PT3724196T - Azetidina di-hidrotienopiridinas substituídas e a sua utilização como inibidores de fosfodiesterase - Google Patents
Azetidina di-hidrotienopiridinas substituídas e a sua utilização como inibidores de fosfodiesteraseInfo
- Publication number
- PT3724196T PT3724196T PT188304224T PT18830422T PT3724196T PT 3724196 T PT3724196 T PT 3724196T PT 188304224 T PT188304224 T PT 188304224T PT 18830422 T PT18830422 T PT 18830422T PT 3724196 T PT3724196 T PT 3724196T
- Authority
- PT
- Portugal
- Prior art keywords
- dihydrothienopyridines
- phosphodiesterase inhibitors
- substituted azetidine
- azetidine
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17207661 | 2017-12-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT3724196T true PT3724196T (pt) | 2023-01-13 |
Family
ID=60673681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT188304224T PT3724196T (pt) | 2017-12-15 | 2018-12-14 | Azetidina di-hidrotienopiridinas substituídas e a sua utilização como inibidores de fosfodiesterase |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11384096B2 (pt) |
| EP (1) | EP3724196B9 (pt) |
| JP (1) | JP7203846B2 (pt) |
| CN (1) | CN111727191B (pt) |
| DK (1) | DK3724196T3 (pt) |
| ES (1) | ES2935615T3 (pt) |
| FI (1) | FI3724196T3 (pt) |
| PT (1) | PT3724196T (pt) |
| WO (1) | WO2019115776A1 (pt) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2020524131A (ja) | 2017-06-20 | 2020-08-13 | レオ ファーマ アクティーゼルスカブ | １，３−ベンゾジオキソール複素環式化合物の調製方法 |
| CN111108109A (zh) | 2017-09-20 | 2020-05-05 | 利奥制药有限公司 | 取代的二氢噻吩并嘧啶及其作为磷酸二酯酶抑制剂的用途 |
| WO2019115776A1 (en) | 2017-12-15 | 2019-06-20 | Leo Pharma A/S | Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03148337A (ja) | 1989-10-31 | 1991-06-25 | Aisin Seiki Co Ltd | ２輪／４輪駆動制御装置 |
| CA2272327A1 (en) | 1996-11-19 | 1998-05-28 | Kyowa Hakko Kogyo Co., Ltd. | Oxygen-containing heterocyclic compounds |
| DE19730847A1 (de) * | 1997-07-18 | 1999-01-28 | Bayer Ag | Tricyclisch substituierte Oxazolidinone |
| JPH1159216A (ja) | 1997-08-26 | 1999-03-02 | Fuji Heavy Ind Ltd | ４輪駆動車の動力配分制御装置 |
| FR2799417B1 (fr) | 1999-10-08 | 2009-01-23 | Toyota Motor Co Ltd | Dispositif de controle de vehicule, notamment pour la repartition des forces de traction avant-arriere |
| AU2002364211A1 (en) | 2001-12-21 | 2003-07-15 | Bayer Pharmaceuticals Corporation | Thienopyrimidine derivative compounds as inhibitors of prolylpeptidase, inducers of apoptosis and cancer treatment agents |
| US6630813B2 (en) | 2002-03-06 | 2003-10-07 | Ford Global Technologies, Llc | Method and apparatus for monitoring the state of the battery of a hybrid electric vehicle |
| JP2007516162A (ja) * | 2003-06-20 | 2007-06-21 | セルテック アール アンド ディ リミテッド | キナーゼ阻害剤としてのチエノピリドン誘導体 |
| US7771742B2 (en) | 2004-04-30 | 2010-08-10 | Allergan, Inc. | Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods |
| ES2328400T3 (es) | 2005-04-21 | 2009-11-12 | Boehringer Ingelheim International Gmbh | Dihidrotienopirimidinas para el tratamiento de enfermedades inflamatorias. |
| KR20080076968A (ko) * | 2005-11-23 | 2008-08-20 | 인터뮨, 인크. | 스트레스-활성화 단백질 키나제 시스템을 조절하는 방법 |
| JP2009523805A (ja) | 2006-01-17 | 2009-06-25 | シグナル ファーマシューティカルズ，エルエルシー | ＴＮＦα、ＰＤＥ４及びＢ−ＲＡＦの阻害剤、それらの組成物及びそれらの使用法 |
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| WO2008045664A2 (en) * | 2006-10-06 | 2008-04-17 | Kalypsys, Inc. | Heterocyclic pde4 inhibitors as antiinflammatory agents |
| WO2008064829A2 (en) * | 2006-11-30 | 2008-06-05 | Ucb Pharma, S.A. | Novel aminothienopyridinone derivatives processes for preparing them and pharmaceutical compositions thereof |
| MX2009009238A (es) | 2007-02-28 | 2009-09-08 | Leo Pharma As | Nuevos inhibidores de fosfodiesterasa. |
| BRPI0817781A2 (pt) | 2007-10-19 | 2019-09-24 | Boehringer Ingelheim Int | piperazino-diidroteinopirimidinas substituídas com heterociclo |
| WO2009050236A1 (de) * | 2007-10-19 | 2009-04-23 | Boehringer Ingelheim International Gmbh | Neue piperazino-dihydrothienopyrimidin-derivate |
| CA2702447A1 (en) | 2007-10-19 | 2009-04-30 | Boehringer Ingelheim International Gmbh | New phenyl-substituted piperazino-dihydrothienopyrimidines |
| PT2215092E (pt) | 2007-10-19 | 2012-04-10 | Boehringer Ingelheim Int | Piperidino-di-hidrotienopirimidinas substituídas |
| MX2011006428A (es) | 2008-12-19 | 2011-07-28 | Leo Pharma As | Triazolopiridinas como inhibidores de fosfodiesterasa para tratamiento de enfermedades dermicas. |
| WO2010097334A1 (de) * | 2009-02-27 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Arzneimittelkombinationen enthaltend pde4-inhibitoren und nsaids |
| US9346809B2 (en) * | 2009-07-08 | 2016-05-24 | Leo Pharma A/S | Heterocyclic compounds as JAK receptor and protein tyrosine kinase inhibitors |
| AR079705A1 (es) | 2009-12-23 | 2012-02-15 | Biocryst Pharm Inc | Compuestos heterociclicos como inhibidores de janus quinasa |
| US20130225609A1 (en) | 2010-04-08 | 2013-08-29 | Boehringer Ingelheim International Gmbh | Combinations of medicaments, containing pde4-inhibitors and ep4-receptor-antagonists |
| US8946230B2 (en) * | 2010-05-13 | 2015-02-03 | Amgen Inc. | Aryl- and heteroaryl- nitrogen-heterocyclic compounds as PDE10 inhibitors |
| CA2802895C (en) | 2010-06-24 | 2019-05-21 | Leo Pharma A/S | Benzodioxole or benzodioxepine heterocyclic compounds as phosphodiesterase inhibitors |
| DK2672957T3 (da) * | 2011-02-07 | 2017-02-06 | Scipharm Sàrl | Hidtil ukendt sammensætning til behandling af cystisk fibrose |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| AU2012357106A1 (en) | 2011-12-21 | 2014-06-05 | Leo Pharma A/S | [1,2,4]triazolopyridines and their use as phospodiesterase inhibitors |
| HRP20230162T1 (hr) | 2012-10-25 | 2023-04-14 | Tetra Discovery Partners Llc | Heteroarilni inhibitori enzima pde4 |
| WO2014124860A1 (en) * | 2013-02-14 | 2014-08-21 | Boehringer Ingelheim International Gmbh | Specific pde4b-inhibitors for the treatment of diabetes mellitus |
| JP6785666B2 (ja) | 2014-06-23 | 2020-11-18 | レオ ファーマ アクティーゼルスカブ | １，３−ベンゾジオキソール複素環化合物の調製方法 |
| JP6934872B2 (ja) | 2015-12-18 | 2021-09-15 | レオ ファーマ アクティーゼルスカブ | １，３−ベンゾジオキソール複素環化合物の製造方法 |
| ES2981006T3 (es) | 2016-12-12 | 2024-10-04 | Union Therapeutics As | Pirazoloazepin-4-onas sustituidas y su uso como inhibidores de la fosfodiesterasa |
| RU2762279C2 (ru) | 2016-12-12 | 2021-12-17 | Юнион Терапьютикс А/С | Замещенные пиразолоазепин-4-оны и их применение в качестве ингибиторов фосфодиэстеразы |
| RU2764273C2 (ru) | 2016-12-12 | 2022-01-17 | Юнион Терапьютикс А/С | Замещенные пиразолоазепин-8-оны и их применение в качестве ингибиторов фосфодиэстеразы |
| JP2020524131A (ja) | 2017-06-20 | 2020-08-13 | レオ ファーマ アクティーゼルスカブ | １，３−ベンゾジオキソール複素環式化合物の調製方法 |
| CN111108109A (zh) | 2017-09-20 | 2020-05-05 | 利奥制药有限公司 | 取代的二氢噻吩并嘧啶及其作为磷酸二酯酶抑制剂的用途 |
| ES2968822T3 (es) | 2017-12-15 | 2024-05-14 | Union Therapeutics As | Azetidina dihidrotienopirimidinas sustituidas y su uso como inhibidores de la fosfodiesterasa |
| WO2019115776A1 (en) | 2017-12-15 | 2019-06-20 | Leo Pharma A/S | Substituted azetidine dihydrothienopyridines and their use as phosphodiesterase inhibitors |
| JP7201688B2 (ja) | 2017-12-15 | 2023-01-10 | ユニオン・セラピューティクス・アクティエセルスカブ | 置換テトラヒドロピランジヒドロチエノピリミジンおよびホスホジエステラーゼ阻害剤としてのそれらの使用 |
| KR20210117300A (ko) | 2019-01-15 | 2021-09-28 | 유니온 테라퓨틱스 에이/에스 | 포스포디에스테라제 억제제를 함유하는 변형 방출 정제 제형 |
-
2018
- 2018-12-14 WO PCT/EP2018/084978 patent/WO2019115776A1/en unknown
- 2018-12-14 JP JP2020532754A patent/JP7203846B2/ja active Active
- 2018-12-14 DK DK18830422.4T patent/DK3724196T3/da active
- 2018-12-14 FI FIEP18830422.4T patent/FI3724196T3/fi active
- 2018-12-14 PT PT188304224T patent/PT3724196T/pt unknown
- 2018-12-14 US US16/772,615 patent/US11384096B2/en active Active
- 2018-12-14 ES ES18830422T patent/ES2935615T3/es active Active
- 2018-12-14 CN CN201880089287.6A patent/CN111727191B/zh active Active
- 2018-12-14 EP EP18830422.4A patent/EP3724196B9/en active Active
-
2022
- 2022-06-08 US US17/805,875 patent/US11981681B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3724196B9 (en) | 2023-03-22 |
| JP2021506806A (ja) | 2021-02-22 |
| DK3724196T3 (da) | 2023-01-16 |
| US20230087354A1 (en) | 2023-03-23 |
| EP3724196B1 (en) | 2022-11-16 |
| US11384096B2 (en) | 2022-07-12 |
| EP3724196A1 (en) | 2020-10-21 |
| WO2019115776A1 (en) | 2019-06-20 |
| CN111727191B (zh) | 2024-01-05 |
| JP7203846B2 (ja) | 2023-01-13 |
| CN111727191A (zh) | 2020-09-29 |
| ES2935615T9 (es) | 2023-04-03 |
| FI3724196T3 (fi) | 2023-01-31 |
| US20210079012A1 (en) | 2021-03-18 |
| ES2935615T3 (es) | 2023-03-08 |
| US11981681B2 (en) | 2024-05-14 |
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