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SI1682541T1 - Postopek za pripravo tiotropijevih soli - Google Patents

Postopek za pripravo tiotropijevih soli

Info

Publication number
SI1682541T1
SI1682541T1 SI200431403T SI200431403T SI1682541T1 SI 1682541 T1 SI1682541 T1 SI 1682541T1 SI 200431403 T SI200431403 T SI 200431403T SI 200431403 T SI200431403 T SI 200431403T SI 1682541 T1 SI1682541 T1 SI 1682541T1
Authority
SI
Slovenia
Prior art keywords
tiotropium salts
producing tiotropium
producing
salts
tiotropium
Prior art date
Application number
SI200431403T
Other languages
English (en)
Inventor
Rolf Banholzer
Waldemar Pfrengle
Peter Sieger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530660&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI1682541(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of SI1682541T1 publication Critical patent/SI1682541T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200431403T 2003-11-03 2004-10-29 Postopek za pripravo tiotropijevih soli SI1682541T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03025075 2003-11-03
PCT/EP2004/012268 WO2005042526A1 (de) 2003-11-03 2004-10-29 Verfahren zur herstellung von tiotropiumsalze, tiotropiumsalze sowie arzneimitte lformulierungen diese enthaltend
EP04791028A EP1682541B1 (de) 2003-11-03 2004-10-29 Verfahren zur herstellung von tiotropiumsalzen

Publications (1)

Publication Number Publication Date
SI1682541T1 true SI1682541T1 (sl) 2010-06-30

Family

ID=34530660

Family Applications (2)

Application Number Title Priority Date Filing Date
SI200431403T SI1682541T1 (sl) 2003-11-03 2004-10-29 Postopek za pripravo tiotropijevih soli
SI200432055T SI2067779T1 (sl) 2003-11-03 2004-10-29 Tiotropijeve soli, postopek za njihovo pripravo in formulacije zdravil, ki jih vsebujejo

Family Applications After (1)

Application Number Title Priority Date Filing Date
SI200432055T SI2067779T1 (sl) 2003-11-03 2004-10-29 Tiotropijeve soli, postopek za njihovo pripravo in formulacije zdravil, ki jih vsebujejo

Country Status (35)

Country Link
US (1) US8686148B2 (sl)
EP (3) EP1682541B1 (sl)
JP (1) JP5165244B2 (sl)
KR (1) KR20060117334A (sl)
CN (3) CN102070630B (sl)
AR (1) AR046317A1 (sl)
AT (1) ATE460414T1 (sl)
AU (1) AU2004285683C1 (sl)
BR (1) BRPI0416136A (sl)
CA (1) CA2544348A1 (sl)
CO (1) CO5690553A2 (sl)
CY (2) CY1110048T1 (sl)
DE (1) DE502004010885D1 (sl)
DK (2) DK1682541T3 (sl)
EA (1) EA012326B1 (sl)
ES (2) ES2342468T3 (sl)
HK (3) HK1099748A1 (sl)
HR (1) HRP20100149T1 (sl)
IL (1) IL175023A (sl)
ME (1) ME00361B (sl)
MX (1) MXPA06004697A (sl)
MY (1) MY143364A (sl)
NO (1) NO335814B1 (sl)
NZ (1) NZ547276A (sl)
PE (1) PE20050446A1 (sl)
PL (2) PL2067779T3 (sl)
PT (2) PT2067779E (sl)
RS (2) RS20060292A (sl)
SG (1) SG137859A1 (sl)
SI (2) SI1682541T1 (sl)
TW (2) TWI363758B (sl)
UA (1) UA82413C2 (sl)
UY (1) UY28590A1 (sl)
WO (1) WO2005042526A1 (sl)
ZA (1) ZA200602342B (sl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE502004010885D1 (de) 2003-11-03 2010-04-22 Boehringer Ingelheim Pharma Verfahren zur herstellung von tiotropiumsalzen
ES2422730T3 (es) * 2003-11-03 2013-09-13 Boehringer Ingelheim Int Sales de tiotropio, procedimiento para su preparación, así como formulaciones de medicamentos que las contienen
US20060079544A1 (en) * 2004-08-13 2006-04-13 Boehringer Ingelheim International Gmbh Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
RU2418796C2 (ru) * 2005-06-15 2011-05-20 Берингер Ингельхайм Интернациональ Гмбх Способ получения новых солей тиотропия
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
TW200738634A (en) * 2005-08-02 2007-10-16 Astrazeneca Ab New salt
WO2007075858A2 (en) * 2005-12-19 2007-07-05 Sicor Inc. Novel forms of tiotropium bromide and processes for preparation thereof
DE602006020620D1 (de) * 2006-01-04 2011-04-21 Boehringer Ingelheim Pharma Verwendung von tiotropium-salzen bei der behandlung von mässigem persistierendem asthma
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
CZ201241A3 (cs) 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
JP6042197B2 (ja) * 2012-12-11 2016-12-14 エア・ウォーター株式会社 肺障害治療剤

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EP1326862B1 (de) * 2000-10-12 2004-09-15 BOEHRINGER INGELHEIM PHARMA GMBH &amp; CO. KG Kristallines monohydrat von tiotropiumbromid, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels
UA75375C2 (en) 2000-10-12 2006-04-17 Boehringer Ingelheim Pharma Method for producing powdery preparations for inhaling
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US20020183292A1 (en) 2000-10-31 2002-12-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and corticosteroids
ES2294045T3 (es) * 2000-10-31 2008-04-01 BOEHRINGER INGELHEIM PHARMA GMBH &amp; CO. KG Formulacion de una solucion de inhalacion con una sal de tiotropio.
US20020111363A1 (en) 2000-10-31 2002-08-15 Karin Drechsel Inhalable formulation of a solution containing a tiotropium salt
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US20020193393A1 (en) 2001-03-07 2002-12-19 Michel Pairet Pharmaceutical compositions based on anticholinergics and PDE-IV inhibitors
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DE10200943A1 (de) * 2002-01-12 2003-07-24 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Scopinestern
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US6908055B2 (en) 2003-02-27 2005-06-21 Tandberg Data Asa System for extracting magnetic recording tape from a tape cartridge for engagement with a take-up reel
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US7968717B2 (en) * 2003-11-03 2011-06-28 Boehringer Ingelhein International Gmbh Crystalline anhydrate with anticholinergic efficacy
DE502004010885D1 (de) 2003-11-03 2010-04-22 Boehringer Ingelheim Pharma Verfahren zur herstellung von tiotropiumsalzen
ES2422730T3 (es) 2003-11-03 2013-09-13 Boehringer Ingelheim Int Sales de tiotropio, procedimiento para su preparación, así como formulaciones de medicamentos que las contienen
SE0303570L (sv) 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
SE0303270L (sv) 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
DE102004041253A1 (de) * 2004-08-26 2006-03-02 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen
RU2418796C2 (ru) 2005-06-15 2011-05-20 Берингер Ингельхайм Интернациональ Гмбх Способ получения новых солей тиотропия

Also Published As

Publication number Publication date
WO2005042526A1 (de) 2005-05-12
UA82413C2 (uk) 2008-04-10
RS51758B (en) 2011-12-31
EA012326B1 (ru) 2009-08-28
MXPA06004697A (es) 2006-07-05
CN101407514A (zh) 2009-04-15
CA2544348A1 (en) 2005-05-12
CY1114157T1 (el) 2016-08-31
TWI363758B (en) 2012-05-11
TW201231465A (en) 2012-08-01
IL175023A0 (en) 2006-08-20
DK2067779T3 (da) 2013-07-29
SI2067779T1 (sl) 2013-08-30
CY1110048T1 (el) 2015-01-14
HK1153409A1 (en) 2012-03-30
JP2007509893A (ja) 2007-04-19
AU2004285683A1 (en) 2005-05-12
ATE460414T1 (de) 2010-03-15
MEP51308A (en) 2011-05-10
PL1682541T3 (pl) 2010-08-31
PT2067779E (pt) 2013-07-25
PT1682541E (pt) 2010-04-14
US8686148B2 (en) 2014-04-01
IL175023A (en) 2011-02-28
BRPI0416136A (pt) 2007-01-02
EP2067779B1 (de) 2013-04-24
HK1129111A1 (en) 2009-11-20
DK1682541T3 (da) 2010-06-28
NO20061440L (no) 2006-07-12
EP1682541B1 (de) 2010-03-10
CN102070630B (zh) 2013-04-17
PL2067779T3 (pl) 2013-09-30
RS20060292A (en) 2008-08-07
EP1682541A1 (de) 2006-07-26
CN1882582A (zh) 2006-12-20
MY143364A (en) 2011-04-29
TW200526653A (en) 2005-08-16
EP2067779B9 (de) 2013-10-16
ZA200602342B (en) 2007-06-27
AU2004285683C1 (en) 2011-09-08
CN102070630A (zh) 2011-05-25
US20050131007A1 (en) 2005-06-16
EA200600886A1 (ru) 2006-10-27
ME00361B (me) 2011-10-10
HRP20100149T1 (hr) 2010-04-30
HK1099748A1 (en) 2007-08-24
TWI435876B (zh) 2014-05-01
EP2067779A1 (de) 2009-06-10
UY28590A1 (es) 2005-06-30
NO335814B1 (no) 2015-02-23
NZ547276A (en) 2009-08-28
ES2422729T3 (es) 2013-09-13
DE502004010885D1 (de) 2010-04-22
CN100549010C (zh) 2009-10-14
JP5165244B2 (ja) 2013-03-21
PE20050446A1 (es) 2005-08-02
CO5690553A2 (es) 2006-10-31
ES2342468T3 (es) 2010-07-07
KR20060117334A (ko) 2006-11-16
AU2004285683B2 (en) 2011-04-21
AR046317A1 (es) 2005-11-30
SG137859A1 (en) 2007-12-28
EP2336126A1 (de) 2011-06-22
CN101407514B (zh) 2013-05-29

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