RO85271B - Procedeu pentru prepararea unor derivati de indolizina - Google Patents
Procedeu pentru prepararea unor derivati de indolizinaInfo
- Publication number
- RO85271B RO85271B RO108949A RO10894980A RO85271B RO 85271 B RO85271 B RO 85271B RO 108949 A RO108949 A RO 108949A RO 10894980 A RO10894980 A RO 10894980A RO 85271 B RO85271 B RO 85271B
- Authority
- RO
- Romania
- Prior art keywords
- bromine
- iodine
- chlorine
- methyl
- fluorine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor derivati de indolizina cu formula generala I: (vezi formula) în care R reprezinta un radical alchil cu catena liniara sau ramificata cu 1...8 atomi de carbon, un radical fenil eventual monosubstituit cu fluor, clor, brom, metil sau metoxi, sau disubstituit cu fluor, brom sau clor, sau un radical metilfenil substituit în nucleul aromatic cu un atom de fluor, clor, brom, X1 reprezinta clor, brom sau iod, A este o grupa aleasa dintre (vezi formula) în care X2 reprezinta clor, brom, iod, metil sau metoxi, X3 reprezinta clor, brom, iod sau metil R1 reprezinta metil, etil, n-propil, sau n-butil, n este un numar întreg cuprins între 2 si 6, caracterizat prin aceea ca un derivat de indolizina cu formula II: (vezi formula) în care R, A, R1 si n au semnificatiile de mai sus se supune reactiei cu N-clorsuccinimida, brom sau iod, ractia avînd loc în mediu de dicloretan sau dioxan, între 0 degree C si temperatura camerei, eventual în prezenta de acetat de metil alcalin cînd se lucreaza cu brom sau iod, obtinîndu-se derivatul de indolizina ca baza libera care eventual reactioneaza cu un acid anorganic sau organic pentru a da o sare de aditie netoxica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7942146 | 1979-12-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO85271A RO85271A (ro) | 1984-09-29 |
| RO85271B true RO85271B (ro) | 1984-10-30 |
Family
ID=10509659
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO108949A RO85271B (ro) | 1979-12-06 | 1980-12-05 | Procedeu pentru prepararea unor derivati de indolizina |
| RO102781A RO81452B (ro) | 1979-12-06 | 1980-12-05 | Procedeu pentru prepararea unor derivati de indolizina |
| RO108948A RO84707B (ro) | 1979-12-06 | 1980-12-05 | Procedeu pentru prepararea unor derivati de indolizina |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO102781A RO81452B (ro) | 1979-12-06 | 1980-12-05 | Procedeu pentru prepararea unor derivati de indolizina |
| RO108948A RO84707B (ro) | 1979-12-06 | 1980-12-05 | Procedeu pentru prepararea unor derivati de indolizina |
Country Status (40)
| Country | Link |
|---|---|
| JP (1) | JPS56103181A (ro) |
| AR (4) | AR227036A1 (ro) |
| AT (1) | AT376438B (ro) |
| AU (1) | AU536320B2 (ro) |
| BE (1) | BE886511A (ro) |
| BG (2) | BG37379A3 (ro) |
| BR (1) | BR8007691A (ro) |
| CA (1) | CA1152077A (ro) |
| CH (1) | CH651041A5 (ro) |
| CS (3) | CS222692B2 (ro) |
| DD (1) | DD155069A5 (ro) |
| DE (1) | DE3046017C2 (ro) |
| DK (1) | DK146977C (ro) |
| ES (4) | ES8205798A1 (ro) |
| FI (1) | FI67846C (ro) |
| GR (1) | GR70224B (ro) |
| HK (1) | HK65884A (ro) |
| HU (1) | HU185019B (ro) |
| IE (1) | IE50519B1 (ro) |
| IL (1) | IL61385A (ro) |
| IN (1) | IN151241B (ro) |
| IS (1) | IS1209B6 (ro) |
| IT (1) | IT1218424B (ro) |
| KE (1) | KE3438A (ro) |
| LU (1) | LU82983A1 (ro) |
| MA (1) | MA19007A1 (ro) |
| NL (1) | NL184683C (ro) |
| NO (1) | NO157019C (ro) |
| NZ (1) | NZ195754A (ro) |
| OA (1) | OA06711A (ro) |
| PH (1) | PH17028A (ro) |
| PL (3) | PL127865B1 (ro) |
| PT (1) | PT72151B (ro) |
| RO (3) | RO85271B (ro) |
| SE (1) | SE441926B (ro) |
| SG (1) | SG33384G (ro) |
| SU (3) | SU1058505A3 (ro) |
| YU (3) | YU42366B (ro) |
| ZA (1) | ZA806831B (ro) |
| ZW (1) | ZW28580A1 (ro) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201704708QA (en) * | 2014-12-10 | 2017-07-28 | Ono Pharmaceutical Co | Dihydroindolizinone derivative |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1518443A (en) | 1976-02-19 | 1978-07-19 | Labaz | Indolizine derivatives and process for preparing the same |
-
1980
- 1980-10-31 IL IL61385A patent/IL61385A/xx unknown
- 1980-11-04 GR GR63275A patent/GR70224B/el unknown
- 1980-11-05 IS IS2594A patent/IS1209B6/is unknown
- 1980-11-05 ZA ZA00806831A patent/ZA806831B/xx unknown
- 1980-11-07 CH CH8289/80A patent/CH651041A5/fr not_active IP Right Cessation
- 1980-11-12 AU AU64292/80A patent/AU536320B2/en not_active Ceased
- 1980-11-13 PH PH24853A patent/PH17028A/en unknown
- 1980-11-19 NL NLAANVRAGE8006310,A patent/NL184683C/xx not_active IP Right Cessation
- 1980-11-25 BR BR8007691A patent/BR8007691A/pt unknown
- 1980-11-26 ZW ZW285/80A patent/ZW28580A1/xx unknown
- 1980-12-01 BG BG062985A patent/BG37379A3/xx unknown
- 1980-12-01 CA CA000365859A patent/CA1152077A/en not_active Expired
- 1980-12-01 BG BG049830A patent/BG35598A3/xx unknown
- 1980-12-02 YU YU3041/80A patent/YU42366B/xx unknown
- 1980-12-02 SE SE8008444A patent/SE441926B/sv not_active IP Right Cessation
- 1980-12-03 MA MA19209A patent/MA19007A1/fr unknown
- 1980-12-03 IE IE2520/80A patent/IE50519B1/en unknown
- 1980-12-04 CS CS808517A patent/CS222692B2/cs unknown
- 1980-12-04 IN IN1344/CAL/80A patent/IN151241B/en unknown
- 1980-12-04 NZ NZ195754A patent/NZ195754A/en unknown
- 1980-12-04 PL PL1980231829A patent/PL127865B1/pl unknown
- 1980-12-04 CS CS814016A patent/CS222698B2/cs unknown
- 1980-12-04 PL PL1980231828A patent/PL129365B1/pl unknown
- 1980-12-04 PL PL1980228265A patent/PL127999B1/pl unknown
- 1980-12-04 PT PT72151A patent/PT72151B/pt unknown
- 1980-12-04 CS CS808517A patent/CS222697B2/cs unknown
- 1980-12-05 NO NO803681A patent/NO157019C/no unknown
- 1980-12-05 IT IT26463/80A patent/IT1218424B/it active
- 1980-12-05 ES ES497504A patent/ES8205798A1/es not_active Expired
- 1980-12-05 AT AT0596780A patent/AT376438B/de not_active IP Right Cessation
- 1980-12-05 DK DK521980A patent/DK146977C/da not_active IP Right Cessation
- 1980-12-05 RO RO108949A patent/RO85271B/ro unknown
- 1980-12-05 HU HU802915A patent/HU185019B/hu not_active IP Right Cessation
- 1980-12-05 LU LU82983A patent/LU82983A1/fr unknown
- 1980-12-05 BE BE0/203053A patent/BE886511A/fr not_active IP Right Cessation
- 1980-12-05 JP JP17252180A patent/JPS56103181A/ja active Granted
- 1980-12-05 RO RO102781A patent/RO81452B/ro unknown
- 1980-12-05 DE DE3046017A patent/DE3046017C2/de not_active Expired
- 1980-12-05 RO RO108948A patent/RO84707B/ro unknown
- 1980-12-05 FI FI803792A patent/FI67846C/fi not_active IP Right Cessation
- 1980-12-05 SU SU803213301A patent/SU1058505A3/ru active
- 1980-12-06 OA OA57269A patent/OA06711A/xx unknown
- 1980-12-06 DD DD80225817A patent/DD155069A5/de unknown
- 1980-12-06 AR AR283495A patent/AR227036A1/es active
-
1981
- 1981-12-16 ES ES508052A patent/ES508052A0/es active Granted
- 1981-12-16 ES ES508051A patent/ES508051A0/es active Granted
- 1981-12-16 ES ES508053A patent/ES8300110A1/es not_active Expired
- 1981-12-22 SU SU813367150A patent/SU1109051A3/ru active
-
1982
- 1982-02-24 AR AR227094A patent/AR227094A1/es active
- 1982-02-24 AR AR288535A patent/AR229692A1/es active
- 1982-02-24 AR AR288533A patent/AR227093A1/es active
-
1983
- 1983-02-24 YU YU443/83A patent/YU42840B/xx unknown
- 1983-02-24 YU YU444/83A patent/YU42127B/xx unknown
-
1984
- 1984-04-25 SG SG33384A patent/SG33384G/en unknown
- 1984-08-13 KE KE3438A patent/KE3438A/xx unknown
- 1984-08-23 HK HK658/84A patent/HK65884A/xx unknown
- 1984-10-12 SU SU843801012A patent/SU1287751A3/ru active
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