PA8586001A1 - Derivados de indol útiles para el tratamiento de enfermedades - Google Patents
Derivados de indol útiles para el tratamiento de enfermedadesInfo
- Publication number
- PA8586001A1 PA8586001A1 PA20038586001A PA8586001A PA8586001A1 PA 8586001 A1 PA8586001 A1 PA 8586001A1 PA 20038586001 A PA20038586001 A PA 20038586001A PA 8586001 A PA8586001 A PA 8586001A PA 8586001 A1 PA8586001 A1 PA 8586001A1
- Authority
- PA
- Panama
- Prior art keywords
- diseases
- treatment
- derivatives useful
- indol
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
LA INVENCION SE REFIERE A DERIVADOS DE INDOL Y A PROCEDIMIENTOS PARA LA PREPARACION DE INTERMEDIOS USADOS EN LA PREPARACION DE COMPOSICIONES QUE LOS CONTIENEN Y EL USO DE DICHOS DERIVADOS. LOS DERIVADOS DE INDOL SEGUN LA PRESENTE INVENCION SON UTILES EN NUMEROSAS ENFERMEDADES, TRASTORNOS Y AFECCIONES, EN PARTICULAR ENFERMEDADES, TRASTORNOS Y AFECCIONES INFLAMATORIAS, ALERGICAS Y RESPIRATORIAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP20020292513 EP1407769A1 (en) | 2002-10-11 | 2002-10-11 | Indole derivatives as beta-2 agonists |
EP03290069A EP1440966A1 (en) | 2003-01-10 | 2003-01-10 | Indole derivatives useful for the treatment of diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8586001A1 true PA8586001A1 (es) | 2005-02-04 |
Family
ID=32095049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20038586001A PA8586001A1 (es) | 2002-10-11 | 2003-10-10 | Derivados de indol útiles para el tratamiento de enfermedades |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1556034B1 (es) |
JP (1) | JP4490911B2 (es) |
KR (1) | KR20050047552A (es) |
AP (1) | AP2005003283A0 (es) |
AR (1) | AR041566A1 (es) |
AT (1) | ATE392206T1 (es) |
AU (1) | AU2003269316A1 (es) |
BR (1) | BR0315234A (es) |
CA (1) | CA2499314C (es) |
CO (1) | CO5550421A2 (es) |
DE (1) | DE60320439T2 (es) |
EA (1) | EA200500618A1 (es) |
EC (1) | ECSP055780A (es) |
ES (1) | ES2302938T3 (es) |
IS (1) | IS7751A (es) |
MA (1) | MA27452A1 (es) |
MX (1) | MXPA05003866A (es) |
NO (1) | NO20051406L (es) |
OA (1) | OA12938A (es) |
PA (1) | PA8586001A1 (es) |
PE (1) | PE20040775A1 (es) |
PL (1) | PL376396A1 (es) |
TW (1) | TW200424171A (es) |
UY (1) | UY28013A1 (es) |
WO (1) | WO2004032921A1 (es) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR028948A1 (es) | 2000-06-20 | 2003-05-28 | Astrazeneca Ab | Compuestos novedosos |
EP1460064A1 (en) | 2003-03-14 | 2004-09-22 | Pfizer Limited | Indole-2-carboxamide derivatives useful as beta-2 agonists |
GB0312832D0 (en) * | 2003-06-04 | 2003-07-09 | Pfizer Ltd | 2-amino-pyridine derivatives useful for the treatment of diseases |
GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
WO2005092841A1 (en) * | 2004-03-23 | 2005-10-06 | Pfizer Limited | Compounds having beta-agonist activity |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
PE20060272A1 (es) | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
GT200500281A (es) | 2004-10-22 | 2006-04-24 | Novartis Ag | Compuestos organicos. |
GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
KR20080036632A (ko) | 2005-08-08 | 2008-04-28 | 아젠터 디스커버리 리미티드 | 바이시클로[2.2.1]헵트-7-일아민 유도체 및 이들의 용도 |
GB0516313D0 (en) | 2005-08-08 | 2005-09-14 | Argenta Discovery Ltd | Azole derivatives and their uses |
KR20080049113A (ko) | 2005-10-21 | 2008-06-03 | 노파르티스 아게 | Il-13에 대항한 인간 항체 및 치료적 용도 |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
MX2008011963A (es) | 2006-03-20 | 2008-10-01 | Pfizer Ltd | Derivados de amina. |
PT2322525E (pt) | 2006-04-21 | 2013-12-26 | Novartis Ag | Derivados de purina para utilização como agonistas do recetor de adenosina a2a |
TW200821316A (en) | 2006-07-19 | 2008-05-16 | Astrazeneca Ab | Novel compounds 243 |
TW200825084A (en) | 2006-11-14 | 2008-06-16 | Astrazeneca Ab | New compounds 521 |
BRPI0721039A2 (pt) | 2006-12-19 | 2014-07-29 | Astrazeneca Ab | " derivados de quinuclidinol como antagonistas de receptores muscarínicos ". |
PT2104535E (pt) | 2007-01-10 | 2011-03-31 | Irm Llc | Compostos e composições como inibidores da protease de activação de canal |
WO2008097673A1 (en) | 2007-02-09 | 2008-08-14 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
EA200901489A1 (ru) | 2007-05-07 | 2010-04-30 | Новартис Аг | Органические соединения |
PE20091096A1 (es) | 2007-12-10 | 2009-08-25 | Novartis Ag | Compuestos organicos |
US8431578B2 (en) | 2008-01-11 | 2013-04-30 | Novartis Ag | Organic compounds |
CN102089304A (zh) | 2008-05-13 | 2011-06-08 | 阿斯利康(瑞典)有限公司 | 作为m3毒蕈碱性受体拮抗剂的奎宁环衍生物 |
CN102105448B (zh) | 2008-05-27 | 2013-11-13 | 阿斯利康(瑞典)有限公司 | 苯氧基吡啶基酰胺衍生物和它们在治疗由pde4介导的病症中的用途 |
MX2010013675A (es) | 2008-06-10 | 2011-02-15 | Novartis Ag | Derivados de pirazina como bloqueadores del canal de sodio epitelial. |
US8236786B2 (en) | 2008-08-07 | 2012-08-07 | Pulmagen Therapeutics (Inflammation) Limited | Respiratory disease treatment |
WO2010067102A1 (en) | 2008-12-09 | 2010-06-17 | Astrazeneca Ab | Diazaspiro [5.5] undecane derivatives and related compounds as muscarinic-receptor antagonists and beta-adrenoreceptor agonists for the treatment of pulmonary disorders |
CN102272104B (zh) | 2008-12-30 | 2014-07-09 | 帕尔马根治疗(炎症)有限公司 | 用于治疗呼吸疾病的磺酰胺化合物 |
WO2010150014A1 (en) | 2009-06-24 | 2010-12-29 | Pulmagen Therapeutics (Inflammation) Limited | 5r- 5 -deuterated glitazones for respiratory disease treatment |
JP5801997B2 (ja) | 2009-07-07 | 2015-10-28 | ファイザー・リミテッドPfizer Limited | 薬品の組合せを吸入するための投薬ユニット、投薬ユニットのパック、および吸入器 |
CN102665715A (zh) | 2009-10-22 | 2012-09-12 | 沃泰克斯药物股份有限公司 | 治疗囊性纤维化和其他慢性疾病的组合物 |
GB0918924D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Azaindole derivatives |
GB0918922D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Aminopyridine derivatives |
GB0918923D0 (en) | 2009-10-28 | 2009-12-16 | Vantia Ltd | Aminothiazole derivatives |
WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
WO2011098746A1 (en) | 2010-02-09 | 2011-08-18 | Pulmagen Therapeutics (Inflammation) Limited | Crystalline acid addition salts of ( 5r) -enanti0mer of pioglitazone |
GB201002243D0 (en) | 2010-02-10 | 2010-03-31 | Argenta Therapeutics Ltd | Respiratory disease treatment |
GB201002224D0 (en) | 2010-02-10 | 2010-03-31 | Argenta Therapeutics Ltd | Respiratory disease treatment |
US8247436B2 (en) | 2010-03-19 | 2012-08-21 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of CF |
US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
US8372845B2 (en) | 2010-09-17 | 2013-02-12 | Novartis Ag | Pyrazine derivatives as enac blockers |
GB201016912D0 (en) | 2010-10-07 | 2010-11-24 | Astrazeneca Ab | Novel combination |
JP5959541B2 (ja) | 2011-02-25 | 2016-08-02 | ノバルティス アーゲー | Trk阻害剤としてのピラゾロ[1,5−a]ピリジン |
AR085509A1 (es) | 2011-03-09 | 2013-10-09 | Bayer Cropscience Ag | Indol- y bencimidazolcarboxamidas como insecticidas y acaricidas |
CN103562198B (zh) | 2011-06-10 | 2016-08-24 | 奇斯药制品公司 | 具有毒蕈碱受体拮抗剂和β2肾上腺素能受体激动剂活性的化合物 |
US8883819B2 (en) | 2011-09-01 | 2014-11-11 | Irm Llc | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
US9034879B2 (en) | 2011-09-16 | 2015-05-19 | Novartis Ag | Heterocyclic compounds for the treatment of CF |
WO2013038390A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | N-substituted heterocyclyl carboxamides |
WO2013038373A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
WO2013038378A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
WO2013038381A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine/pyrazine amide derivatives |
US8809340B2 (en) | 2012-03-19 | 2014-08-19 | Novartis Ag | Crystalline form |
PT2928889T (pt) | 2012-12-06 | 2018-05-29 | Chiesi Farm Spa | Compostos com atividade antagonista dos recetores muscarínicos e agonista dos recetores adrenérgicos beta2 |
ES2663878T3 (es) | 2012-12-06 | 2018-04-17 | Chiesi Farmaceutici S.P.A. | Compuestos que tienen actividad antagonista del receptor muscarínico y actividad agonista del receptor beta-2 adrenérgico |
US9073921B2 (en) | 2013-03-01 | 2015-07-07 | Novartis Ag | Salt forms of bicyclic heterocyclic derivatives |
AR099336A1 (es) | 2014-02-17 | 2016-07-13 | Bayer Cropscience Ag | Indol- y bencimidazolcarboxamidas como insecticidas y acaricidas |
CN106458979B (zh) | 2014-04-24 | 2020-03-27 | 诺华股份有限公司 | 作为磷脂酰肌醇3-激酶抑制剂的氨基吡嗪衍生物 |
AU2014391605A1 (en) | 2014-04-24 | 2016-10-27 | Novartis Ag | Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors |
MX2016013983A (es) | 2014-04-24 | 2017-04-06 | Novartis Ag | Derivados de pirazina como inhibidores de fosfatidil-inositol-3-ci nasa. |
WO2020250116A1 (en) | 2019-06-10 | 2020-12-17 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of cf, copd, and bronchiectasis |
CN114341132A (zh) | 2019-08-28 | 2022-04-12 | 诺华股份有限公司 | 经取代的1,3-苯基杂芳基衍生物及其在治疗疾病中的用途 |
EP4171525A1 (en) | 2020-06-26 | 2023-05-03 | Mylan Pharma UK Limited | Formulations including 5-[3-(3-hydroxyphenoxy)azetidin-1-yl]-5-methyl-2,2-diphenylhexanamide |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9406823A (pt) * | 1993-06-14 | 1996-03-26 | Pfizer | Aminas secundárias e agentes anti-diabéticos e antiobesidade |
EP0801060A1 (en) * | 1996-04-09 | 1997-10-15 | Pfizer Inc. | Heterocyclic Beta-3 Adrenergenic Agonists |
EP0822185A1 (en) * | 1996-07-31 | 1998-02-04 | Pfizer Inc. | B-3-adrenergic agonists as antidiabetic and antiobesity agents |
-
2003
- 2003-10-06 EP EP03751095A patent/EP1556034B1/en not_active Expired - Lifetime
- 2003-10-06 AP AP2005003283A patent/AP2005003283A0/xx unknown
- 2003-10-06 ES ES03751095T patent/ES2302938T3/es not_active Expired - Lifetime
- 2003-10-06 DE DE60320439T patent/DE60320439T2/de not_active Expired - Lifetime
- 2003-10-06 KR KR1020057006090A patent/KR20050047552A/ko not_active Application Discontinuation
- 2003-10-06 AU AU2003269316A patent/AU2003269316A1/en not_active Abandoned
- 2003-10-06 BR BR0315234-0A patent/BR0315234A/pt not_active IP Right Cessation
- 2003-10-06 PL PL03376396A patent/PL376396A1/xx unknown
- 2003-10-06 JP JP2005501006A patent/JP4490911B2/ja not_active Expired - Fee Related
- 2003-10-06 EA EA200500618A patent/EA200500618A1/ru unknown
- 2003-10-06 CA CA2499314A patent/CA2499314C/en not_active Expired - Fee Related
- 2003-10-06 OA OA1200500099A patent/OA12938A/en unknown
- 2003-10-06 MX MXPA05003866A patent/MXPA05003866A/es not_active Application Discontinuation
- 2003-10-06 AT AT03751095T patent/ATE392206T1/de not_active IP Right Cessation
- 2003-10-06 WO PCT/IB2003/004441 patent/WO2004032921A1/en active IP Right Grant
- 2003-10-09 AR ARP030103677A patent/AR041566A1/es unknown
- 2003-10-09 TW TW092128121A patent/TW200424171A/zh unknown
- 2003-10-09 PE PE2003001024A patent/PE20040775A1/es not_active Application Discontinuation
- 2003-10-10 UY UY28013A patent/UY28013A1/es not_active Application Discontinuation
- 2003-10-10 PA PA20038586001A patent/PA8586001A1/es unknown
-
2005
- 2005-03-17 IS IS7751A patent/IS7751A/is unknown
- 2005-03-17 NO NO20051406A patent/NO20051406L/no unknown
- 2005-04-08 CO CO05032119A patent/CO5550421A2/es not_active Application Discontinuation
- 2005-04-11 MA MA28210A patent/MA27452A1/fr unknown
- 2005-05-05 EC EC2005005780A patent/ECSP055780A/es unknown
Also Published As
Publication number | Publication date |
---|---|
DE60320439D1 (de) | 2008-05-29 |
MA27452A1 (fr) | 2005-07-01 |
EP1556034B1 (en) | 2008-04-16 |
MXPA05003866A (es) | 2005-06-22 |
ES2302938T3 (es) | 2008-08-01 |
KR20050047552A (ko) | 2005-05-20 |
CO5550421A2 (es) | 2005-08-31 |
UY28013A1 (es) | 2004-04-30 |
TW200424171A (en) | 2004-11-16 |
EP1556034A1 (en) | 2005-07-27 |
CA2499314C (en) | 2010-08-24 |
ATE392206T1 (de) | 2008-05-15 |
EA200500618A1 (ru) | 2005-12-29 |
OA12938A (en) | 2006-10-13 |
IS7751A (is) | 2005-03-17 |
AR041566A1 (es) | 2005-05-18 |
AP2005003283A0 (en) | 2005-06-30 |
JP4490911B2 (ja) | 2010-06-30 |
AU2003269316A1 (en) | 2004-05-04 |
PE20040775A1 (es) | 2004-12-10 |
ECSP055780A (es) | 2005-08-11 |
CA2499314A1 (en) | 2004-04-22 |
PL376396A1 (en) | 2005-12-27 |
DE60320439T2 (de) | 2009-05-20 |
WO2004032921A1 (en) | 2004-04-22 |
JP2006511596A (ja) | 2006-04-06 |
BR0315234A (pt) | 2005-08-23 |
NO20051406L (no) | 2005-04-22 |
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