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MX2018015721A - Anticuerpos biespecificos que exhiben actividad de funcion de cofactor fviii alternativa mejorada. - Google Patents

Anticuerpos biespecificos que exhiben actividad de funcion de cofactor fviii alternativa mejorada.

Info

Publication number
MX2018015721A
MX2018015721A MX2018015721A MX2018015721A MX2018015721A MX 2018015721 A MX2018015721 A MX 2018015721A MX 2018015721 A MX2018015721 A MX 2018015721A MX 2018015721 A MX2018015721 A MX 2018015721A MX 2018015721 A MX2018015721 A MX 2018015721A
Authority
MX
Mexico
Prior art keywords
fviii
cofactor
function activity
bispecific antibody
alternative
Prior art date
Application number
MX2018015721A
Other languages
English (en)
Inventor
Kato Kazuki
Igawa Tomoyuki
Teranishi Yuri
Koga Hikaru
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MX2018015721A publication Critical patent/MX2018015721A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Exposure Of Semiconductors, Excluding Electron Or Ion Beam Exposure (AREA)

Abstract

La presente invención proporciona sustituciones de aminoácidos de cadena ligera que mejoran la actividad de sustitución de la función del cofactor FVITI de ACE910 (Emicizumab), nuevas cadenas ligeras que muestran actividad de sustitución de la función del cofactor FVIII y sustituciones de aminoácidos de cadena pesada que mejoran la actividad de sustitución de la función del cofactor FVIII de nuevos anticuerpos biespecíficos que contienen cadenas ligeras.
MX2018015721A 2016-07-29 2017-07-27 Anticuerpos biespecificos que exhiben actividad de funcion de cofactor fviii alternativa mejorada. MX2018015721A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2016150769 2016-07-29
PCT/JP2017/027152 WO2018021450A1 (ja) 2016-07-29 2017-07-27 増強されたｆｖｉｉｉ補因子機能代替活性を有する二重特異性抗体

Publications (1)

Publication Number Publication Date
MX2018015721A true MX2018015721A (es) 2019-05-27

Family

ID=61016987

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018015721A MX2018015721A (es) 2016-07-29 2017-07-27 Anticuerpos biespecificos que exhiben actividad de funcion de cofactor fviii alternativa mejorada.

Country Status (10)

Country Link
US (2) US20190185578A1 (es)
EP (1) EP3492496A4 (es)
JP (1) JP7050677B2 (es)
KR (1) KR102591955B1 (es)
CN (2) CN109415444B (es)
AU (1) AU2017303205B2 (es)
BR (1) BR112019001179A2 (es)
CA (1) CA3027018A1 (es)
MX (1) MX2018015721A (es)
WO (1) WO2018021450A1 (es)

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TWI609698B (zh) 2010-01-20 2018-01-01 Chugai Pharmaceutical Co Ltd 穩定化的含抗體溶液製劑
HUE038305T2 (hu) 2010-11-17 2018-10-29 Chugai Pharmaceutical Co Ltd A VIII vérkoagulációs faktor mûködésére alternatív funkciójú multispecifikus antigén-kötõ molekula
WO2017110980A1 (ja) 2015-12-25 2017-06-29 中外製薬株式会社 増強された活性を有する抗体及びその改変方法
PE20191347A1 (es) 2017-02-01 2019-09-30 Novo Nordisk As Anticuerpos procoagulantes
GB201709970D0 (en) 2017-06-22 2017-08-09 Kymab Ltd Bispecific antigen-binding molecules
MA50667A (fr) * 2017-09-29 2020-08-05 Chugai Pharmaceutical Co Ltd Molécule multispécifique de liaison à l'antigène ayant une activité de substitution de la fonction de cofacteur du facteur viii de coagulation sanguine (fviii), et formulation pharmaceutique contenant ladite molécule en tant que principe actif
CN111386285B (zh) 2017-11-15 2024-08-27 诺和诺德股份有限公司 增强fx活化的因子x结合物
US11220554B2 (en) 2018-09-07 2022-01-11 Novo Nordisk A/S Procoagulant antibodies
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KR20230130560A (ko) 2022-03-02 2023-09-12 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Fviii 모방 이중특이적 항체의 주 1회 투여 방법
KR20230130558A (ko) 2022-03-02 2023-09-12 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Fviii 모방 이중특이적 항체의 월 1회 투여 방법
KR20230130561A (ko) 2022-03-02 2023-09-12 노보 노르디스크 헬스 케어 악티엔게젤샤프트 Fviii 모방 이중특이적 항체를 2주마다 1회 투여하는 방법
WO2024261245A1 (en) 2023-06-23 2024-12-26 Novo Nordisk Health Care Ag Methods of administering fviii mimetic bispecific antibodies once every second month

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Also Published As

Publication number Publication date
WO2018021450A1 (ja) 2018-02-01
AU2017303205B2 (en) 2024-08-01
CN117986372A (zh) 2024-05-07
KR102591955B1 (ko) 2023-10-19
RU2019104730A3 (es) 2020-11-30
BR112019001179A2 (pt) 2019-04-30
EP3492496A1 (en) 2019-06-05
AU2017303205A1 (en) 2019-01-17
US20190185578A1 (en) 2019-06-20
RU2019104730A (ru) 2020-08-28
EP3492496A4 (en) 2020-07-29
CA3027018A1 (en) 2018-02-01
JPWO2018021450A1 (ja) 2019-05-23
CN109415444B (zh) 2024-03-01
JP7050677B2 (ja) 2022-04-08
KR20190037271A (ko) 2019-04-05
CN109415444A (zh) 2019-03-01
US20220073644A1 (en) 2022-03-10

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