PT3402782T - Derivados de 8-amino-2-oxo-1,3-diaza-spiro-[4,5]-decano - Google Patents
Derivados de 8-amino-2-oxo-1,3-diaza-spiro-[4,5]-decanoInfo
- Publication number
- PT3402782T PT3402782T PT177003902T PT17700390T PT3402782T PT 3402782 T PT3402782 T PT 3402782T PT 177003902 T PT177003902 T PT 177003902T PT 17700390 T PT17700390 T PT 17700390T PT 3402782 T PT3402782 T PT 3402782T
- Authority
- PT
- Portugal
- Prior art keywords
- diaza
- spiro
- oxo
- amino
- decane derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16151015 | 2016-01-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3402782T true PT3402782T (pt) | 2020-10-01 |
Family
ID=55129636
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT177003902T PT3402782T (pt) | 2016-01-13 | 2017-01-13 | Derivados de 8-amino-2-oxo-1,3-diaza-spiro-[4,5]-decano |
Country Status (26)
| Country | Link |
|---|---|
| US (7) | US20170197949A1 (pt) |
| EP (1) | EP3402782B1 (pt) |
| JP (1) | JP6917379B2 (pt) |
| KR (1) | KR20180097734A (pt) |
| CN (1) | CN108602778B (pt) |
| AR (1) | AR107359A1 (pt) |
| AU (1) | AU2017206911B2 (pt) |
| BR (1) | BR112018014301B1 (pt) |
| CA (1) | CA3011182A1 (pt) |
| CL (1) | CL2018001909A1 (pt) |
| CO (1) | CO2018008450A2 (pt) |
| CY (1) | CY1123366T1 (pt) |
| DK (1) | DK3402782T3 (pt) |
| EA (1) | EA034898B1 (pt) |
| EC (1) | ECSP18060875A (pt) |
| ES (1) | ES2821969T3 (pt) |
| HR (1) | HRP20201660T1 (pt) |
| HU (1) | HUE051642T2 (pt) |
| IL (1) | IL260488B (pt) |
| LT (1) | LT3402782T (pt) |
| MX (1) | MX2018008645A (pt) |
| PT (1) | PT3402782T (pt) |
| RS (1) | RS60855B1 (pt) |
| SI (1) | SI3402782T1 (pt) |
| TW (1) | TWI654181B (pt) |
| WO (1) | WO2017121650A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3402783T (pt) | 2016-01-13 | 2020-07-03 | Gruenenthal Gmbh | Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diazaespiro- [4,5]-decano |
| PT3402781T (pt) | 2016-01-13 | 2020-07-07 | Gruenenthal Gmbh | Derivados de 3-((hetero-)aril)-8-amino-2-oxo-1,3-diazaespiro[ 4.5]decano |
| PT3402782T (pt) | 2016-01-13 | 2020-10-01 | Gruenenthal Gmbh | Derivados de 8-amino-2-oxo-1,3-diaza-spiro-[4,5]-decano |
| US20170197947A1 (en) | 2016-01-13 | 2017-07-13 | Gruenenthal Gmbh | 3-((Hetero-)Aryl)-Alkyl-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives |
| WO2017121649A1 (en) | 2016-01-13 | 2017-07-20 | Grünenthal GmbH | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| WO2019039852A1 (ko) | 2017-08-22 | 2019-02-28 | 주식회사 엘지화학 | 방열 소재 디스펜싱 장치의 결정방법 |
| CN110092790B (zh) * | 2019-06-11 | 2020-07-24 | 东北农业大学 | 一种生物碱类化合物及其制备方法和应用 |
| WO2024223726A1 (en) | 2023-04-25 | 2024-10-31 | Grünenthal GmbH | Cis-8-(3,5-difluorophenyl)-8-(dimethylamino)-1,3-diazaspiro[4.5]decan-2-one derivatives |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2734265B1 (fr) | 1995-05-17 | 1997-06-13 | Adir | Nouveaux composes spiro heterocycliques, leur procede de preparation et les compositions pharmaceutiques les contenant |
| KR100722207B1 (ko) | 2001-04-18 | 2007-05-29 | 유로-셀티크 소시에떼 아노뉨 | 노시셉틴 유사체 |
| DE10130020A1 (de) | 2001-06-25 | 2003-12-04 | Gruenenthal Gmbh | Substituierte 1-Oxa-2,8-diaza-spiro[4.5]dec-2-en-derivate |
| DE10135636A1 (de) * | 2001-07-17 | 2003-02-06 | Gruenenthal Gmbh | Substituierte 4-Aminocyclohexanole |
| DE10210195B4 (de) | 2002-03-07 | 2005-12-15 | Schwarz Pharma Ag | Verwendung von 1,3-Diazaspiro-[4,5]decan-2,4-dithion zur Behandlung von Schmerz |
| ES2355157T3 (es) | 2002-07-05 | 2011-03-23 | Targacept, Inc. | Compuestos diazaspirocíclico n-arilo y métodos de preparación y uso de las mismas. |
| DE10252667A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| US20080287478A1 (en) | 2003-05-23 | 2008-11-20 | Lars Bo Laurenborg Hansen | Nociceptin Analogues and Uses Thereof |
| JO2676B1 (en) | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
| DE102005044813A1 (de) | 2005-05-19 | 2007-10-04 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| DE102005023784A1 (de) | 2005-05-19 | 2006-11-30 | Grünenthal GmbH | Substituierte Spiro-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| DE102005030051A1 (de) | 2005-06-27 | 2006-12-28 | Grünenthal GmbH | Substituierte 1-Oxa-3,8-diazaspiro[4,5]-decan-2-on-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln |
| DE102006019597A1 (de) | 2006-04-27 | 2007-10-31 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
| EP2104665A2 (en) | 2006-10-19 | 2009-09-30 | F. Hoffmann-Roche AG | Imidazolone and imidazolidinone derivatives as 11b-hsd1 inhibitors for diabetes |
| JP5490677B2 (ja) | 2007-04-09 | 2014-05-14 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 不安及び鬱病の処置のためのｏｒｌ−１受容体リガンドとしての１，３，８−三置換−１，３，８−トリアザ−スピロ［４．５］デカン−４−オン誘導体 |
| EP2260021B1 (de) * | 2008-03-27 | 2014-04-23 | Grünenthal GmbH | Substituierte 4-aminocyclohexan-derivate |
| TW201038572A (en) | 2009-03-25 | 2010-11-01 | Gruenenthal Gmbh | Substituted spiro-amide compounds |
| WO2010151815A2 (en) | 2009-06-25 | 2010-12-29 | Abbott Laboratories | 3,9-diazaspiro[5,5]undecane amides and ureas and methods of use thereof |
| TWI582092B (zh) | 2010-07-28 | 2017-05-11 | 歌林達股份有限公司 | 順式－四氫－螺旋（環己烷－１,１’－吡啶［３,４－b］吲哚）－４－胺－衍生物 |
| AU2013369649B2 (en) * | 2012-12-31 | 2018-07-26 | Sunovion Pharmaceuticals Inc. | Heterocyclic compounds and methods of use thereof |
| CN106103416B (zh) * | 2014-03-14 | 2021-03-02 | 拉夸里亚创药株式会社 | 作为trpm8拮抗剂的氮杂螺衍生物 |
| US10131666B2 (en) | 2014-06-13 | 2018-11-20 | Purdue Pharma L.P. | Heterocyclic morphinan derivatives and use thereof |
| PT3402783T (pt) | 2016-01-13 | 2020-07-03 | Gruenenthal Gmbh | Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diazaespiro- [4,5]-decano |
| AR107354A1 (es) | 2016-01-13 | 2018-04-18 | Bristol Myers Squibb Co | Salicilamidas espiroheptanos y compuestos relacionados como inhibidores de rock |
| US20170197947A1 (en) | 2016-01-13 | 2017-07-13 | Gruenenthal Gmbh | 3-((Hetero-)Aryl)-Alkyl-8-Amino-2-Oxo-1,3-Diaza-Spiro-[4.5]-Decane Derivatives |
| PT3402782T (pt) | 2016-01-13 | 2020-10-01 | Gruenenthal Gmbh | Derivados de 8-amino-2-oxo-1,3-diaza-spiro-[4,5]-decano |
| WO2017121649A1 (en) | 2016-01-13 | 2017-07-20 | Grünenthal GmbH | 3-(carboxymethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives |
| PT3402781T (pt) | 2016-01-13 | 2020-07-07 | Gruenenthal Gmbh | Derivados de 3-((hetero-)aril)-8-amino-2-oxo-1,3-diazaespiro[ 4.5]decano |
| AU2017207862B2 (en) | 2016-01-13 | 2020-12-17 | Novo Nordisk A/S | EGF(A) analogues with fatty acid substituents |
-
2017
- 2017-01-13 PT PT177003902T patent/PT3402782T/pt unknown
- 2017-01-13 CA CA3011182A patent/CA3011182A1/en active Pending
- 2017-01-13 WO PCT/EP2017/025008 patent/WO2017121650A1/en active Application Filing
- 2017-01-13 AU AU2017206911A patent/AU2017206911B2/en active Active
- 2017-01-13 DK DK17700390.2T patent/DK3402782T3/da active
- 2017-01-13 RS RS20201155A patent/RS60855B1/sr unknown
- 2017-01-13 ES ES17700390T patent/ES2821969T3/es active Active
- 2017-01-13 US US15/405,627 patent/US20170197949A1/en not_active Abandoned
- 2017-01-13 AR ARP170100094A patent/AR107359A1/es unknown
- 2017-01-13 CO CONC2018/0008450A patent/CO2018008450A2/es unknown
- 2017-01-13 LT LTEP17700390.2T patent/LT3402782T/lt unknown
- 2017-01-13 BR BR112018014301-4A patent/BR112018014301B1/pt active IP Right Grant
- 2017-01-13 JP JP2018536384A patent/JP6917379B2/ja active Active
- 2017-01-13 EA EA201891608A patent/EA034898B1/ru not_active IP Right Cessation
- 2017-01-13 CN CN201780006515.4A patent/CN108602778B/zh active Active
- 2017-01-13 HU HUE17700390A patent/HUE051642T2/hu unknown
- 2017-01-13 KR KR1020187021559A patent/KR20180097734A/ko active IP Right Grant
- 2017-01-13 EP EP17700390.2A patent/EP3402782B1/en active Active
- 2017-01-13 TW TW106101127A patent/TWI654181B/zh active
- 2017-01-13 MX MX2018008645A patent/MX2018008645A/es unknown
- 2017-01-13 SI SI201730473T patent/SI3402782T1/sl unknown
-
2018
- 2018-05-21 US US15/984,995 patent/US20180273516A1/en not_active Abandoned
- 2018-07-09 IL IL260488A patent/IL260488B/en unknown
- 2018-07-13 CL CL2018001909A patent/CL2018001909A1/es unknown
- 2018-08-13 EC ECSENADI201860875A patent/ECSP18060875A/es unknown
- 2018-12-03 US US16/207,916 patent/US20190100515A1/en not_active Abandoned
-
2019
- 2019-06-24 US US16/450,259 patent/US10793556B2/en active Active
-
2020
- 2020-08-31 US US17/007,150 patent/US20200399255A1/en not_active Abandoned
- 2020-09-28 CY CY20201100913T patent/CY1123366T1/el unknown
- 2020-10-14 HR HRP20201660TT patent/HRP20201660T1/hr unknown
-
2021
- 2021-03-01 US US17/188,706 patent/US20210179595A1/en not_active Abandoned
-
2023
- 2023-01-30 US US18/103,371 patent/US20230183222A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL264092A (en) | 1, 3-dihydroxy-phenyl derivatives are useful as immunomodulators | |
| IL260488B (en) | History of 8-amino-2-oxo-3,1-diaza-spiro-[5.4]-decane | |
| IL260491B (en) | History of 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-3,1-diaza-spiro-[5.4]-decane | |
| IL260497B (en) | History of 3-(Carboxymethyl)-8-amino-2-oxo-3,1-diaza-spiro-[5.4]-decane | |
| IL285355A (en) | History of 3-((hetero-)aryl)-8-amino-2-oxo-3,1-diaza-spiro-[5.4]-decane | |
| IL260495B (en) | History of 3-(carboxyethyl)-8-amino-2-oxo-3,1-diaza-spiro-[5.4]-decane | |
| SG11201803584RA (en) | 1,4-dicarbonyl-piperidyl derivatives | |
| HK1254800A1 (zh) | 2，3，4，5-四氫吡啶-6-胺衍生物 | |
| HRP20180940T1 (hr) | Derivati supstituiranog azaspiro(4,5)dekana | |
| GB201716156D0 (en) | Mrbr.4. | |
| GB201618461D0 (en) | Mrbr.3 | |
| GB201611093D0 (en) | . | |
| GB201605155D0 (en) | Supervoucher.com | |
| GB201600418D0 (en) | Products, uses & methods (1.2) | |
| GB201519732D0 (en) | Mrbr.2 | |
| AU2016037V (en) | P090502 Plectranthus hilliardiae x P. saccatus |