PT1355668E - Utilização de inibidores da il-18 para o tratamento e/ou prevenção de doença cardíaca - Google Patents

Utilização de inibidores da il-18 para o tratamento e/ou prevenção de doença cardíaca Download PDF

Info

Publication number: PT1355668E
Authority: PT; Portugal
Prior art keywords: inhibitors; prevention; treatment; heart disease; heart
Prior art date: 2001-01-29

Application number

PT02718052T

Other languages

English (en)

Inventor

Charles Dinarello

Yolande Chvatchko

Benjamin Pomerantz

Leonid Reznikov

Alden Harken

Original Assignee

Serono Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-01-29

Filing date

2002-01-28

Publication date

2008-01-04

2002-01-28 Application filed by Serono Lab filed Critical Serono Lab

2008-01-04 Publication of PT1355668E publication Critical patent/PT1355668E/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Heart & Thoracic Surgery (AREA)
Cell Biology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Microbiology (AREA)
Mycology (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

PT02718052T 2001-01-29 2002-01-28 Utilização de inibidores da il-18 para o tratamento e/ou prevenção de doença cardíaca PT1355668E (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP01101959		2001-01-29

Publications (1)

Publication Number	Publication Date
PT1355668E true PT1355668E (pt)	2008-01-04

Family

ID=8176323

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT02718052T PT1355668E (pt)	2001-01-29	2002-01-28	Utilização de inibidores da il-18 para o tratamento e/ou prevenção de doença cardíaca

Country Status (32)

Country	Link
US (1)	US20040234523A1 (pt)
EP (1)	EP1355668B1 (pt)
JP (2)	JP4860897B2 (pt)
KR (1)	KR100857376B1 (pt)
CN (1)	CN1326562C (pt)
AR (1)	AR032422A1 (pt)
AT (1)	ATE380558T1 (pt)
BG (1)	BG66483B1 (pt)
BR (1)	BR0206819A (pt)
CA (1)	CA2435466C (pt)
CY (1)	CY1107203T1 (pt)
CZ (1)	CZ305653B6 (pt)
DE (1)	DE60224004T2 (pt)
DK (1)	DK1355668T3 (pt)
EA (2)	EA010180B1 (pt)
EE (1)	EE05534B1 (pt)
ES (1)	ES2295332T3 (pt)
HK (1)	HK1062810A1 (pt)
HR (1)	HRP20030609A2 (pt)
HU (1)	HU229164B1 (pt)
IL (2)	IL157024A0 (pt)
ME (1)	ME00549B (pt)
MX (1)	MXPA03006776A (pt)
NO (1)	NO331083B1 (pt)
PL (1)	PL213568B1 (pt)
PT (1)	PT1355668E (pt)
RS (1)	RS51125B (pt)
SI (1)	SI1355668T1 (pt)
SK (1)	SK287620B6 (pt)
UA (1)	UA80676C2 (pt)
WO (1)	WO2002060479A1 (pt)
ZA (1)	ZA200305439B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR101111103B1 (ko)	2000-02-10	2012-02-13	아보트 러보러터리즈	사람 인터류킨-18에 결합하는 항체 및 이를 제조하고 사용하는 방법
AU2002211744B8 (en)	2000-10-11	2008-03-20	Viron Therapeutics, Inc.	Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en)	2000-12-04	2010-05-18	Viron Therapeutics Inc.	Immunomodulatory protein and useful embodiments thereof
US20080076708A1 (en)	2003-05-13	2008-03-27	Valter Altarocca	Active Variants of the Il-18 Binding Protein and Medical Uses Thereof
US7968684B2 (en) *	2003-11-12	2011-06-28	Abbott Laboratories	IL-18 binding proteins
JP4961559B2 (ja) *	2004-03-11	2012-06-27	友昭星野	インターロイキン１８阻害剤を有効成分とする疾患の予防又は治療剤
DK1885753T3 (da)	2005-06-03	2011-10-03	Ares Trading Sa	Fremstilling af rekombinant II-18-proteiner
PT1891088E (pt)	2005-06-10	2011-12-19	Ares Trading Sa	Processo para a purificação da proteína de ligação il-18
WO2009061832A1 (en)	2007-11-05	2009-05-14	Kci Licensing Inc.	Identification of tissue for debridement
JOP20200308A1 (ar)	2012-09-07	2017-06-16	Novartis Ag	جزيئات إرتباط il-18
SG11201601717VA (en) *	2013-09-05	2016-04-28	Ab2 Bio Sa	Il-18 binding protein (il-18bp) in inflammatory diseases
RU2755691C2 (ru) *	2015-03-05	2021-09-20	Аб2 Био Са	Il-18-связывающие белок (il-18bp) и антитела при воспалительных заболеваниях
US11091795B2 (en)	2016-07-11	2021-08-17	Arizona Board Of Regents On Behalf Of The University Of Arizona	Compositions and methods for diagnosing and treating arrhythmias

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6204261B1 (en) *	1995-12-20	2001-03-20	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1β Converting enzyme inhibitors
US5605690A (en) *	1989-09-05	1997-02-25	Immunex Corporation	Methods of lowering active TNF-α levels in mammals using tumor necrosis factor receptor
NZ322197A (en) *	1995-11-21	1999-02-25	Yamanouchi Pharma Co Ltd	Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof
DE69734718T2 (de) *	1996-09-12	2006-08-24	Idun Pharmaceuticals, Inc., San Diego	Hemmung der apoptose unter verwendung von inhibitoren der interleukin-1 beta converting enzym (ice)/ced-3 familie
EP0942925B1 (en) *	1996-12-06	2006-11-22	Vertex Pharmaceuticals Incorporated	Inhibitors of interleukin-1 beta converting enzyme
SK122199A3 (en) *	1997-03-18	2000-12-11	Basf Ag	Methods and compositions for modulating responsiveness to corticosteroids
IL121860A0 (en) *	1997-08-14	1998-02-22	Yeda Res & Dev	Interleukin-18 binding proteins their preparation and use
DE19743687C1 (de) *	1997-10-06	1998-11-26	Henkel Kgaa	Detergensgemische und deren Verwendung
AU4961499A (en) *	1998-06-26	2000-01-17	Eli Lilly And Company	5-HT1f agonists
KR100537558B1 (ko) *	1998-09-01	2005-12-19	가부시끼가이샤 하야시바라 세이부쓰 가가꾸 겐꾸조	인터류킨-18 결합 단백질
EP1022027A1 (en) *	1999-01-22	2000-07-26	Applied Research Systems ARS Holding N.V.	Tumor necrosis factor antagonists and their use in endometriosis
ATE336480T1 (de) *	1999-03-16	2006-09-15	Cytovia Inc	Substituierte 2-aminobenzamin caspase inhibitoren und ihre verwendung
DE60035037T2 (de) *	1999-04-09	2008-01-31	Cytovia, Inc., San Diego	Caspase inhibitoren und ihre verwendung
WO2001003719A2 (en) *	1999-07-09	2001-01-18	Amgen Inc.	Combination therapy for conditions leading to bone loss
KR101111103B1 (ko) *	2000-02-10	2012-02-13	아보트 러보러터리즈	사람 인터류킨-18에 결합하는 항체 및 이를 제조하고 사용하는 방법
ATE395075T1 (de) *	2000-05-05	2008-05-15	Serono Lab	Verwendung von il-18 inhibitoren zur behandlung und/oder prävention von atherosklerose
AU2002224417A1 (en) *	2000-10-18	2002-04-29	Immunex Corporation	Methods for treating il-18 mediated disorders

2002
- 2002-01-28 ME MEP-2008-681A patent/ME00549B/me unknown
- 2002-01-28 RS YUP-578/03A patent/RS51125B/sr unknown
- 2002-01-28 EA EA200501549A patent/EA010180B1/ru not_active IP Right Cessation
- 2002-01-28 AT AT02718052T patent/ATE380558T1/de active
- 2002-01-28 SK SK1089-2003A patent/SK287620B6/sk not_active IP Right Cessation
- 2002-01-28 CN CNB02807503XA patent/CN1326562C/zh not_active Expired - Lifetime
- 2002-01-28 ES ES02718052T patent/ES2295332T3/es not_active Expired - Lifetime
- 2002-01-28 UA UA2003088056A patent/UA80676C2/uk unknown
- 2002-01-28 WO PCT/EP2002/000844 patent/WO2002060479A1/en active IP Right Grant
- 2002-01-28 KR KR1020037009941A patent/KR100857376B1/ko active IP Right Grant
- 2002-01-28 HU HU0303306A patent/HU229164B1/hu unknown
- 2002-01-28 EE EEP200300328A patent/EE05534B1/xx unknown
- 2002-01-28 IL IL15702402A patent/IL157024A0/xx unknown
- 2002-01-28 US US10/470,303 patent/US20040234523A1/en not_active Abandoned
- 2002-01-28 JP JP2002560670A patent/JP4860897B2/ja not_active Expired - Lifetime
- 2002-01-28 DE DE60224004T patent/DE60224004T2/de not_active Expired - Lifetime
- 2002-01-28 CA CA2435466A patent/CA2435466C/en not_active Expired - Lifetime
- 2002-01-28 CZ CZ2003-2335A patent/CZ305653B6/cs not_active IP Right Cessation
- 2002-01-28 MX MXPA03006776A patent/MXPA03006776A/es active IP Right Grant
- 2002-01-28 PT PT02718052T patent/PT1355668E/pt unknown
- 2002-01-28 PL PL366802A patent/PL213568B1/pl unknown
- 2002-01-28 ZA ZA200305439A patent/ZA200305439B/en unknown
- 2002-01-28 EA EA200300844A patent/EA006767B1/ru not_active IP Right Cessation
- 2002-01-28 SI SI200230667T patent/SI1355668T1/sl unknown
- 2002-01-28 DK DK02718052T patent/DK1355668T3/da active
- 2002-01-28 EP EP02718052A patent/EP1355668B1/en not_active Expired - Lifetime
- 2002-01-28 BR BR0206819-2A patent/BR0206819A/pt not_active Application Discontinuation
- 2002-01-29 AR ARP020100315A patent/AR032422A1/es unknown
2003
- 2003-07-16 NO NO20033228A patent/NO331083B1/no not_active IP Right Cessation
- 2003-07-20 IL IL157024A patent/IL157024A/en active IP Right Grant
- 2003-07-28 HR HR20030609A patent/HRP20030609A2/xx not_active Application Discontinuation
- 2003-08-25 BG BG108128A patent/BG66483B1/bg unknown
2004
- 2004-08-02 HK HK04105655A patent/HK1062810A1/xx not_active IP Right Cessation
2008
- 2008-02-18 CY CY20081100195T patent/CY1107203T1/el unknown
- 2008-12-16 JP JP2008319532A patent/JP2009102354A/ja active Pending

Also Published As

Publication number	Publication date
KR20030070143A (ko)	2003-08-27
CZ305653B6 (cs)	2016-01-27
YU57803A (sh)	2006-05-25
HUP0303306A3 (en)	2005-12-28
SK287620B6 (sk)	2011-04-05
CN1499982A (zh)	2004-05-26
HUP0303306A2 (hu)	2004-01-28
AR032422A1 (es)	2003-11-05
EP1355668B1 (en)	2007-12-12
SI1355668T1 (sl)	2008-06-30
NO20033228D0 (no)	2003-07-16
US20040234523A1 (en)	2004-11-25
WO2002060479A1 (en)	2002-08-08
PL366802A1 (en)	2005-02-07
UA80676C2 (en)	2007-10-25
EA010180B1 (ru)	2008-06-30
EA200300844A1 (ru)	2003-12-25
PL213568B1 (pl)	2013-03-29
ZA200305439B (en)	2004-07-15
IL157024A0 (en)	2004-02-08
HK1062810A1 (en)	2004-11-26
ATE380558T1 (de)	2007-12-15
EP1355668A1 (en)	2003-10-29
ME00549B (me)	2011-10-10
EE05534B1 (et)	2012-04-16
ES2295332T3 (es)	2008-04-16
MXPA03006776A (es)	2003-10-24
EE200300328A (et)	2003-10-15
BG108128A (bg)	2004-11-30
EA006767B1 (ru)	2006-04-28
CN1326562C (zh)	2007-07-18
JP4860897B2 (ja)	2012-01-25
HU229164B1 (en)	2013-09-30
EA200501549A1 (ru)	2006-04-28
SK10892003A3 (sk)	2004-02-03
CY1107203T1 (el)	2012-11-21
JP2004522748A (ja)	2004-07-29
NO331083B1 (no)	2011-10-03
KR100857376B1 (ko)	2008-09-05
BR0206819A (pt)	2004-02-03
JP2009102354A (ja)	2009-05-14
IL157024A (en)	2014-02-27
HRP20030609A2 (en)	2005-06-30
CA2435466C (en)	2012-04-03
DE60224004D1 (de)	2008-01-24
DE60224004T2 (de)	2009-07-23
DK1355668T3 (da)	2008-05-05
CZ20032335A3 (en)	2004-07-14
RS51125B (sr)	2010-10-31
NO20033228L (no)	2003-09-26
CA2435466A1 (en)	2002-08-08
BG66483B1 (bg)	2015-03-31

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