[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

PL2041259T3 - Udoskonalony sposób hodowania komórek - Google Patents

Udoskonalony sposób hodowania komórek

Info

Publication number
PL2041259T3
PL2041259T3 PL07765049T PL07765049T PL2041259T3 PL 2041259 T3 PL2041259 T3 PL 2041259T3 PL 07765049 T PL07765049 T PL 07765049T PL 07765049 T PL07765049 T PL 07765049T PL 2041259 T3 PL2041259 T3 PL 2041259T3
Authority
PL
Poland
Prior art keywords
culturing
cells
improved process
improved
Prior art date
Application number
PL07765049T
Other languages
English (en)
Inventor
Gerben Meile Zijlstra
Robert Patrick Hof
Jacob Schilder
Original Assignee
Dpx Holdings Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38441437&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2041259(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dpx Holdings Bv filed Critical Dpx Holdings Bv
Publication of PL2041259T3 publication Critical patent/PL2041259T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/08—Hollow fibre membranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/28—Constructional details, e.g. recesses, hinges disposable or single use
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/18—External loop; Means for reintroduction of fermented biomass or liquid percolate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C12N2500/92—Medium free of human- or animal-derived components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/99—Serum-free medium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C12N2510/04—Immortalised cells

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurosurgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Clinical Laboratory Science (AREA)
  • Water Supply & Treatment (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Peptides Or Proteins (AREA)
PL07765049T 2006-07-14 2007-07-04 Udoskonalony sposób hodowania komórek PL2041259T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP06014671 2006-07-14
EP07002571 2007-02-06
PCT/EP2007/005915 WO2008006494A1 (en) 2006-07-14 2007-07-04 Improved process for the culturing of cells
EP07765049.7A EP2041259B2 (en) 2006-07-14 2007-07-04 Improved process for the culturing of cells

Publications (1)

Publication Number Publication Date
PL2041259T3 true PL2041259T3 (pl) 2016-04-29

Family

ID=38441437

Family Applications (5)

Application Number Title Priority Date Filing Date
PL13169694T PL2634250T3 (pl) 2006-07-14 2007-07-04 Ulepszony sposób hodowli komórek
PL07765049T PL2041259T3 (pl) 2006-07-14 2007-07-04 Udoskonalony sposób hodowania komórek
PL10183677.3T PL2343362T3 (pl) 2006-07-14 2007-07-04 Udoskonalony sposób hodowania komórek
PL13169693T PL2634243T3 (pl) 2006-07-14 2007-07-04 Ulepszony sposób hodowli komórkowej
PL13169685T PL2634242T3 (pl) 2006-07-14 2007-07-04 Ulepszony sposób hodowli komórek

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL13169694T PL2634250T3 (pl) 2006-07-14 2007-07-04 Ulepszony sposób hodowli komórek

Family Applications After (3)

Application Number Title Priority Date Filing Date
PL10183677.3T PL2343362T3 (pl) 2006-07-14 2007-07-04 Udoskonalony sposób hodowania komórek
PL13169693T PL2634243T3 (pl) 2006-07-14 2007-07-04 Ulepszony sposób hodowli komórkowej
PL13169685T PL2634242T3 (pl) 2006-07-14 2007-07-04 Ulepszony sposób hodowli komórek

Country Status (22)

Country Link
US (7) US8119368B2 (pl)
EP (5) EP2343362B2 (pl)
JP (4) JP5092129B2 (pl)
KR (3) KR101143796B1 (pl)
CN (2) CN104263700A (pl)
AR (1) AR062072A1 (pl)
AU (1) AU2007272054C1 (pl)
BR (1) BRPI0714347A2 (pl)
CA (1) CA2657040C (pl)
CL (1) CL2007002060A1 (pl)
DK (4) DK2634243T4 (pl)
EA (2) EA201101581A1 (pl)
ES (5) ES2625062T3 (pl)
FI (1) FI2343362T4 (pl)
HU (5) HUE028593T2 (pl)
IL (2) IL196322A0 (pl)
MX (2) MX340242B (pl)
PL (5) PL2634250T3 (pl)
PT (5) PT2634250T (pl)
SI (5) SI2634242T1 (pl)
TW (3) TWI413689B (pl)
WO (1) WO2008006494A1 (pl)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1720972E (pt) * 2004-03-05 2014-04-07 Dsm Ip Assets Bv Processo para cultura de células por perfusão contínua e fluxo alternativo tangencial
US8585594B2 (en) * 2006-05-24 2013-11-19 Phoenix Biomedical, Inc. Methods of assessing inner surfaces of body lumens or organs
DK2634243T4 (da) 2006-07-14 2024-09-23 Patheon Holdings I B V Forbedret fremgangsmåde til dyrkning af celler
US9109193B2 (en) 2007-07-30 2015-08-18 Ge Healthcare Bio-Sciences Corp. Continuous perfusion bioreactor system
US8623650B2 (en) 2007-10-19 2014-01-07 Viacyte, Inc. Methods and compositions for feeder-free pluripotent stem cell media containing human serum
US9238792B2 (en) * 2009-09-15 2016-01-19 E I Du Pont De Nemours And Company Compartmentalized simultaneous saccharification and fermentation of biomass
JP5465331B2 (ja) 2009-10-15 2014-04-09 クルセル ホランド ベー ヴェー 高細胞密度の培養物からのアデノウイルスの精製方法
CA2776461C (en) 2009-10-15 2020-08-25 Crucell Holland B.V. Method for the purification of adenovirus particles.
WO2012030512A1 (en) 2010-09-03 2012-03-08 Percivia Llc. Flow-through protein purification process
CN107190034A (zh) * 2010-10-05 2017-09-22 诺沃—诺迪斯克保健股份有限公司 生产蛋白质的方法
MX344465B (es) 2011-02-10 2016-12-14 Crucell Holland Bv Sistema de separacion de celulas a traves de membrana por presion alternamente neumatica.
KR101591671B1 (ko) * 2011-04-29 2016-02-04 바이오콘 리서치 리미티드 항체의 이질성을 감소시키는 방법 및 그 항체의 제조방법
CN103517919B (zh) 2011-05-13 2016-11-16 欧克塔医药公司 在重组fviii的生产中提高真核细胞生产率的方法
HUE033279T2 (en) 2011-07-01 2017-11-28 Amgen Inc Mammalian cell culture
TWI637057B (zh) 2012-11-09 2018-10-01 拜爾沙納有限公司 具交替生物反應器用途之不連續進料批次製程
JP6017060B2 (ja) * 2012-11-29 2016-10-26 イー・エム・デイー・ミリポア・コーポレイシヨン フード付き磁気インペラアセンブリを備える容器
RU2668796C2 (ru) * 2013-03-15 2018-10-02 Джензим Корпорейшн Способы формирования банка клеток высокой плотности (варианты)
EP2976418B1 (en) 2013-03-19 2020-09-30 CMC Biologics A/S A method for producing a product (e.g. polypeptide) in a continuous cell culture fermentation process.
AU2014318420B2 (en) * 2013-09-16 2020-01-16 Genzyme Corporation Methods and systems for processing a cell culture
CA2924042C (en) * 2013-09-30 2023-04-18 Crucell Holland B.V. Method for the clarification of high density crude cell culture harvest
PL3926051T3 (pl) 2014-06-04 2024-08-26 Amgen Inc. Sposoby zbierania hodowli komórek ssaczych
EP3158055B1 (en) * 2014-06-13 2019-09-11 CSL Limited Improved production of recombinant von willebrand factor in a bioreactor
JP6385559B2 (ja) 2014-07-24 2018-09-05 ヤンセン ファッシンズ アンド プリベンション ベーフェーＪａｎｓｓｅｎ Ｖａｃｃｉｎｅｓ ＆ Ｐｒｅｖｅｎｔｉｏｎ Ｂ．Ｖ． 細胞培養体からのポリオウイルスの精製プロセス
JP6530171B2 (ja) * 2014-09-09 2019-06-12 旭化成メディカル株式会社 培養産生物の回収方法
US11674952B2 (en) 2016-02-24 2023-06-13 The Rockefeller University Embryonic cell-based therapeutic candidate screening systems, models for Huntington's Disease and uses thereof
US10358626B2 (en) 2016-04-12 2019-07-23 Artemis Biosystems, Inc. Perfusion filtration systems
JP6682172B2 (ja) 2017-03-03 2020-04-15 富士フイルム株式会社 細胞培養装置及び細胞培養方法
WO2019071076A1 (en) 2017-10-06 2019-04-11 Lonza Ltd. AUTOMATED CONTROL OF CELL CULTURE BY SPECTROSCOPY RAMAN
TW202426623A (zh) 2017-10-16 2024-07-01 美商再生元醫藥公司 灌注生物反應器及相關使用方法
CN111263631A (zh) 2017-10-26 2020-06-09 瑞普利金公司 微型交替切向流灌注过滤器、处理容器及其使用方法
AR113491A1 (es) * 2017-12-11 2020-05-06 Amgen Inc Proceso de elaboración continuo para productos de anticuerpos biespecíficos
SG11202005782UA (en) * 2018-03-08 2020-09-29 Repligen Corp Tangential flow depth filtration systems and methods of filtration using same
EP3770266A4 (en) * 2018-03-19 2021-06-09 FUJIFILM Corporation PRODUCT MANUFACTURING PROCESS
CN109157690A (zh) * 2018-06-15 2019-01-08 翁炳焕 猴-人细胞融合母胎血型不合治疗杂交株的制备
EP3647405A1 (en) * 2018-11-02 2020-05-06 Microfluidx Cell culture device and method of using the same
SG11202104417UA (en) * 2018-11-02 2021-05-28 Wuxi Biologics Ireland Ltd Cell culture process by intensified perfusion with continuous harvest and without cell bleeding
EP3976753A4 (en) * 2019-05-28 2023-07-19 Wuxi Biologics Ireland Limited INTEGRATED RAMAN SPECTROSCOPY PERFUSION CELL CULTURE SYSTEM FOR AUTOMATICALLY MONITORING AND CONTROL OF PERFUSION CELL CULTURE
JP2023500719A (ja) * 2019-11-07 2023-01-10 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 灌流細胞培養を実施するための方法およびシステム
US20210283565A1 (en) 2020-03-10 2021-09-16 Cellares Corporation Systems and methods for cell processing
US11898127B1 (en) 2022-09-26 2024-02-13 Upside Foods, Inc. Harvesting cell-based meat
WO2024072444A1 (en) * 2022-09-26 2024-04-04 Upside Foods, Inc. Harvesting cell-based meat
WO2024226439A1 (en) 2023-04-24 2024-10-31 Quantitative Biosciences, Inc. Engineered biosensor strains of e. coli for continuous aerobic detection of analytes

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4477342A (en) 1982-08-31 1984-10-16 Becton, Dickinson And Company Apparatus and method for controlling ultrafiltration during hemodialysis
US4885166A (en) * 1985-06-11 1989-12-05 Ciba-Geigy Corporation Hybrid interferons
US5286646A (en) * 1985-11-25 1994-02-15 Boehringer Mannheim Gmbh Method for mammalian cell culture
IL82746A (en) * 1986-06-06 1994-10-07 Genentech Inc A process for producing a biologically active tissue plasminogen activator
JPH0642905B2 (ja) 1986-06-13 1994-06-08 東レ株式会社 血液透析膜
GB8617646D0 (en) 1986-07-18 1986-08-28 Manchester Inst Science Tech Recovery of biological material
US6022742A (en) * 1986-11-26 2000-02-08 Kopf; Henry B. Culture device and method
US4806484A (en) * 1987-08-07 1989-02-21 Igb Products, Ltd. Perfusion airlift bioreactor
JPH0797982B2 (ja) * 1987-09-24 1995-10-25 東洋紡績株式会社 細胞培養装置
US4921792A (en) 1987-11-27 1990-05-01 Miles Inc. Continuous cell dispersion, cultivation and substance recovery process
JPH01243985A (ja) 1988-03-25 1989-09-28 P C C Technol:Kk 植物器官の培養法及びその培養槽
US5595909A (en) * 1988-05-23 1997-01-21 Regents Of The University Of Minnesota Filter device
JPH02119772A (ja) * 1988-10-29 1990-05-07 Shimadzu Corp 細胞培養装置
JP2625990B2 (ja) * 1988-11-19 1997-07-02 株式会社島津製作所 細胞培養装置
US5019512A (en) * 1989-03-17 1991-05-28 Baxter International Inc. Spin filter for removing substantially cell-free culture medium from suspension cell culture system
JP2690144B2 (ja) * 1989-04-24 1997-12-10 哲哉 峠 膜型細胞培養装置
JPH0793874B2 (ja) * 1989-04-27 1995-10-11 日本碍子株式会社 バイオリアクタ
US5256294A (en) 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
JP2948675B2 (ja) * 1991-03-20 1999-09-13 日本碍子株式会社 発酵液中の有価物を回収するクロスフロー濾過方法
JPH0531332A (ja) * 1991-07-30 1993-02-09 Toto Ltd 微生物の膜分離方法
GB9118664D0 (en) 1991-08-30 1991-10-16 Celltech Ltd Cell culture
JPH07123972A (ja) * 1993-11-01 1995-05-16 Fumio Yamauchi 膜型バイオリアクター
JPH07298871A (ja) * 1994-05-06 1995-11-14 Fumio Yamauchi 膜型バイオリアクター
US6204000B1 (en) 1995-04-28 2001-03-20 The United States Of America As Represented By The Department Of Health And Human Services Diagnostic methods and gene therapy using reagents derived from the human metastasis suppressor gene KAI1
US5994128A (en) 1995-06-15 1999-11-30 Introgene B.V. Packaging systems for human recombinant adenovirus to be used in gene therapy
US5994728A (en) * 1995-11-15 1999-11-30 Matsushita Electronics Corporation Field effect transistor and method for producing the same
JPH1015357A (ja) * 1996-07-01 1998-01-20 Nitto Denko Corp 排水の処理方法
JPH1033671A (ja) * 1996-07-24 1998-02-10 Jms Co Ltd 中空糸型人工肝臓とその灌流及び培養システム
JP3346996B2 (ja) 1996-09-18 2002-11-18 金剛株式会社 免震自立棚
JPH10108673A (ja) * 1996-10-04 1998-04-28 Asahi Medical Co Ltd 中空糸型培養器を用いた動物細胞の培養方法
JPH10108666A (ja) * 1996-10-04 1998-04-28 Asahi Medical Co Ltd 中空糸型培養器
US6001585A (en) 1997-11-14 1999-12-14 Cellex Biosciences, Inc. Micro hollow fiber bioreactor
US8026096B1 (en) 1998-10-08 2011-09-27 Protein Sciences Corporation In vivo active erythropoietin produced in insect cells
SI1147180T1 (sl) 1999-01-26 2009-06-30 Schering Plough Ltd Razmnoževnje govejega korona virusa v ovarijskih celicah kitajskega hrčka
PT1533380E (pt) 1999-04-15 2010-02-09 Crucell Holland Bv Produção de proteínas recombinantes numa célula humana compreendendo pelo menos uma proteína e1 de adenovírus
US6855544B1 (en) * 1999-04-15 2005-02-15 Crucell Holland B.V. Recombinant protein production in a human cell
JP2001149099A (ja) 1999-11-26 2001-06-05 Olympus Optical Co Ltd 染色体異常解析のための有核細胞の標本作製方法
EP1103610A1 (en) 1999-11-26 2001-05-30 Introgene B.V. Production of vaccines from immortalised mammalian cell lines
US6544424B1 (en) 1999-12-03 2003-04-08 Refined Technology Company Fluid filtration system
US6168941B1 (en) * 2000-04-07 2001-01-02 Genvec, Inc. Method of producing adenoviral vector stocks
JP4138209B2 (ja) 2000-06-29 2008-08-27 エーザイ・アール・アンド・ディー・マネジメント株式会社 プラバスタチン含有組成物
JP2002113896A (ja) 2000-10-05 2002-04-16 Seiko Epson Corp 画像形成装置
CA2476614A1 (en) 2001-02-23 2002-09-19 V.A.I. Ltd. Methods and apparatus for biological treatment of waste waters
JP3547715B2 (ja) * 2001-03-06 2004-07-28 榮 新垣 ベクター精製用装置及び方法
US6716354B2 (en) 2001-03-08 2004-04-06 Cdg Technology, Inc. Methods of treating water using combinations of chlorine dioxide, chlorine and ammonia
ATE422216T1 (de) * 2001-04-17 2009-02-15 Seiren Kabushiki Kaisha Mediumzusätze und medien für tierzellkulturen
DE10120835C2 (de) 2001-04-27 2003-04-10 Sifin Inst Fuer Immunpraeparat Verfahren zur Herstellung von monoklonalen Antikörpern
DE10120838A1 (de) 2001-04-27 2002-10-31 Basf Ag Stoffmischung zur UV-Stabilisierung von Kunststoffen und Herstellung davon
DK1451290T3 (da) 2001-08-31 2011-04-26 Bayer Schering Pharma Ag Indretning og fremgangsmåde til udførelse af fermentering af høj celledensitet
EA006776B1 (ru) 2001-09-05 2006-04-28 Ямаса Корпорейшн Фармацевтическая композиция для лечения диабетической невропатии
US20030054544A1 (en) * 2001-09-14 2003-03-20 Medcell Biologics, Inc. Oxygen enriched bioreactor and method of culturing cells
GB0123098D0 (en) * 2001-09-26 2001-11-14 Lonza Biologics Plc Use of aminoglycoside resistance gene
WO2003041749A1 (de) 2001-11-15 2003-05-22 Aesculap Ag & Co. Kg Sterilbehälter
JP2003219873A (ja) 2002-01-24 2003-08-05 Japan Science & Technology Corp サケ科キングサーモン由来の不死化細胞
US20030186335A1 (en) 2002-03-28 2003-10-02 National Institute Of Advanced Industrial Science And Technology Monoclonal antibodies, hybridomas, cell isolation method, isolated cells and immunological diagnostic method
US6902909B2 (en) 2002-07-09 2005-06-07 Synthecon, Inc. Methods for efficient production of mammalian recombinant proteins
DE10237082B4 (de) * 2002-08-09 2014-12-31 Sartorius Stedim Biotech Gmbh Verfahren und Vorrichtung zur biotechnologischen Herstellung von Wertstoffen
JP2006525015A (ja) * 2003-05-01 2006-11-09 ディーエスエム アイピー アセッツ ビー．ブイ． 懸濁した動物細胞の灌流培養による生物学的物質の製造方法
NZ542585A (en) 2003-05-09 2007-11-30 Crucell Holland Bv Cultures of PER.C6-immortalized cells and processes for culturing the same to increase product yields therefrom
JP2007535902A (ja) * 2003-07-17 2007-12-13 グローバル セル ソリューションズ エルエルシー． 自動細胞培養システムおよび方法
JP2005041984A (ja) 2003-07-22 2005-02-17 Shin Kobe Electric Mach Co Ltd 水架橋ポリオレフィン製シートの製造法
PT1720972E (pt) 2004-03-05 2014-04-07 Dsm Ip Assets Bv Processo para cultura de células por perfusão contínua e fluxo alternativo tangencial
US20080230488A1 (en) * 2004-03-29 2008-09-25 Pall Corporation Pleated, Crossflow Fluid Treatment Elements, Methods for Making Them, and Methods for Treating Cellular Solutions
DK1835022T3 (en) * 2005-01-05 2015-02-23 Chugai Pharmaceutical Co Ltd CELL CULTIVATION PROCEDURE AND UTILIZATION OF THIS
CN100354408C (zh) * 2005-10-09 2007-12-12 南京工业大学 一种高密度细胞培养方法及其生物反应装置
EP1968740B8 (en) * 2005-12-17 2017-02-22 AirInSpace S.E. Air purification devices
JP5031332B2 (ja) 2006-03-31 2012-09-19 旭化成ホームズ株式会社 線切断具
DK2634243T4 (da) * 2006-07-14 2024-09-23 Patheon Holdings I B V Forbedret fremgangsmåde til dyrkning af celler
EP2014760A1 (en) 2007-06-13 2009-01-14 CMC Biopharmaceuticals A/S A method for producing a biopolymer (e.g. polypeptide) in a continuous fermentation process
JP2008308560A (ja) 2007-06-13 2008-12-25 Tohcello Co Ltd 表面防汚性複合フィルムの製造方法
JP5426937B2 (ja) * 2009-06-19 2014-02-26 興和株式会社 光学的反応測定装置および光学的反応測定方法

Also Published As

Publication number Publication date
SI2634242T1 (sl) 2017-07-31
HUE032608T2 (en) 2017-10-30
JP2009543565A (ja) 2009-12-10
TW201604277A (zh) 2016-02-01
JP5448010B2 (ja) 2014-03-19
US8222001B2 (en) 2012-07-17
IL234890A (en) 2016-05-31
TWI627274B (zh) 2018-06-21
SI2634250T1 (sl) 2017-06-30
AU2007272054C1 (en) 2014-08-28
TW200813216A (en) 2008-03-16
PT2041259E (pt) 2016-02-15
KR20130014640A (ko) 2013-02-07
FI2343362T4 (fi) 2024-07-04
EP2343362B1 (en) 2016-03-30
ES2579957T3 (es) 2016-08-17
AU2007272054B2 (en) 2011-09-08
CN102876628A (zh) 2013-01-16
AR062072A1 (es) 2008-10-15
JP2011067222A (ja) 2011-04-07
US20120149107A1 (en) 2012-06-14
DK2343362T3 (en) 2016-07-18
ES2559308T3 (es) 2016-02-11
EP2634243A1 (en) 2013-09-04
ES2625062T3 (es) 2017-07-18
CN104263700A (zh) 2015-01-07
HUE028365T2 (en) 2016-12-28
EP2343362A1 (en) 2011-07-13
JP2014217395A (ja) 2014-11-20
US20120149063A1 (en) 2012-06-14
DK2343362T4 (da) 2024-07-08
IL196322A0 (en) 2009-09-22
EP2343362B8 (en) 2016-05-18
TWI512102B (zh) 2015-12-11
EP2634242B1 (en) 2017-04-05
US20100075413A1 (en) 2010-03-25
KR20120009530A (ko) 2012-01-31
MX340242B (es) 2016-07-01
US8119368B2 (en) 2012-02-21
BRPI0714347A2 (pt) 2013-05-07
KR101143796B1 (ko) 2012-05-21
EA016451B1 (ru) 2012-05-30
DK2634242T3 (en) 2017-05-22
AU2007272054A1 (en) 2008-01-17
EA201101581A1 (ru) 2012-04-30
HUE034299T2 (en) 2018-02-28
EP2041259A1 (en) 2009-04-01
PT2343362T (pt) 2016-07-13
US20140154745A1 (en) 2014-06-05
EP2634242A1 (en) 2013-09-04
US8685731B2 (en) 2014-04-01
ES2650042T3 (es) 2018-01-16
EP2041259B2 (en) 2024-10-09
CL2007002060A1 (es) 2008-04-18
US9670520B2 (en) 2017-06-06
US20160265017A1 (en) 2016-09-15
EP2634243B2 (en) 2024-07-24
JP2012165764A (ja) 2012-09-06
EA200900188A1 (ru) 2009-06-30
SI2343362T1 (sl) 2016-09-30
DK2634243T3 (en) 2017-12-11
US8440458B2 (en) 2013-05-14
WO2008006494A1 (en) 2008-01-17
US9469865B2 (en) 2016-10-18
EP2634250B1 (en) 2017-04-05
PL2634250T3 (pl) 2017-09-29
PL2634242T3 (pl) 2017-09-29
PL2343362T3 (pl) 2016-11-30
EP2041259B1 (en) 2015-10-14
HUE028593T2 (en) 2016-12-28
PL2634243T3 (pl) 2018-02-28
DK2041259T3 (en) 2016-01-25
US20130095527A1 (en) 2013-04-18
EP2634250A1 (en) 2013-09-04
HUE035109T2 (en) 2018-05-02
TWI413689B (zh) 2013-11-01
SI2041259T1 (sl) 2016-04-29
PT2634242T (pt) 2017-07-12
KR20090031899A (ko) 2009-03-30
SI2634243T1 (en) 2018-01-31
PT2634250T (pt) 2017-07-13
PT2634243T (pt) 2017-12-18
EP2634243B1 (en) 2017-09-06
TW201341527A (zh) 2013-10-16
JP5092129B2 (ja) 2012-12-05
CA2657040C (en) 2013-10-01
MX2009000522A (es) 2009-01-27
US20120064623A1 (en) 2012-03-15
CA2657040A1 (en) 2008-01-17
DK2634243T4 (da) 2024-09-23
EP2343362B2 (en) 2024-04-03
ES2625066T3 (es) 2017-07-18
KR101685246B1 (ko) 2016-12-09

Similar Documents

Publication Publication Date Title
IL196322A0 (en) Improved process for the culturing of cells
HK1246827A1 (zh) 細胞培養方法
IL197444A0 (en) Cell culture improvements
IL211176A0 (en) Methods for the production of ips cells
GB0605450D0 (en) Cell co-culture
AP2010005116A0 (en) Process for the cultivation of micro-algae
EP1997877A4 (en) CELL CULTURE SUBSTRATE
EP2064324A4 (en) SUBSTRATES FOR CELL CULTURE AND MANUFACTURING METHOD THEREFOR
EP2011857A4 (en) METHOD FOR PRODUCING A CELL CULTURAL CONTAINER
IL206859A0 (en) Process for the manufacture of solar cells
IL184262A (en) A method for culturing cells in culture
PT1976960E (pt) Processo para a preparação de biodiesel
PT2079843T (pt) Processo para a produção de biogás
EP2021464A4 (en) METHOD FOR CULTURING HUMAN EMBRYONIC STEM CELLS
GB0814443D0 (en) Process for cultivating cells
GB0606671D0 (en) Cell Culture
ZA200809399B (en) Process for the production of yeast
GB0718014D0 (en) Cell culture apparatus