PH25148A - Pyrrolo (1,2-a) (4,1) benzoxazepine derivatives useful as calmodulin and histamine inhibitors - Google Patents

Pyrrolo (1,2-a) (4,1) benzoxazepine derivatives useful as calmodulin and histamine inhibitors

Info

Publication number: PH25148A
Authority: PH; Philippines
Prior art keywords: lower alkyl; image; calmodulin; represents hydrogen; pyrrolo
Prior art date: 1986-01-21

Application number

PH34722A

Other languages

English (en)

Inventor

Jan William Francis Wasley

Jon Norman

Original Assignee

Ciba Geigy Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-01-21

Filing date

1987-01-14

Publication date

1991-03-13

1987-01-14 Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag

1991-03-13 Publication of PH25148A publication Critical patent/PH25148A/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

PH34722A 1986-01-21 1987-01-14 Pyrrolo (1,2-a) (4,1) benzoxazepine derivatives useful as calmodulin and histamine inhibitors PH25148A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/821,110 US4758559A (en)	1986-01-21	1986-01-21	Pyrrolo[1,2-a] [4,1]benzoxazepine derivatives useful as calmodulin and histamine inhibitors

Publications (1)

Publication Number	Publication Date
PH25148A true PH25148A (en)	1991-03-13

Family

ID=25232538

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PH34722A PH25148A (en)	1986-01-21	1987-01-14	Pyrrolo (1,2-a) (4,1) benzoxazepine derivatives useful as calmodulin and histamine inhibitors

Country Status (25)

Country	Link
US (1)	US4758559A (fi)
EP (1)	EP0233483B1 (fi)
JP (2)	JPH0780888B2 (fi)
KR (1)	KR900004148B1 (fi)
AT (1)	ATE62244T1 (fi)
AU (1)	AU598510B2 (fi)
CA (1)	CA1273335A (fi)
CY (1)	CY1749A (fi)
DD (1)	DD257430A5 (fi)
DE (1)	DE3768978D1 (fi)
DK (1)	DK169239B1 (fi)
ES (1)	ES2039363T3 (fi)
FI (1)	FI86636C (fi)
GR (1)	GR3001737T3 (fi)
HK (1)	HK24194A (fi)
HU (1)	HU198061B (fi)
IE (1)	IE59653B1 (fi)
IL (1)	IL81302A (fi)
MA (1)	MA20857A1 (fi)
MY (1)	MY100914A (fi)
PH (1)	PH25148A (fi)
PT (1)	PT84136B (fi)
TN (1)	TNSN87003A1 (fi)
ZA (1)	ZA87389B (fi)
ZW (1)	ZW787A1 (fi)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SG48855A1 (en) *	1992-04-20	1998-05-18	Takeda Chemical Industries Ltd	4,1-benzoxazepin derivatives and their use
US5452434A (en) *	1992-07-14	1995-09-19	Advanced Micro Devices, Inc.	Clock control for power savings in high performance central processing units
US5321012A (en) *	1993-01-28	1994-06-14	Virginia Commonwealth University Medical College	Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
USRE39300E1 (en)	1993-01-28	2006-09-19	Virginia Commonwealth University Medical College Of Virginia	Inhibiting the development of tolerance to and/or dependence on an addictive substance
US5439524A (en) *	1993-04-05	1995-08-08	Vlsi Technology, Inc.	Plasma processing apparatus
US5698518A (en) *	1994-03-30	1997-12-16	Oklahoma Medical Research Foundation	Method for regulating inflammation and tumor growth with calmodulin, calmodulin analogues or calmodulin antagonists
US5624902A (en) *	1995-06-07	1997-04-29	Torrey Pines Institute For Molecular Studies	Peptide inhibitors of calmodulin
US6423329B1 (en)	1999-02-12	2002-07-23	The Procter & Gamble Company	Skin sanitizing compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4045448A (en) *	1976-02-26	1977-08-30	American Hoechst Corporation	Pyrrolo[2,1-c][1,4]benzoxazepine and benzoxazocine derivatives
US4029672A (en) *	1976-02-26	1977-06-14	American Hoechst Corporation	Aminoalkylpyrrolobenzoxazalkanes
US4053599A (en) *	1976-02-26	1977-10-11	American Hoechst Corporation	Piperazionalkylpyrrolobenzoxazalkanes
US4169095A (en) *	1977-01-19	1979-09-25	American Hoechst Corporation	Process for preparing aminoalkylpyrrolobenzoxazalkanes
US4608374A (en) *	1983-11-07	1986-08-26	Hoechst-Roussel Pharmaceuticals Inc.	11-substituted 5H,11H-pyrrolo[2,1-c][1,4]benzoxazepines as antipsychotic and analgesic agents

1986
- 1986-01-21 US US06/821,110 patent/US4758559A/en not_active Expired - Lifetime
1987
- 1987-01-05 MY MYPI87000013A patent/MY100914A/en unknown
- 1987-01-14 PH PH34722A patent/PH25148A/en unknown
- 1987-01-19 EP EP87100598A patent/EP0233483B1/de not_active Expired - Lifetime
- 1987-01-19 AT AT87100598T patent/ATE62244T1/de not_active IP Right Cessation
- 1987-01-19 IL IL81302A patent/IL81302A/xx not_active IP Right Cessation
- 1987-01-19 ES ES87100598T patent/ES2039363T3/es not_active Expired - Lifetime
- 1987-01-19 FI FI870207A patent/FI86636C/fi not_active IP Right Cessation
- 1987-01-19 CA CA000527583A patent/CA1273335A/en not_active Expired - Lifetime
- 1987-01-19 DE DE8787100598T patent/DE3768978D1/de not_active Expired - Lifetime
- 1987-01-19 PT PT84136A patent/PT84136B/pt unknown
- 1987-01-19 DD DD87299332A patent/DD257430A5/de unknown
- 1987-01-20 DK DK029587A patent/DK169239B1/da not_active IP Right Cessation
- 1987-01-20 ZA ZA87389A patent/ZA87389B/xx unknown
- 1987-01-20 ZW ZW7/87A patent/ZW787A1/xx unknown
- 1987-01-20 AU AU67813/87A patent/AU598510B2/en not_active Ceased
- 1987-01-20 TN TNTNSN87003A patent/TNSN87003A1/fr unknown
- 1987-01-20 IE IE13987A patent/IE59653B1/en not_active IP Right Cessation
- 1987-01-20 MA MA21090A patent/MA20857A1/fr unknown
- 1987-01-20 JP JP62009181A patent/JPH0780888B2/ja not_active Expired - Fee Related
- 1987-01-20 HU HU87152A patent/HU198061B/hu not_active IP Right Cessation
- 1987-01-21 KR KR1019870000454A patent/KR900004148B1/ko not_active IP Right Cessation
1991
- 1991-04-04 GR GR91400317T patent/GR3001737T3/el unknown
1993
- 1993-12-22 JP JP5324407A patent/JPH0826028B2/ja not_active Expired - Lifetime
1994
- 1994-03-17 HK HK241/94A patent/HK24194A/xx not_active IP Right Cessation
- 1994-06-03 CY CY174994A patent/CY1749A/xx unknown

Also Published As

Publication number	Publication date
EP0233483B1 (de)	1991-04-03
FI870207A0 (fi)	1987-01-19
MY100914A (en)	1991-05-31
CY1749A (en)	1994-06-03
ES2039363T3 (es)	1995-04-01
IL81302A0 (en)	1987-08-31
JPH0826028B2 (ja)	1996-03-13
FI86636B (fi)	1992-06-15
FI86636C (fi)	1992-09-25
FI870207A (fi)	1987-07-22
EP0233483A3 (en)	1988-10-19
TNSN87003A1 (fr)	1990-01-01
HU198061B (en)	1989-07-28
IE870139L (en)	1987-07-21
DK29587A (da)	1987-07-22
DE3768978D1 (de)	1991-05-08
PT84136A (en)	1987-02-01
PT84136B (pt)	1989-07-31
JPS62169791A (ja)	1987-07-25
AU6781387A (en)	1987-07-23
JPH0780888B2 (ja)	1995-08-30
EP0233483A2 (de)	1987-08-26
JPH0789966A (ja)	1995-04-04
ZW787A1 (en)	1987-08-12
DK29587D0 (da)	1987-01-20
IL81302A (en)	1990-11-29
DK169239B1 (da)	1994-09-19
DD257430A5 (de)	1988-06-15
KR900004148B1 (ko)	1990-06-16
MA20857A1 (fr)	1987-10-01
IE59653B1 (en)	1994-03-09
KR870007181A (ko)	1987-08-17
ZA87389B (en)	1987-11-25
HUT45259A (en)	1988-06-28
AU598510B2 (en)	1990-06-28
ATE62244T1 (de)	1991-04-15
HK24194A (en)	1994-03-25
CA1273335A (en)	1990-08-28
US4758559A (en)	1988-07-19
GR3001737T3 (en)	1992-11-23

Publication	Publication Date	Title
GB9314884D0 (en)	1993-09-01	Tricyclic derivatives
IL101327A0 (en)	1992-11-15	Heterocyclic-cyclic amine derivatives
GR3019490T3 (en)	1996-07-31	Substituted piperazines as central nervous system agents
AU2722288A (en)	1989-04-18	Certain 3-substituted 2-alkyl benzofuran derivatives
PH25148A (en)	1991-03-13	Pyrrolo (1,2-a) (4,1) benzoxazepine derivatives useful as calmodulin and histamine inhibitors
ZA815043B (en)	1983-03-30	Diazepine derivatives,process for their preparation,and pharmaceutical compositions thereof
IE880246L (en)	1988-07-30	TRIAZOLO £3,2-b\| £1,2,4\| TRIAZIN-7-ONES
ZA877562B (en)	1988-04-11	Aralkyl-4h-1,2,4-triazole derivatives
BG50775A1 (en)	1992-11-16	Derivatives of 2, 3- dimethyl- 1- phenyl- 4- (2- phenylmorpholinomethyl)- 5- pyrazolones and method for their preparation