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SE0001803D0 - New compounds i - Google Patents

New compounds i

Info

Publication number
SE0001803D0
SE0001803D0 SE0001803A SE0001803A SE0001803D0 SE 0001803 D0 SE0001803 D0 SE 0001803D0 SE 0001803 A SE0001803 A SE 0001803A SE 0001803 A SE0001803 A SE 0001803A SE 0001803 D0 SE0001803 D0 SE 0001803D0
Authority
SE
Sweden
Prior art keywords
new compounds
thrombin
iawherein
anticoagulants
thrombosis
Prior art date
Application number
SE0001803A
Other languages
English (en)
Inventor
Kjell Andersson
Tord Inghardt
Olle Karlsson
Marcel Linschoten
Jan-Erik Nystroem
Gunnel Sunden
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0001803A priority Critical patent/SE0001803D0/sv
Publication of SE0001803D0 publication Critical patent/SE0001803D0/sv
Priority to ARP010102072A priority patent/AR028068A1/es
Priority to JP2001584273A priority patent/JP2003533522A/ja
Priority to PCT/SE2001/001052 priority patent/WO2001087879A1/en
Priority to AU2001256931A priority patent/AU2001256931B2/en
Priority to MXPA02010711A priority patent/MXPA02010711A/es
Priority to NZ522133A priority patent/NZ522133A/en
Priority to BR0110794-1A priority patent/BR0110794A/pt
Priority to KR1020027015397A priority patent/KR100874393B1/ko
Priority to IL15239601A priority patent/IL152396A0/xx
Priority to CNB018127487A priority patent/CN1196696C/zh
Priority to EP01930400A priority patent/EP1283837B1/en
Priority to US10/276,150 priority patent/US6716834B2/en
Priority to AT01930400T priority patent/ATE260273T1/de
Priority to AU5693101A priority patent/AU5693101A/xx
Priority to CA002407222A priority patent/CA2407222A1/en
Priority to DE60102151T priority patent/DE60102151T2/de
Priority to IL152396A priority patent/IL152396A/en
Priority to ZA200208805A priority patent/ZA200208805B/en
Priority to NO20025504A priority patent/NO323829B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SE0001803A 2000-05-16 2000-05-16 New compounds i SE0001803D0 (sv)

Priority Applications (20)

Application Number Priority Date Filing Date Title
SE0001803A SE0001803D0 (sv) 2000-05-16 2000-05-16 New compounds i
ARP010102072A AR028068A1 (es) 2000-05-16 2001-05-02 Nuevos derivados de 1,1-dioxotiocromano y su uso como inhibidores de trombina
DE60102151T DE60102151T2 (de) 2000-05-16 2001-05-14 Neue thiochromanderivate und ihre verwendung als thrombininhibitoren
KR1020027015397A KR100874393B1 (ko) 2000-05-16 2001-05-14 신규한 티오크로만 유도체 및 이것의 트롬빈 억제제로서의용도
EP01930400A EP1283837B1 (en) 2000-05-16 2001-05-14 New thiochromane derivatives and their use as thrombin inhibitors
AU2001256931A AU2001256931B2 (en) 2000-05-16 2001-05-14 New thiochromane derivatives and their use as thrombin inhibitors
MXPA02010711A MXPA02010711A (es) 2000-05-16 2001-05-14 Nuevos derivados de tiocromano y su uso como inhibidores de trombina.
NZ522133A NZ522133A (en) 2000-05-16 2001-05-14 New thiochromane derivatives and their use as thrombin inhibitors
BR0110794-1A BR0110794A (pt) 2000-05-16 2001-05-14 Composto, processo para a preparação do mesmo, formulação farmacêutica, uso de um composto, e, método de tratamento de uma condição onde a inibição de trombina é requerida
JP2001584273A JP2003533522A (ja) 2000-05-16 2001-05-14 新規チオクロマン誘導体とトロンビン阻害剤としてのその使用
IL15239601A IL152396A0 (en) 2000-05-16 2001-05-14 New thiochromane derivatives derivatives and their use as thrombin inhibitors
CNB018127487A CN1196696C (zh) 2000-05-16 2001-05-14 新的二氢苯并噻喃衍生物和它们作为凝血酶抑制剂的用途
PCT/SE2001/001052 WO2001087879A1 (en) 2000-05-16 2001-05-14 New thiochromane derivatives and their use as thrombin inhibitors
US10/276,150 US6716834B2 (en) 2000-05-16 2001-05-14 Thiochromane derivatives and their use as thrombin inhibitors
AT01930400T ATE260273T1 (de) 2000-05-16 2001-05-14 Neue thiochromanderivate und ihre verwendung als thrombininhibitoren
AU5693101A AU5693101A (en) 2000-05-16 2001-05-14 New thiochromane derivatives and their use as thrombin inhibitors
CA002407222A CA2407222A1 (en) 2000-05-16 2001-05-14 New thiochromane derivatives and their use as thrombin inhibitors
IL152396A IL152396A (en) 2000-05-16 2002-10-21 Thiochroman derivatives and their use in the preparation of a drug for the treatment of a condition requiring inhibition of thrombin
ZA200208805A ZA200208805B (en) 2000-05-16 2002-10-30 New thiochromane derivatives and their use as thrombin inhibitors.
NO20025504A NO323829B1 (no) 2000-05-16 2002-11-15 Nye tiokromanderivater, fremgangsmate for fremstilling og anvendelse derav, samt farmasoytisk preparat.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0001803A SE0001803D0 (sv) 2000-05-16 2000-05-16 New compounds i

Publications (1)

Publication Number Publication Date
SE0001803D0 true SE0001803D0 (sv) 2000-05-16

Family

ID=20279688

Family Applications (1)

Application Number Title Priority Date Filing Date
SE0001803A SE0001803D0 (sv) 2000-05-16 2000-05-16 New compounds i

Country Status (18)

Country Link
US (1) US6716834B2 (sv)
EP (1) EP1283837B1 (sv)
JP (1) JP2003533522A (sv)
KR (1) KR100874393B1 (sv)
CN (1) CN1196696C (sv)
AR (1) AR028068A1 (sv)
AT (1) ATE260273T1 (sv)
AU (2) AU2001256931B2 (sv)
BR (1) BR0110794A (sv)
CA (1) CA2407222A1 (sv)
DE (1) DE60102151T2 (sv)
IL (2) IL152396A0 (sv)
MX (1) MXPA02010711A (sv)
NO (1) NO323829B1 (sv)
NZ (1) NZ522133A (sv)
SE (1) SE0001803D0 (sv)
WO (1) WO2001087879A1 (sv)
ZA (1) ZA200208805B (sv)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9804313D0 (sv) * 1998-12-14 1998-12-14 Astra Ab New compounds
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
US7129233B2 (en) * 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR034517A1 (es) * 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
US7524354B2 (en) * 2005-07-07 2009-04-28 Research Foundation Of State University Of New York Controlled synthesis of highly monodispersed gold nanoparticles
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030
BRPI0914323A2 (pt) * 2008-06-23 2017-03-28 Astrazeneca Ab composto, formulação farmacêutica, uso de um composto, e, métodos de tratamento de uma condição e de tratamento e prevenção de distúrbios
CN103819464B (zh) * 2014-03-11 2015-10-07 南京工业大学 硫色满类化合物及其合成方法和制备抗真菌药物的应用
DE102014108210A1 (de) * 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178398B (en) 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
GB2161801B (en) 1984-07-17 1987-10-07 Erba Farmitalia N-imidazolyl derivatives and process for their preparation
HU192646B (en) 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
IL77748A (en) 1985-02-04 1991-11-21 Merrell Dow Pharma Amino acid and peptide derivatives as peptidase inhibitors
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
ZA897514B (en) 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
TW201303B (sv) 1990-07-05 1993-03-01 Hoffmann La Roche
CA2075154A1 (en) 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
SE9102462D0 (sv) 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
ZA928581B (en) 1991-11-12 1994-05-06 Lilly Co Eli Antithrombotic agents
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
CA2131367A1 (en) 1992-03-04 1993-09-16 Sandor Bajusz New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof
TW223629B (sv) 1992-03-06 1994-05-11 Hoffmann La Roche
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (en) 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
TW394760B (en) 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
AU1025795A (en) 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
ZA951617B (en) 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5510369A (en) 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
MX9706069A (es) 1995-02-17 1997-10-31 Basf Ag Nuevos inhibidores de la trombina.
AU698911B2 (en) 1995-04-04 1998-11-12 Merck & Co., Inc. Thrombin inhibitors
US5629324A (en) 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
SA96170106A (ar) * 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
TW541316B (en) 1995-12-21 2003-07-11 Astrazeneca Ab Prodrugs of thrombin inhibitors
US6080767A (en) 1996-01-02 2000-06-27 Aventis Pharmaceuticals Products Inc. Substituted n-[(aminoiminomethyl or aminomethyl)phenyl]propyl amides
WO1997033576A1 (en) 1996-03-12 1997-09-18 Bristol-Myers Squibb Company Carbamyl guanidine and amidine prodrugs
SE9601556D0 (sv) 1996-04-24 1996-04-24 Astra Ab New pharmaceutical formulation of a thrombin inhibitor for parenteral use
ES2320316T3 (es) * 1996-05-01 2009-05-21 Ortho-Mcneil Pharmaceutical, Inc. Derivados carboxamida de pirrolidina, piperidina y hexahidroazepina utiles en el tratamiento de trastornos tromboticos.
SE9602263D0 (sv) * 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
CA2258915A1 (en) 1996-06-25 1997-12-31 Michael Robert Wiley Anticoagulant agents
EP0994104A4 (en) 1996-06-27 2001-09-12 Ono Pharmaceutical Co ARYL SULFIDE, SULFOXIDE AND SULPHONE DERIVATIVES AND MEDICINAL PRODUCTS CONTAINING THEM AS AN ACTIVE INGREDIENT
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
WO1998057934A1 (en) 1997-06-19 1998-12-23 The Du Pont Merck Pharmaceutical Company (AMIDINO)6-MEMBERED AROMATICS AS FACTOR Xa INHIBITORS
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
SE9804313D0 (sv) * 1998-12-14 1998-12-14 Astra Ab New compounds
EP1150996B1 (en) * 1999-01-13 2007-11-21 AstraZeneca AB New amidinobenzylamine derivatives and their use as thrombin inhibitors
AR023819A1 (es) 1999-05-03 2002-09-04 Astrazeneca Ab FORMULACIoN FARMACEUTICA, KIT DE PARTES Y UTILIZACION DE DICHA FORMULACION

Also Published As

Publication number Publication date
NO20025504L (no) 2002-11-15
KR20030001507A (ko) 2003-01-06
JP2003533522A (ja) 2003-11-11
KR100874393B1 (ko) 2008-12-17
IL152396A (en) 2009-07-20
EP1283837B1 (en) 2004-02-25
US6716834B2 (en) 2004-04-06
ATE260273T1 (de) 2004-03-15
DE60102151D1 (de) 2004-04-01
BR0110794A (pt) 2003-05-06
NO323829B1 (no) 2007-07-09
CA2407222A1 (en) 2001-11-22
AU5693101A (en) 2001-11-26
WO2001087879A1 (en) 2001-11-22
AR028068A1 (es) 2003-04-23
EP1283837A1 (en) 2003-02-19
NO20025504D0 (no) 2002-11-15
NZ522133A (en) 2004-11-26
CN1196696C (zh) 2005-04-13
IL152396A0 (en) 2003-05-29
US20030220317A1 (en) 2003-11-27
ZA200208805B (en) 2004-02-09
AU2001256931B2 (en) 2005-08-04
CN1441799A (zh) 2003-09-10
MXPA02010711A (es) 2003-03-10
DE60102151T2 (de) 2004-09-16

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