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LT2714712T - Estetrolio tarpinių junginių gamybos būdas - Google Patents

Estetrolio tarpinių junginių gamybos būdas

Info

Publication number
LT2714712T
LT2714712T LTEP12729053.4T LT12729053T LT2714712T LT 2714712 T LT2714712 T LT 2714712T LT 12729053 T LT12729053 T LT 12729053T LT 2714712 T LT2714712 T LT 2714712T
Authority
LT
Lithuania
Prior art keywords
production
estetrol
intermediates
estetrol intermediates
Prior art date
Application number
LTEP12729053.4T
Other languages
English (en)
Inventor
Jean-Claude Pascal
Original Assignee
Estetra S.P.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Estetra S.P.R.L. filed Critical Estetra S.P.R.L.
Publication of LT2714712T publication Critical patent/LT2714712T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0059—Estrane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0066—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa
    • C07J1/007—Estrane derivatives substituted in position 17 beta not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
LTEP12729053.4T 2011-06-01 2012-06-01 Estetrolio tarpinių junginių gamybos būdas LT2714712T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161492297P 2011-06-01 2011-06-01
EP11168560 2011-06-01
PCT/EP2012/060446 WO2012164095A1 (en) 2011-06-01 2012-06-01 Process for the production of estetrol intermediates

Publications (1)

Publication Number Publication Date
LT2714712T true LT2714712T (lt) 2016-11-25

Family

ID=44588329

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP12729053.4T LT2714712T (lt) 2011-06-01 2012-06-01 Estetrolio tarpinių junginių gamybos būdas

Country Status (25)

Country Link
US (1) US11053273B2 (lt)
EP (1) EP2714712B1 (lt)
JP (1) JP6116550B2 (lt)
KR (1) KR101957937B1 (lt)
CN (1) CN103619867B (lt)
AU (1) AU2012264601C1 (lt)
BR (1) BR112013030833B1 (lt)
CA (1) CA2835979C (lt)
CY (1) CY1118164T1 (lt)
DK (1) DK2714712T3 (lt)
EA (1) EA025511B1 (lt)
ES (1) ES2600703T3 (lt)
HR (1) HRP20161369T1 (lt)
HU (1) HUE031809T2 (lt)
LT (1) LT2714712T (lt)
ME (1) ME02585B (lt)
MX (1) MX342537B (lt)
PL (1) PL2714712T3 (lt)
PT (1) PT2714712T (lt)
RS (1) RS55293B1 (lt)
SG (1) SG195121A1 (lt)
SI (1) SI2714712T1 (lt)
SM (1) SMT201600408B (lt)
WO (1) WO2012164095A1 (lt)
ZA (1) ZA201308445B (lt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2714710B1 (en) 2011-06-01 2016-04-06 Estetra S.P.R.L. Process for the production of estetrol intermediates
LT2714712T (lt) 2011-06-01 2016-11-25 Estetra S.P.R.L. Estetrolio tarpinių junginių gamybos būdas
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
AU2012320423C1 (en) 2011-10-07 2018-01-25 Estetra Srl Process for the production of estetrol
MD3310345T2 (ro) 2015-06-18 2021-07-31 Estetra Sprl Comprimată orodispersabilă ce conține estetrol
UA123098C2 (uk) 2015-06-18 2021-02-17 Естетра Спрл Диспергована у порожнині рота одиниця дозування, що містить естетрольний компонент
GEP20217243B (en) 2015-06-18 2021-04-26 Sprl Estetra Orodispersible dosage unit containing an estetrol component
JP6813150B2 (ja) 2015-06-18 2021-01-13 エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ エステトロールを含有する口腔内崩壊錠
KR102712911B1 (ko) 2016-08-05 2024-10-04 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 월경통 및 생리통의 관리방법
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
WO2023021026A1 (en) 2021-08-17 2023-02-23 Aspen Oss B.V. A synthetic pathway to estra-1,3,5(10)-triene-3,15a,16a,17b-tetrol

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EP2714710B1 (en) 2011-06-01 2016-04-06 Estetra S.P.R.L. Process for the production of estetrol intermediates
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
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UA123098C2 (uk) 2015-06-18 2021-02-17 Естетра Спрл Диспергована у порожнині рота одиниця дозування, що містить естетрольний компонент
GEP20217243B (en) 2015-06-18 2021-04-26 Sprl Estetra Orodispersible dosage unit containing an estetrol component
JP6813150B2 (ja) 2015-06-18 2021-01-13 エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ エステトロールを含有する口腔内崩壊錠
MD3310345T2 (ro) 2015-06-18 2021-07-31 Estetra Sprl Comprimată orodispersabilă ce conține estetrol

Also Published As

Publication number Publication date
EA201301315A1 (ru) 2014-05-30
US20140107091A1 (en) 2014-04-17
CN103619867A (zh) 2014-03-05
CA2835979C (en) 2018-05-01
EP2714712B1 (en) 2016-08-24
HRP20161369T1 (hr) 2016-12-02
CY1118164T1 (el) 2017-06-28
PT2714712T (pt) 2016-11-08
KR101957937B1 (ko) 2019-03-14
ES2600703T3 (es) 2017-02-10
SI2714712T1 (sl) 2016-11-30
RS55293B1 (sr) 2017-03-31
SMT201600408B (lt) 2017-01-10
PL2714712T3 (pl) 2017-05-31
AU2012264601A1 (en) 2013-11-28
DK2714712T3 (en) 2016-12-05
ME02585B (me) 2017-06-20
JP2014515391A (ja) 2014-06-30
ZA201308445B (en) 2015-07-29
JP6116550B2 (ja) 2017-04-19
US11053273B2 (en) 2021-07-06
HUE031809T2 (en) 2017-08-28
WO2012164095A1 (en) 2012-12-06
KR20140036206A (ko) 2014-03-25
BR112013030833A2 (pt) 2016-09-06
EP2714712A1 (en) 2014-04-09
EA025511B1 (ru) 2016-12-30
SG195121A1 (en) 2013-12-30
CN103619867B (zh) 2015-12-23
CA2835979A1 (en) 2012-12-06
NZ617591A (en) 2015-12-24
AU2012264601B2 (en) 2017-02-16
AU2012264601C1 (en) 2018-01-25
BR112013030833B1 (pt) 2019-09-03
MX2013014044A (es) 2014-08-21
MX342537B (es) 2016-10-04

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