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SG10201913643YA - N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors - Google Patents

N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors

Info

Publication number
SG10201913643YA
SG10201913643YA SG10201913643YA SG10201913643YA SG10201913643YA SG 10201913643Y A SG10201913643Y A SG 10201913643YA SG 10201913643Y A SG10201913643Y A SG 10201913643YA SG 10201913643Y A SG10201913643Y A SG 10201913643YA SG 10201913643Y A SG10201913643Y A SG 10201913643YA
Authority
SG
Singapore
Prior art keywords
benzamides
phenylsulfonyl
bcl
inhibitors
related compounds
Prior art date
Application number
SG10201913643YA
Other languages
English (en)
Inventor
Shaomeng Wang
Jianyong Chen
Original Assignee
Univ Michigan Regents
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Michigan Regents filed Critical Univ Michigan Regents
Publication of SG10201913643YA publication Critical patent/SG10201913643YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
SG10201913643YA 2016-08-05 2017-08-04 N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors SG10201913643YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662371504P 2016-08-05 2016-08-05
US201762454101P 2017-02-03 2017-02-03

Publications (1)

Publication Number Publication Date
SG10201913643YA true SG10201913643YA (en) 2020-03-30

Family

ID=59677319

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201913643YA SG10201913643YA (en) 2016-08-05 2017-08-04 N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors
SG11201900135YA SG11201900135YA (en) 2016-08-05 2017-08-04 N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201900135YA SG11201900135YA (en) 2016-08-05 2017-08-04 N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors

Country Status (26)

Country Link
US (3) US10829488B2 (sr)
EP (3) EP4129999A1 (sr)
JP (2) JP6651180B2 (sr)
KR (2) KR102429704B1 (sr)
CN (2) CN110483501B (sr)
AU (2) AU2017305508B2 (sr)
BR (1) BR112019001666A2 (sr)
CA (1) CA3031419C (sr)
CY (1) CY1123859T1 (sr)
DK (1) DK3494115T3 (sr)
ES (1) ES2849959T3 (sr)
HR (1) HRP20202073T1 (sr)
HU (1) HUE053414T2 (sr)
IL (2) IL264059B (sr)
LT (1) LT3494115T (sr)
MX (2) MX2019001391A (sr)
PE (1) PE20190711A1 (sr)
PH (1) PH12019500231A1 (sr)
PT (1) PT3494115T (sr)
RS (1) RS61821B1 (sr)
RU (3) RU2744358C2 (sr)
SA (1) SA519401020B1 (sr)
SG (2) SG10201913643YA (sr)
SI (1) SI3494115T1 (sr)
WO (1) WO2018027097A1 (sr)
ZA (2) ZA201900240B (sr)

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WO2022002178A1 (en) * 2020-07-01 2022-01-06 Ascentage Pharma (Suzhou) Co., Ltd. Methods for synthesizing n-(phenylsulfonyl)benzamide compounds and intermediates thereof
CN111537654B (zh) * 2020-07-07 2020-11-10 上海亚盛医药科技有限公司 N-(苯基磺酰基)苯甲酰胺化合物的hplc分析方法
TW202214565A (zh) * 2020-07-10 2022-04-16 大陸商江蘇恆瑞醫藥股份有限公司 磺醯苯甲醯胺類衍生物及其偶聯物、其製備方法及其應用
CN114057728A (zh) * 2020-08-06 2022-02-18 北京诺诚健华医药科技有限公司 作为bcl-2抑制剂的杂环化合物
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CN114073707A (zh) * 2020-08-21 2022-02-22 苏州亚盛药业有限公司 治疗系统性红斑狼疮的组合物和方法
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Also Published As

Publication number Publication date
US10829488B2 (en) 2020-11-10
IL282099A (en) 2021-05-31
KR102429704B1 (ko) 2022-08-04
BR112019001666A2 (pt) 2019-05-28
MX2020013014A (es) 2021-02-22
AU2017305508B2 (en) 2021-01-07
CY1123859T1 (el) 2022-05-27
US10221174B2 (en) 2019-03-05
AU2017305508A1 (en) 2019-02-07
JP2019527705A (ja) 2019-10-03
KR20210107170A (ko) 2021-08-31
SG11201900135YA (en) 2019-02-27
AU2021202113B2 (en) 2022-08-18
US20180354950A1 (en) 2018-12-13
ES2849959T3 (es) 2021-08-24
NZ750100A (en) 2021-01-29
CN109311871A (zh) 2019-02-05
US20190315739A1 (en) 2019-10-17
ZA201908466B (en) 2020-05-27
KR20190035710A (ko) 2019-04-03
AU2021202113A1 (en) 2021-05-06
CA3031419A1 (en) 2018-02-08
IL264059A (en) 2019-01-31
SA519401020B1 (ar) 2022-03-16
EP3569601A2 (en) 2019-11-20
RU2722560C1 (ru) 2020-06-01
RS61821B1 (sr) 2021-06-30
MX2019001391A (es) 2019-06-06
EP3494115B1 (en) 2020-10-21
RU2020114660A (ru) 2020-06-19
US20210002277A1 (en) 2021-01-07
WO2018027097A1 (en) 2018-02-08
JP2020007311A (ja) 2020-01-16
IL282099B (en) 2022-03-01
CN109311871B (zh) 2020-02-28
IL264059B (en) 2021-05-31
US11718613B2 (en) 2023-08-08
PE20190711A1 (es) 2019-05-17
LT3494115T (lt) 2021-01-25
CN110483501A (zh) 2019-11-22
RU2744358C2 (ru) 2021-03-05
HUE053414T2 (hu) 2021-06-28
CN110483501B (zh) 2022-07-01
SI3494115T1 (sl) 2021-02-26
EP3569601A3 (en) 2019-11-27
EP4129999A1 (en) 2023-02-08
EP3494115A1 (en) 2019-06-12
EP3569601B1 (en) 2022-06-22
RU2020134802A (ru) 2022-04-25
PH12019500231A1 (en) 2019-07-29
JP6651180B2 (ja) 2020-02-19
JP7205903B2 (ja) 2023-01-17
DK3494115T3 (da) 2021-01-18
KR102376764B1 (ko) 2022-03-18
ZA201900240B (en) 2020-05-27
PT3494115T (pt) 2021-01-15
CA3031419C (en) 2021-08-24
HRP20202073T1 (hr) 2021-02-19
RU2020114660A3 (sr) 2020-09-15

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