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RS20060293A - Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same - Google Patents

Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same

Info

Publication number
RS20060293A
RS20060293A YUP-2006/0293A YUP20060293A RS20060293A RS 20060293 A RS20060293 A RS 20060293A YU P20060293 A YUP20060293 A YU P20060293A RS 20060293 A RS20060293 A RS 20060293A
Authority
RS
Serbia
Prior art keywords
production
methods
same
pharmaceutical formulations
formulations containing
Prior art date
Application number
YUP-2006/0293A
Other languages
English (en)
Inventor
Rolf Banholzer
Peter Sieger
Waldemar Pfrengle
Original Assignee
Boehringer Ingelheim International Gmbh.,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34530661&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RS20060293(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim International Gmbh., filed Critical Boehringer Ingelheim International Gmbh.,
Publication of RS20060293A publication Critical patent/RS20060293A/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pulmonology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Pronalazak se odnosi na nove soli tiotropijuma, na postupke za njihovo dobijanje, zatim na farmaceutske formulacije koje ih sadrže, kao i na njihovu primenu za pripremanje leka za lečenje bolesti disajnih puteva, a naročito za lečenje COPD (chronic obstructive pulmonary disease = hronična opstruktivna bolest pluća) i astme.
YUP-2006/0293A 2003-11-03 2004-10-29 Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same RS20060293A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03025076 2003-11-03
PCT/EP2004/012270 WO2005042528A1 (de) 2003-11-03 2004-10-29 Neue tiotropiumsalze, verfahren zu deren herstellung sowie diese enthaltende arzneimittelformulierungen

Publications (1)

Publication Number Publication Date
RS20060293A true RS20060293A (en) 2008-08-07

Family

ID=34530661

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-2006/0293A RS20060293A (en) 2003-11-03 2004-10-29 Novel tiotropium salts, methods for the production thereof, and pharmaceutical formulations containing the same

Country Status (28)

Country Link
US (1) US20050096341A1 (sr)
EP (5) EP1682543B1 (sr)
JP (1) JP5165245B2 (sr)
KR (1) KR20060102561A (sr)
CN (3) CN101648950B (sr)
AR (1) AR046318A1 (sr)
AT (1) ATE478071T1 (sr)
AU (1) AU2004285685B2 (sr)
CA (1) CA2544357A1 (sr)
CO (1) CO5690554A2 (sr)
DE (1) DE502004011562D1 (sr)
DK (2) DK2083007T3 (sr)
EA (1) EA012369B1 (sr)
EC (2) ECSP066544A (sr)
ES (2) ES2350981T3 (sr)
IL (1) IL175127A (sr)
MY (1) MY145166A (sr)
NO (1) NO20061441L (sr)
NZ (1) NZ547523A (sr)
PE (1) PE20050485A1 (sr)
PL (1) PL2083007T3 (sr)
RS (1) RS20060293A (sr)
SG (1) SG149876A1 (sr)
TW (1) TW200523263A (sr)
UA (1) UA82414C2 (sr)
UY (1) UY28589A1 (sr)
WO (1) WO2005042528A1 (sr)
ZA (1) ZA200602343B (sr)

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PE20050446A1 (es) * 2003-11-03 2005-08-02 Boehringer Ingelheim Int Procedimiento para la preparacion de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, asi como las formulaciones medicamentosas que las contienen
KR20080024532A (ko) * 2005-06-15 2008-03-18 베링거 인겔하임 인터내셔날 게엠베하 신규한 티오트로퓸 염의 제조방법, 신규한 티오트로퓸 염및 이의 약제학적 조성물
WO2006134022A1 (en) * 2005-06-17 2006-12-21 Boehringer Ingelheim International Gmbh Mrp iv inhibitors for the treatment of respiratory diseases
DE102005035112A1 (de) * 2005-07-27 2007-02-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neues Verfahren zur Herstellung von Tiotropiumsalzen unter Anwendung von in organischen Lösungsmitteln löslichen N-Methylscopiniumsalzen
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
KR20080079586A (ko) * 2005-12-19 2008-09-01 시코르, 인크. 순수하고 안정한 티오트로퓸 브로마이드
RS52663B2 (sr) * 2005-12-19 2018-05-31 Sicor Inc Nova kristalna forma tiotropijum bromida i proces njene pripreme
US20080051582A1 (en) * 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
EP1925295A1 (de) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
WO2008089852A1 (de) * 2007-01-26 2008-07-31 Boehringer Ingelheim Pharma Gmbh & Co.Kg Neues verfahren zur herstellung von tiotropiumsalzen
EP1953156A1 (de) * 2007-01-29 2008-08-06 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Scopiniumsalzen
EP2411008B1 (en) * 2009-03-27 2017-03-22 Mahmut Bilgic Complexes of tiotropium with improved properties of solubility and stability
PL388070A1 (pl) * 2009-05-19 2010-11-22 Adamed Spółka Z Ograniczoną Odpowiedzialnością Nowe sole tiotropium
CZ201241A3 (cs) * 2012-01-20 2013-07-31 Zentiva, K.S. Nové polymorfní formy tiotropium jodidu a zpusob jejich prípravy
JP6335798B2 (ja) * 2012-02-28 2018-05-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規噴射剤含有チオトロピウム製剤

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DE10056104A1 (de) * 2000-11-13 2002-05-23 Boehringer Ingelheim Pharma Neue Arzneimittelkompositionen auf der Basis von Tiotropiumsalzen und Salzen des Salmeterols
US20020193392A1 (en) * 2000-11-13 2002-12-19 Christel Schmelzer Pharmaceutical compositions based on tiotropium salts of salts of salmeterol
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PE20050446A1 (es) * 2003-11-03 2005-08-02 Boehringer Ingelheim Int Procedimiento para la preparacion de nuevas sales de tiotropio, nuevas sales de tiotropio como tales, asi como las formulaciones medicamentosas que las contienen
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KR20080024532A (ko) * 2005-06-15 2008-03-18 베링거 인겔하임 인터내셔날 게엠베하 신규한 티오트로퓸 염의 제조방법, 신규한 티오트로퓸 염및 이의 약제학적 조성물

Also Published As

Publication number Publication date
AU2004285685A1 (en) 2005-05-12
CN102964344B (zh) 2014-12-31
EP2083007A1 (de) 2009-07-29
HK1099753A1 (zh) 2007-08-24
CA2544357A1 (en) 2005-05-12
MY145166A (en) 2011-12-30
EP2083007B1 (de) 2013-04-24
ATE478071T1 (de) 2010-09-15
EP2322522A1 (de) 2011-05-18
CN1875020B (zh) 2010-04-28
DK1682543T3 (da) 2010-12-13
EA200600854A1 (ru) 2006-10-27
AU2004285685B2 (en) 2011-03-24
CN102964344A (zh) 2013-03-13
IL175127A0 (en) 2006-09-05
NO20061441L (no) 2006-07-12
EP2336127A1 (de) 2011-06-22
UY28589A1 (es) 2005-06-30
ECSP066544A (es) 2006-10-17
ES2422730T3 (es) 2013-09-13
ECSP066545A (es) 2006-10-17
JP5165245B2 (ja) 2013-03-21
NZ547523A (en) 2009-07-31
DE502004011562D1 (de) 2010-09-30
SG149876A1 (en) 2009-02-27
TW200523263A (en) 2005-07-16
DK2083007T3 (da) 2013-07-29
EA012369B1 (ru) 2009-10-30
JP2007509895A (ja) 2007-04-19
PL2083007T3 (pl) 2013-09-30
CO5690554A2 (es) 2006-10-31
CN101648950A (zh) 2010-02-17
CN101648950B (zh) 2014-05-07
KR20060102561A (ko) 2006-09-27
IL175127A (en) 2011-10-31
AR046318A1 (es) 2005-11-30
US20050096341A1 (en) 2005-05-05
ZA200602343B (en) 2007-12-27
EP1682543A1 (de) 2006-07-26
UA82414C2 (uk) 2008-04-10
ES2350981T3 (es) 2011-01-28
EP1682543B1 (de) 2010-08-18
PE20050485A1 (es) 2005-10-05
EP2319844A1 (de) 2011-05-11
CN1875020A (zh) 2006-12-06
WO2005042528A1 (de) 2005-05-12

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