[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

KR900004700A - 아릴렌디아민 치환 피리미딘 - Google Patents

아릴렌디아민 치환 피리미딘 Download PDF

Info

Publication number
KR900004700A
KR900004700A KR1019890013422A KR890013422A KR900004700A KR 900004700 A KR900004700 A KR 900004700A KR 1019890013422 A KR1019890013422 A KR 1019890013422A KR 890013422 A KR890013422 A KR 890013422A KR 900004700 A KR900004700 A KR 900004700A
Authority
KR
South Korea
Prior art keywords
alkyl
hydrogen
phenyl
cycloalkyl
substituted
Prior art date
Application number
KR1019890013422A
Other languages
English (en)
Other versions
KR0120735B1 (ko
Inventor
록우드 윌러 에드워드
허버트바로우 프랭클린
존 프랭코 로버트
Original Assignee
아이.제이.크라코워
유니로얄 케미칼 컴페니 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아이.제이.크라코워, 유니로얄 케미칼 컴페니 인코포레이티드 filed Critical 아이.제이.크라코워
Publication of KR900004700A publication Critical patent/KR900004700A/ko
Application granted granted Critical
Publication of KR0120735B1 publication Critical patent/KR0120735B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/50—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/16—Nitrogen-containing compounds
    • C08K5/34—Heterocyclic compounds having nitrogen in the ring
    • C08K5/3442—Heterocyclic compounds having nitrogen in the ring having two nitrogen atoms in the ring
    • C08K5/3462—Six-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

내용 없음

Description

아릴렌디아민 치환 피리미딘
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 하기 일반식(I)의 화합물:
    R1은 수소, C1-C11알킬, C3-C6시클로알킬 페닐 또는 C1-C4알킬 또는 페닐로 치환된 페닐; R2는 C1-C11알킬, C3-C6시클로알킬 또는
    R3는 수소, 페닐 또는 C1-C11알킬(R1이 수소일때); R4는 수소 또는 C1-C8알킬; R5는 수소 또는 C1-C8알킬; R6는 수소, C1-C11알킬 또는 C1-C4알콕시 Y는 X, 수소, C1-C4알킬, -SH, SR7, -OH, OR7
    R7은 C1-C12R8은 C1-C11R9및 R10은 C1-C4알킬
    Z는 X 또는 Y 또는
    R11은 C2-C10직쇄알킬;C5-C10시클로알킬 또는 C7-C9페닐알킬; m은 2-6이다.
    Y=X일 경우 R6는 수소일 수 있다.
  2. 불포화 폴리마 및 내붕궤성에 유효한 양의 하기 구조식(I)의 화합물을 포함하는, 내붕궤성 조성물:
    여기서, X는
    R1은 수소, C1-C11알킬, C3-C6시클로알킬 페닐 또는 C1-C4알킬 또는 페닐로 치환된 페닐; R2는 C1-C11알킬, C3-C6시클로알킬 또는
    R3은 수소, 페닐 또는 C1-C11알킬(R1이 수소일 때); R4은 수소, C1-C11알킬; R5는 수소 또는 C1-C8알킬; R6은 수소, C1-C11알킬 또는 C1-C4알콕시 Y는 X, 수소, C1-C4알킬, -SH, SR7, -OH, OR7,
    R7은 C1-C12R7은 C1-C11R9및 R10은 C1-C4알킬
    Z는 X 또는 Y 또는
    R11은 C2-C10직쇄알킬; C5-C10시클로알킬 또는 C7-C9페닐알킬; m은 2-6이다.
    Y=X일 경우 R6는 수소일 수 있다.
  3. 내붕궤성에 유효한 양의 하기 구조식(I)의 화합물이 내부에 첨합되어 있는 불포화 폴리마를 포함하는, 엘라스토마 제품:
    여기서, X는
    R1은 수소, C1-C11알킬, C3-C6시클로알킬 페닐 또는 C1-C4알킬 또는 페닐로 치환된 페닐; R2는 C1-C11알킬, C3-C6시클로알킬 또는
    R3은 수소, 페닐 또는 C1-C11알킬(R1이 수소일 때); R4은 수소 또는 C1-C8알킬; R5는 수소 또는 C1-C8알킬; R6은 수소, C1-C11알킬 또는 C1-C4알콕시 Y는 X, 수소, C1-C4알킬, -SH, SR7, -OH, OR7,
    R7은 C1-C12R8은 C1-C11R9및 R10은 C1-C4알킬
    Z는 X 또는 Y 또는
    R11은 C2-C10직쇄알킬; C5-C10시클로알킬 또는 C7-C9페닐알킬; m은 2-6이다.
    Y=X일 경우 R6는 수소일 수 있다.
  4. 하기 단계를 포함하는, 2,4,6-트리스(N-치환-파라-페닐렌디아미노)피리미딘의 제조방법. 용매내에서 N-치환-p-페닐렌디아민을 트리-할로피리미딘과 반응시켜, 2,4,6-트리스(N-치환-p-페닐렌디아미노)-피리미딘 트리히드로할라이드를 내포하고 있는 반응 혼합물을 형성하고; 및 상기 2,4,6-트리스(N-치환-p-페닐렌디아미노)-피리미딘 트리히드로할라이드를 염기로 중화하여 2,4,6-트리스(N-치환-p-페닐렌디아미노)피리미딘을 형성.
  5. 2,4,6-트리스(N-알킬-파라-페닐렌디아미노)피리미딘.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890013422A 1988-09-21 1989-09-19 아릴렌디아민 치환 피리미딘 KR0120735B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/247,143 US4946956A (en) 1988-09-21 1988-09-21 Arylenediamine substituted pyrimidines
US247,143 1988-09-21

Publications (2)

Publication Number Publication Date
KR900004700A true KR900004700A (ko) 1990-04-12
KR0120735B1 KR0120735B1 (ko) 1997-10-30

Family

ID=22933755

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890013422A KR0120735B1 (ko) 1988-09-21 1989-09-19 아릴렌디아민 치환 피리미딘

Country Status (7)

Country Link
US (1) US4946956A (ko)
EP (1) EP0363002B1 (ko)
KR (1) KR0120735B1 (ko)
AT (1) ATE107635T1 (ko)
BR (1) BR8904702A (ko)
CA (1) CA1339846C (ko)
DE (1) DE68916359T2 (ko)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012486A1 (en) 1998-08-29 2000-03-09 Astrazeneca Ab Pyrimidine compounds
WO2000012485A1 (en) 1998-08-29 2000-03-09 Astrazeneca Ab Pyrimidine compounds
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
GB9905075D0 (en) 1999-03-06 1999-04-28 Zeneca Ltd Chemical compounds
GB9907658D0 (en) 1999-04-06 1999-05-26 Zeneca Ltd Chemical compounds
GB9919778D0 (en) 1999-08-21 1999-10-27 Zeneca Ltd Chemical compounds
GB0004887D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004888D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004886D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
KR100706415B1 (ko) * 2000-03-21 2007-04-10 플렉시스 아메리카, 엘.피. 경도 안정화제로서의 피리미딘 유도체
US6465604B2 (en) 2000-03-21 2002-10-15 Flexsys America L.P. Pyrimidine derivatives as hardness stabilizers
GB0007371D0 (en) 2000-03-28 2000-05-17 Astrazeneca Uk Ltd Chemical compounds
GB0016877D0 (en) 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
GB0021726D0 (en) 2000-09-05 2000-10-18 Astrazeneca Ab Chemical compounds
US20030078271A1 (en) * 2001-01-31 2003-04-24 Blackburn Thomas P. Use of GAL3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
US7081470B2 (en) * 2001-01-31 2006-07-25 H. Lundbeck A/S Use of GALR3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods
US20040127502A1 (en) * 2001-01-31 2004-07-01 Synaptic Pharmaceutical Corporation Use of GAL3 antagonist for treatment of depression
CN100446767C (zh) * 2001-01-31 2008-12-31 H.隆德贝克有限公司 Gal3受体拮抗剂在制备治疗抑郁和/或焦虑药物中的应用及在这种方法中有用的化合物
GB0103926D0 (en) 2001-02-17 2001-04-04 Astrazeneca Ab Chemical compounds
GB0113041D0 (en) 2001-05-30 2001-07-18 Astrazeneca Ab Chemical compounds
GB0205690D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
GB0205688D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
GB0205693D0 (en) 2002-03-09 2002-04-24 Astrazeneca Ab Chemical compounds
AU2003208479A1 (en) 2002-03-09 2003-09-22 Astrazeneca Ab 4- imidazolyl substuited pyrimidine derivatives with cdk inhibitiory activity
US6936607B2 (en) * 2002-08-07 2005-08-30 H. Lunobeck A/S 2,4,6-Triaminopyrimidines for the treatment of depression and/or anxiety
GB0311274D0 (en) 2003-05-16 2003-06-18 Astrazeneca Ab Chemical compounds
GB0311276D0 (en) 2003-05-16 2003-06-18 Astrazeneca Ab Chemical compounds
TW200528101A (en) 2004-02-03 2005-09-01 Astrazeneca Ab Chemical compounds
WO2007036732A1 (en) 2005-09-30 2007-04-05 Astrazeneca Ab Imidazo [1,2-a] pyridine having anti-cell-proliferation activity

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3206398A1 (de) * 1982-02-23 1983-09-01 Basf Ag, 6700 Ludwigshafen S-triazinderivate und ihre verwendung als lichtschutzmittel
US4650867A (en) * 1985-03-26 1987-03-17 Ciba-Geigy Corporation Process for the preparation of 2,4,6-tris(aminophenylamino)triazines
US4786672A (en) * 1986-07-31 1988-11-22 Ciba-Geigy Corporation Anilinotriazines and the use thereof
US4794134A (en) * 1987-08-28 1988-12-27 Uniroyal Chemical Company, Inc. Ozone resistant elastomeric articles
JPH033982A (ja) * 1989-05-31 1991-01-10 Matsushita Electric Works Ltd エアーポンプ

Also Published As

Publication number Publication date
BR8904702A (pt) 1990-05-01
EP0363002B1 (en) 1994-06-22
KR0120735B1 (ko) 1997-10-30
CA1339846C (en) 1998-04-28
ATE107635T1 (de) 1994-07-15
US4946956A (en) 1990-08-07
DE68916359T2 (de) 1994-10-27
EP0363002A1 (en) 1990-04-11
DE68916359D1 (de) 1994-07-28

Similar Documents

Publication Publication Date Title
KR900004700A (ko) 아릴렌디아민 치환 피리미딘
DE69733406D1 (de) Kunststoffgegenstände für medizinische Anwendungen
ATE126517T1 (de) Verwendung von bis(3,4- dialkylbenzyliden)sorbitolacetale und diese enthaltende zusammensetzungen.
KR900009935A (ko) 액정 조성물
DE3884156D1 (de) Harzzusammensetzung.
KR910004589A (ko) 3-페닐벤조푸란-2-온
ES2193746T3 (es) Acelerantes para sistemas reticulables.
KR910002800A (ko) 4-아실록시퀴놀린 유도체와 이를 함유하는 살충 또는 살비조성물
KR920701219A (ko) 디옥사포스포리난 화합물 및 이것으로 안정화된 폴리올레핀 조성물
KR910016860A (ko) 유기 폴리이소시아네이트의 안정화 방법
ATE56434T1 (de) Indolinonderivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung.
KR910009837A (ko) 탄성중합체용 안정화제 혼합물
FI885036A (fi) Hiilivetykoostumus, kuten polttoaineöljy, ja sen lisäaineet
KR910004639A (ko) 방염성 인 화합물 및 이를 함유하는 조성물과 그의 용도
KR920006480A (ko) 활성 매트릭스에 적용하기 위한 네마틱 액정 조성물
ES2103371T3 (es) Compuestos antifungicos.
KR910015537A (ko) 신규 1-아릴술포닐-2-피페리디논 유도체, 이의 제조방법, 제조용 중간체, 의약품으로서의 용도 및 이 화합물을 함유하는 조성물
FI801745A (fi) Stabiliserade halogenkolvaeten
PT84367B (pt) Processo para a preparacao de uma composicao fungicida contendo uma naftimidazolona
DE69006552D1 (de) Formalverbindungen, Kraftstoffzusätze und Kraftstoffmischungen.
KR970070055A (ko) 에틸렌성 불포화기를 갖는 중합체의 안정화된 수성 분산액
DE58900265D1 (de) Klebstoff.
KR930007906A (ko) N-헤테로사이클 화합물
KR910001016A (ko) 수성조성물
KR900018171A (ko) 중합체 및 그의 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20030811

Year of fee payment: 7

LAPS Lapse due to unpaid annual fee