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LT3600B - Nucleic acid fragment which codes for human proapolipoprotein a-i - Google Patents

Nucleic acid fragment which codes for human proapolipoprotein a-i Download PDF

Info

Publication number
LT3600B
LT3600B LTIP828A LTIP828A LT3600B LT 3600 B LT3600 B LT 3600B LT IP828 A LTIP828 A LT IP828A LT IP828 A LTIP828 A LT IP828A LT 3600 B LT3600 B LT 3600B
Authority
LT
Lithuania
Prior art keywords
sequence
human
dna sequence
proapo
dna
Prior art date
Application number
LTIP828A
Other languages
English (en)
Lithuanian (lt)
Inventor
Alex Bollen
Jean Gobert
Ernst Wuelfert
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of LTIP828A publication Critical patent/LTIP828A/xx
Publication of LT3600B publication Critical patent/LT3600B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
LTIP828A 1987-05-28 1993-08-03 Nucleic acid fragment which codes for human proapolipoprotein a-i LT3600B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB878712540A GB8712540D0 (en) 1987-05-28 1987-05-28 Expression of human proapolipoprotein a-i

Publications (2)

Publication Number Publication Date
LTIP828A LTIP828A (en) 1995-02-27
LT3600B true LT3600B (en) 1995-12-27

Family

ID=10618034

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP828A LT3600B (en) 1987-05-28 1993-08-03 Nucleic acid fragment which codes for human proapolipoprotein a-i

Country Status (33)

Country Link
US (1) US5059528A (pt)
EP (1) EP0293357B1 (pt)
JP (1) JP2634193B2 (pt)
KR (1) KR970000808B1 (pt)
CN (1) CN1031892C (pt)
AT (1) ATE89006T1 (pt)
AU (1) AU615654B2 (pt)
CA (1) CA1323851C (pt)
CY (1) CY1809A (pt)
CZ (1) CZ283648B6 (pt)
DD (1) DD291093A5 (pt)
DE (1) DE3880739T2 (pt)
DK (1) DK175686B1 (pt)
EG (1) EG19101A (pt)
ES (1) ES2054878T3 (pt)
FI (1) FI100056B (pt)
GB (1) GB8712540D0 (pt)
HK (1) HK137794A (pt)
HU (1) HU204562B (pt)
IE (1) IE62422B1 (pt)
IL (1) IL86480A (pt)
LT (1) LT3600B (pt)
LV (1) LV5288A3 (pt)
NO (1) NO179253C (pt)
NZ (1) NZ224808A (pt)
PL (1) PL158064B1 (pt)
PT (1) PT87562B (pt)
RU (1) RU2009198C1 (pt)
SG (1) SG131594G (pt)
SK (1) SK363888A3 (pt)
SU (1) SU1834904A3 (pt)
UA (1) UA19765A (pt)
ZA (1) ZA883824B (pt)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU587989B2 (en) * 1984-10-16 1989-09-07 Mitsubishi Chemical Corporation DMA fragments, expression vectors, proteins, hosts, and process for production of the proteins
JP2606228B2 (ja) * 1987-09-18 1997-04-30 三菱化学株式会社 ヒトプロアポリポプロテインａ−ｉ様蛋白の産生法
DE68917379T2 (de) * 1988-05-31 1994-12-01 Mitsubishi Chem Ind Verfahren zur Herstellung von Proteinen, die ähnlich dem natürlich-menschlichen Apolipoprotein-E sind.
US5846799A (en) * 1988-06-14 1998-12-08 La Region Wallone Human myeloperoxidase and its therapeutic application
US5460961A (en) * 1988-06-14 1995-10-24 La Region Wallonne Human myeloperoxidase and its therapeutic application
IT1229996B (it) * 1989-04-20 1991-09-20 Cesare Sirtori Espressione di apolipoproteina ai e apolipoproteina ai-milano in lievito e composizioni farmaceutiche che contengono dette apolipoproteine.
DK0574402T3 (da) * 1990-11-26 1998-05-18 Chiron Corp Ekspression af PACE i værtsceller og fremgangsmåder til anvendelse deraf
US5844097A (en) * 1990-11-30 1998-12-01 Monoclonetics International, Inc. Methods for the diagnosis of peripheral nerve damage
DK0559795T3 (da) * 1990-11-30 1996-01-29 Monoclonetics Int Fremgangsmåder til diagnosticering af kroniske smerter i lænderegionen og halshvrivelsøjlen
SE9500778D0 (sv) * 1995-03-03 1995-03-03 Pharmacia Ab Process for producing a protein
US5994061A (en) * 1995-09-29 1999-11-30 Queen's University At Kingston DNA constructs and methods for screening for increased expression of human apo AI gene
SE9603068D0 (sv) 1996-08-23 1996-08-23 Pharmacia & Upjohn Ab Process for purifying a protein
SE9603303D0 (sv) 1996-09-11 1996-09-11 Pharmacia & Upjohn Ab Process for purifying a protein
SE9603304D0 (sv) 1996-09-11 1996-09-11 Pharmacia & Upjohn Ab Process for purifying a compound
KR100330355B1 (ko) * 1999-06-04 2002-04-01 장인순 회전유동발생 날개를 가진 덕트형 핵연료 집합체 지지격자
US20040047853A1 (en) * 2000-06-09 2004-03-11 Dahl Soren W Purified proenzyme of dipeptidyl peptidase i (pro-dppi)
WO2002048333A2 (en) * 2000-12-12 2002-06-20 Lexicon Genetics Incorporated Novel human kinases and uses thereof
KR100560102B1 (ko) * 2004-06-25 2006-03-13 한국생명공학연구원 프로아포리포단백질 ａ－ⅰ 변이체와, 이를 포함하는고지혈증 또는 동맥경화증 예방 및 치료제
US7427662B2 (en) * 2005-02-01 2008-09-23 Baord Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Inhibition of angiogenesis and destruction of angiogenic vessels by apolipoprotein A-I and high density lipoprotein
US8206750B2 (en) 2005-03-24 2012-06-26 Cerenis Therapeutics Holding S.A. Charged lipoprotein complexes and their uses
KR20080049066A (ko) * 2005-08-26 2008-06-03 세레니스 쎄라퓨틱스 홀딩 에스에이 유산균에서의 아포지단백질 유전자 생성물의 생성을 위한조성물 및 방법
US20080293102A1 (en) * 2007-02-28 2008-11-27 Cerenis Therapeutics Holding, S.A. Compositions and methods for producing apolipoprotein
CN102239260B (zh) * 2008-10-03 2017-04-12 库尔纳公司 通过抑制针对载脂蛋白‑a1的天然反义转录物治疗载脂蛋白‑a1相关疾病
EP3284482B1 (en) 2008-11-10 2020-06-03 Arbutus Biopharma Corporation Novel lipids and compositions for the delivery of therapeutics
CA2751342C (en) 2009-01-29 2019-05-07 Alnylam Pharmaceuticals, Inc. Lipid formulations comprising cationic lipid and a targeting lipid comprising n-acetyl galactosamine for delivery of nucleic acid
CN104922699B (zh) 2009-03-12 2020-07-24 阿尔尼拉姆医药品有限公司 脂质配制的组合物以及用于抑制Eg5和VEGF基因表达的方法
NZ621981A (en) 2009-05-05 2015-09-25 Tekmira Pharmaceuticals Corp Lipid compositions
CN102459596B (zh) 2009-05-06 2016-09-07 库尔纳公司 通过针对脂质转运和代谢基因的天然反义转录物的抑制治疗脂质转运和代谢基因相关疾病
CA3014827A1 (en) 2009-06-10 2010-12-16 Jianxin Chen Improved cationic lipid of formula i
AP2015008874A0 (en) 2009-08-14 2015-11-30 Alnylam Pharmaceuticals Inc Lipid formulated compositions and methods for inhibiting expression of a gene from the ebola virus
US10894098B2 (en) 2012-04-09 2021-01-19 Signablok, Inc. Methods and compositions for targeted imaging
WO2011044545A2 (en) 2009-10-09 2011-04-14 Sigalov Alexander B Methods and compositions for targeted imaging
EP2509636B1 (en) 2009-12-07 2017-07-19 Arbutus Biopharma Corporation Compositions for nucleic acid delivery
EP2512449B1 (en) 2009-12-18 2019-08-07 The University of British Columbia Methods and compositions for delivery of nucleic acids
WO2011139911A2 (en) 2010-04-29 2011-11-10 Isis Pharmaceuticals, Inc. Lipid formulated single stranded rna
US20130137628A1 (en) 2010-05-11 2013-05-30 Esperion Therapeutics, Inc. Dimeric Oxidation-Resistant Apolipoprotein A1 Variants
EP2575764B1 (en) 2010-06-03 2017-04-19 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
WO2012016188A2 (en) 2010-07-30 2012-02-02 Alnylam Pharmaceuticals, Inc. Methods and compositions for delivery of active agents
US20130323269A1 (en) 2010-07-30 2013-12-05 Muthiah Manoharan Methods and compositions for delivery of active agents
WO2012064824A1 (en) 2010-11-09 2012-05-18 Alnylam Pharmaceuticals, Inc. Lipid formulated compositions and methods for inhibiting expression of eg5 and vegf genes
WO2012099755A1 (en) 2011-01-11 2012-07-26 Alnylam Pharmaceuticals, Inc. Pegylated lipids and their use for drug delivery
KR20140053848A (ko) 2011-02-07 2014-05-08 세레니스 쎄라퓨틱스 홀딩 에스에이 지단백질 복합체 및 그의 제조 및 용도
CA2849476A1 (en) 2011-09-27 2013-04-04 Alnylam Pharmaceuticals, Inc. Di-aliphatic substituted pegylated lipids
US9610324B2 (en) * 2012-07-11 2017-04-04 Esperion Therapeutics, Inc. Apolipoprotein mixtures
HUE050394T2 (hu) * 2013-05-01 2020-11-30 Ionis Pharmaceuticals Inc Apolipoprotein(a) expressziójának módosítására szolgáló eljárások és készítmények
EP2853259A1 (en) 2013-09-30 2015-04-01 Université Pierre et Marie Curie (Paris 6) Reconstituted high density lipoproteins composition and uses thereof
AU2015260929A1 (en) 2014-05-02 2016-12-15 Cerenis Therapeutics Holding Sa HDL therapy markers
US11492616B2 (en) * 2016-10-27 2022-11-08 Institute Of Microbiology, Chinese Academy Of Sciences Method for modifying amino acid attenuator and use of same in production
EP3668600B1 (en) 2017-08-10 2024-05-15 Abionyx Pharma SA Cargomers
WO2019030575A1 (en) 2017-08-10 2019-02-14 Cerenis Therapeutics Holding APOMÈRES
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MX2022012969A (es) 2020-04-16 2022-11-09 Abionyx Pharma Sa Metodos para el tratamiento de condiciones agudas usando complejos basados en proteinas de union a lipidos.
JP2023543498A (ja) 2020-10-01 2023-10-16 アビオニクス ファーマ エスエー 脂質結合タンパク質ベースの複合体を使用した、眼疾患を治療するための方法
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6198998A (ja) 1984-10-18 1986-05-17 Matsushita Electric Ind Co Ltd 電動送風機
EP0186643A1 (fr) 1984-11-23 1986-07-02 Région Wallonne représentée par l'Exécutif Régional Wallon Procédé de préparation de plasmides vecteurs capables de transformer un hôte bactérien Escherichia coli et d'y promouvoir et contrôler l'expression d'un ADN hétérologue
WO1986004920A1 (en) 1985-02-13 1986-08-28 Biotechnology Research Partners, Limited Human metallothionein-ii promoter in mammalian expression system
WO1987002062A1 (en) 1985-10-04 1987-04-09 Biotechnology Research Partners, Ltd. Recombinant apolipoproteins and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU587989B2 (en) * 1984-10-16 1989-09-07 Mitsubishi Chemical Corporation DMA fragments, expression vectors, proteins, hosts, and process for production of the proteins
GB8507833D0 (en) * 1985-03-26 1985-05-01 Biogen Nv Production of human somatomedin c
GB8625435D0 (en) * 1986-10-23 1986-11-26 Erba Farmitalia Human apolipoprotein ai
WO1988003175A1 (en) * 1986-10-29 1988-05-05 Biotechnology Research Partners, Ltd. Apoai-ciii-aiv, apoaii, apob, apoci, and ldl receptor polymorphisms for genetic fingerprinting and predictive of atherosclerosis

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6198998A (ja) 1984-10-18 1986-05-17 Matsushita Electric Ind Co Ltd 電動送風機
EP0186643A1 (fr) 1984-11-23 1986-07-02 Région Wallonne représentée par l'Exécutif Régional Wallon Procédé de préparation de plasmides vecteurs capables de transformer un hôte bactérien Escherichia coli et d'y promouvoir et contrôler l'expression d'un ADN hétérologue
WO1986004920A1 (en) 1985-02-13 1986-08-28 Biotechnology Research Partners, Limited Human metallothionein-ii promoter in mammalian expression system
WO1987002062A1 (en) 1985-10-04 1987-04-09 Biotechnology Research Partners, Ltd. Recombinant apolipoproteins and methods

Non-Patent Citations (16)

* Cited by examiner, † Cited by third party
Title
A M MAXAM AND W GILBERT: "A new method for sequencing DNA", PROC NATL ACAD SCI U S A., 1974, pages 560 - 564
BARKER W.C. ET AL.: "Evolution of lipoproteins deduced from protein sequence data", COMP BIOCHEM PHYSIOL, 1977, pages 309 - 315, XP025827046, DOI: doi:10.1016/0305-0491(77)90060-8
BREWER HB JR: "The amino acid sequence of human APOA-I, an apolipoprotein isolated from high density lipoproteins", BIOCHEM BIOPHYS RES COMMUN., 1978, pages 623 - 630, XP024839665, DOI: doi:10.1016/0006-291X(78)91614-5
BROACH JR, STRATHERN JN, HICKS JB.: "Transformation in yeast: development of a hybrid cloning vector and isolation of the CAN1 gene", GENE, pages 121 - 133
BROACH, J. R. ET AL.: "Transformation in yeast: development of a hybrid cloning vector and isolation of the CAN1 gene", GENE, 121-133
GHRAYEB J ET AL.: "Secretion cloning vectors in Escherichia coli", EMBO J., 1984, pages 2437 - 2442
J E MOTT ET AL.: "Maximizing gene expression from plasmid vectors containing the lambda PL promoter: strategies for overproducing transcription termination factor rho", PROC NATL ACAD SCI U S A., 1985, pages 88 - 92, XP001064522, DOI: doi:10.1073/pnas.82.1.88
JEFFREY H. MILLER: "Experiments in Molecular Genetics"
JEFFREY J. SEILHAMER ET AL.: "Isolation and DNA Sequence of Full-Length cDNA and of the Entire Gene for Human Apolipoprotein AIâ€"Discovery of a New Genetic Polymorphism in the apo AI Gene", DNA, 1984, pages 309 - 317
L. VILLA KOMAROFF ET AL.: "A bacterial clone synthesizing proinsulin", PROC. NATI. ACAD. SCI. USA, 1978, pages 3727 - 3731
LORENZETTI R ET AL.: "Expression of the human apolipoprotein AI gene fused to the E. coli gene for beta-galactosidase", FEBS LETT., 1986, pages 343 - 346
MALLORY JB ET AL.: "Expression and characterization of human apolipoprotein A-I in Chinese hamster ovary cells", J. BIOL. CHEM., 1987, pages 4241 - 4247
MANIATIS T. ET AL.: "Molecular cloning"
MATSUURA Y, POSSEE RD, BISHOP DH.: "Expression of the S-coded genes of lymphocytic choriomeningitis arenavirus using a baculovirus vector", J GEN VIROL., 1986, pages 1515 - 1529
P CHEUNG AND L CHAN: "Nucleotide sequence of cloned cDNA of human apolipoprotein A-I.", NUCLEIC ACIDS RES, 1983, pages 3703 - 3715
RÜTHER U, MÜLLER-HILL B.: "Easy identification of cDNA clones", EMBO J., 1983, pages 1791 - 1794

Also Published As

Publication number Publication date
DK175686B1 (da) 2005-01-17
FI882456A (fi) 1988-11-29
IE881597L (en) 1988-11-28
JPS6416589A (en) 1989-01-20
HU204562B (en) 1992-01-28
NO179253B (no) 1996-05-28
UA19765A (uk) 1997-12-25
AU615654B2 (en) 1991-10-10
EP0293357B1 (fr) 1993-05-05
AU1672388A (en) 1988-12-01
PT87562B (pt) 1992-09-30
DD291093A5 (de) 1991-06-20
ES2054878T3 (es) 1994-08-16
ATE89006T1 (de) 1993-05-15
CN88103118A (zh) 1988-12-14
IL86480A0 (en) 1988-11-15
PL272698A1 (en) 1989-03-06
NO882341D0 (no) 1988-05-27
US5059528A (en) 1991-10-22
CZ283648B6 (cs) 1998-05-13
HK137794A (en) 1994-12-16
PT87562A (pt) 1989-05-31
CZ363888A3 (cs) 1998-02-18
NZ224808A (en) 1990-01-29
DE3880739D1 (de) 1993-06-09
NO179253C (no) 1996-09-04
SK279166B6 (sk) 1998-07-08
PL158064B1 (pl) 1992-07-31
FI882456A0 (fi) 1988-05-25
IE62422B1 (en) 1995-02-08
DE3880739T2 (de) 1993-08-19
SU1834904A3 (ru) 1993-08-15
EG19101A (en) 1994-09-29
LTIP828A (en) 1995-02-27
DK289688A (da) 1988-11-29
CN1031892C (zh) 1996-05-29
ZA883824B (en) 1989-02-22
CY1809A (en) 1995-10-20
CA1323851C (en) 1993-11-02
EP0293357A1 (fr) 1988-11-30
DK289688D0 (da) 1988-05-27
GB8712540D0 (en) 1987-07-01
KR880014110A (ko) 1988-12-22
NO882341L (no) 1988-11-29
IL86480A (en) 1992-08-18
SG131594G (en) 1995-01-13
LV5288A3 (lv) 1993-10-10
SK363888A3 (en) 1998-07-08
HUT47153A (en) 1989-01-30
KR970000808B1 (en) 1997-01-20
FI100056B (fi) 1997-09-15
JP2634193B2 (ja) 1997-07-23
RU2009198C1 (ru) 1994-03-15

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