PE20190705A1 - COMPUESTOS DE BENZO[b] TIOFENO COMO AGONISTAS DE STING - Google Patents
COMPUESTOS DE BENZO[b] TIOFENO COMO AGONISTAS DE STINGInfo
- Publication number
- PE20190705A1 PE20190705A1 PE2019000764A PE2019000764A PE20190705A1 PE 20190705 A1 PE20190705 A1 PE 20190705A1 PE 2019000764 A PE2019000764 A PE 2019000764A PE 2019000764 A PE2019000764 A PE 2019000764A PE 20190705 A1 PE20190705 A1 PE 20190705A1
- Authority
- PE
- Peru
- Prior art keywords
- thiophen
- sting agonists
- compounds
- benzo compounds
- haloalkyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Se refiere a un compuesto de formula (Ia') o su sal farmaceuticamente aceptable, donde: R1 es H, halogeno, entre otros; R2 es H, CN, entre otros; R3 es H, COOR6, entre otros; R4 es H, OR6, entre otros; R5 es H, N(R6)2, entre otros; R6 es H, alquilo C1-C6, y haloalquilo C1-C6, pudiendo estar los 2 ultimos sustituidos con OH, O(alquilo C1-C3), y O(haloalquilo C1-C3); X1 es C(O); X2 es (C(R8)2)(1-3); R8 es H, CN, entre otros; y X3 es C(S)OR6, SO2R6, entre otros. Tambien se refiere a composiciones farmaceuticas que comprenden al compuesto de la invencion y a metodos de preparacion. Dichos compuestos son agonistas de STING (estimulador de genes de interferon) y son utiles en el tratamiento de enfermedades como el cancer
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662404062P | 2016-10-04 | 2016-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20190705A1 true PE20190705A1 (es) | 2019-05-17 |
Family
ID=60084122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2019000764A PE20190705A1 (es) | 2016-10-04 | 2017-10-02 | COMPUESTOS DE BENZO[b] TIOFENO COMO AGONISTAS DE STING |
Country Status (39)
| Country | Link |
|---|---|
| US (3) | US10414747B2 (es) |
| EP (1) | EP3523287B1 (es) |
| JP (1) | JP6636673B2 (es) |
| KR (1) | KR102312721B1 (es) |
| CN (1) | CN110036001B (es) |
| AR (1) | AR109788A1 (es) |
| AU (1) | AU2017339418C1 (es) |
| CA (1) | CA3038903C (es) |
| CL (1) | CL2019000902A1 (es) |
| CO (1) | CO2019003349A2 (es) |
| CR (1) | CR20190168A (es) |
| CY (1) | CY1124837T1 (es) |
| DK (1) | DK3523287T3 (es) |
| DO (1) | DOP2019000083A (es) |
| EA (1) | EA037626B1 (es) |
| EC (1) | ECSP19026680A (es) |
| ES (1) | ES2893532T3 (es) |
| GE (1) | GEP20217285B (es) |
| HR (1) | HRP20211617T1 (es) |
| HU (1) | HUE056502T2 (es) |
| IL (1) | IL265678B2 (es) |
| JO (1) | JOP20190070B1 (es) |
| LT (1) | LT3523287T (es) |
| MA (1) | MA46452B1 (es) |
| MD (1) | MD3523287T2 (es) |
| MX (1) | MX2019003829A (es) |
| MY (1) | MY196383A (es) |
| NI (1) | NI201900029A (es) |
| PE (1) | PE20190705A1 (es) |
| PH (1) | PH12019500712A1 (es) |
| PL (1) | PL3523287T3 (es) |
| PT (1) | PT3523287T (es) |
| RS (1) | RS62410B1 (es) |
| SG (1) | SG10202008647TA (es) |
| SI (1) | SI3523287T1 (es) |
| TN (2) | TN2020000158A1 (es) |
| TW (1) | TWI796306B (es) |
| UA (1) | UA125223C2 (es) |
| WO (1) | WO2018067423A1 (es) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114230625A (zh) | 2016-03-18 | 2022-03-25 | 免疫传感器公司 | 环二核苷酸化合物及使用方法 |
| EP3481402A4 (en) | 2016-07-06 | 2020-01-22 | Sperovie Biosciences, Inc. | CONNECTIONS, COMPOSITIONS AND METHODS FOR TREATING A DISEASE |
| CN110036001B (zh) * | 2016-10-04 | 2022-03-22 | 默沙东公司 | 作为STING激动剂的苯并[b]噻吩化合物 |
| CN110023495A (zh) | 2016-10-14 | 2019-07-16 | 精密生物科学公司 | 对乙肝病毒基因组中的识别序列特异性的工程化大范围核酸酶 |
| JOP20170192A1 (ar) | 2016-12-01 | 2019-01-30 | Takeda Pharmaceuticals Co | داي نوكليوتيد حلقي |
| MX2019012233A (es) | 2017-04-13 | 2020-01-14 | Aduro Biotech Holdings Europe Bv | Anticuerpos anti-sirpa. |
| MA49773A (fr) * | 2017-08-04 | 2021-04-21 | Merck Sharp & Dohme | Combinaisons d'antagonistes de pd-1 et d'agonistes de sting benzo[b |
| WO2019027858A1 (en) * | 2017-08-04 | 2019-02-07 | Merck Sharp & Dohme Corp. | BENZO [B] STING THIOPHEN AGONISTS FOR THE TREATMENT OF CANCER |
| US11638716B2 (en) | 2017-08-31 | 2023-05-02 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
| US11707531B2 (en) | 2017-09-11 | 2023-07-25 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
| WO2019051488A1 (en) | 2017-09-11 | 2019-03-14 | Sperovie Biosciences, Inc. | COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISEASE |
| WO2019069275A1 (en) * | 2017-10-05 | 2019-04-11 | Glaxosmithkline Intellectual Property Development Limited | STING AGONIST ADMINISTRATION METHODS |
| BR112020009126A2 (pt) | 2017-11-10 | 2020-10-20 | Takeda Pharmaceutical Company Limited | compostos do modulador sting e métodos de fabricação e uso |
| BR112020009431A2 (pt) | 2017-12-01 | 2020-10-13 | The Texas A&M University System | tratamento antisense da síndrome de angelman |
| EP3728283B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| EP3728282B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| AU2019223182B2 (en) | 2018-02-26 | 2021-08-19 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds as HBV replication inhibitors |
| US11702430B2 (en) | 2018-04-03 | 2023-07-18 | Merck Sharp & Dohme Llc | Aza-benzothiophene compounds as STING agonists |
| AU2019248545B2 (en) | 2018-04-03 | 2022-08-11 | Merck Sharp & Dohme Llc | Benzothiophenes and related compounds as sting agonists |
| US10870691B2 (en) | 2018-04-05 | 2020-12-22 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis B virus protein X |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| US11142750B2 (en) | 2018-04-12 | 2021-10-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
| TW202014193A (zh) | 2018-05-03 | 2020-04-16 | 捷克科學院有機化學與生物化學研究所 | 包含碳環核苷酸之2’3’－環二核苷酸 |
| GB201807924D0 (en) | 2018-05-16 | 2018-06-27 | Ctxt Pty Ltd | Compounds |
| ES2929415T3 (es) | 2018-05-25 | 2022-11-29 | Incyte Corp | Compuestos heterocíclicos tricíclicos como activadores de STING |
| WO2020010451A1 (en) * | 2018-07-10 | 2020-01-16 | Trillium Therapeutics Inc. | Heteroaromatic-fused imidazolyl amides, compositions and uses thereof as sting agonists |
| EP3826660A1 (en) * | 2018-07-26 | 2021-06-02 | Bristol-Myers Squibb Company | Lag-3 combination therapy for the treatment of cancer |
| WO2020028566A1 (en) | 2018-07-31 | 2020-02-06 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
| WO2020028565A1 (en) | 2018-07-31 | 2020-02-06 | Incyte Corporation | Tricyclic heteraryl compounds as sting activators |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
| JP7254818B2 (ja) | 2018-09-06 | 2023-04-10 | 第一三共株式会社 | 新規環状ジヌクレオチド誘導体及びその抗体薬物コンジュゲート |
| MX2021003958A (es) | 2018-10-11 | 2021-05-27 | Ono Pharmaceutical Co | Compuesto agonista de la proteina estimuladora de genes de interferon (sting). |
| JP7273172B2 (ja) | 2018-10-31 | 2023-05-12 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｐｋ１阻害活性を有する置換６－アザベンゾイミダゾール化合物 |
| CA3117556A1 (en) | 2018-10-31 | 2020-05-07 | Gilead Sciences, Inc. | Substituted 6-azabenzimidazole compounds as hpk1 inhibitors |
| US11596692B1 (en) | 2018-11-21 | 2023-03-07 | Incyte Corporation | PD-L1/STING conjugates and methods of use |
| CN111393405B (zh) | 2019-01-02 | 2022-11-25 | 中国科学院上海药物研究所 | 一类含氟取代的苯并噻吩类化合物及其药物组合物及应用 |
| CN111393404B (zh) * | 2019-01-02 | 2023-02-17 | 中国科学院上海药物研究所 | 一类苯并噻吩类化合物及其药物组合物及应用 |
| US12129267B2 (en) | 2019-01-07 | 2024-10-29 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
| WO2020165600A1 (en) | 2019-02-14 | 2020-08-20 | Bicycletx Limited | Bicyclic peptide ligand sting conjugates and uses thereof |
| CA3129011C (en) | 2019-03-07 | 2023-12-19 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| EP3935065A1 (en) | 2019-03-07 | 2022-01-12 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| WO2020178769A1 (en) | 2019-03-07 | 2020-09-10 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
| TW202212339A (zh) | 2019-04-17 | 2022-04-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TW202210480A (zh) | 2019-04-17 | 2022-03-16 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| CN118108716A (zh) * | 2019-04-30 | 2024-05-31 | 四川科伦博泰生物医药股份有限公司 | 苯并噻吩类化合物及其制备方法和用途 |
| CN111848573B (zh) * | 2019-04-30 | 2023-04-07 | 四川科伦博泰生物医药股份有限公司 | 苯并噻吩酰胺类化合物及其制备方法和用途 |
| CN111848572B (zh) * | 2019-04-30 | 2023-03-31 | 四川科伦博泰生物医药股份有限公司 | 酰胺类化合物及其制备方法和用途 |
| EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| AU2020301161B2 (en) | 2019-06-25 | 2023-10-26 | Gilead Sciences, Inc. | FLT3L-Fc fusion proteins and methods of use |
| CA3145889A1 (en) | 2019-07-05 | 2021-01-14 | Tambo, Inc. | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
| GB201910305D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| GB201910304D0 (en) | 2019-07-18 | 2019-09-04 | Ctxt Pty Ltd | Compounds |
| TW202120500A (zh) | 2019-08-02 | 2021-06-01 | 美商梅爾莎納醫療公司 | 干擾素基因刺激蛋白（ｓｔｉｎｇ）激動劑化合物及用途 |
| WO2021034804A1 (en) | 2019-08-19 | 2021-02-25 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
| CN115003383B (zh) * | 2019-08-21 | 2024-10-01 | 斯克里普斯研究学院 | 干扰素基因刺激物sting的双环激动剂 |
| CA3151846A1 (en) * | 2019-08-21 | 2021-02-25 | The Scripps Research Institute | Monocyclic agonists of stimulator of interferon genes sting |
| BR112022005687A2 (pt) | 2019-09-30 | 2022-06-21 | Gilead Sciences Inc | Vacinas contra o hbv e métodos para tratar o hbv |
| CA3156370A1 (en) * | 2019-10-28 | 2021-05-06 | Wenhu Duan | Five-membered heterocyclic oxocarboxylic acid compound and medical use thereof |
| EP4069729A1 (en) | 2019-12-06 | 2022-10-12 | Precision BioSciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome |
| WO2021113679A1 (en) * | 2019-12-06 | 2021-06-10 | Mersana Therapeutics, Inc. | Dimeric compounds as sting agonists |
| US20230330248A1 (en) | 2020-03-06 | 2023-10-19 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate including novel cyclic dinucleotide derivative |
| AR121620A1 (es) | 2020-03-20 | 2022-06-22 | Gilead Sciences Inc | Profármacos de nucleósidos 4-c-sustituidos-2-halo-2-deoxiadenosina y métodos de preparación y uso de los mismos |
| US20230141284A1 (en) | 2020-04-10 | 2023-05-11 | Ono Pharmaceutical Co., Ltd. | Cancer therapeutic method |
| US20230151024A1 (en) | 2020-04-10 | 2023-05-18 | Ono Pharmaceutical Co., Ltd. | Sting agonistic compound |
| MX2022014191A (es) | 2020-05-13 | 2022-12-07 | Massachusetts Inst Technology | Composiciones de microdispositivos polimericos y su uso en la inmunoterapia de cancer. |
| CN113861161A (zh) * | 2020-06-30 | 2021-12-31 | 上海海和药物研究开发股份有限公司 | 一种芳基并芳杂环衍生物及其制备方法和用途 |
| US20230303599A1 (en) | 2020-08-07 | 2023-09-28 | Gilead Sciences, Inc. | Prodrugs of phosphonamide nucleotide analogues and their pharmaceutical use |
| EP4192506A1 (en) | 2020-08-07 | 2023-06-14 | Tambo, Inc. | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
| EP4209506A4 (en) | 2020-09-02 | 2024-10-09 | Daiichi Sankyo Co Ltd | NEW ENDO-?-N-ACETYLGLUCOSAMINIDASE |
| MX2023005381A (es) | 2020-11-09 | 2023-05-23 | Takeda Pharmaceuticals Co | Conjugados de anticuerpo y farmaco. |
| CN113429384B (zh) * | 2021-05-12 | 2022-04-08 | 中山大学附属第五医院 | 一类干扰素基因刺激因子靶向的放射性pet显像剂 |
| WO2022241134A1 (en) | 2021-05-13 | 2022-11-17 | Gilead Sciences, Inc. | COMBINATION OF A TLR8 MODULATING COMPOUND AND ANTI-HBV siRNA THERAPEUTICS |
| WO2022245671A1 (en) | 2021-05-18 | 2022-11-24 | Gilead Sciences, Inc. | Methods of using flt3l-fc fusion proteins |
| WO2022271659A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| AU2022297373A1 (en) | 2021-06-23 | 2024-01-04 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| JP2024522594A (ja) | 2021-06-23 | 2024-06-21 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| AU2022299051A1 (en) | 2021-06-23 | 2023-12-07 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| CN117836007A (zh) * | 2021-07-13 | 2024-04-05 | 南京大学 | 一种pt偶联物及其用途 |
| CN113429387B (zh) * | 2021-07-27 | 2022-10-28 | 中国药科大学 | 一种苯并[b]硒吩类STING调控剂、其制备方法及用途 |
| CN115772154B (zh) * | 2021-09-08 | 2024-04-30 | 上海交通大学 | 一类含有氘取代的苯并噻吩类衍生物及其制备与用途 |
| JPWO2023167238A1 (es) | 2022-03-02 | 2023-09-07 | ||
| WO2023211940A1 (en) * | 2022-04-25 | 2023-11-02 | The Regents Of The University Of Michigan | Sting agonists, formulations, and uses thereof |
| WO2023211930A1 (en) * | 2022-04-25 | 2023-11-02 | The Regents Of The University Of Michigan | Dual functioning immune modulating compounds, formulations, and uses thereof |
| WO2024175086A1 (zh) * | 2023-02-24 | 2024-08-29 | 深圳真实生物医药科技有限公司 | 芳基三并环类sting激动剂及其用途 |
| CN116354922A (zh) * | 2023-03-31 | 2023-06-30 | 药康众拓(江苏)医药科技有限公司 | 氘代苯并噻吩类化合物及其药物组合物和用途 |
| WO2024211577A1 (en) | 2023-04-05 | 2024-10-10 | Massachusetts Institute Of Technology | Hybrid polymeric systems and methods of use thereof |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB532822A (en) * | 1939-08-11 | 1941-01-31 | John David Kendall | Improvements in and relating to the production of ª‡-coumarilyl and ª‡-thionaphthenoyl-acetic acid esters |
| GB1383114A (en) * | 1972-06-22 | 1975-02-05 | English Electric Valve Co Ltd | Magnetrons |
| US4299769A (en) * | 1980-04-28 | 1981-11-10 | American Cyanamid Company | ω-Heteroaroyl(propionyl or butyryl)-L-prolines |
| US4342690A (en) | 1980-04-28 | 1982-08-03 | American Cyanamid Company | ω-Heteroaroyl(propionyl or butyryl)-L-prolines |
| US4342691A (en) | 1980-04-28 | 1982-08-03 | American Cyanamid Company | ω-Heteroaroyl(propionyl or butyryl)-L-prolines |
| US4342689A (en) | 1980-04-28 | 1982-08-03 | American Cyanamid Company | ω-Heteroaroyl(propionyl or butyryl)-L-prolines |
| EP0146243A1 (en) | 1983-10-31 | 1985-06-26 | Merck Frosst Canada Inc. | Lipoxygenase inhibitors |
| ES2080064T3 (es) | 1988-07-11 | 1996-02-01 | Akzo Nobel Nv | Derivados de piridazinona. |
| CA2144763A1 (en) | 1992-10-14 | 1994-04-28 | George D. Hartman | Fibrinogen receptor antagonists |
| US5569655A (en) | 1993-09-14 | 1996-10-29 | Sterling Winthrop Inc. | Substituted heterocyclylisoquinolinium salts and compositions and method of use thereof |
| US6262055B1 (en) | 1998-06-03 | 2001-07-17 | Merck & Co., Inc. | HIV integrase inhibitors |
| JP2002517390A (ja) | 1998-06-03 | 2002-06-18 | メルク エンド カムパニー インコーポレーテッド | Ｈｉｖインテグラーゼ阻害薬 |
| PE20010306A1 (es) | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| GB0018891D0 (en) | 2000-08-01 | 2000-09-20 | Novartis Ag | Organic compounds |
| DE60143520D1 (de) | 2000-03-24 | 2011-01-05 | Methylgene Inc | Inhibitoren der histon-deacetylase |
| CA2437898A1 (en) | 2001-02-26 | 2002-09-06 | Pharma Pacific Pty. Ltd | Interferon-alpha induced gene |
| DK2206517T3 (da) | 2002-07-03 | 2023-11-06 | Ono Pharmaceutical Co | Immunpotentierende sammensætninger omfattende af anti-PD-L1-antistoffer |
| CA2508660C (en) | 2002-12-23 | 2013-08-20 | Wyeth | Antibodies against pd-1 and uses therefor |
| EP2270051B1 (en) | 2003-01-23 | 2019-05-15 | Ono Pharmaceutical Co., Ltd. | Antibody specific for human PD-1 and CD3 |
| WO2005020917A2 (en) | 2003-09-02 | 2005-03-10 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
| US7709458B2 (en) | 2004-03-15 | 2010-05-04 | David K. R. Karaolis | Method for inhibiting cancer cell proliferation or increasing cancer cell apoptosis |
| EP2161336B2 (en) | 2005-05-09 | 2017-03-29 | ONO Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
| PT1907424E (pt) | 2005-07-01 | 2015-10-09 | Squibb & Sons Llc | Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1) |
| EP1782826A1 (en) | 2005-11-08 | 2007-05-09 | GBF Gesellschaft für Biotechnologische Forschung mbH | PQS and c-diGMP and its conjugates as adjuvants and their uses in pharmaceutical compositions |
| ES2616355T3 (es) | 2007-06-18 | 2017-06-12 | Merck Sharp & Dohme B.V. | Anticuerpos para el receptor humano de muerte programada PD-1 |
| US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
| EP2328919A2 (en) | 2008-08-25 | 2011-06-08 | Amplimmune, Inc. | Pd-i antagonists and methods for treating infectious disease |
| CA2998281C (en) | 2008-09-26 | 2022-08-16 | Dana-Farber Cancer Institute, Inc. | Human anti-pd-1 antobodies and uses therefor |
| WO2010047774A2 (en) | 2008-10-20 | 2010-04-29 | The Texas A & M University System | Inhibitors of mycobacterium tuberculosis malate synthase, methods of marking and uses thereof |
| KR20180089573A (ko) | 2008-12-09 | 2018-08-08 | 제넨테크, 인크. | 항-ｐｄ-ｌ１ 항체 및 ｔ 세포 기능을 향상시키기 위한 그의 용도 |
| WO2011066342A2 (en) | 2009-11-24 | 2011-06-03 | Amplimmune, Inc. | Simultaneous inhibition of pd-l1/pd-l2 |
| WO2012068702A1 (zh) * | 2010-11-23 | 2012-05-31 | 中国医学科学院医药生物技术研究所 | 苯并五元不饱和杂环类化合物及其制备方法 |
| JP5887947B2 (ja) | 2011-03-28 | 2016-03-16 | ソニー株式会社 | 透明導電膜、ヒータ、タッチパネル、太陽電池、有機ｅｌ装置、液晶装置および電子ペーパ |
| US9156872B2 (en) | 2011-04-13 | 2015-10-13 | Merck Sharp & Dohme Corp. | 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| WO2013019906A1 (en) | 2011-08-01 | 2013-02-07 | Genentech, Inc. | Methods of treating cancer using pd-1 axis binding antagonists and mek inhibitors |
| SG10201610251PA (en) | 2012-06-08 | 2017-01-27 | Aduro Biotech | Compositions and methods for cancer immunotherapy |
| CN103840995B (zh) | 2012-11-26 | 2017-10-24 | 华为技术有限公司 | Ip报文处理方法、装置及网络系统 |
| KR20150095668A (ko) | 2012-12-13 | 2015-08-21 | 아두로 바이오테크, 인코포레이티드 | 규정된 입체화학을 갖는 환식 퓨린 다이뉴클레오타이드를 포함하는 조성물, 그리고 이의 제조 방법 및 용도 |
| US9211300B2 (en) | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
| JP2016506408A (ja) | 2012-12-19 | 2016-03-03 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 哺乳動物の環状ジヌクレオチドシグナル伝達経路の薬学的標的化 |
| EP2970119B1 (en) | 2013-03-14 | 2021-11-03 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| EP2992000B1 (en) | 2013-05-03 | 2020-07-08 | The Regents of The University of California | Cyclic di-nucleotide induction of type i interferon |
| JP6453855B2 (ja) | 2013-05-18 | 2019-01-16 | アドゥロ バイオテック，インク． | 「インターフェロン遺伝子の刺激因子」依存性シグナル伝達を活性化するための組成物及び方法 |
| JP6400082B2 (ja) | 2013-05-18 | 2018-10-03 | アデュロ バイオテック，インコーポレイテッド | 「インターフェロン遺伝子の刺激因子」依存性シグナル伝達を抑制するための組成物および方法 |
| US9549944B2 (en) | 2013-05-18 | 2017-01-24 | Aduro Biotech, Inc. | Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling |
| US10176292B2 (en) | 2013-07-31 | 2019-01-08 | Memorial Sloan-Kettering Cancer Center | STING crystals and modulators |
| WO2015077354A1 (en) * | 2013-11-19 | 2015-05-28 | The University Of Chicago | Use of sting agonist as cancer treatment |
| EP3071229A4 (en) | 2013-11-22 | 2017-05-10 | Brock University | Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants |
| US9315523B2 (en) | 2013-12-06 | 2016-04-19 | Rutgers, The State University Of New Jersey | Cyclic dinucleosides |
| WO2015143712A1 (en) | 2014-03-28 | 2015-10-01 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors |
| US10202411B2 (en) | 2014-04-16 | 2019-02-12 | Idenix Pharmaceuticals Llc | 3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV |
| CN103908468B (zh) | 2014-04-21 | 2017-02-08 | 上海捌加壹医药科技有限公司 | 环二核苷酸cGAMP在制备抗肿瘤药物中的应用 |
| CR20160564A (es) | 2014-06-04 | 2017-01-20 | Glaxosmithkline Ip Dev Ltd | Dinucleótidos cíclicos como moduladores de sting |
| US20170121315A1 (en) | 2014-06-12 | 2017-05-04 | Bayer Pharma Aktiengesellschaft | Heterobicyclically substituted 4-oxobutane acid derivatives and use thereof |
| ES2764178T3 (es) | 2014-12-16 | 2020-06-02 | Kayla Therapeutics | Dinucleótidos cíclicos fluorados para inducción de citocinas |
| EP3233191A1 (en) | 2014-12-16 | 2017-10-25 | Invivogen | Combined use of a chemotherapeutic agent and a cyclic dinucleotide for cancer treatment |
| EP3233089A4 (en) | 2014-12-17 | 2018-11-14 | Lipogen LLC | Method of treating cancer with cgamp or cgasmp |
| GB201501462D0 (en) * | 2015-01-29 | 2015-03-18 | Glaxosmithkline Ip Dev Ltd | Novel compounds |
| US10449211B2 (en) | 2015-03-10 | 2019-10-22 | Aduro Biotech, Inc. | Compositions and methods for activating “stimulator of interferon gene”—dependent signalling |
| TW201717968A (zh) | 2015-07-14 | 2017-06-01 | 春季銀行製藥公司 | 誘導ｒｉｇ－ｉ和其他模式辨識受體之化合物及組成物 |
| WO2017011920A1 (en) | 2015-07-22 | 2017-01-26 | The Royal Institution For The Advancement Of Learning/Mcgill University | Compounds and uses thereof in the treatment of cancers and other medical conditions |
| TWI696629B (zh) | 2015-08-13 | 2020-06-21 | 美商默沙東藥廠 | 作為ｓｔｉｎｇ促效劑之環狀雙核苷酸化合物 |
| US9809597B2 (en) | 2015-08-20 | 2017-11-07 | The Board Of Trustees Of The Leland Stanford Junior University | Ganciclovir derivatives for modulating innate and adaptive immunity and for use in immunotherapy |
| JP2018534295A (ja) | 2015-10-28 | 2018-11-22 | アドゥロ バイオテック，インク． | 「インターフェロン遺伝子刺激因子」依存性シグナル伝達を活性化するための組成物および方法 |
| RU2722019C2 (ru) | 2015-12-03 | 2020-05-26 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Циклические пуриновые динуклеотиды в качестве модуляторов sting |
| CA3007311A1 (en) | 2015-12-07 | 2017-06-15 | Opi Vi - Ip Holdco Llc | Compositions of antibody construct-agonist conjugates and methods of use thereof |
| WO2017123657A1 (en) | 2016-01-11 | 2017-07-20 | Gary Glick | Cyclic dinucleotides for treating conditions associated with sting activity such as cancer |
| BR112018013808A2 (pt) | 2016-01-11 | 2018-12-11 | Innate Tumor Immunity, Inc. | dinucleotídeos cíclicos para o tratamento de condições associadas à atividade de sting, tal como câncer |
| CN114230625A (zh) | 2016-03-18 | 2022-03-25 | 免疫传感器公司 | 环二核苷酸化合物及使用方法 |
| EP3440072B1 (en) | 2016-04-07 | 2020-01-29 | GlaxoSmithKline Intellectual Property Development Ltd | Heterocyclic amides useful as protein modulators |
| SG11201808621TA (en) | 2016-04-07 | 2018-10-30 | Glaxosmithkline Ip Dev Ltd | Heterocyclic amides useful as protein modulators |
| WO2017216727A1 (en) | 2016-06-13 | 2017-12-21 | Glaxosmithkline Intellectual Property Development Limited | Substituted pyridines as inhibitors of dnmt1 |
| EP3507367A4 (en) | 2016-07-05 | 2020-03-25 | Aduro BioTech, Inc. | CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF |
| CN110036001B (zh) * | 2016-10-04 | 2022-03-22 | 默沙东公司 | 作为STING激动剂的苯并[b]噻吩化合物 |
| MA49773A (fr) * | 2017-08-04 | 2021-04-21 | Merck Sharp & Dohme | Combinaisons d'antagonistes de pd-1 et d'agonistes de sting benzo[b |
| WO2019027858A1 (en) * | 2017-08-04 | 2019-02-07 | Merck Sharp & Dohme Corp. | BENZO [B] STING THIOPHEN AGONISTS FOR THE TREATMENT OF CANCER |
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