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KR920703028A - 벽으로 둘러싸이고 하나이상의 활성물질로 전체적으로 또는 부분적으로 충전된 중공공간을 포함하는 활성물질의 배출량을 조절하는 제품 - Google Patents

벽으로 둘러싸이고 하나이상의 활성물질로 전체적으로 또는 부분적으로 충전된 중공공간을 포함하는 활성물질의 배출량을 조절하는 제품

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Publication number
KR920703028A
KR920703028A KR1019920701819A KR920701819A KR920703028A KR 920703028 A KR920703028 A KR 920703028A KR 1019920701819 A KR1019920701819 A KR 1019920701819A KR 920701819 A KR920701819 A KR 920701819A KR 920703028 A KR920703028 A KR 920703028A
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KR
South Korea
Prior art keywords
product
permeable
active material
active
wall
Prior art date
Application number
KR1019920701819A
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English (en)
Inventor
페이엔 얀
어셀브루게 힐러트
Original Assignee
에프.지.엠.헤르만스
악조 엔. 브이.
에이.지.제이.베르미렌
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 에프.지.엠.헤르만스, 악조 엔. 브이., 에이.지.제이.베르미렌 filed Critical 에프.지.엠.헤르만스
Publication of KR920703028A publication Critical patent/KR920703028A/ko

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0092Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules or nanotubes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Medicinal Chemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Medicinal Preparation (AREA)
  • Biological Depolymerization Polymers (AREA)
  • Materials For Medical Uses (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Building Environments (AREA)
  • Cultivation Receptacles Or Flower-Pots, Or Pots For Seedlings (AREA)

Abstract

내용 없음

Description

벽으로 둘러싸이고 하나이상의 활성물질로 전체적으로 또는 부분적으로 충전된 중공공간을 포함하는 활성물질의 배출량을 조절하는 제품
[도면의 간단한 설명]
제1a도, 제1b도, 제2도, 제3a도 및 제3b도는 서로 다른 유형의 중공 튜브의 단면구조의 예를 도시적으로 나타낸다.
제1a도 및 제1b도는 활성 물질에 투과성이 낮은 중합체층이 투과성이 높은 층의 내부 또는 외부에 부분적으로 피복되는 방법을 나타낸다. 투과성이 낮은 중합체로 피복된 표면을 변화시킴으로써, 활성물질의 전달속도를 조절할 수 있다.
제2도는 활성물질에 거의 불투과성이거나 또는 투과성이 낮은 중합체의 중공튜브의 다른 단면을 도식적으로 나타내며. 상기 벽의 일부분은 활성물질에 투과성인 중합체로 치환되어 있다. 투과성/낮은 투과성 중합체의 표면비를 변화시키면서 전달속도를 조정할 수 있다.
제3a도 및 제3b도는 활성물질에 대해서 2개 이상의 투과성 층과 투과성이 낮은 층의 조성물로 구성된 벽을 갖는 중공튜브의 단면을 도식적으로 나타낸다. 그래서, 중공튜브의 벽의 구조를 형성시킴으로써, 활성물질의 전달을 통해서 유용한 표면을 형성시킬 뿐만 아니라, 투과성 층을 통해서 활성물질이 확산되는 거리는 상당하게 연장되어야 한다. 이는 활성물질의 전달수준을 조절할 수 있는 가능성을 제공할 수 있다.
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (14)

  1. 벽이 적어도 2개의 서로 다른 중합체 물질의 조합으로 주로 구성되고, 이때 하나의 중합체 물질은 활성물질에 투과성이고 분해될 수 있으며, 다른 중합체 물질은 활성물질에 상대적으로 투과성이 낮고 분해될 수 있으며, 중공 공간에서 제품의 주변까지의 활성물질의 전달에 대한 전달장치 경로가 적어도 활성물질에 투과성인 중합체 물질을 통한 연속 거리 리딩인 것을 특징으로 하는, 활성물질에 대해 투과성인 성분해성 중합체 물질을 사용하여 만들어진 벽으로 완전하게 둘러싸이고, 전체적으로 또는 부분적으로 하나이상의 활성물질로 충전된 중공공간을 포함하는 활성물질의 배출량을 조절하는 제품.
  2. 제1항에 있어서, 상기 제품이 서로 다른 기하학적 형태를 갖는 것을 특징으로 하는 제품.
  3. 제1항 내지 제2항에 있어서, 활성물질에 대해서 투과성인 중합체 물질과 투과성이 상대적으로 낮은 중합체 물질을 각각 벽의 일부에 형성시키며, 상기 벽의 일부가 부분적으로 겹치는 부위에서 서로 덮어싸는 2층으로 된 적층물로 구성되어 제품의 벽을 형성하는 2가지의 중합체 물질로 형성된 중공튜브를 주성분으로 하는 것을 특징으로 하는 제품.
  4. 제3항에 있어서, 상기 활성물질에 대해 투과성인 중합체 물질과 상대적으로 투과성이 낮은 중합체 물질로 구성되어 각각 중합체 물질중 하나로 구성원 2가지 이상의 층을 주성분으로 하는 제품의 벽을 형성하며, 상기 층이 서로 다른 층과 부분적으로 겹쳐 덮어싸는 것을 특징으로 하는 제품.
  5. 제3항에 있어서, 활성물질에 대해 루과성인 중합체 물질과 활성물질에 대해 상대적으로 투과성이 낮은 중합체 물질의 각각의 벽의 일부가 단층으로 된 벽을 구성하는 것을 특징으로 하는 제품.
  6. 제1항에 있어서, 적어도 2개의 서로 다른 중합체 물질의 조합이 폴리락트산, 폴리글리콜산, 폴리(ε-카프롤락톤), 폴리(β-히드록시부티르산, 폴리(히드록시발레레이트), 폴리(오르토에 스테르), 폴리(α-아미노산)과 같은 폴리에스테르, 폴리글루탐산의 에스테르, 폴리뎁시펩티드, 폴리무수물 및 폴리포스파젠, 이를로부터 유도된 모든 중합체로 구성된 생분해성 중합체, 상기 중합체의 공중합체 또는 블록 공중합체 및 상기 군으로부터의 광학 활성 단량체로 형성된 중합체의 입체착물로 부터 선택되는 것을 특징으로 하는 제품.
  7. 제1항 내지 제6항 중 어느 한 항에 있어서, 상기 활성물질이 약제인 것을 특징으로 하는 제품.
  8. 제6항에 있어서, 상기 활성물질이 세포증식억제제인 것을 특징으로 하는 제품.
  9. 제1항 내지 제6항 중 어느 한 항에 있어서, 상기 활성물질이 호르몬인 것을 특징으로 하는 제품.
  10. 제1항 내지 제6항 중 어느 한 항에 있어서, 상기 활성물질이 펩티드인 것을 특징으로 하는 제품.
  11. 제1항 내지 제6항중 어느 한 항에 있어서, 상기 활성물질이 살충제. 제초제, 페로몬 또는 방충제인 것을 특징으로 하는 제품.
  12. 제3항 내지 제11항 중 어느 한 항에 있어서, 중공튜브의 외부직경이 5㎜이하이고, 길이가 10㎝이하인 것을 특징으로 하는 제품.
  13. 제12항에 있어서, 사람에게 투여할 경우, 중공튜브의 외부직경이 1.8㎜이고, 길이가 4㎝이며, 동물에게 투여할 경우, 중공튜브의 외부직경이 3㎜이고, 길이가 5㎝인 것을 특징으로 하는 제품.
  14. 제1항 내지 제13항 중 어느 한 항에 있어서, 활성물질에 대한 투과성의 차이가 적어도 2가지의 중합체 물질의 상호의 상대적인 다공도를 조절함으로써 적어도 2가지의 중합체 물질의 사용된 조합내에서 영향을 미칠 수 있는 제품.
    ※ 참고사항: 최초출원 내용에 의하여 공개하는 것임.
KR1019920701819A 1990-01-30 1991-01-30 벽으로 둘러싸이고 하나이상의 활성물질로 전체적으로 또는 부분적으로 충전된 중공공간을 포함하는 활성물질의 배출량을 조절하는 제품 KR920703028A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL9000221 1990-01-30
NL9000221 1990-01-30
PCT/NL1991/000013 WO1991011176A1 (en) 1990-01-30 1991-01-30 Article for the controlled delivery of an active substance, comprising a hollow space fully enclosed by a wall and filled in full or in part with one or more active substances

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KR920703028A true KR920703028A (ko) 1992-12-17

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US (1) US5496557A (ko)
EP (1) EP0514406B1 (ko)
JP (1) JPH05503934A (ko)
KR (1) KR920703028A (ko)
AU (1) AU651084B2 (ko)
CA (1) CA2069644A1 (ko)
DE (1) DE69101313T2 (ko)
DK (1) DK0514406T3 (ko)
ES (1) ES2052369T3 (ko)
FI (1) FI922832A0 (ko)
WO (1) WO1991011176A1 (ko)

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