MA49773A - Combinaisons d'antagonistes de pd-1 et d'agonistes de sting benzo[b - Google Patents
Combinaisons d'antagonistes de pd-1 et d'agonistes de sting benzo[bInfo
- Publication number
- MA49773A MA49773A MA049773A MA49773A MA49773A MA 49773 A MA49773 A MA 49773A MA 049773 A MA049773 A MA 049773A MA 49773 A MA49773 A MA 49773A MA 49773 A MA49773 A MA 49773A
- Authority
- MA
- Morocco
- Prior art keywords
- sting
- agonists
- benzo
- antagonists
- combinations
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762541180P | 2017-08-04 | 2017-08-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA49773A true MA49773A (fr) | 2021-04-21 |
Family
ID=65234179
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA049773A MA49773A (fr) | 2017-08-04 | 2018-07-30 | Combinaisons d'antagonistes de pd-1 et d'agonistes de sting benzo[b |
Country Status (8)
Country | Link |
---|---|
US (1) | US11312772B2 (fr) |
EP (1) | EP3661499A4 (fr) |
JP (1) | JP2020529421A (fr) |
AU (1) | AU2018311965A1 (fr) |
CA (1) | CA3071537A1 (fr) |
MA (1) | MA49773A (fr) |
RU (1) | RU2020109328A (fr) |
WO (1) | WO2019027857A1 (fr) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG10202008647TA (en) * | 2016-10-04 | 2020-10-29 | Merck Sharp & Dohme | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS |
US11638716B2 (en) | 2017-08-31 | 2023-05-02 | F-star Therapeutics, Inc. | Compounds, compositions, and methods for the treatment of disease |
EP3802534B1 (fr) | 2018-05-25 | 2022-07-13 | Incyte Corporation | Composés hétérocycliques tricycliques en tant qu'activateurs de sting |
WO2020028566A1 (fr) | 2018-07-31 | 2020-02-06 | Incyte Corporation | Composés amides hétéroaryles en tant qu'activateurs de sting |
US11008344B2 (en) | 2018-07-31 | 2021-05-18 | Incyte Corporation | Tricyclic heteroaryl compounds as STING activators |
IL282129B2 (en) | 2018-10-11 | 2024-08-01 | Ono Pharmaceutical Co | STING agonistic compound |
US11596692B1 (en) | 2018-11-21 | 2023-03-07 | Incyte Corporation | PD-L1/STING conjugates and methods of use |
US12129267B2 (en) | 2019-01-07 | 2024-10-29 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
SG11202109191SA (en) | 2019-03-28 | 2021-09-29 | Lupin Ltd | Macrocyclic compounds as sting agonists |
US20220162199A1 (en) * | 2019-04-30 | 2022-05-26 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Benzothiophene compound, preparation method therefor and use thereof |
MA55805A (fr) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V Inc | Métodes de modulation de l'activité immunitaire |
EP3996718A1 (fr) * | 2019-07-09 | 2022-05-18 | Takeda Pharmaceutical Company Limited | Administration d'un agoniste de sting et d'inhibiteurs de points de contrôle |
EP4004002B1 (fr) | 2019-07-22 | 2024-07-10 | Lupin Limited | Composés macrocycliques utilisés en tant qu'agonistes sting et procédés et utilisations de ceux-ci |
BR112022001931A2 (pt) | 2019-08-02 | 2022-06-21 | Mersana Therapeutics Inc | Derivados de bis-[n-((5-carbamoil)-1h-benzo[d]imidazol-2-il)-pirazol-5-carboxamida e compostos relacionados como agonistas de sting (estimulador de genes de interferon) para o tratamento de câncer |
JPWO2021206158A1 (fr) | 2020-04-10 | 2021-10-14 | ||
AU2021383424A1 (en) * | 2020-11-18 | 2023-06-08 | Takeda Pharmaceutical Company Limited | Administration of sting agonist, checkpoint inhibitors, and radiation |
CN113429384B (zh) * | 2021-05-12 | 2022-04-08 | 中山大学附属第五医院 | 一类干扰素基因刺激因子靶向的放射性pet显像剂 |
CN113521303B (zh) * | 2021-07-07 | 2024-01-02 | 中山大学附属第一医院 | 一种共同负载pd-l1抗体和sting激动剂的纳米囊泡及其制备方法与应用 |
CN115772154B (zh) * | 2021-09-08 | 2024-04-30 | 上海交通大学 | 一类含有氘取代的苯并噻吩类衍生物及其制备与用途 |
WO2023172501A2 (fr) * | 2022-03-07 | 2023-09-14 | Arima Genomics, Inc. | Méthodes de sélection et de traitement de sujets cancéreux candidats à un traitement par inhibiteurs d'une voie pd-1 |
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US4342690A (en) | 1980-04-28 | 1982-08-03 | American Cyanamid Company | ω-Heteroaroyl(propionyl or butyryl)-L-prolines |
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KR20180066241A (ko) | 2015-10-28 | 2018-06-18 | 아두로 바이오테크, 인코포레이티드 | “인터페론 유전자의 자극제”-의존성 신호전달을 활성화시키기 위한 조성물 및 방법 |
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KR101949108B1 (ko) * | 2015-12-03 | 2019-02-15 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Sting의 조정제로서의 시클릭 푸린 디뉴클레오티드 |
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EA036421B1 (ru) | 2016-01-11 | 2020-11-09 | Иннэйт Тьюмор Иммьюнити, Инк. | Соединения и композиции для лечения состояний, ассоциированных с активностью sting |
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CN109475570B (zh) | 2016-03-18 | 2022-04-01 | 免疫传感器公司 | 环二核苷酸化合物及使用方法 |
MX2020009948A (es) | 2016-04-07 | 2021-10-26 | Glaxosmithkline Ip Dev Ltd | Amidas heterocíclicas útiles como moduladores de proteínas. |
RU2018137389A (ru) | 2016-04-07 | 2020-05-12 | Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Гетероциклические амиды, полезные в качестве модуляторов |
WO2017216727A1 (fr) | 2016-06-13 | 2017-12-21 | Glaxosmithkline Intellectual Property Development Limited | Pyridines substituées utilisées en tant qu'inhibiteurs de dnmt1 |
US11098077B2 (en) | 2016-07-05 | 2021-08-24 | Chinook Therapeutics, Inc. | Locked nucleic acid cyclic dinucleotide compounds and uses thereof |
SG10202008647TA (en) * | 2016-10-04 | 2020-10-29 | Merck Sharp & Dohme | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS |
-
2018
- 2018-07-30 EP EP18841987.3A patent/EP3661499A4/fr not_active Withdrawn
- 2018-07-30 AU AU2018311965A patent/AU2018311965A1/en not_active Abandoned
- 2018-07-30 US US16/635,059 patent/US11312772B2/en active Active
- 2018-07-30 CA CA3071537A patent/CA3071537A1/fr active Pending
- 2018-07-30 JP JP2020505417A patent/JP2020529421A/ja active Pending
- 2018-07-30 MA MA049773A patent/MA49773A/fr unknown
- 2018-07-30 RU RU2020109328A patent/RU2020109328A/ru unknown
- 2018-07-30 WO PCT/US2018/044275 patent/WO2019027857A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
EP3661499A4 (fr) | 2021-04-21 |
US11312772B2 (en) | 2022-04-26 |
EP3661499A1 (fr) | 2020-06-10 |
WO2019027857A1 (fr) | 2019-02-07 |
RU2020109328A3 (fr) | 2021-11-09 |
AU2018311965A1 (en) | 2020-02-13 |
JP2020529421A (ja) | 2020-10-08 |
US20210130466A1 (en) | 2021-05-06 |
RU2020109328A (ru) | 2021-09-06 |
CA3071537A1 (fr) | 2019-02-07 |
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