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LTPA2018507I1 - Daugiaspecifinė antigeną surišanti molekulė, turinti alternatyvią funkciją kraujo krešėjimo VIII faktoriaus funkcijai - Google Patents

Daugiaspecifinė antigeną surišanti molekulė, turinti alternatyvią funkciją kraujo krešėjimo VIII faktoriaus funkcijai

Info

Publication number
LTPA2018507I1
LTPA2018507I1 LTPA2018507C LTPA2018507C LTPA2018507I1 LT PA2018507 I1 LTPA2018507 I1 LT PA2018507I1 LT PA2018507 C LTPA2018507 C LT PA2018507C LT PA2018507 C LTPA2018507 C LT PA2018507C LT PA2018507 I1 LTPA2018507 I1 LT PA2018507I1
Authority
LT
Lithuania
Prior art keywords
antigen binding
binding molecule
factor viii
specific antigen
blood coagulation
Prior art date
Application number
LTPA2018507C
Other languages
English (en)
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Publication of LTPA2018507I1 publication Critical patent/LTPA2018507I1/lt
Publication of LTC2644698I2 publication Critical patent/LTC2644698I2/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Magnetically Actuated Valves (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
LTPA2018507C 2010-11-17 2018-06-13 Daugiaspecifinė antigeną surišanti molekulė, turinti alternatyvią funkciją kraujo krešėjimo VIII faktoriaus funkcijai LTC2644698I2 (lt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010257022 2010-11-17
PCT/JP2011/076486 WO2012067176A1 (ja) 2010-11-17 2011-11-17 血液凝固第viii因子の機能を代替する機能を有する多重特異性抗原結合分子

Publications (2)

Publication Number Publication Date
LTPA2018507I1 true LTPA2018507I1 (lt) 2018-06-25
LTC2644698I2 LTC2644698I2 (lt) 2019-09-10

Family

ID=46084097

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP11842145.2T LT2644698T (lt) 2010-11-17 2011-11-17 Daugiaspecifinė antigeną surišanti molekulė, turinti alternatyvią funkciją kraujo krešėjimo viii faktoriaus funkcijai
LTPA2018507C LTC2644698I2 (lt) 2010-11-17 2018-06-13 Daugiaspecifinė antigeną surišanti molekulė, turinti alternatyvią funkciją kraujo krešėjimo VIII faktoriaus funkcijai

Family Applications Before (1)

Application Number Title Priority Date Filing Date
LTEP11842145.2T LT2644698T (lt) 2010-11-17 2011-11-17 Daugiaspecifinė antigeną surišanti molekulė, turinti alternatyvią funkciją kraujo krešėjimo viii faktoriaus funkcijai

Country Status (29)

Country Link
US (10) US9334331B2 (lt)
EP (2) EP2644698B1 (lt)
JP (8) JP6013915B2 (lt)
KR (4) KR102099580B1 (lt)
CN (2) CN105859889B (lt)
AU (2) AU2011330184B2 (lt)
BR (1) BR112013012213A2 (lt)
CA (1) CA2817964C (lt)
DK (1) DK2644698T3 (lt)
ES (1) ES2660151T3 (lt)
FR (1) FR18C1031I2 (lt)
HK (1) HK1223379A1 (lt)
HR (1) HRP20180421T1 (lt)
HU (2) HUE038305T2 (lt)
LT (2) LT2644698T (lt)
LU (1) LUC00076I2 (lt)
MX (1) MX355060B (lt)
MY (1) MY166429A (lt)
NL (1) NL300940I2 (lt)
NO (3) NO2644698T3 (lt)
PH (2) PH12013500974A1 (lt)
PL (1) PL2644698T3 (lt)
PT (1) PT2644698T (lt)
RS (1) RS57038B1 (lt)
RU (3) RU2620071C2 (lt)
SI (1) SI2644698T1 (lt)
TR (1) TR201802772T4 (lt)
TW (4) TWI629355B (lt)
WO (1) WO2012067176A1 (lt)

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