|
US4269846A
(en)
|
1979-10-29 |
1981-05-26 |
Usv Pharmaceutical Corporation |
Heterocyclic compounds useful as anti-allergy agents
|
|
US5137876A
(en)
|
1990-10-12 |
1992-08-11 |
Merck & Co., Inc. |
Nucleoside antiviral and anti-inflammatory compounds and compositions and methods for using same
|
|
US5521184A
(en)
|
1992-04-03 |
1996-05-28 |
Ciba-Geigy Corporation |
Pyrimidine derivatives and processes for the preparation thereof
|
|
ATE459616T1
(de)
|
1998-08-11 |
2010-03-15 |
Novartis Ag |
Isochinoline derivate mit angiogenesis-hemmender wirkung
|
|
US6133031A
(en)
|
1999-08-19 |
2000-10-17 |
Isis Pharmaceuticals Inc. |
Antisense inhibition of focal adhesion kinase expression
|
|
GB9905075D0
(en)
|
1999-03-06 |
1999-04-28 |
Zeneca Ltd |
Chemical compounds
|
|
GB0004890D0
(en)
|
2000-03-01 |
2000-04-19 |
Astrazeneca Uk Ltd |
Chemical compounds
|
|
GB0011092D0
(en)
|
2000-05-08 |
2000-06-28 |
Black James Foundation |
Gastrin and cholecystokinin receptor ligands (III)
|
|
WO2002000196A2
(en)
|
2000-06-28 |
2002-01-03 |
Smithkline Beecham P.L.C. |
Wet milling process
|
|
EA007983B1
(ru)
|
2001-09-19 |
2007-02-27 |
Авентис Фарма С.А. |
Индолизины в качестве ингибиторов киназных белков
|
|
EP1441725A1
(en)
|
2001-10-26 |
2004-08-04 |
Aventis Pharmaceuticals Inc. |
Benzimidazoles and analogues and their use as protein kinases inhibitors
|
|
FR2831536A1
(fr)
|
2001-10-26 |
2003-05-02 |
Aventis Pharma Sa |
Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr
|
|
TWI302836B
(en)
|
2001-10-30 |
2008-11-11 |
Novartis Ag |
Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity
|
|
DE10207843A1
(de)
|
2002-02-15 |
2003-09-04 |
Schering Ag |
Mikrolia-Inhibitoren zur Unterbrechung von Interleukin 12 und IFN-gamma vermittelten Immunreaktionen
|
|
TW200406374A
(en)
|
2002-05-29 |
2004-05-01 |
Novartis Ag |
Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
|
|
GB0215676D0
(en)
|
2002-07-05 |
2002-08-14 |
Novartis Ag |
Organic compounds
|
|
AR042052A1
(es)
|
2002-11-15 |
2005-06-08 |
Vertex Pharma |
Diaminotriazoles utiles como inhibidores de proteinquinasas
|
|
UA80767C2
(en)
|
2002-12-20 |
2007-10-25 |
Pfizer Prod Inc |
Pyrimidine derivatives for the treatment of abnormal cell growth
|
|
US7186832B2
(en)
*
|
2003-02-20 |
2007-03-06 |
Sugen Inc. |
Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
|
|
US7157460B2
(en)
|
2003-02-20 |
2007-01-02 |
Sugen Inc. |
Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors
|
|
EP1599474B1
(en)
|
2003-03-04 |
2013-04-24 |
California Institute Of Technology |
Heterocyclic oligomeric compounds for DNA recognition
|
|
GB0305929D0
(en)
|
2003-03-14 |
2003-04-23 |
Novartis Ag |
Organic compounds
|
|
TW200517381A
(en)
|
2003-08-01 |
2005-06-01 |
Genelabs Tech Inc |
Bicyclic heteroaryl derivatives
|
|
AR045944A1
(es)
|
2003-09-24 |
2005-11-16 |
Novartis Ag |
Derivados de isoquinolina 1.4-disustituidas
|
|
BRPI0415395A
(pt)
*
|
2003-10-15 |
2006-12-12 |
Osi Pharm Inc |
composto, métodos para inibir a atividade da proteìna quinase e para tratar um paciente que tenha uma condição que seja mediada pela atividade da proteìna quinase, e, composição
|
|
WO2005118580A2
(en)
|
2004-05-12 |
2005-12-15 |
The Government Of The United States Of America As Represented By The Secretary, Department Of Health |
Tricyclic compounds as inhibitors of the hypoxic signaling pathway
|
|
MXPA06014247A
(es)
|
2004-06-10 |
2007-03-12 |
Irm Llc |
Compuestos y composiciones como inhibidores de la proteina quinasa.
|
|
US20090156602A1
(en)
|
2004-11-24 |
2009-06-18 |
Nigel Graham Cooke |
Organic Compounds
|
|
WO2007019417A1
(en)
|
2005-08-04 |
2007-02-15 |
Sirtris Pharmaceuticals, Inc. |
Oxazolopyridine derivatives as sirtuin modulators
|
|
EP1928237A4
(en)
|
2005-09-02 |
2011-03-09 |
Abbott Lab |
NEW HETEROCYCLES BASED ON IMIDAZO
|
|
EP2044051B1
(en)
|
2006-06-22 |
2010-01-27 |
BIOVITRUM AB (publ) |
Pyridine and pyrazine derivatives as mnk kinase inhibitors
|
|
CA2681813A1
(en)
|
2007-03-27 |
2009-01-08 |
Paratek Pharmaceuticals, Inc. |
Transcription factor modulating compounds and methods of use thereof
|
|
DE102007035333A1
(de)
|
2007-07-27 |
2009-01-29 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Neue substituierte Arylsulfonylglycine, deren Herstellung und deren Verwendung als Arzneimittel
|
|
GB0716292D0
(en)
|
2007-08-21 |
2007-09-26 |
Biofocus Dpi Ltd |
Imidazopyrazine compounds
|
|
ES2569528T3
(es)
|
2007-11-16 |
2016-05-11 |
Incyte Holdings Corporation |
4-pirazolil-N-arilpirimidin-2-aminas y 4-pirazolil-N-heteroarilpirimidin-2-aminas como inhibidores de quinasas Janus
|
|
EP2234487A4
(en)
|
2007-12-19 |
2011-09-07 |
Scripps Research Inst |
ANILIDES AND ANALOGUES AS INHIBITORS OF RHO KINASE
|
|
CA2712071A1
(en)
|
2008-01-15 |
2009-10-08 |
Siga Technologies, Inc. |
Antiviral drugs for treatment of arenavirus infection
|
|
EP2257161B1
(en)
|
2008-02-26 |
2012-04-25 |
Merck Sharp & Dohme Corp. |
Ahcy hydrolase inhibitors for treatment of hyper homocysteinemia
|
|
US8158616B2
(en)
|
2008-03-11 |
2012-04-17 |
Incyte Corporation |
Azetidine and cyclobutane derivatives as JAK inhibitors
|
|
WO2009133127A1
(en)
|
2008-04-30 |
2009-11-05 |
Merck Serono S.A. |
Fused bicyclic compounds and use thereof as pi3k inhibitors
|
|
CA2763536C
(en)
|
2008-05-30 |
2017-05-09 |
Marvin J. Miller |
Anti-bacterial agents from benzo[d]heterocyclic scaffolds for prevention and treatment of multidrug resistant bacteria
|
|
EP2358202B1
(en)
|
2008-11-03 |
2016-06-15 |
Merck Sharp & Dohme Corp. |
Benzimidazole and aza-benzimidazole carboxamides
|
|
WO2010061903A1
(ja)
|
2008-11-27 |
2010-06-03 |
塩野義製薬株式会社 |
Pi3k阻害活性を有するピリミジン誘導体およびピリジン誘導体
|
|
GB0822981D0
(en)
|
2008-12-17 |
2009-01-21 |
Summit Corp Plc |
Compounds for treatment of duchenne muscular dystrophy
|
|
CA2753560A1
(en)
|
2009-02-27 |
2010-11-25 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of phosphatidylinositol 3-kinase
|
|
BRPI1014572B8
(pt)
*
|
2009-04-16 |
2022-07-19 |
Fundacion Centro Nac De Investigaciones Oncologicas Carlos Iii |
Imidazopirazinas para uso como inibidores de cinase
|
|
WO2010135650A1
(en)
|
2009-05-22 |
2010-11-25 |
Incyte Corporation |
N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS
|
|
RS53494B9
(sr)
|
2009-06-29 |
2020-11-30 |
Incyte Holdings Corp |
Pirimidinoni kao inhibitori pi3k
|
|
US9249145B2
(en)
|
2009-09-01 |
2016-02-02 |
Incyte Holdings Corporation |
Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
|
|
US8680108B2
(en)
|
2009-12-18 |
2014-03-25 |
Incyte Corporation |
Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
|
|
WO2011075643A1
(en)
|
2009-12-18 |
2011-06-23 |
Incyte Corporation |
Substituted heteroaryl fused derivatives as pi3k inhibitors
|
|
WO2011099832A2
(en)
|
2010-02-12 |
2011-08-18 |
Crystalgenomics, Inc. |
Novel benzimidazole compound, preparation method thereof and pharmaceutical composition comprising the same
|
|
AR080754A1
(es)
|
2010-03-09 |
2012-05-09 |
Janssen Pharmaceutica Nv |
Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
|
|
EP4036088B1
(en)
|
2010-03-10 |
2024-04-03 |
Incyte Holdings Corporation |
Piperidin-4-yl azetidine derivatives as jak1 inhibitors
|
|
US20130018039A1
(en)
|
2010-03-31 |
2013-01-17 |
Bodmer Vera Q |
Imidazolyl-imidazoles as kinase inhibitors
|
|
AR081823A1
(es)
|
2010-04-14 |
2012-10-24 |
Incyte Corp |
DERIVADOS FUSIONADOS COMO INHIBIDORES DE PI3Kd
|
|
CA2800509A1
(en)
|
2010-05-24 |
2011-12-01 |
Presidio Pharmaceuticals, Inc. |
Inhibitors of hcv ns5a
|
|
US8623857B2
(en)
|
2010-05-26 |
2014-01-07 |
Merck Sharp & Dohme Corp. |
N-phenyl imidazole carboxamide inhibitors of 3-phosphoinositide-dependent protein kinase-1
|
|
WO2011163195A1
(en)
|
2010-06-21 |
2011-12-29 |
Incyte Corporation |
Fused pyrrole derivatives as pi3k inhibitors
|
|
WO2012051410A2
(en)
|
2010-10-13 |
2012-04-19 |
Millennium Pharmaceuticals, Inc. |
Heteroaryls and uses thereof
|
|
BR112013012502A2
(pt)
|
2010-11-19 |
2019-03-06 |
Incyte Corporation |
pirrolopiridina ciclobutil substituída e derivados de pirrolopirimidina derivativos como inibidores de jak
|
|
CA2818545C
(en)
|
2010-11-19 |
2019-04-16 |
Incyte Corporation |
Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
|
|
EP2649062B1
(en)
|
2010-11-30 |
2015-04-08 |
Takeda Pharmaceutical Company Limited |
Bicyclic compounds as inhibitors of acetyl-coa carboxylase (acc)
|
|
ES2764848T3
(es)
|
2010-12-20 |
2020-06-04 |
Incyte Holdings Corp |
N-(1-(fenilo sustituido)etilo)-9H-purina-6-aminas como inhibidores de PI3K
|
|
US9108984B2
(en)
|
2011-03-14 |
2015-08-18 |
Incyte Corporation |
Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
|
|
US8673905B2
(en)
|
2011-03-17 |
2014-03-18 |
Hoffmann-La Roche Inc. |
Imidazo pyrazines
|
|
US9126948B2
(en)
|
2011-03-25 |
2015-09-08 |
Incyte Holdings Corporation |
Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
|
|
WO2012143796A2
(en)
|
2011-04-21 |
2012-10-26 |
Institut Pasteur Korea |
Anti-inflammation compounds
|
|
AU2012267556B9
(en)
|
2011-06-09 |
2017-05-11 |
Rhizen Pharmaceuticals Sa |
Novel compounds as modulators of GPR-119
|
|
EP2721028B1
(en)
|
2011-06-20 |
2015-11-04 |
Incyte Corporation |
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
|
|
TW201313721A
(zh)
|
2011-08-18 |
2013-04-01 |
Incyte Corp |
作為ｊａｋ抑制劑之環己基氮雜環丁烷衍生物
|
|
JP6067709B2
(ja)
|
2011-09-02 |
2017-01-25 |
インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ |
Ｐｉ３ｋ阻害剤としてのヘテロシクリルアミン
|
|
CN104066735B
(zh)
*
|
2012-01-10 |
2016-08-31 |
拜耳知识产权有限责任公司 |
作为akt激酶抑制剂的取代的咪唑并吡嗪
|
|
WO2013129674A1
(ja)
|
2012-03-01 |
2013-09-06 |
学校法人兵庫医科大学 |
新規ベンズイミダゾール誘導体及びその用途
|
|
AR090548A1
(es)
|
2012-04-02 |
2014-11-19 |
Incyte Corp |
Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
|
|
WO2013173720A1
(en)
|
2012-05-18 |
2013-11-21 |
Incyte Corporation |
Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
|
|
WO2013180193A1
(ja)
|
2012-05-31 |
2013-12-05 |
住友化学株式会社 |
縮合複素環化合物
|
|
JP6259823B2
(ja)
|
2012-07-13 |
2018-01-10 |
ユーシービー バイオファルマ エスピーアールエル |
Ｔｎｆ活性の調節物質としてのイミダゾピリジン誘導体
|
|
WO2014071031A1
(en)
|
2012-11-01 |
2014-05-08 |
Incyte Corporation |
Tricyclic fused thiophene derivatives as jak inhibitors
|
|
TWI687220B
(zh)
|
2013-03-01 |
2020-03-11 |
美商英塞特控股公司 |
吡唑并嘧啶衍生物治療PI3Kδ相關病症之用途
|
|
WO2014149207A2
(en)
|
2013-03-15 |
2014-09-25 |
Dow Agrosciences Llc |
Benzimidazole-based insecticidal compositions and related methods
|
|
US8999992B2
(en)
|
2013-03-15 |
2015-04-07 |
Vm Pharma Llc |
Crystalline forms of tryosine kinase inhibitors and their salts
|
|
WO2014153529A1
(en)
|
2013-03-22 |
2014-09-25 |
The Scripps Research Institute |
Substituted benzimidazoles as nociceptin receptor modulators
|
|
US9394254B2
(en)
|
2013-05-08 |
2016-07-19 |
The University of Denver and Regis University |
Antibiotic and anti-parasitic agents that modulate class II fructose 1,6-bisphosphate aldolase
|
|
EP3786162B1
(en)
|
2013-05-17 |
2023-08-09 |
Incyte Holdings Corporation |
Bipyrazole derivatives as jak inhibitors
|
|
EP4219477A1
(en)
|
2013-07-17 |
2023-08-02 |
Otsuka Pharmaceutical Co., Ltd. |
Cyanotriazole compounds
|
|
US9751888B2
(en)
|
2013-10-04 |
2017-09-05 |
Infinity Pharmaceuticals, Inc. |
Heterocyclic compounds and uses thereof
|
|
MX2020004398A
(es)
|
2014-04-08 |
2022-06-06 |
Incyte Corp |
Tratamiento de neoplasias malignas de linfocitos b mediante una combinacion de inhibidores de janus cinasa (jak) y fosfatidilinositol 3 cinasa (pi3k).
|
|
EP2930048A1
(en)
|
2014-04-10 |
2015-10-14 |
Johnson Controls Automotive Electronics SAS |
Head up display projecting visual information onto a screen
|
|
WO2015191677A1
(en)
|
2014-06-11 |
2015-12-17 |
Incyte Corporation |
Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
|
|
BR112017005128A2
(pt)
|
2014-09-16 |
2018-07-31 |
Celgene Quanticel Res Inc |
inibidores de histona desmetilase
|
|
US10214537B2
(en)
*
|
2014-10-22 |
2019-02-26 |
Bristol-Myers Squibb Company |
Bicyclic heteroaryl amine compounds
|
|
EP3209665B1
(en)
*
|
2014-10-22 |
2019-08-14 |
Bristol-Myers Squibb Company |
Substituted pyrrolotriazine amine compounds as pi3k inhibitors
|
|
MA40933A
(fr)
|
2014-11-11 |
2017-09-19 |
Piqur Therapeutics Ag |
Difluorométhyl-aminopyridines et difluorométhyl-aminopyrimidines
|
|
WO2016106624A1
(en)
*
|
2014-12-31 |
2016-07-07 |
Merck Sharp & Dohme Corp. |
Tertiary alcohol imidazopyrazine btk inhibitors
|
|
WO2016130501A1
(en)
|
2015-02-09 |
2016-08-18 |
Incyte Corporation |
Aza-heteroaryl compounds as pi3k-gamma inhibitors
|
|
US9968604B2
(en)
|
2015-04-16 |
2018-05-15 |
Chiesi Farmaceutici S.P.A. |
Chromene derivatives as phoshoinositide 3-kinases inhibitors
|
|
BR112017024163A2
(pt)
|
2015-05-12 |
2018-07-17 |
Kalyra Pharmaceuticals Inc |
compostos bicíclicos
|
|
MD3371190T2
(ro)
|
2015-11-06 |
2022-09-30 |
Incyte Corp |
Compuși heterociclici ca inhibitori PI3K-gamma
|
|
ES2833955T3
(es)
|
2016-01-05 |
2021-06-16 |
Incyte Corp |
Piridinas sustituidas con pirazol/imidazol como inhibidores de PI3K-Gamma
|
|
TW201803871A
(zh)
*
|
2016-06-24 |
2018-02-01 |
英塞特公司 |
作為ＰＩ３Ｋ-γ抑制劑之雜環化合物
|
|
RU2019108464A
(ru)
|
2016-08-26 |
2020-09-28 |
Мицубиси Танабе Фарма Корпорейшн |
Бициклическое азотсодержащее гетероциклическое соединение
|
|
US20200000713A1
(en)
|
2017-01-20 |
2020-01-02 |
Massachusetts Institute Of Technology |
Injectable polymer micro-depots for controlled local drug delivery
|
|
TWI674261B
(zh)
|
2017-02-17 |
2019-10-11 |
美商英能腫瘤免疫股份有限公司 |
Nlrp3 調節劑
|
|
SG11201912166XA
(en)
|
2017-07-24 |
2020-02-27 |
Novartis Inflammasome Research Inc |
Compounds and compositions for treating conditions associated with nlrp activity
|
|
US10988454B2
(en)
|
2017-09-14 |
2021-04-27 |
Abbvie Overseas S.À.R.L. |
Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
|
|
MD3697789T2
(ro)
|
2017-10-18 |
2022-02-28 |
Incyte Corp |
Derivați imidazol condensați substituiți cu grupări hidroxi terțiare ca inhibitori PI3K-GAMA
|
|
CA3079273A1
(en)
|
2017-10-18 |
2019-04-25 |
Epizyme, Inc. |
Amine-substituted heterocyclic compounds as ehmt2 inhibitors, salts thereof, and methods of synthesis thereof
|
|
CA3083674A1
(en)
|
2017-12-19 |
2019-06-27 |
Turning Point Therapeutics, Inc. |
Macrocyclic compounds for treating disease
|
|
CA3086083A1
(en)
|
2017-12-21 |
2019-06-27 |
Basf Se |
Pesticidal compounds
|
|
BR112020010123A2
(pt)
|
2017-12-21 |
2020-11-10 |
Boehringer Ingelheim International Gmbh |
piridopirimidinonas substituídas por benzilamino e derivados como inibidores de sos1
|
|
CA3111629A1
(en)
|
2018-09-05 |
2020-03-12 |
Incyte Corporation |
Crystalline forms of a phosphoinositide 3-kinase (pi3k) inhibitor
|