RU2557894C2 - Cosmetic product for fast skin repair - Google Patents

Abstract

FIELD: medicine.

SUBSTANCE: invention refers to medicine and cosmetology, namely to deep cosmetic products, and can be used for normalising physiological functions of skin and eliminating endogenous or exogenous defects. The invention represents a cosmetic product for fast skin repair containing superoxide dismutase, dexpanthenol, succinic acid, trolox and L-arginine. The product is applied on the skin for 20 minutes with using a material holding the agent and feeding it to the skin over the period of exposure.

EFFECT: cosmetic product enables extending the range of products for improving the skin state, reducing the risk of lower controllability of the effect, and a probability of allergic and inflammatory reactions.

3 cl, 10 ex

Description

The invention relates to medicine and cosmetology, namely to deep-acting cosmetic preparations, and can be used to normalize the physiological functions of the skin and eliminate defects that are endogenous (e.g., the general condition of the body) or exogenous (e.g., ultraviolet (UV) radiation, high or low temperatures, improper cosmetic care) nature.

Impaired physiological functions of the skin and skin defects are a fairly common problem. In particular, this is an increased production of sebum, irritation, redness, peeling, tightness and discomfort, swelling after traumatic cosmetic procedures (for example, after peeling, face cleansing, depilation, hair removal, mesotherapy and biorevitalization - swelling around the papules at the injection site) burns (for example, thermal, chemical), suppuration and rashes, the effects of acne, capillary nets, uneven skin tone. Discomfort causes the duration of the skin restoration process.

The objective of the present invention is to achieve rapid restoration of the skin with impaired function and cosmetic defects, without the induction of irritating and allergic reactions.

To solve this problem, a cosmetic product has been proposed that contains superoxide dismutase (SOD), arginine, a water-soluble analogue of vitamin E trolox, dexpanthenol (D-panthenol) and succinic acid in an aqueous solution.

This composition is unique due to the careful selection of components.

During inflammation, free radicals are released on the skin [1], which cause damage to surrounding healthy tissues and inhibit reparative processes. The key enzyme that protects tissues from free radicals is SOD, which removes superoxide radicals and prevents the formation of other oxygen radicals that are more dangerous for the body [2]. SOD-based drugs are the most promising among anti-inflammatory drugs.

Arginine, an aliphatic basic α-amino acid, is a substrate of NO synthases in the synthesis of nitric oxide NO, which is a local tissue hormone that regulates blood microcirculation in skin tissues. The intensification of blood circulation in the skin is necessary to maintain and regulate the basic biochemical processes. There are very few cosmetics that stimulate microcirculation in skin tissues. Due to vasodilation and blood circulation intensification, the components of the agent penetrate the skin better, which enhances its effect in a short exposure time. Arginine also increases the healing rate of damaged tissue.

Arginine is also an “indirect antioxidant,” activating enzymes responsible for rejuvenation and tissue repair before free radicals cause cell damage and are used in cosmetics, such as sunscreens [3].

L-Arginine is also a good stabilizer, allowing you to store the product at room temperature, while maintaining the integrity and activity of the components of the product and, accordingly, its properties.

The water-soluble analogue of vitamin E trolox acts as an antioxidant. Trolox (TEAC) is the equivalent for measuring the antioxidant strength of complex mixtures, as well as the ability of plasma to reduce iron (FRAP).

It is known to use trolox as a preservative for stem cells or progenitor cells in a hypothermic solution [4]. It is shown that it allows you to save nerve stem cells for 2 days in saline at room temperature.

It is known to use trolox (vitamin E or its derivatives) in a composition to reduce the leakage of potassium ions from red blood cells undergoing photoinactivation in the presence of a photosensitizing agent [5].

It is known to use trolox in combination with gallate as a cytoprotective composition against oxyradical damage (introduced into the blood or as part of food), and also as a composition for slowing down the breakdown of edible and inedible (fuel) oils [6].

It is also known to use this compound to initiate the recovery of amino acid radicals resulting from radiolytic degradation of a protein in solution [7]. A known composition in which the protein is protected from ionizing radiation by the addition of antioxidants o-vanillin and trolox [8].

Dexpanthenol (R-2,4-dihydroxy-N- (3-hydroxypropyl) -3,3-dimethylbutanamide) refers to water-soluble vitamins. When applied topically, it is rapidly absorbed by the skin and converted into pantothenic acid, which is also known as vitamin B5, and as a component of coenzyme A plays a central role in skin metabolism. In addition, topical application of dexpanthenol increases the skin's ability to retain moisture and, therefore, helps to increase the elasticity of the treated skin. The regeneration of damaged tissue after the use of dexpanthenol is faster. In addition, dexpanthenol and pantothenic acid are anti-inflammatory and antipruritic agents. Dexpanthenol is distinguished by its excellent tolerance [9].

Succinic acid (butanedioic acid, ethane-1,2-dicarboxylic acid) is a dibasic limiting carboxylic acid soluble in water. Succinic acid when used externally has a multiple effect: it has a powerful antioxidant effect, preventing lipid peroxidation of the cell wall and stopping the formation of free radicals, cleans the ducts of the sebaceous glands, preventing the clogging of pores of the skin, thereby preventing the formation of comedones, inhibiting inflammatory processes, and normalizing the histamine content and serotonin, eliminates acne and acne, exfoliates dead cells of the stratum corneum of the epidermis, giving the skin more m Luda, a healthy and well-groomed appearance, helps to saturate skin cells with oxygen, normalizes cellular respiration (participates in the tricarboxylic acid cycle), helps smooth out scars, scars and stretch marks on the skin, removes excess fluid from tissues, eliminates swelling, tightens the skin, and improves its elasticity and elasticity, contributes to the perception by skin cells of other active components, enhancing their effect.

Known compositions containing from one to three of the above components, for various aesthetic purposes, various forms of administration. Basically, such compositions are used to improve the condition of the body, in particular to improve the condition of the skin.

Known cosmetic product for removing wrinkles containing botulinum toxin type A, ozone and saline, which may also contain vitamin E (0.1-1 part), alpha - hydroxy acids (0.1-1 part) or SOD (0.1-1 part), as well as serum human albumin [10]. This drug is injectable. It is not indicated how human serum albumin is obtained. Obtaining using only a recombinant protein ensures the safety of the composition to which this protein is added.

There is a known essence that allows you to maintain health, containing the fruit of the ordinary dereza, SOD, taurine, arginine, phytic acid, shrimp extract and vitamin C [11]. The essence is used in the form of wine.

A known anti-aging composition for administration to warm-blooded animals, including one or more mono-, di- or trivalent metal salts, one or more amino acids, amino alcohol and vitamin B complex [12]. The amino acid is represented by glutamine, arginine, lysine, ornithine, proline or histidine, the vitamin B complex is a pair of aminobenzoic acid, B1 (thiamine), B2 (riboflavin), B3, B5, B6 (pyridoxine) or B12 (cobalamin). The composition may also contain L-taurine, inositol, choline, vitamin P, oligopeptide, resveratrol, folic acid, biotin, vitamin D, vitamin A, ginkgo biloba extract, lycopene, proanthocyanidin, gymnosperm extract, bromelain, lipase, silicon catalase, colloid , iodine and immunostimulant. This composition is for oral administration (oral administration).

Known multifunctional face cream containing Sargassum fusiforme extract, which, in turn, contains polysaccharides, vitamin E, vitamin C, SOD and other skin care ingredients [13]. The disadvantage of this invention is that some components of the extract of this plant can have a negative effect on the skin, for example, polysaccharides are a rich nutrient medium for various microorganisms, which can cause their active reproduction and metabolism both during storage and on the skin, which can, for example cause inflammation on the skin. It has been shown that vitamin C can lighten the skin [14], which is not relevant for all consumers. The disadvantage of this invention is to reduce the degree of control of the function of the funds due to the multicomponent.

A cosmetic product is known containing royal jelly, ginseng extract, the active component is one or more of vitamin C, ethyl ether, vitamin E acetate, allantoin, ethoxy urea, licorice flavonoids, Barbados aloe extract, papain, tea tree oil, phenolic acid meadowsweet, extract of virgin hazel, pine pollen, matrine, vitamin A, horse chestnut extract or purslane [15]. We used saponins, polysaccharides, amino acids, vitamins, minerals, SOD, in the composition of royal jelly and ginseng extract. The disadvantages of this invention is the decrease in the degree of control of the function of the drug due to the multicomponent nature and the risk of side effects associated with the presence of allergens in the mixture, as well as components that can serve as a nutrient medium for microorganisms (polysaccharides) with the simultaneous absence of an antimicrobial component. An antiseptic can also kill microorganisms that are beneficial to humans.

A known composition containing SOD, as well as vitamin Ε and vitamin C [16]. SOD is proposed to be isolated from the blood of animals, especially from the blood of oxen, which is a disadvantage of the present invention, since with this method of obtaining a high probability of an unclean drug (for example, contaminated with viruses). Obtaining SOD using biotechnology or chemical synthesis allows you to get a sterile drug.

Known composite fat-soluble antioxidant containing fat-soluble vitamin E, coenzyme Q10 and SOD, to protect the lipid part of the cell membrane from free radicals [17]. However, fat solubility determines that these substances are used with a base of fats, which is also a prerequisite for the multiplication of various microorganisms with the simultaneous absence of an antimicrobial component.

Known cosmetic composition to improve the barrier function of the skin to protect against aging, to initiate regeneration and prolonged hydration of the skin, containing natural ingredients with a long-lasting moisturizing effect: 0.1-5% by weight - soybean extract, 0.05-0.2% by weight - aromatic essential oil, 1- 30% of the weight - hyaluronic acid, 1.5-3.5% of the weight - vitamins (0.3-0.7 weight - Vitamin C, 0.3-0.7% of the weight - Vitamin B3, 0.3-0.7% of the weight - Vitamin B5, 0.3-0.7% of the weight - Vitamin B6, 0.3-0.7% of the weight - vitamin E), 0.1-5% - sodium citrate, 0.1-5% of the weight - citric acid, 0.1-5% of the weight - lactic acid, 0.5-2% esa - arginine, the rest - purified water [18]. The composition also contains jojoba oil (2-8% by weight), lecithin (3-8% by weight) and xanthan gum (0.01-10% by weight). The disadvantage of this invention is to reduce the degree of control of the function of the funds due to the multicomponent. The presence of citric acid and vitamin C in the composition provides lightening of the skin, which is not suitable for all patients.

Known composition for hair care containing Australian walnut oil, seed oil Shorea stenoptera, D-panthenol, dl-alpha-tocopherol acetate, vitamin E, all in the composition of liposomes, and non-ionic emulsifying agent [19]. This composition is for creating products for treating dry, very dry and damaged hair, especially creams, shampoos, balms for use after shampoo, gels or milk.

Known nanoemulsion containing SOD modified with polyethylene glycol (mPEG-SOD) for external use, which is made using isopropyl myristate, saprilocaproyl macrogolglyceride, polyglyceryl-3-dioleate, an aqueous solution of mPEG-SOD, vitamin E [20].

A well-known product of the oil series, represented by a composition containing SOD, a composition containing SOD and vitamin A, a composition containing SOD, vitamins A and D, a composition containing SOD, vitamins A, D and E [21].

It is known a means for the eyelids, a cream containing a cosmetic base, eftederm, malavit, eleutherococcus extract, juniper oil, jojoba oil, citric and succinic acid, tocopherol acetate (vitamin E) and retinol acetate (vitamin A) [22].

A known composition for external use on the skin, containing a mixture of panthenol, fish oil, alpha-tocopherol acetate, arginine, isoleucine, leucine, methionine, phenylalanine, threonine and valine with a suitable carrier [23]. The mixture is used to treat burns, cuts, abrasions, insect bites, inflammation from the sun and wind, dry skin, psoriasis, seborrheic dermatitis and eczema.

Fat-based products (vegetable, animal fats) without antiseptics in the composition are, as already mentioned above, a nutrient medium for microorganisms, which is a prerequisite for their reproduction, which can negatively affect the effect when applied to the skin. The use of an antiseptic can also negatively affect the quantitative and qualitative composition of the “useful” human microbiota.

Known fluid for repairing damaged cells, containing SOD, aloe juice, a solution of hyaluronic acid, alpha lipoic acid and vitamin E (0.5-4). Every 100 g of reducing fluid contains 40000-4000000 units of activity of SOD. The disadvantages of this invention include the complexity of the manufacture of the solution, namely the need to obtain each component, and only then the creation of the composition (obtaining plant extracts).

A known composition that helps with sexual disorders and having the effect of an aphrodisiac, the active components of which are lycopene, vitamin B1, vitamin B2, vitamin B3, vitamin B5 (less than 0.2% or 0.2% -0.6%), vitamin B6, vitamin B12, vitamin C, caffeine, epicatechin, epicatechin gallate, epigallocatechin, epigallocatechin gallate, L-arginine (less than 3.5% or 3.5% -12.0%), quercetin and vitamin E (up to 1.4% or 1.4% -18.0%) [24]. The disadvantages of this invention include the absence in the formula of the type of introduction into the body of this composition. The purpose of this composition is to treat sexual dysfunction, which is different from the proposed one.

The closest analogue of the invention is a composition for whitening the skin, containing component A and component B [25]. Component A is represented by astaxanthin, component B by at least one of many compounds, including succinic acid, vitamin E, vitamin B and its derivatives, SOD. The disadvantages of the prototype of the invention include the fact that in addition to the above components, a large number of other components are claimed, which increases the likelihood of the mixture components reacting, which can negatively affect the properties of the composition. At the same time, it is rather difficult to identify such components: the disadvantage is the difficulty in controlling the components in the mixture. Moreover, the quantitative ratio of the ingredients is not indicated, which makes it difficult to reproduce this composition and evaluate its effectiveness. The disadvantage of this composition is the lack of clarification which particular vitamin from the B vitamins is used, which is essential for determining the properties of the composition. Component (s) B of the composition is also a minor additive, while the main properties of the composition according to the invention are due to component A.

The claimed invention is free from these disadvantages.

The technical result from the use of cosmetic products according to the invention is to expand the arsenal of tools to improve skin condition.

The technical result from the use of the cosmetic product according to the invention is also atraumatic due to the external use of the product, which allows to reduce the risks of side effects (compared with the injection, mainly, and the oral types of administration - no effect on the gastrointestinal tract (GIT)).

The technical result from the use of cosmetic products according to the invention also lies in the absence of the induction of allergic and irritating reactions. The specified technical result is achieved in that the agent is water-based and contains exclusively water-soluble components, does not contain a nutrient medium for microorganisms, and therefore there is no need to use an antiseptic. Use water-soluble components, including the water-soluble form of vitamin E, and an aqueous base, which eliminates the likelihood of multiplication and metabolism of microorganisms on the patient's skin, therefore, skin irritation and / or inflammation.

The form of the drug involves the single use of one unit of the drug (ampoule, vial), which excludes the possibility of ingestion and multiplication of microorganisms in the product during storage.

The technical result from the use of cosmetic products according to the invention is also expressed in increasing the safety of the drug. This technical result is achieved by the fact that to create the means according to the invention use only harmless components. Use recombinant SOD, do not use components that serve as a nutrient medium for microorganisms, do not use an antiseptic.

The technical result from the use of the cosmetic product according to the invention is its versatility - the product does not cause discomfort, is applicable for all skin types, for all ages, for both sexes, for different skin areas, due to the fact that normalize the work of skin cells and improves its external appearance - eliminates functional and cosmetic defects, in the absence of a brightening effect, tightens the skin, in the absence of belonging to anti-aging products.

The technical result from the use of the product is also expressed in the quick (see examples) restoration of normal functioning and improvement of the appearance of the skin by eliminating the effects of aggressive environmental factors and / or disturbances in the body, due to a combination of selected components in the composition of the product and the specifics of use - external local application, applications for sufficient time for a deep impact. The use of an external method of application of the agent allows targeted delivery of the active components, which increases the effectiveness of the agent and allows it to be used in a smaller amount compared to the oral route of administration, due to the reduction of quantitative and qualitative losses during passage through the gastrointestinal tract.

Products containing only a water-soluble component, in contrast to those with a fat-soluble component, do not form a film on the skin that impedes metabolic processes with the environment, including impeding cellular respiration. It also allows for quick skin repair.

The technical result from the use of the tool is also expressed in reducing the risk of reducing the control of the effect due to the lack of multicomponent.

The technical result is also expressed in the simplification of the manufacture of this tool. The specified technical result is achieved through the use of finished components, which are mixed in the absence of special conditions to obtain funds according to the invention.

SUMMARY OF THE INVENTION

A cosmetic product for rapid skin regeneration is proposed, containing superoxide dismutase, vitamin B group, succinic acid, characterized in that it additionally contains a water-soluble analogue of vitamin E trolox and L-arginine, the activity of superoxide dismutase is 200000-300000 U / mg, vitamin B group is represented by dexpanthenol, the ratio of the components is the following, wt.%: superoxide dismutase 0.1 (0.01 - 32), dexpanthenol 0.2 (0.1 - 20), succinic acid 0.6 (0.5 - up to pH 6.0), trolox 0.23 (0.13 - 45), L-arginine 1 (0.9-64), water for injection. The product is applied to the skin in a condition that requires the elimination of defects - with impaired function and / or cosmetic defects - for 20 minutes (15-20 minutes), using a material that holds the product in itself and gives the product to the skin during the exposure time. The tool allows you to quickly restore the skin without inducing irritating and allergic reactions.

Studies have been conducted reflecting specific examples of the implementation of this invention. Studies were conducted to confirm the technical result.

Example 1. Obtaining a composition.

The following substances were mixed under sterile conditions at room temperature until the indicated percentages of the total weight were reached:

SOD (LLC NPP Enzymatic Technologies, Russia) - 0.1%

Trolox (HYDROXY-2,5,7,8-TETRAMETHYLCHROMANE-2-CARBOXYLIC

ACID) (Aldrich, Russia) - 0.23%

L-arginine (Panreac, Spain) - 1%

Succinic acid (ZAO Lenreaktiv, Russia) - 0.6%

Dexpanthenol (Fluka, Switzerland) - 0.2%

Water for injection - the rest.

To obtain a cosmetic product, these substances of other manufacturers can be used.

Example 2. A patient of a dermatocosmetologist after a biorevitalization procedure.

Gender, age: wives, 32 years old.

Number of applications, exposure time: 1, 20 minutes.

Skin characteristics before use: capillary network, papules (patient with severe vascular pathology).

Characteristics of the skin after application: a noticeable equalization of skin tone, lightening, narrowing of blood vessels.

Example 3. A patient of a dermatocosmetologist after a laser peeling procedure.

Gender, age: husband, 27 years old.

Number of applications, exposure time: 1, 20 minutes.

Skin characteristics before use: characteristic redness, the initial stage of the inflammatory process, subjective discomfort in the area of the procedure.

Characteristics of the skin after application: a decrease in the inflammatory process, a noticeable decrease in redness, a feeling of tightness.

Comment of a dermatocosmetologist:

1. Ease of application and especially removal of funds (does not require additional rinsing);

2. It is convenient to use after injection and aggressive procedures;

3. Indispensable for peeling, laser, warming procedures;

4. Convenient for use on male skin.

Example 4. Patient - skin care prone to oily.

Gender, age: wives, 24 years old.

Number of applications, exposure time: 5, 15 minutes. Frequency: every other day.

Characteristics of the skin before use: skin prone to oiliness, with the consequences of acne, on the cheek - a trace of a chemical burn.

Characteristics of the skin after application: reduction of redness, regeneration after a burn (the burn spot has brightened significantly after five applications, the wounds have healed) and overall improvement of the skin condition (oiliness has decreased and good condition has been maintained throughout the day).

Patient's comment: pleasant sensations when using the drug - a feeling of freshness, a relaxing effect.

Example 5. Beautician patient - final masks in complex care (home care).

Gender, age: wives, 29 years old.

Number of applications, exposure time: daily use for 3 days, 20 minutes each.

Characteristics of the skin before use: dermatitis, complicated by mixed seborrhea, rashes with elements of suppuration.

Characteristics of the skin after application: a significant decrease in the release of sebum and rashes with elements of suppuration.

Example 6. The patient is a cosmetologist after the enzyme peeling procedure.

Gender, age: wives, 43 years old.

Number of applications, exposure time: 1, 20 minutes.

Characteristics of the skin before use: flushing of the skin after enzymatic peeling based on papain.

Skin characteristics after application: reduction of hyperemia.

Example 7. The patient is a cosmetologist after the procedure of waxing.

Gender, age: wives, 36 years old.

Number of applications, exposure time: 1, 10 minutes.

Skin characteristics before use: irritation in the area of hair removal (bikini).

Characteristics of the skin after application: a decrease in hyperemia, a decrease in swelling during the exposure of the product.

Example 8. The patient is a cosmetologist - sunburn

Gender, age: husband, 34 years.

Number of applications, exposure time: daily use for 2 days, 15 minutes.

Characteristics of the skin before use: hyperemia, peeling of the skin.

Characteristics of the skin after application: a decrease in hyperemia, the absence of peeling on the face, in contrast to other areas exposed to intense sun exposure.

Beautician's comment: the results are good, it is interesting to use the product in other cosmetic procedures, in the nursing period, and for home use.

Example 9. A patient of a dermatocosmetologist after a thermal burn

Gender, age: wives, 23 years old.

The number of applications, exposure time: 2, the first use of the product - 5 hours after receiving a burn, 20 minutes, the second - the next day, 20 minutes.

Skin characteristics before use: redness, blisters at the burn site.

Characteristics of the skin after use: acceleration of the rehabilitation process - a week after receiving a burn, complete restoration of the skin.

Example 10. A patient of a dermatocosmetologist after a mesotherapy procedure

Gender, age: wives, 40 years old.

Number of applications, exposure time: a course of 3 procedures, daily, immediately after each mesotherapy procedure 1 time per day. The exposure time every day is 20 minutes.

Skin characteristics before use: papules at the injection site (face).

Characteristics of the skin after application: papules at the injection site (face), lack of edema around the papules.

Information sources

1. Gourley S.T., Rice R.M., Hegueli A.F., et al. // J. Biomed Mat. Res. 1978, - V.12, N 2, - P. 219-232.

2. Datsenko B.M., Belov S.G., Tamm G.I. Purulent wound. Kiev: Health, 1985. - 136 p.

3. UV radiation and skin: effects, problems, solutions, collection of articles: Publishing House "Cosmetics and Medicine", 2004, 391 pp.

4. WO 2010064054 (A1), priority date 20081205.

5. WO 9520961 (A1), priority date 19900515.

6. CA 2073479 (A1), priority date 19920708.

7. Bisby, et al., Biochem. Biophys. Res. Comm., 119, 245-251 (1984).

8. US 6764993 (B2), priority date 20000314.

9. Römpp Chemie Lexikon, 10th Edition, 1999, Georg Thieme Verlag, Stuttgart / New-York, pp. 927, 3107-3108.

10. CN 1383811 (A), priority date 20020516.

11. CN 1876796 (A), priority date 20060417.

12. NZ 526350 (A), priority date 20030609.

13. CN 101249060 (A), priority date 20080328.

14. Alexis AF, Blackcloud P. Natural ingredients for darker skin types: growing options for hyperpigmentation. J Drugs Dermatol. 2013 Sep 1; 12 (9): s123-7.

15. CN 102366390 (A), priority date 20111114.

16. CN 1654640 (A), priority date 20050224.

17. CN 102441161 (A), priority date 20101015.

18. KR 101167936 (B1), priority date 20101228.

19. FR 2700954 (A1), priority date 19930129.

20. CN 101947312 (A), priority date 20100826.

21. CN 1163055 (A), priority date 19960425.

22. RU 2286135 (C1), priority date 20050221.

23. US 5425954 (A), priority date 19930930.

24. CN 101254206 (A), priority date 20080403.

25. JP 2011032171 (A), priority date 20090729.

Claims (3)

1. A cosmetic product for quick skin regeneration, containing superoxide dismutase, vitamin B group, succinic acid, characterized in that it additionally contains a water-soluble analogue of vitamin E trolox and L-arginine, the activity of superoxide dismutase is 200000-300000 U / mg, group B vitamin is represented by dexpanthenol , the ratio of components, wt. %: superoxide dismutase 0.01-32, dexpanthenol 0.1-20, succinic acid 0.5 - up to pH 6.0, trolox 0.13-45, L-arginine 0.9-64, water for injection - the rest. 2. Cosmetic under item 1, characterized in that the optimal ratio of components, wt. %: superoxide dismutase 0.1, dexpanthenol 0.2, succinic acid 0.6, trolox 0.23, L-arginine 1, water for injection - the rest. 3. A cosmetic product according to claim 1 or 2, characterized in that the product is applied to the skin in a condition requiring the elimination of defects, using a material that holds the product in itself and gives the product to the skin during the exposure time, the exposure time is 15-20 minutes.