PE20071168A1 - Compuestos derivados de 5,6-difenilfuro[2,3-d]pirimidina como activadores no prostanoides del receptor ip - Google Patents
Compuestos derivados de 5,6-difenilfuro[2,3-d]pirimidina como activadores no prostanoides del receptor ipInfo
- Publication number
- PE20071168A1 PE20071168A1 PE2006001653A PE2006001653A PE20071168A1 PE 20071168 A1 PE20071168 A1 PE 20071168A1 PE 2006001653 A PE2006001653 A PE 2006001653A PE 2006001653 A PE2006001653 A PE 2006001653A PE 20071168 A1 PE20071168 A1 PE 20071168A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- pyrimidin
- diphenylfide
- pyrimidine
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE A ES O, S, NR5; R5 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C7, CICLOALQUENILO C4-C7; L ES ALCANO C1-C7 DIILO, SUSTITUIDO O NO; Z ES A, B, ENTRE OTROS; R7 ES H, ALQUILO C1-C4; R1 Y R2 SON CADA UNO HALOGENO, CIANO, NITRO, ALQUILO C1-C6, CICLOALQUILO C3-C7, TRIFLUOROMETOXI, ENTRE OTROS; n Y o SON 0-3; R3 ES H, ALQUILO C1-C4; R4 ES H, CICLOPROPILO, ALQUILO C1-C4. SON COMPUESTOS PREFERIDOS: ACIDO 6-{[5-(4-METOXIFENIL)-6-FENILFURO[2,3-d]PIRIMIDIN-4-IL]AMINO}HEXANOICO; ACIDO 7-{[5-(4-METOXIFENIL)6-FENILFURO[2,3-d]PIRIMIDIN-4-IL]AMINO}HEPTANOICO; 5-(4-METOXIFENIL)-6-FENIL-N-{3-[2-(1H-TETRAZOL-5-IL)ETOXI]PROPIL}FURO[2,3-d]PIRIMIDIN-4-AMINA; ENTRE OTROS. REFERIDA TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005061170A DE102005061170A1 (de) | 2005-12-21 | 2005-12-21 | Neue, acyclisch substituierte Furopyrimidin-Derivate und ihre Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20071168A1 true PE20071168A1 (es) | 2008-02-07 |
Family
ID=37876878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2006001653A PE20071168A1 (es) | 2005-12-21 | 2006-12-20 | Compuestos derivados de 5,6-difenilfuro[2,3-d]pirimidina como activadores no prostanoides del receptor ip |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US8183246B2 (es) |
| EP (1) | EP1966217B1 (es) |
| JP (1) | JP5254032B2 (es) |
| KR (1) | KR101429777B1 (es) |
| CN (1) | CN101384603B (es) |
| AR (1) | AR058108A1 (es) |
| AU (1) | AU2006334856B2 (es) |
| BR (1) | BRPI0620317A2 (es) |
| CA (1) | CA2633701C (es) |
| CR (1) | CR10092A (es) |
| DE (1) | DE102005061170A1 (es) |
| DK (1) | DK1966217T3 (es) |
| DO (1) | DOP2006000280A (es) |
| EC (1) | ECSP088569A (es) |
| ES (1) | ES2418855T3 (es) |
| GT (1) | GT200800117A (es) |
| HK (1) | HK1130054A1 (es) |
| IL (1) | IL192062A0 (es) |
| MA (1) | MA30039B1 (es) |
| NO (1) | NO20082986L (es) |
| NZ (1) | NZ569214A (es) |
| PE (1) | PE20071168A1 (es) |
| PL (1) | PL1966217T3 (es) |
| PT (1) | PT1966217E (es) |
| RU (1) | RU2454419C2 (es) |
| SV (1) | SV2009002953A (es) |
| TN (1) | TNSN08279A1 (es) |
| TW (1) | TWI405764B (es) |
| UA (1) | UA94080C2 (es) |
| UY (1) | UY30046A1 (es) |
| WO (1) | WO2007079862A1 (es) |
| ZA (1) | ZA200805385B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007019691A1 (de) * | 2007-04-26 | 2008-10-30 | Bayer Healthcare Ag | Verwendung von acyclisch substituierten Furopyrimidin-Derivaten zur Behandlung der pulmonalen arteriellen Hypertonie |
| DE102007027799A1 (de) * | 2007-06-16 | 2008-12-18 | Bayer Healthcare Ag | Substituierte Furopyrimidine und ihre Verwendung |
| DE102007051762A1 (de) | 2007-10-30 | 2009-05-07 | Bayer Healthcare Ag | Substituierte Pyrrolotriazine und ihre Verwendung |
| DE102007054786A1 (de) | 2007-11-16 | 2009-05-20 | Bayer Healthcare Ag | Trisubstituierte Furopyrimidine und ihre Verwendung |
| US9440987B2 (en) | 2012-05-10 | 2016-09-13 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
| US9505772B2 (en) | 2012-05-10 | 2016-11-29 | Takeda Pharmaceutical Company Limited | Aromatic ring compound |
| MX2019007803A (es) | 2016-12-28 | 2019-08-29 | Dart Neuroscience Llc | Compuestos de pirazolopirimidinona sustituida como inhibidores de fosfodiesterasas 2 (pde2). |
| DK3717488T3 (da) | 2017-11-27 | 2021-12-13 | Dart Neuroscience Llc | Substituerede furanopyrimidinforbindelser som pde1-inhibitorer |
| SG11202111327XA (en) * | 2019-05-13 | 2021-11-29 | Relay Therapeutics Inc | Fgfr inhibitors and methods of use thereof |
| KR102094337B1 (ko) | 2019-10-01 | 2020-03-27 | 안문호 | 금속이물질 제거장치 |
| TW202233625A (zh) | 2020-11-18 | 2022-09-01 | 美商傳達治療有限公司 | Ｆｇｆｒ抑制劑及其製造及使用方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3577420A (en) | 1968-01-05 | 1971-05-04 | Pfizer | Certain 4-aminofuro(2,3-d)pyrimidines |
| ATE266662T1 (de) | 1998-07-22 | 2004-05-15 | Daiichi Suntory Pharma Co Ltd | Nf-kappa b inhibitoren, die indanderivate als aktiven bestandteil enthalten |
| WO2000075145A1 (en) | 1999-06-03 | 2000-12-14 | Abbott Laboratories | Cell adhesion-inhibiting antiinflammatory compounds |
| CN1212861C (zh) | 1999-09-17 | 2005-08-03 | 第一三得利制药株式会社 | 以NF－κB抑制剂为有效成分的心肌炎、扩张型心肌病和心衰的预防或治疗药 |
| EP1390371B1 (en) | 2001-05-14 | 2006-03-08 | Novartis AG | Oxazolo-and furopyrimidines and their use in medicaments against tumors |
| DE10141212A1 (de) | 2001-08-22 | 2003-03-06 | Bayer Ag | Neue 4-Aminofuropyrimidine und ihre Verwendung |
| AU2002333524A1 (en) | 2001-09-11 | 2003-03-24 | Glaxosmithkline K.K. | Furo-and thienopyrimidine derivatives as angiogenesis inhibitors |
| DE10148883A1 (de) * | 2001-10-04 | 2003-04-10 | Merck Patent Gmbh | Pyrimidinderivate |
| US20030225098A1 (en) * | 2002-03-21 | 2003-12-04 | Hirst Gavin C. | Kinase inhibitors |
| KR20050091462A (ko) | 2004-03-12 | 2005-09-15 | 한국과학기술연구원 | 푸로피리미딘 화합물 및 이를 포함하는 ｄｄｒ2 티로신키나아제 활성 저해제 |
| MXPA06014256A (es) | 2004-06-10 | 2007-03-12 | Xention Discovery Ltd | Compuestos de furano-pirimidina efectivos como inhibidores del canal de potasio. |
| MXPA06015223A (es) | 2004-06-29 | 2007-11-09 | Amgen Inc | Furanopirimidinas. |
-
2005
- 2005-12-21 DE DE102005061170A patent/DE102005061170A1/de not_active Withdrawn
-
2006
- 2006-12-08 RU RU2008129363/04A patent/RU2454419C2/ru not_active IP Right Cessation
- 2006-12-08 CA CA2633701A patent/CA2633701C/en not_active Expired - Fee Related
- 2006-12-08 JP JP2008546193A patent/JP5254032B2/ja not_active Expired - Fee Related
- 2006-12-08 WO PCT/EP2006/011826 patent/WO2007079862A1/de active Application Filing
- 2006-12-08 PL PL06829427T patent/PL1966217T3/pl unknown
- 2006-12-08 BR BRPI0620317-5A patent/BRPI0620317A2/pt not_active IP Right Cessation
- 2006-12-08 KR KR1020087017526A patent/KR101429777B1/ko not_active IP Right Cessation
- 2006-12-08 DK DK06829427.1T patent/DK1966217T3/da active
- 2006-12-08 EP EP06829427.1A patent/EP1966217B1/de not_active Not-in-force
- 2006-12-08 CN CN2006800532242A patent/CN101384603B/zh not_active Expired - Fee Related
- 2006-12-08 NZ NZ569214A patent/NZ569214A/en not_active IP Right Cessation
- 2006-12-08 UA UAA200809519A patent/UA94080C2/ru unknown
- 2006-12-08 ES ES06829427T patent/ES2418855T3/es active Active
- 2006-12-08 AU AU2006334856A patent/AU2006334856B2/en not_active Ceased
- 2006-12-08 PT PT68294271T patent/PT1966217E/pt unknown
- 2006-12-08 US US12/086,783 patent/US8183246B2/en not_active Expired - Fee Related
- 2006-12-14 DO DO2006000280A patent/DOP2006000280A/es unknown
- 2006-12-18 AR ARP060105587A patent/AR058108A1/es not_active Application Discontinuation
- 2006-12-20 PE PE2006001653A patent/PE20071168A1/es not_active Application Discontinuation
- 2006-12-20 UY UY30046A patent/UY30046A1/es not_active Application Discontinuation
- 2006-12-20 TW TW095147761A patent/TWI405764B/zh not_active IP Right Cessation
-
2008
- 2008-06-11 MA MA31016A patent/MA30039B1/fr unknown
- 2008-06-11 IL IL192062A patent/IL192062A0/en unknown
- 2008-06-19 SV SV2008002953A patent/SV2009002953A/es not_active Application Discontinuation
- 2008-06-19 GT GT200800117A patent/GT200800117A/es unknown
- 2008-06-20 CR CR10092A patent/CR10092A/es not_active Application Discontinuation
- 2008-06-20 EC EC2008008569A patent/ECSP088569A/es unknown
- 2008-06-20 TN TNP2008000279A patent/TNSN08279A1/en unknown
- 2008-06-20 ZA ZA200805385A patent/ZA200805385B/xx unknown
- 2008-07-02 NO NO20082986A patent/NO20082986L/no not_active Application Discontinuation
-
2009
- 2009-09-03 HK HK09108053.8A patent/HK1130054A1/xx not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal | ||
| AE | Restoration of lapsed or forfeited application | ||
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |