PT2810937T - Derivado de piridona - Google Patents
Derivado de piridonaInfo
- Publication number
- PT2810937T PT2810937T PT137439857T PT13743985T PT2810937T PT 2810937 T PT2810937 T PT 2810937T PT 137439857 T PT137439857 T PT 137439857T PT 13743985 T PT13743985 T PT 13743985T PT 2810937 T PT2810937 T PT 2810937T
- Authority
- PT
- Portugal
- Prior art keywords
- pyridone derivative
- pyridone
- derivative
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012017971 | 2012-01-31 | ||
US201261746039P | 2012-12-26 | 2012-12-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2810937T true PT2810937T (pt) | 2017-03-03 |
Family
ID=48905312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT137439857T PT2810937T (pt) | 2012-01-31 | 2013-01-30 | Derivado de piridona |
Country Status (31)
Country | Link |
---|---|
US (1) | US8933103B2 (pt) |
EP (1) | EP2810937B1 (pt) |
JP (1) | JP6006241B2 (pt) |
KR (1) | KR102078530B1 (pt) |
CN (1) | CN104185627B (pt) |
AU (1) | AU2013216006B2 (pt) |
BR (1) | BR112014018702B1 (pt) |
CA (1) | CA2863515C (pt) |
CO (1) | CO7071126A2 (pt) |
CY (1) | CY1118656T1 (pt) |
DK (1) | DK2810937T3 (pt) |
ES (1) | ES2617484T3 (pt) |
HK (1) | HK1203504A1 (pt) |
HR (1) | HRP20170303T1 (pt) |
HU (1) | HUE031624T2 (pt) |
IL (1) | IL233863A (pt) |
LT (1) | LT2810937T (pt) |
MX (1) | MX351812B (pt) |
MY (1) | MY165215A (pt) |
NZ (1) | NZ627586A (pt) |
PH (1) | PH12014501719A1 (pt) |
PL (1) | PL2810937T3 (pt) |
PT (1) | PT2810937T (pt) |
RS (1) | RS55728B1 (pt) |
RU (1) | RU2632885C2 (pt) |
SG (1) | SG11201404505PA (pt) |
SI (1) | SI2810937T1 (pt) |
SM (1) | SMT201700065B (pt) |
TW (1) | TWI537259B (pt) |
WO (1) | WO2013115280A1 (pt) |
ZA (1) | ZA201405486B (pt) |
Families Citing this family (29)
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WO2013162061A1 (ja) * | 2012-04-26 | 2013-10-31 | 第一三共株式会社 | 二環性ピリミジン化合物 |
JP6493218B2 (ja) * | 2013-11-08 | 2019-04-03 | 小野薬品工業株式会社 | ピロロピリミジン誘導体 |
US9771333B2 (en) | 2013-11-20 | 2017-09-26 | Signalchem Lifesciences Corp. | Quinazoline derivatives as TAM family kinase inhibitors |
CA2930324C (en) | 2013-11-27 | 2022-01-18 | Signalchem Lifesciences Corporation | Aminopyridine derivatives as tam family kinase inhibitors |
CN106659765B (zh) | 2014-04-04 | 2021-08-13 | 德玛医药 | 二脱水半乳糖醇及其类似物或衍生物用于治疗非小细胞肺癌和卵巢癌的用途 |
TWI690525B (zh) | 2014-07-07 | 2020-04-11 | 日商第一三共股份有限公司 | 具有四氫吡喃基甲基之吡啶酮衍生物及其用途 |
US9840503B2 (en) | 2015-05-11 | 2017-12-12 | Incyte Corporation | Heterocyclic compounds and uses thereof |
WO2017027717A1 (en) | 2015-08-12 | 2017-02-16 | Incyte Corporation | Bicyclic fused pyrimidine compounds as tam inhibitors |
WO2017035366A1 (en) | 2015-08-26 | 2017-03-02 | Incyte Corporation | Pyrrolopyrimidine derivatives as tam inhibitors |
ES2896079T3 (es) | 2016-02-26 | 2022-02-23 | Ono Pharmaceutical Co | Fármaco para la terapia del cáncer, caracterizado por la administración de la combinación entre un inhibidor de Axl y un inhibidor del punto de control inmunitario |
MD3436461T2 (ro) | 2016-03-28 | 2024-05-31 | Incyte Corp | Compuși pirolotriazină ca inhibitori TAM |
CN108250200A (zh) * | 2016-12-28 | 2018-07-06 | 中国科学院上海药物研究所 | 一种具有Axl抑制活性的化合物及其制备和应用 |
EP3673907A4 (en) | 2017-08-23 | 2020-08-19 | ONO Pharmaceutical Co., Ltd. | CANCER TREATMENT PHARMACEUTICAL INCLUDING AX1 INHIBITOR AS AN EFFECTIVE INGREDIENT |
MA50655B1 (fr) | 2017-09-27 | 2021-11-30 | Incyte Corp | Sels de dérivés de pyrrolotriazine utiles en tant qu'inhibiteurs de tam |
JP7223998B2 (ja) | 2017-10-13 | 2023-02-17 | 小野薬品工業株式会社 | Axl阻害剤を有効成分として含む固形がん治療剤 |
EP3746070A4 (en) * | 2018-01-29 | 2021-09-01 | Capulus Therapeutics, LLC | SREBP INHIBITORS INCLUDING A 6-CHAIN CENTRAL CORE |
MX2020009228A (es) | 2018-03-08 | 2021-01-08 | Incyte Corp | Compuestos diolicos de aminopirazina como inhibidores de fosfoinositida 3-cinasas-gamma. |
AU2019293618A1 (en) | 2018-06-29 | 2021-02-18 | Incyte Corporation | Formulations of an AXL/MER inhibitor |
WO2020010003A1 (en) | 2018-07-02 | 2020-01-09 | Incyte Corporation | AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS |
TWI840378B (zh) * | 2018-07-04 | 2024-05-01 | 日商第一三共股份有限公司 | 二芳基吡啶衍生物之製造方法 |
CN110857293B (zh) * | 2018-08-24 | 2023-01-10 | 药捷安康(南京)科技股份有限公司 | 一种新型的喹啉衍生物抑制剂 |
BR112021018168B1 (pt) | 2019-03-21 | 2023-11-28 | Onxeo | Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer |
US11718612B2 (en) | 2019-09-06 | 2023-08-08 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase I for the treatment of disease |
CN112625026B (zh) * | 2019-09-24 | 2022-09-09 | 药捷安康(南京)科技股份有限公司 | Tam家族激酶抑制剂的喹啉衍生物 |
EP4034530A4 (en) | 2019-09-27 | 2023-09-06 | Board of Regents, The University of Texas System | PROTEIN KINASE I INHIBITORS INTERACTING WITH RECEPTORS FOR THE TREATMENT OF DISEASE |
CA3159348A1 (en) | 2019-11-08 | 2021-05-14 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
WO2021108198A1 (en) * | 2019-11-26 | 2021-06-03 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase i for the treatment of disease |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
JPWO2022220227A1 (pt) * | 2021-04-14 | 2022-10-20 |
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ATE383153T1 (de) * | 1999-05-07 | 2008-01-15 | Encysive Pharmaceuticals Inc | Carbonsäurederivate die die bindung von integrinen an ihre rezeptoren hemmen |
EP1136485A1 (en) * | 2000-03-23 | 2001-09-26 | Sanofi-Synthelabo | Aminophenyl pyrimidone derivatives |
IL163547A0 (en) | 2002-02-12 | 2005-12-18 | Quark Biotech Inc | Use of the axl receptor for diagnosis and treatment of renal disease |
CA2621503C (en) | 2005-09-07 | 2014-05-20 | Rigel Pharmaceuticals, Inc. | Triazole derivatives useful as axl inhibitors |
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EP1900727A1 (en) | 2006-08-30 | 2008-03-19 | Cellzome Ag | Aminopyridine derivatives as kinase inhibitors |
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GB0625659D0 (en) | 2006-12-21 | 2007-01-31 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
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ES2404668T3 (es) | 2006-12-29 | 2013-05-28 | Rigel Pharmaceuticals, Inc. | Triazoles sustituidos con arilo bicíclico puenteado y heteroarilo bicíclico puenteado, útiles como agentes inhibidores del axl |
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ES2460894T3 (es) | 2006-12-29 | 2014-05-14 | Rigel Pharmaceuticals, Inc. | Triazoles sustituidos con heteroarilo policíclico útiles como inhibidores de Axl |
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WO2009024825A1 (en) | 2007-08-21 | 2009-02-26 | Astrazeneca Ab | 2-pyrazinylbenzimidazole derivatives as receptor tyrosine kinase inhibitors |
GB0719803D0 (en) * | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
WO2009053737A2 (en) * | 2007-10-25 | 2009-04-30 | Astrazeneca Ab | Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders |
RU2010120536A (ru) * | 2007-10-25 | 2011-11-27 | Астразенека Аб (Se) | Производные пиридина и пиразина, полезные для лечения клеточных проферативных расстройств |
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JP2011502991A (ja) | 2007-11-02 | 2011-01-27 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 骨癌並びに骨癌に伴う骨喪失及び骨痛の処置又は予防のためのcfms阻害物質の使用 |
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UY31800A (es) | 2008-05-05 | 2009-11-10 | Smithkline Beckman Corp | Metodo de tratamiento de cancer usando un inhibidor de cmet y axl y un inhibidor de erbb |
WO2009138799A1 (en) | 2008-05-14 | 2009-11-19 | Astex Therapeutics Limited | Therapeutic uses of 1-cycl0pr0pyl-3 - [3- ( 5 -morpholin- 4 -ylmethyl- 1h-benz0imidaz0l- 2 -yl) -lh-pyrazol-4-yl] -urea |
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PL2328888T3 (pl) | 2008-07-09 | 2013-04-30 | Rigel Pharmaceuticals Inc | Triazole podstawione mostkowanym bicyklicznym heteroarylem użyteczne jako inhibitory AXL |
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MX2011011326A (es) | 2009-04-27 | 2012-02-13 | Elan Pharm Inc | Antagonistas de piridinona de las integrinas alfa-4. |
EP2311809A1 (en) | 2009-10-16 | 2011-04-20 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Quinolinyloxyphenylsulfonamides |
US8962623B2 (en) | 2011-03-04 | 2015-02-24 | Locus Pharmaceuticals, Inc. | Aminopyrazine compounds |
-
2013
- 2013-01-30 ES ES13743985.7T patent/ES2617484T3/es active Active
- 2013-01-30 BR BR112014018702-9A patent/BR112014018702B1/pt active IP Right Grant
- 2013-01-30 PT PT137439857T patent/PT2810937T/pt unknown
- 2013-01-30 PL PL13743985T patent/PL2810937T3/pl unknown
- 2013-01-30 WO PCT/JP2013/052111 patent/WO2013115280A1/ja active Application Filing
- 2013-01-30 CA CA2863515A patent/CA2863515C/en active Active
- 2013-01-30 LT LTEP13743985.7T patent/LT2810937T/lt unknown
- 2013-01-30 KR KR1020147020852A patent/KR102078530B1/ko active IP Right Grant
- 2013-01-30 MX MX2014009246A patent/MX351812B/es active IP Right Grant
- 2013-01-30 AU AU2013216006A patent/AU2013216006B2/en active Active
- 2013-01-30 HU HUE13743985A patent/HUE031624T2/en unknown
- 2013-01-30 SG SG11201404505PA patent/SG11201404505PA/en unknown
- 2013-01-30 RS RS20170211A patent/RS55728B1/sr unknown
- 2013-01-30 EP EP13743985.7A patent/EP2810937B1/en active Active
- 2013-01-30 CN CN201380017353.6A patent/CN104185627B/zh active Active
- 2013-01-30 DK DK13743985.7T patent/DK2810937T3/en active
- 2013-01-30 SI SI201330421A patent/SI2810937T1/sl unknown
- 2013-01-30 TW TW102103411A patent/TWI537259B/zh active
- 2013-01-30 JP JP2013556479A patent/JP6006241B2/ja active Active
- 2013-01-30 RU RU2014135401A patent/RU2632885C2/ru active
- 2013-01-30 MY MYPI2014002198A patent/MY165215A/en unknown
- 2013-01-30 NZ NZ627586A patent/NZ627586A/en unknown
- 2013-01-30 US US13/753,926 patent/US8933103B2/en active Active
-
2014
- 2014-07-24 ZA ZA2014/05486A patent/ZA201405486B/en unknown
- 2014-07-30 IL IL233863A patent/IL233863A/en active IP Right Grant
- 2014-07-30 PH PH12014501719A patent/PH12014501719A1/en unknown
- 2014-08-28 CO CO14189810A patent/CO7071126A2/es unknown
-
2015
- 2015-04-28 HK HK15104103.9A patent/HK1203504A1/xx unknown
-
2017
- 2017-01-30 SM SM201700065T patent/SMT201700065B/it unknown
- 2017-02-23 CY CY20171100251T patent/CY1118656T1/el unknown
- 2017-02-23 HR HRP20170303TT patent/HRP20170303T1/hr unknown
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