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SE9103612D0 - New peptide derivatives - Google Patents

New peptide derivatives

Info

Publication number
SE9103612D0
SE9103612D0 SE9103612A SE9103612A SE9103612D0 SE 9103612 D0 SE9103612 D0 SE 9103612D0 SE 9103612 A SE9103612 A SE 9103612A SE 9103612 A SE9103612 A SE 9103612A SE 9103612 D0 SE9103612 D0 SE 9103612D0
Authority
SE
Sweden
Prior art keywords
peptide derivatives
new peptide
hypercoaguability
treating
disclosed
Prior art date
Application number
SE9103612A
Other languages
English (en)
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Priority to SE9103612A priority Critical patent/SE9103612D0/sv
Publication of SE9103612D0 publication Critical patent/SE9103612D0/sv
Priority to ZA929099A priority patent/ZA929099B/xx
Priority to TW081109412A priority patent/TW223078B/zh
Priority to IL103910A priority patent/IL103910A0/xx
Priority to CZ953338A priority patent/CZ333895A3/cs
Priority to NZ280762A priority patent/NZ280762A/en
Priority to AT92924993T priority patent/ATE190066T1/de
Priority to EP92924993A priority patent/EP0618926B1/en
Priority to DE69230727T priority patent/DE69230727T2/de
Priority to CZ941296A priority patent/CZ129694A3/cs
Priority to JP51005393A priority patent/JP3306826B2/ja
Priority to NZ246106A priority patent/NZ246106A/en
Priority to AU31209/93A priority patent/AU670052B2/en
Priority to SK631-94A priority patent/SK63194A3/sk
Priority to CA002125175A priority patent/CA2125175C/en
Priority to HU9401474A priority patent/HUT70431A/hu
Priority to PCT/SE1992/000832 priority patent/WO1993011152A1/en
Priority to MX9206938A priority patent/MX9206938A/es
Priority to MA23019A priority patent/MA22729A1/fr
Priority to US07/984,884 priority patent/US5614499A/en
Priority to TNTNSN92109A priority patent/TNSN92109A1/fr
Priority to IS3954A priority patent/IS3954A/is
Priority to APAP/P/1992/000457A priority patent/AP353A/en
Priority to YU104592A priority patent/YU104592A/sh
Priority to SI19929200363A priority patent/SI9200363A/sl
Priority to CN92115304A priority patent/CN1076199A/zh
Priority to NO19942066A priority patent/NO311361B1/no
Priority to FI942645A priority patent/FI115770B/sv
Priority to EE9400455A priority patent/EE9400455A/xx
Priority to US08/481,810 priority patent/US5736521A/en
Priority to US08/480,818 priority patent/US5955433A/en
Priority to US08/484,426 priority patent/US5747460A/en
Priority to AU50616/96A priority patent/AU683793B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SE9103612A 1991-12-04 1991-12-04 New peptide derivatives SE9103612D0 (sv)

Priority Applications (33)

Application Number Priority Date Filing Date Title
SE9103612A SE9103612D0 (sv) 1991-12-04 1991-12-04 New peptide derivatives
ZA929099A ZA929099B (en) 1991-12-04 1992-11-24 New peptide derivatives.
TW081109412A TW223078B (sv) 1991-12-04 1992-11-24
IL103910A IL103910A0 (en) 1991-12-04 1992-11-27 New peptide derivatives and pharmaceutical compositions containing them
NZ246106A NZ246106A (en) 1991-12-04 1992-12-01 Modified peptides derived from human fibrinogen aalpha-chain
CA002125175A CA2125175C (en) 1991-12-04 1992-12-01 New peptide derivatives
PCT/SE1992/000832 WO1993011152A1 (en) 1991-12-04 1992-12-01 New peptide derivatives
AT92924993T ATE190066T1 (de) 1991-12-04 1992-12-01 Neuartige peptidderivate
EP92924993A EP0618926B1 (en) 1991-12-04 1992-12-01 New peptide derivatives
DE69230727T DE69230727T2 (de) 1991-12-04 1992-12-01 Neuartige peptidderivate
CZ941296A CZ129694A3 (en) 1991-12-04 1992-12-01 Novel peptide derivatives
JP51005393A JP3306826B2 (ja) 1991-12-04 1992-12-01 新規なペプチド誘導体
NZ280762A NZ280762A (en) 1991-12-04 1992-12-01 Noragmatine derivatives and their use in preparing serine protease inhibitors
AU31209/93A AU670052B2 (en) 1991-12-04 1992-12-01 New peptide derivatives
SK631-94A SK63194A3 (en) 1991-12-04 1992-12-01 Peptide derivatives
CZ953338A CZ333895A3 (en) 1991-12-04 1992-12-01 Starting compounds for synthesis of serine-prosthetic inhibitor
HU9401474A HUT70431A (en) 1991-12-04 1992-12-01 New peptide derivatives
US07/984,884 US5614499A (en) 1991-12-04 1992-12-02 Peptide derivatives as thrombin inhibitors
MX9206938A MX9206938A (es) 1991-12-04 1992-12-02 Nuevos derivados peptidos, proceso para su preparacion y preparacion farmaceutica que comprende tales derivados.
MA23019A MA22729A1 (fr) 1991-12-04 1992-12-02 Nouveaux derives de peptide
TNTNSN92109A TNSN92109A1 (fr) 1991-12-04 1992-12-03 Nouveaux derives de peptide
IS3954A IS3954A (is) 1991-12-04 1992-12-03 Hliðstæð aðferð við framleiðslu nýrra peptíðafleiða
APAP/P/1992/000457A AP353A (en) 1991-12-04 1992-12-04 New peptides derivatives.
YU104592A YU104592A (sh) 1991-12-04 1992-12-04 Novi peptidni derivati
SI19929200363A SI9200363A (en) 1991-12-04 1992-12-04 New peptide derivatives
CN92115304A CN1076199A (zh) 1991-12-04 1992-12-04 新的肽衍生物
NO19942066A NO311361B1 (no) 1991-12-04 1994-06-03 Peptidderivater, fremgangsmåte for fremstilling, farmasöytisk preparat og anvendelse av peptidderivatene
FI942645A FI115770B (sv) 1991-12-04 1994-06-03 Förfarande för framställning av farmakologiskt aktiva peptidderivat
EE9400455A EE9400455A (et) 1991-12-04 1994-11-23 Peptiidi derivaadid, nende valmistamise protsess, neid sisaldavad ravimpreparaadid ja nende kasutamine
US08/481,810 US5736521A (en) 1991-12-04 1995-06-07 Method of treatment and prophylaxis of arterial thrombosis
US08/480,818 US5955433A (en) 1991-12-04 1995-06-07 Method of thrombin inhibition
US08/484,426 US5747460A (en) 1991-12-04 1995-06-07 Method of treatment and prophylaxis of venous thrombosis
AU50616/96A AU683793B2 (en) 1991-12-04 1996-04-12 Synthesis of a serine protease inhibitor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9103612A SE9103612D0 (sv) 1991-12-04 1991-12-04 New peptide derivatives

Publications (1)

Publication Number Publication Date
SE9103612D0 true SE9103612D0 (sv) 1991-12-04

Family

ID=20384531

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9103612A SE9103612D0 (sv) 1991-12-04 1991-12-04 New peptide derivatives

Country Status (27)

Country Link
US (4) US5614499A (sv)
EP (1) EP0618926B1 (sv)
JP (1) JP3306826B2 (sv)
CN (1) CN1076199A (sv)
AP (1) AP353A (sv)
AT (1) ATE190066T1 (sv)
AU (2) AU670052B2 (sv)
CA (1) CA2125175C (sv)
CZ (2) CZ129694A3 (sv)
DE (1) DE69230727T2 (sv)
EE (1) EE9400455A (sv)
FI (1) FI115770B (sv)
HU (1) HUT70431A (sv)
IL (1) IL103910A0 (sv)
IS (1) IS3954A (sv)
MA (1) MA22729A1 (sv)
MX (1) MX9206938A (sv)
NO (1) NO311361B1 (sv)
NZ (2) NZ246106A (sv)
SE (1) SE9103612D0 (sv)
SI (1) SI9200363A (sv)
SK (1) SK63194A3 (sv)
TN (1) TNSN92109A1 (sv)
TW (1) TW223078B (sv)
WO (1) WO1993011152A1 (sv)
YU (1) YU104592A (sv)
ZA (1) ZA929099B (sv)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5583146A (en) * 1992-12-02 1996-12-10 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
US6534536B1 (en) 1994-03-16 2003-03-18 Bristol-Myers Squibb Company Alkylsulfonamido heterocyclic thrombin inhibitors
SE9900043D0 (sv) * 1999-01-11 1999-01-11 Astra Ab New use
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US6984627B1 (en) 1993-06-03 2006-01-10 Astrazeneca Ab Peptide derivatives
EP0648780A1 (en) * 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
GB9318637D0 (en) * 1993-09-08 1993-10-27 Ferring Res Ltd Enzyme inhibitors
US5705487A (en) * 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
US5885967A (en) * 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
IL112795A (en) * 1994-03-04 2001-01-28 Astrazeneca Ab Derivatives of peptides as antithrombotic drugs, their preparation, and pharmaceutical preparations containing them
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
ZA951618B (en) * 1994-03-04 1996-08-27 Lilly Co Eli Antithrombotic agents
US5726159A (en) * 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5488037A (en) * 1994-03-04 1996-01-30 Eli Lilly And Company Antithrombotic agents
US5602101A (en) * 1994-03-04 1997-02-11 Eli Lilly And Company Antithrombotic agents
US5707966A (en) * 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5484772A (en) * 1994-03-04 1996-01-16 Eli Lilly And Company Antithrombotic agents
US5691356A (en) * 1994-03-21 1997-11-25 Bristol-Myers Squibb Company Disubstituted heterocyclic thrombin inhibitors
US5681844A (en) * 1994-04-18 1997-10-28 Corvas International, Inc. Methionine sulfone and s-substituted cysteine sulfone derivatives as enzyme inhibitors
US5561146A (en) * 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
DE4436772A1 (de) * 1994-10-14 1996-04-18 Boehringer Mannheim Gmbh Neues Dipeptid-Derivat, Verfahren zu seiner Herstellung sowie diese Verbindung enthaltende Arzneimittel
SE504185C2 (sv) * 1994-11-08 1996-12-02 Astra Ab Lagringsstabil vattenlösning för infusion av trombininhibitorer
SE9404196D0 (sv) * 1994-12-02 1994-12-02 Astra Ab New antithrombotic formulation
DE4443390A1 (de) * 1994-12-06 1996-06-13 Basf Ag Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
TR199700803T1 (xx) * 1995-02-17 1998-02-21 Basf Aktiengesellschaft Trombin-inhibit�rleri olarak yeni dipeptidik amidinler.
US5914319A (en) * 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
US5710130A (en) * 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
DE19512484A1 (de) 1995-04-04 1996-10-17 Bayer Ag Kohlenhydratmodifizierte Cytostatika
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
AR005245A1 (es) 1995-12-21 1999-04-28 Astrazeneca Ab Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion
SE9600216D0 (sv) * 1996-01-18 1996-01-18 Hans Arne Hansson Styrning av läkningsprocesser
US5811402A (en) * 1996-03-22 1998-09-22 Eli Lilly And Company Antithrombotic diamides
CA2200163A1 (en) * 1996-03-22 1997-09-22 Michael Robert Wiley Antithrombotic diamides
SE9602263D0 (sv) 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
US5863929A (en) 1996-06-25 1999-01-26 Eli Lilly And Company Anticoagulant agents
US6200967B1 (en) 1996-06-25 2001-03-13 Eli Lilly And Company Anticoagulant agents
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
SE9603724D0 (sv) * 1996-10-11 1996-10-11 Astra Ab New pharmaceutical parenteral formulation of a thrombin inhibitor
US5877156A (en) * 1997-04-24 1999-03-02 Akzo Nobel, N.V. Thrombin inhibitors
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
CN1289341A (zh) 1998-01-26 2001-03-28 Basf公司 凝血酶抑制剂
WO1999055355A1 (en) * 1998-04-24 1999-11-04 3-Dimensional Pharmaceuticals, Inc. Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors
SE9802938D0 (sv) * 1998-09-01 1998-09-01 Astra Ab Improved stability for injection solutions
SE9802973D0 (sv) 1998-09-03 1998-09-03 Astra Ab Immediate release tablet
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
CZ20012529A3 (cs) 1999-01-13 2001-11-14 Astrazeneca Ab Nový amidinobenzylamidový derivát a jeho pouľití jako inhibitoru thrombinu
KR20000060566A (ko) * 1999-03-17 2000-10-16 이경하 치환된 방향족 아미딘 유도체 및 이를 함유하는 의약조성물
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
AR023819A1 (es) * 1999-05-03 2002-09-04 Astrazeneca Ab FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION
US6290662B1 (en) * 1999-05-28 2001-09-18 John K. Morris Portable, self-contained apparatus for deep vein thrombosis (DVT) prophylaxis
SE9902202D0 (sv) * 1999-06-10 1999-06-10 Astra Ab Production of aggregates
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
JP2002155086A (ja) * 2000-11-16 2002-05-28 Ube Ind Ltd ７ａ−アルコキシ−４Ｈ−ピラノ［３，２−ｄ］−オキサゾール−２（３Ｈ）−オン類、及びその製造法
AR035216A1 (es) 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR034517A1 (es) 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
US7332227B2 (en) * 2003-03-14 2008-02-19 Becton, Dickinson And Company Non-volatile lubricant system for medical devices
US7641623B2 (en) 2003-04-11 2010-01-05 Hill-Rom Services, Inc. System for compression therapy with patient support
US7795205B2 (en) 2004-04-12 2010-09-14 Canyon Pharmaceuticals, Inc. Methods for effecting regression of tumor mass and size in a metastasized pancreatic tumor
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
US8070678B2 (en) * 2005-10-05 2011-12-06 Gurbel Paul A Detection of restenosis risk in patients receiving a stent by measuring the characteristics of blood clotting including the measurement of maximum thrombin-induced clot strength
TW200827336A (en) 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
CN102924567B (zh) * 2008-10-28 2014-06-04 上海医药工业研究院 一类肽化合物、其制备方法及用途
CN102464701B (zh) 2010-11-08 2015-10-21 上海医药工业研究院 一类新型化合物、其制备方法及用途
WO2012171982A1 (en) * 2011-06-16 2012-12-20 Lonza Ltd A process for extraction of peptides and its application in liquid phase peptide synthesis
US9737454B2 (en) 2012-03-02 2017-08-22 Hill-Rom Services, Inc. Sequential compression therapy compliance monitoring systems and methods
EP3207911B1 (en) 2016-02-18 2019-04-03 Hill-Rom Services, Inc. Patient support apparatus having an integrated limb compression device
RU2712194C1 (ru) * 2019-10-02 2020-01-27 Федеральное государственное бюджетное учреждение "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Национального исследовательского центра "Курчатовский институт" (НИЦ "Курчатовский институт" - ГосНИИгенетика) Антикоагулянтное лекарственное средство, представляющее собой синтетический дипептид Ac-Trp-Arg-Pip ⋅HCl, фармацевтическая композиция, включающая это антикоагулянтное лекарственное средство

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178398B (en) * 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
US4568636A (en) * 1981-03-25 1986-02-04 Pentapharm Ag Tripeptide derivatives
US4395401A (en) * 1981-09-09 1983-07-26 Smithkline Beckman Corporation Renally active dipeptides
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
US4906659A (en) * 1985-06-18 1990-03-06 Takeda Chemical Industries, Ltd. Antibiotic tan-749, its derivatives, production and use thereof
DE3606480A1 (de) * 1986-02-28 1987-09-03 Behringwerke Ag Oligopeptidylnitrilderivate, diese enthaltende mittel, verfahren zu ihrer herstellung und ihre verwendung
US5187157A (en) * 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
US5037819A (en) * 1990-06-04 1991-08-06 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5110812A (en) * 1990-06-04 1992-05-05 Bristol-Myers Squibb Co. Azetidin-2-one derivatives as serine protease inhibitors
TW201303B (sv) * 1990-07-05 1993-03-01 Hoffmann La Roche
GB9019558D0 (en) * 1990-09-07 1990-10-24 Szelke Michael Enzyme inhibitors
GB9024129D0 (en) * 1990-11-06 1990-12-19 Thrombosis Research Trust Inhibitors and substrates of thrombin
EP0503203A1 (en) * 1991-03-15 1992-09-16 Merrell Dow Pharmaceuticals Inc. Novel thrombin inhibitors
SE9102462D0 (sv) * 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
NZ245039A (en) * 1991-11-12 1994-12-22 Lilly Co Eli N-phenylalanyl and n-phenylglycyl derivatives of the dipeptide of l-azetidine-2-carboxylic acid and l-arginine aldehyde; anti-blood clotting compositions

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EE9400455A (et) 1996-06-17
CZ333895A3 (en) 1996-04-17
WO1993011152A1 (en) 1993-06-10
NZ280762A (en) 1998-08-26
EP0618926B1 (en) 2000-03-01
FI942645A0 (sv) 1994-06-03
FI115770B (sv) 2005-07-15
US5747460A (en) 1998-05-05
JPH09500356A (ja) 1997-01-14
HU9401474D0 (en) 1994-08-29
SI9200363A (en) 1993-06-30
TW223078B (sv) 1994-05-01
IS3954A (is) 1993-06-05
AP9200457A0 (en) 1993-01-31
FI942645A (sv) 1994-06-03
AU5061696A (en) 1996-08-01
NO942066D0 (no) 1994-06-03
HUT70431A (en) 1995-10-30
CA2125175C (en) 2001-09-11
TNSN92109A1 (fr) 1993-06-08
SK63194A3 (en) 1994-12-07
IL103910A0 (en) 1993-04-04
AU3120993A (en) 1993-06-28
MX9206938A (es) 1993-06-01
EP0618926A1 (en) 1994-10-12
NZ246106A (en) 1996-07-26
AP353A (en) 1994-08-14
US5736521A (en) 1998-04-07
US5614499A (en) 1997-03-25
CN1076199A (zh) 1993-09-15
NO311361B1 (no) 2001-11-19
CA2125175A1 (en) 1993-06-10
ATE190066T1 (de) 2000-03-15
AU670052B2 (en) 1996-07-04
YU104592A (sh) 1995-12-04
AU683793B2 (en) 1997-11-20
JP3306826B2 (ja) 2002-07-24
MA22729A1 (fr) 1993-07-01
US5955433A (en) 1999-09-21
DE69230727T2 (de) 2000-08-03
NO942066L (no) 1994-06-03
CZ129694A3 (en) 1994-12-15
ZA929099B (en) 1993-06-07
DE69230727D1 (de) 2000-04-06

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