[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

PE106599A1 - 2-aminopiridinas que contienen sustituyentes de anillos condensados - Google Patents

2-aminopiridinas que contienen sustituyentes de anillos condensados

Info

Publication number
PE106599A1
PE106599A1 PE1998000772A PE00077298A PE106599A1 PE 106599 A1 PE106599 A1 PE 106599A1 PE 1998000772 A PE1998000772 A PE 1998000772A PE 00077298 A PE00077298 A PE 00077298A PE 106599 A1 PE106599 A1 PE 106599A1
Authority
PE
Peru
Prior art keywords
members
ring
heteroatomes
condensed rings
containing substitutes
Prior art date
Application number
PE1998000772A
Other languages
English (en)
Inventor
Adams Lowe John Iii
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE106599A1 publication Critical patent/PE106599A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A UNA AMINOPIRIDINA DE FORMULA I, DONDE A ES UN ANILLO CONDENSADO DE 5-7 MIEMBROS, DE CERO A 2 MIEMBROS SON HETEROATOMOS, CON LA CONDICION QUE 2 MIEMBROS ADYACENTES DEL ANILLO NO SEAN HETEROATOMOS; X ES OXIGENO O UN ENLACE; n ES 2-6; R1 Y R2 SON ALQUILO C1-C6, ARILO, TETRAHIDRONAFTALENO Y ARALQUILO OPCIONALMENTE SUSTITUIDOS; O R1 Y R2 CON N FORMAN JUNTOS UN ANILLO DE PIPERAZINA, PIPERIDINA, PIRROLIDINA O UN ANILLO AZABICICLO DE 6 A 14 MIEMBROS; O R1 Y R2 JUNTO A (CH2)n FORMAN UN ANILLO DE 4-7 MIEMBROS. EL COMPUESTO I INHIBE A LA OXIDO NITRICO SINTASA POR LO QUE PUEDE SER UTIL PARA TRATAR O PREVENIR MIGRANA, ENFERMEDADES INFLAMATORIAS, ACCIDENTES CEREBRO VASCULARES, DOLOR AGUDO Y CRONICO, CHOQUE HIPOVOLEMICO O TRAUMATICO
PE1998000772A 1997-08-27 1998-08-24 2-aminopiridinas que contienen sustituyentes de anillos condensados PE106599A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5709497P 1997-08-27 1997-08-27

Publications (1)

Publication Number Publication Date
PE106599A1 true PE106599A1 (es) 1999-11-02

Family

ID=22008463

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998000772A PE106599A1 (es) 1997-08-27 1998-08-24 2-aminopiridinas que contienen sustituyentes de anillos condensados

Country Status (40)

Country Link
EP (1) EP1007520B1 (es)
JP (1) JP3411271B2 (es)
KR (1) KR100367277B1 (es)
CN (1) CN1268133A (es)
AP (1) AP1213A (es)
AR (1) AR014110A1 (es)
AT (1) ATE248161T1 (es)
AU (1) AU8458898A (es)
BG (1) BG104138A (es)
BR (1) BR9811555A (es)
CA (1) CA2296313C (es)
CO (1) CO4970728A1 (es)
DE (1) DE69817584T2 (es)
DK (1) DK1007520T3 (es)
DZ (1) DZ2594A1 (es)
EA (1) EA003839B1 (es)
ES (1) ES2203976T3 (es)
GT (1) GT199800128A (es)
HN (1) HN1998000118A (es)
HR (1) HRP980470A2 (es)
HU (1) HUP0003700A3 (es)
ID (1) ID24087A (es)
IL (1) IL133958A0 (es)
IS (1) IS5344A (es)
MA (1) MA26537A1 (es)
NO (1) NO20000958L (es)
NZ (1) NZ502281A (es)
OA (1) OA11288A (es)
PA (1) PA8456901A1 (es)
PE (1) PE106599A1 (es)
PL (1) PL338987A1 (es)
PT (1) PT1007520E (es)
SK (1) SK1402000A3 (es)
TN (1) TNSN98154A1 (es)
TR (1) TR200000535T2 (es)
UA (1) UA55461C2 (es)
UY (1) UY25158A1 (es)
WO (1) WO1999010339A1 (es)
YU (1) YU10900A (es)
ZA (1) ZA987726B (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010049379A1 (en) 1997-08-27 2001-12-06 Lowe John Adams 2-aminopyridines containing fused ring substituents
SG74717A1 (en) 1998-04-10 2000-08-22 Japan Tobacco Inc Amidine compound
OA11557A (en) * 1998-06-03 2004-05-24 Pfizer Prod Inc 2-Aminopyridines containing fused ring substituents as nitric oxide synthase inhibitors.
CN1323211A (zh) * 1998-08-11 2001-11-21 辉瑞产品公司 Nos抑制剂的新药学用途
PL350219A1 (en) 1999-02-25 2002-11-18 Pfizer Prod Inc 2-aminopyridines containing fused ring substituents
GB0004149D0 (en) * 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel compounds
GB0004151D0 (en) * 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel use
GB0004152D0 (en) * 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel compounds
GB0004153D0 (en) * 2000-02-23 2000-04-12 Astrazeneca Uk Ltd Novel use
FR2805818B1 (fr) * 2000-03-03 2002-04-26 Aventis Pharma Sa Derives d'azetidine, leur preparation et les compositions pharmaceutiques les contenant
CA2413762A1 (en) * 2000-08-16 2002-02-21 Pharmacia & Upjohn Company Compounds for the treatment of addictive disorders
IL158589A0 (en) 2001-05-15 2004-05-12 Hoffmann La Roche Carboxylic acid substituted oxazole derivatives for use as ppar-alpha and -gamma activators in the treatment of diabetes
SE0102640D0 (sv) 2001-07-31 2001-07-31 Astrazeneca Ab Novel compounds
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
DE10159922A1 (de) * 2001-12-06 2003-06-26 Gruenenthal Gmbh Substituierte 2-Pyrrolidin-2-yl-1H-indol-Derivate
DE60316290T2 (de) 2002-07-03 2008-06-12 F. Hoffmann-La Roche Ag Oxazolderivate und deren verwendung als insulinsensibilisatoren
WO2004016608A1 (en) * 2002-08-14 2004-02-26 Neurosearch A/S Novel quinuclidine derivatives and their use
WO2004020420A1 (en) 2002-08-30 2004-03-11 F.Hoffmann-La Roche Ag Novel 2-arylthiazole compounds as pparalpha and ppargama agonists
BR0314261A (pt) 2002-09-12 2005-07-26 Hoffmann La Roche Compostos, processo de preparação de um composto, composição farmacêutica que compreende o mesmo, utilização de um composto, método para tratamento e/ou profilaxia de enfermidades e utilização e/ou método de tratamento
US20040092741A1 (en) * 2002-11-08 2004-05-13 Pfizer Inc Substituted pyridines via boronic acid coupling
EP1567523B1 (en) 2002-11-25 2008-08-20 F.Hoffmann-La Roche Ag Indolyl derivatives
US7655657B2 (en) 2003-12-22 2010-02-02 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
US7160876B2 (en) 2003-12-22 2007-01-09 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
EP1773847A2 (en) * 2004-07-09 2007-04-18 Glaxo Group Limited Antibacterial agents
CN1922176A (zh) * 2004-12-10 2007-02-28 艾博特公司 稠合的双环杂环取代的奎宁环衍生物
WO2009029592A1 (en) * 2007-08-27 2009-03-05 Kalypsys, Inc. Heterobicyclic-substituted quinolones useful as nitric oxide synthase inhibitors
WO2009029617A1 (en) * 2007-08-27 2009-03-05 Kalypsys, Inc. Diarylamine-substituted quinolones useful as inducible nitric oxide synthase inhibitors
UA105182C2 (ru) 2008-07-03 2014-04-25 Ньюрексон, Інк. Бензоксазины, бензотиазины и родственные соединения, которые имеют ингибирующую nos активность
DE102008054141A1 (de) 2008-10-31 2010-05-06 Merck Patent Gmbh Neue Materialien für organische Elektrolumineszenzvorrichtungen
DE102009033371A1 (de) 2009-07-16 2011-05-12 Merck Patent Gmbh Materialien für elektronische Vorrichtungen
US9120750B2 (en) 2013-03-07 2015-09-01 Northwestern University 2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors
CN104725249B (zh) * 2013-12-20 2019-02-12 广东东阳光药业有限公司 苄胺类衍生物及其在药物上的应用
EP3215497A4 (en) 2014-11-04 2018-11-07 Northwestern University Mammalian and bacterial nitric oxide synthase inhibitors
US10759791B2 (en) 2014-11-04 2020-09-01 Northwestern University Mammalian and bacterial nitric oxide synthase inhibitors
CN106478376A (zh) * 2016-10-08 2017-03-08 贵州大学 一种4‑氟萘‑1‑醇的制备工艺
EP3897592A1 (en) * 2018-12-17 2021-10-27 Godavari Biorefineries Ltd. Compounds for the inhibition of unregulated cell growth
CN114560779B (zh) * 2022-01-25 2024-06-25 杭州华东医药集团浙江华义制药有限公司 一种米拉贝隆关键中间体的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400845B (de) * 1993-12-06 1996-03-25 Chem Pharm Forsch Gmbh Neue thienothiazinderivate, ein verfahren zu ihrer herstellung und ihre verwendung
WO1996018616A1 (en) * 1994-12-12 1996-06-20 Merck & Co., Inc. Substituted 2-aminopyridines as inhibitors of nitric oxide synthase
JPH08311028A (ja) * 1995-05-17 1996-11-26 Japan Tobacco Inc ２−アミノピリジン誘導体及びそれら化合物を含有してなる一酸化窒素合成酵素阻害剤
JPH09132529A (ja) * 1995-11-09 1997-05-20 Ono Pharmaceut Co Ltd 一酸化窒素合成酵素阻害剤
CZ291647B6 (cs) * 1996-03-29 2003-04-16 Pfizer Inc. 6-Fenylpyridyl-2-aminové deriváty, jejich použití a farmaceutické kompozice na jejich bázi
HN1997000027A (es) * 1996-12-06 1997-06-05 Pfizer Prod Inc Derivados de 6-fenil piridil - 2 amina

Also Published As

Publication number Publication date
WO1999010339A1 (en) 1999-03-04
MA26537A1 (fr) 2004-12-20
NZ502281A (en) 2002-09-27
EA200000171A1 (ru) 2000-10-30
AP1213A (en) 2003-10-07
ID24087A (id) 2000-07-06
KR20010022433A (ko) 2001-03-15
IL133958A0 (en) 2001-04-30
HRP980470A2 (en) 1999-06-30
HN1998000118A (es) 1999-02-09
DE69817584D1 (de) 2003-10-02
AR014110A1 (es) 2001-02-07
OA11288A (en) 2003-08-22
SK1402000A3 (en) 2000-07-11
TR200000535T2 (tr) 2000-11-21
UY25158A1 (es) 2000-12-29
KR100367277B1 (ko) 2003-01-09
UA55461C2 (uk) 2003-04-15
EA003839B1 (ru) 2003-10-30
DK1007520T3 (da) 2003-11-24
EP1007520A1 (en) 2000-06-14
AP9801330A0 (en) 1998-09-30
CA2296313A1 (en) 1999-03-04
ATE248161T1 (de) 2003-09-15
EP1007520B1 (en) 2003-08-27
CN1268133A (zh) 2000-09-27
JP3411271B2 (ja) 2003-05-26
ES2203976T3 (es) 2004-04-16
BR9811555A (pt) 2000-09-12
DE69817584T2 (de) 2004-04-01
DZ2594A1 (fr) 2003-02-22
AU8458898A (en) 1999-03-16
JP2001514176A (ja) 2001-09-11
YU10900A (sh) 2002-12-10
IS5344A (is) 2000-01-14
PT1007520E (pt) 2003-12-31
PA8456901A1 (es) 2000-05-24
CO4970728A1 (es) 2000-11-07
NO20000958L (no) 2000-04-14
GT199800128A (es) 2000-02-01
HUP0003700A2 (hu) 2001-10-28
TNSN98154A1 (fr) 2005-03-15
BG104138A (en) 2000-11-30
NO20000958D0 (no) 2000-02-25
HUP0003700A3 (en) 2002-09-30
ZA987726B (en) 2000-02-28
CA2296313C (en) 2004-11-02
PL338987A1 (en) 2000-12-04

Similar Documents

Publication Publication Date Title
PE106599A1 (es) 2-aminopiridinas que contienen sustituyentes de anillos condensados
FI931370A0 (fi) Kvaeve innehaollande analoger av icke-aromatiska heterocykliska foereningar med en fusionerad ring
MX9304698A (es) Heterociclos que contienen nitrogeno substituido.
FR2512024B1 (es)
IT1075251B (it) Procedimento e composizione per la cementazione di pozzi di petrolio
ATE44528T1 (de) Arzneimittel mit antipsychotischer wirkung.
ES2115054T3 (es) Inhibicion de la hipotension y del shock septico, causados por oxido nitrico, mediante el uso de hemoproteina conteniendo hierro.
PE55098A1 (es) Derivados de 6-fenilpiridil-2-amina
TR22158A (tr) Nitrometilen tuerevleri,bunlarin meydana getirilmesine mahsus usuel,ve ensektisid,mitisid ve nemotosid olarak kullanilabilen madde
FI952797A0 (fi) D-vitamiinianalogin uusi kiteinen muoto
PE106699A1 (es) 2-aminopiridinas con sustituyentes alcoxi ramificados
IT1188166B (it) Stabilizzanti a struttura arilfosfinica per olii e grassi perfluoropolieterei
IT7848138A0 (it) Alchenilammine e loro applicazione come additivi per oli lubrificanti e carburanti
MX9304399A (es) Proceso novedoso para preparar [[2-bromoetil)-amino]metil]-2-nitro-1h-imidazol-1-etanol quiral y compuestos relacionados.
AR246520A1 (es) Procedimiento para producir 6,11-dihidro-11-(4-piperidilideno)-5h-benzo¡5.6¿ciclohepta¡1,2-b¿piridinas y metodo para preparar una composicion que utiliza el compuesto asi obtenido.
MX168361B (es) Compuestos que contienen boro y azufre y concentrados aditivos y aceites lubricantes que los contienen
CO4970744A1 (es) Caspasas y apoptosis
ES2139669T3 (es) Nuevos derivados triciclicos de indan-2-mercaptoacetilamida 2-substituidos utiles como inhibidores de la encefalinasa.
SE7709745L (sv) Forfarande for framstellning av ett fast cefalosporinderivat
FI861949A (fi) 2,4-difenyl-1,3-dioxaner.
DE3672266D1 (de) Brennstoffzusammensetzungen.
DE68914711D1 (de) 1,4-Disubstituierte-2,3,4,6-tetrahydroxy-1,4-diphosphorinan und ihre Oxide oder Sulfides.
KR850005433A (ko) 나프티리딘 및 피리도피리미딘 화합물의 제조방법
ES553413A0 (es) Un procedimiento para la produccion de derivados de benzoilurea
EP0390739A3 (de) Substituierte Aminopyrrole als Stabilisatoren chlorhaltige Polymerisate

Legal Events

Date Code Title Description
FG Grant, registration
FD Application declared void or lapsed