RS RS20181491A patent/RS58036B1/sr unknown
- 2011-07-27 EP EP14000496.1A patent/EP2740476B1/de active Active
- 2011-07-27 AU AU2011285217A patent/AU2011285217B8/en not_active Ceased
- 2011-07-27 JP JP2013521013A patent/JP5898193B2/ja not_active Expired - Fee Related
- 2011-07-27 NZ NZ607529A patent/NZ607529A/en not_active IP Right Cessation
- 2011-07-27 BR BR112013003642A patent/BR112013003642A2/pt not_active IP Right Cessation
- 2011-07-27 LT LTEP14000496.1T patent/LT2740476T/lt unknown
- 2011-07-27 KR KR1020137004985A patent/KR101927054B1/ko active IP Right Grant
- 2011-07-27 WO PCT/EP2011/003771 patent/WO2012013343A1/de active Application Filing
- 2011-07-27 EP EP11737904.0A patent/EP2598503B1/de active Active
- 2011-07-27 ES ES11737904.0T patent/ES2474644T3/es active Active
- 2011-07-27 TR TR2018/21273T patent/TR201821273T4/tr unknown
- 2011-07-27 HU HUE14000496A patent/HUE042732T2/hu unknown
- 2011-07-27 PL PL14000496T patent/PL2740476T3/pl unknown
- 2011-07-27 PE PE2013000150A patent/PE20130808A1/es active IP Right Grant
- 2011-07-27 SI SI201131631T patent/SI2740476T1/sl unknown
- 2011-07-27 PT PT14000496T patent/PT2740476T/pt unknown
- 2011-07-27 SI SI201130137T patent/SI2598503T1/sl unknown
- 2011-07-28 US US13/192,641 patent/US20120029006A1/en not_active Abandoned
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2012
- 2012-12-20 IL IL223756A patent/IL223756A/en active IP Right Grant
-
2013
- 2013-01-28 CL CL2013000266A patent/CL2013000266A1/es unknown
- 2013-01-28 EC ECSP13012409 patent/ECSP13012409A/es unknown
- 2013-01-28 CO CO13014969A patent/CO6650378A2/es not_active Application Discontinuation
- 2013-02-27 ZA ZA2013/01505A patent/ZA201301505B/en unknown
- 2013-08-16 HK HK13109586.6A patent/HK1183660A1/xx not_active IP Right Cessation
-
2014
- 2014-05-13 CY CY20141100338T patent/CY1115186T1/el unknown
- 2014-06-17 HR HRP20140569AT patent/HRP20140569T1/hr unknown
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2015
- 2015-09-04 US US14/846,155 patent/US20160159787A1/en not_active Abandoned
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2017
- 2017-07-19 US US15/654,389 patent/US20170313703A1/en not_active Abandoned
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2018
- 2018-12-10 HR HRP20182078TT patent/HRP20182078T1/hr unknown
- 2018-12-12 CY CY181101335T patent/CY1120993T1/el unknown
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