PT2094708E - Pirrolopirazina como inibidor da cinase syk - Google Patents

Pirrolopirazina como inibidor da cinase syk Download PDF

Info

Publication number: PT2094708E
Authority: PT; Portugal
Prior art keywords: pyrrolopyrazin; syk; kinase inhibitor; kinase; inhibitor
Prior art date: 2006-09-11

Application number

PT78422078T

Other languages

English (en)

Inventor

Timothy A Gillespy

Paul Eynott

Elizabeth M Allen

Kin T Yu

Asher Zilberstein

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-11

Filing date

2007-09-11

Publication date

2014-01-07

2007-09-11 Application filed by Sanofi Sa filed Critical Sanofi Sa

2014-01-07 Publication of PT2094708E publication Critical patent/PT2094708E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Urology & Nephrology (AREA)
Transplantation (AREA)
Oncology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)
Obesity (AREA)
Otolaryngology (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

PT78422078T 2006-09-11 2007-09-11 Pirrolopirazina como inibidor da cinase syk PT2094708E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US82516806P	2006-09-11	2006-09-11

Publications (1)

Publication Number	Publication Date
PT2094708E true PT2094708E (pt)	2014-01-07

Family

ID=39032357

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT78422078T PT2094708E (pt)	2006-09-11	2007-09-11	Pirrolopirazina como inibidor da cinase syk

Country Status (32)

Country	Link
US (2)	US8658649B2 (pt)
EP (1)	EP2094708B1 (pt)
JP (1)	JP5161237B2 (pt)
KR (1)	KR101443056B1 (pt)
CN (2)	CN101511838A (pt)
AR (1)	AR062745A1 (pt)
AU (1)	AU2007296592B8 (pt)
BR (1)	BRPI0716781A2 (pt)
CA (1)	CA2663175C (pt)
CL (1)	CL2007002617A1 (pt)
CO (1)	CO6160236A2 (pt)
CR (1)	CR10636A (pt)
DK (1)	DK2094708T3 (pt)
ES (1)	ES2437318T3 (pt)
GT (1)	GT200900055A (pt)
HN (1)	HN2009000455A (pt)
IL (1)	IL197381A (pt)
MA (1)	MA30781B1 (pt)
MX (1)	MX2009002616A (pt)
MY (1)	MY148107A (pt)
NI (1)	NI200900021A (pt)
NO (1)	NO20091265L (pt)
NZ (1)	NZ575496A (pt)
PE (1)	PE20081372A1 (pt)
PT (1)	PT2094708E (pt)
RU (1)	RU2440352C2 (pt)
TN (2)	TN2009000049A1 (pt)
TW (1)	TWI399379B (pt)
UA (1)	UA94622C2 (pt)
UY (1)	UY30584A1 (pt)
WO (1)	WO2008033798A2 (pt)
ZA (1)	ZA200901073B (pt)

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PT2247592E (pt)	2008-02-25	2011-11-03	Hoffmann La Roche	Inibidores de pirrolpirazina-cinase
JP5529049B2 (ja)	2008-02-25	2014-06-25	エフ．ホフマン−ラロシュアーゲー	ピロロピラジンキナーゼ阻害剤
JP5368484B2 (ja) *	2008-02-25	2013-12-18	エフ．ホフマン−ラロシュアーゲー	ピロロピラジンキナーゼ阻害剤
JP5485178B2 (ja)	2008-02-25	2014-05-07	エフ．ホフマン−ラロシュアーゲー	ピロロピラジンキナーゼ阻害剤
MX2010009023A (es)	2008-02-25	2010-09-07	Hoffmann La Roche	Inhibidores de cinasas de pirrolopirazina.
RU2010141560A (ru) *	2008-03-10	2012-04-20	Санофи-Авентис (Fr)	Лечение офтальмологических заболеваний
FR2929851B1 (fr) *	2008-04-09	2012-11-30	Centre Nat Rech Scient	Molecules inhibant une voie metabolique impliquant la proteine tyrosine kinase syk et procede d'identification de ces molecules
AR074437A1 (es)	2008-12-03	2011-01-19	Sanofi Aventis	Tratamiento para la glomerulonefritis
RU2011127147A (ru) *	2008-12-04	2013-01-10	Санофи	Кристаллические формы
TW201034675A (en) *	2008-12-18	2010-10-01	Sanofi Aventis	Method for treating macular degeneration
US20110112101A1 (en) *	2009-03-05	2011-05-12	Sanofi-Aventis	Treatment for ocular-related disorders
AR075869A1 (es) *	2009-03-19	2011-05-04	Sanofi Aventis	Sintesis de azaindoles
DK2516434T3 (en)	2009-12-23	2015-08-31	Takeda Pharmaceutical	FUSED HETEROAROMATIC PYRROLIDINONS AS SICK INHIBITORS
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TWI496785B (zh)	2010-05-20	2015-08-21	Hoffmann La Roche	吡咯并吡激酶抑制劑
EP2441755A1 (en)	2010-09-30	2012-04-18	Almirall, S.A.	Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors
EP2489663A1 (en)	2011-02-16	2012-08-22	Almirall, S.A.	Compounds as syk kinase inhibitors
EP2723739B1 (en)	2011-06-22	2016-08-24	Takeda Pharmaceutical Company Limited	Substituted 6-aza-isoindolin-1-one derivatives
CN104507945B (zh) *	2012-08-21	2018-03-23	霍夫曼-拉罗奇有限公司	作为syk抑制剂的吡咯并[2,3‑b]吡嗪
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WO2020188015A1 (en)	2019-03-21	2020-09-24	Onxeo	A dbait molecule in combination with kinase inhibitor for the treatment of cancer
CA3159348A1 (en)	2019-11-08	2021-05-14	Inserm (Institut National De La Sante Et De La Recherche Medicale)	Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
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2007
- 2007-09-10 CL CL200702617A patent/CL2007002617A1/es unknown
- 2007-09-11 PT PT78422078T patent/PT2094708E/pt unknown
- 2007-09-11 EP EP07842207.8A patent/EP2094708B1/en active Active
- 2007-09-11 CA CA2663175A patent/CA2663175C/en not_active Expired - Fee Related
- 2007-09-11 RU RU2009113615/04A patent/RU2440352C2/ru not_active IP Right Cessation
- 2007-09-11 AR ARP070104013A patent/AR062745A1/es not_active Application Discontinuation
- 2007-09-11 UY UY30584A patent/UY30584A1/es not_active Application Discontinuation
- 2007-09-11 CN CNA2007800336608A patent/CN101511838A/zh active Pending
- 2007-09-11 ES ES07842207.8T patent/ES2437318T3/es active Active
- 2007-09-11 MX MX2009002616A patent/MX2009002616A/es active IP Right Grant
- 2007-09-11 TW TW096133786A patent/TWI399379B/zh not_active IP Right Cessation
- 2007-09-11 KR KR1020097005040A patent/KR101443056B1/ko not_active IP Right Cessation
- 2007-09-11 MY MYPI20090720A patent/MY148107A/en unknown
- 2007-09-11 NZ NZ575496A patent/NZ575496A/en not_active IP Right Cessation
- 2007-09-11 DK DK07842207.8T patent/DK2094708T3/da active
- 2007-09-11 BR BRPI0716781-4A2A patent/BRPI0716781A2/pt not_active IP Right Cessation
- 2007-09-11 AU AU2007296592A patent/AU2007296592B8/en not_active Ceased
- 2007-09-11 JP JP2009538434A patent/JP5161237B2/ja not_active Expired - Fee Related
- 2007-09-11 WO PCT/US2007/078103 patent/WO2008033798A2/en active Search and Examination
- 2007-09-11 CN CN201310652393.XA patent/CN103804383A/zh active Pending
- 2007-09-11 PE PE2007001220A patent/PE20081372A1/es not_active Application Discontinuation
- 2007-11-09 UA UAA200903417A patent/UA94622C2/ru unknown
2009
- 2009-02-16 ZA ZA2009/01073A patent/ZA200901073B/en unknown
- 2009-02-17 TN TN2009000049A patent/TN2009000049A1/fr unknown
- 2009-02-17 NI NI200900021A patent/NI200900021A/es unknown
- 2009-02-17 TN TN2009000050A patent/TN2009000050A1/fr unknown
- 2009-02-25 CR CR10636A patent/CR10636A/es not_active Application Discontinuation
- 2009-03-03 IL IL197381A patent/IL197381A/en not_active IP Right Cessation
- 2009-03-10 HN HN2009000455A patent/HN2009000455A/es unknown
- 2009-03-10 GT GT200900055A patent/GT200900055A/es unknown
- 2009-03-10 US US12/401,254 patent/US8658649B2/en not_active Expired - Fee Related
- 2009-03-11 CO CO09025278A patent/CO6160236A2/es unknown
- 2009-03-26 NO NO20091265A patent/NO20091265L/no not_active Application Discontinuation
- 2009-04-06 MA MA31765A patent/MA30781B1/fr unknown
2014
- 2014-01-28 US US14/166,396 patent/US20140142110A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CL2007002617A1 (es)	2008-05-16
US8658649B2 (en)	2014-02-25
CA2663175A1 (en)	2008-03-20
GT200900055A (es)	2010-07-28
IL197381A (en)	2013-11-28
RU2009113615A (ru)	2010-10-20
AU2007296592A1 (en)	2008-03-20
TW200829590A (en)	2008-07-16
MA30781B1 (fr)	2009-10-01
CA2663175C (en)	2012-03-13
KR20090063214A (ko)	2009-06-17
JP2010502767A (ja)	2010-01-28
US20100035884A1 (en)	2010-02-11
IL197381A0 (en)	2009-12-24
EP2094708B1 (en)	2013-10-23
UA94622C2 (en)	2011-05-25
WO2008033798A3 (en)	2008-05-15
AU2007296592B2 (en)	2011-12-15
JP5161237B2 (ja)	2013-03-13
HN2009000455A (es)	2012-02-13
PE20081372A1 (es)	2008-11-27
EP2094708A2 (en)	2009-09-02
NI200900021A (es)	2010-01-29
CO6160236A2 (es)	2010-05-20
NZ575496A (en)	2011-09-30
DK2094708T3 (da)	2014-01-27
RU2440352C2 (ru)	2012-01-20
KR101443056B1 (ko)	2014-09-22
US20140142110A1 (en)	2014-05-22
CR10636A (es)	2009-03-20
TN2009000049A1 (en)	2010-08-19
NO20091265L (no)	2009-04-03
ES2437318T3 (es)	2014-01-10
BRPI0716781A2 (pt)	2014-11-18
AR062745A1 (es)	2008-12-03
CN101511838A (zh)	2009-08-19
CN103804383A (zh)	2014-05-21
ZA200901073B (en)	2009-12-30
UY30584A1 (es)	2008-05-02
MY148107A (en)	2013-02-28
WO2008033798A2 (en)	2008-03-20
MX2009002616A (es)	2009-03-24
TN2009000050A1 (en)	2010-08-19
AU2007296592B8 (en)	2012-01-12
TWI399379B (zh)	2013-06-21

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