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KR890003778A - 결정성 7-[2-(2-아미노티아졸-4-일)- 2- 히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산[신 이성체] - Google Patents

결정성 7-[2-(2-아미노티아졸-4-일)- 2- 히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산[신 이성체] Download PDF

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Publication number
KR890003778A
KR890003778A KR1019880010489A KR880010489A KR890003778A KR 890003778 A KR890003778 A KR 890003778A KR 1019880010489 A KR1019880010489 A KR 1019880010489A KR 880010489 A KR880010489 A KR 880010489A KR 890003778 A KR890003778 A KR 890003778A
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KR
South Korea
Prior art keywords
aminothiazol
vinyl
carboxylic acid
hydroxyiminoacetamido
solution
Prior art date
Application number
KR1019880010489A
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English (en)
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KR970008126B1 (ko
Inventor
다까오 다까야
후미유끼 시라이
히또시 나까무라
야스노부 이나바
Original Assignee
후지사와 도모끼찌로
후지사와 세이야꾸 고교 가부시끼가이샤
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Application filed by 후지사와 도모끼찌로, 후지사와 세이야꾸 고교 가부시끼가이샤 filed Critical 후지사와 도모끼찌로
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

결정성 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산[신 이성체]
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제 1 도는 화합물(Ⅰ)의 크리스탈 A의 분말 X-선 회절패턴의 챠트를 나타낸다. 제 2도는 화합물(Ⅰ)의 크리스탈 A의 적외선 흡수 스펙트럼의 차트를 나타낸다.

Claims (9)

  1. 분말 X-선 회절 패턴에서 하기표에 나타낸 회절각에서 피크를 나타내는 결정성 7-[2-(2-아미노티아졸-4-일)-2-히드록이미노아세트아미도]-3-비닐-3-세팸-4-카복실산(신 이성체).
    회절각(°)
    약 14.7
    약 17.8
    약 21.5
    약 22.0
    약 23.4
    약 24.5
    약 28.1
  2. 7--[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체)을 함유하는 용액을 실온 또는 가온하에서 산성화함으로써 수득할수 있는 결정성7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체).
  3. 제 2 항에 있어서,7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체)을 함유하는 용액이 상기한 화합물의 알칼리금속염 수용액인 결정성 물질.
  4. 제 3 항에 있어서, 용액의 산성화를 실온 내지 40℃의 온도에서 1 내지 4의 pH에서 수행하는 결정성 물질.
  5. 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체)을 알코올중에 용해시키고 계속해서 용액을 가온하에서 천천히 교반시킨다음, 용액을 실온으로 냉각시켜 용액을 정지시킴으로써 수득할 수 있는 결정성 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체).
  6. 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체)을 함유하는 용액을 실온 또는 가온하에서 산성화시킴을 특지으로 하는 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체)의 제조방법.
  7. 제 6 항에 있어서,7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체)을 함유하는 용액이 상기한 화합물의 알칼리금속염 수용액인 방법.
  8. 제 7 항에 있어서, 용액의 산성화를 실온 내지 40℃의 온도에서 1 내지 4의 pH에서 수행하는 방법.
  9. 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체)을 알코올중에 용해시키고 계속해서 용액을 가온하에서 천천히 교반시킨다음, 용액을 실온으로 냉각시켜 용액을 정지시킴을 특징으로 하는 결정성 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산(신 이성체)의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880010489A 1987-08-19 1988-08-18 결정성 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산[신 이성체] KR970008126B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP62-206199 1987-08-19
JP20619987 1987-08-19

Publications (2)

Publication Number Publication Date
KR890003778A true KR890003778A (ko) 1989-04-18
KR970008126B1 KR970008126B1 (ko) 1997-05-21

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KR1019880010489A KR970008126B1 (ko) 1987-08-19 1988-08-18 결정성 7-[2-(2-아미노티아졸-4-일)-2-히드록시이미노아세트아미도]-3-비닐-3-세펨-4-카복실산[신 이성체]

Country Status (11)

Country Link
US (1) US4935507A (ko)
EP (1) EP0304019B1 (ko)
KR (1) KR970008126B1 (ko)
AT (1) ATE123221T1 (ko)
AU (1) AU617347B2 (ko)
CA (1) CA1297096C (ko)
DE (1) DE3853901T2 (ko)
ES (1) ES2072856T3 (ko)
HK (1) HK18496A (ko)
IE (1) IE67348B1 (ko)
ZA (1) ZA885709B (ko)

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IE882411L (en) 1989-02-19
ES2072856T3 (es) 1995-08-01
EP0304019A2 (en) 1989-02-22
HK18496A (en) 1996-02-09
EP0304019A3 (en) 1990-12-27
DE3853901D1 (de) 1995-07-06
ZA885709B (en) 1989-04-26
AU617347B2 (en) 1991-11-28
KR970008126B1 (ko) 1997-05-21
IE67348B1 (en) 1996-03-20
US4935507A (en) 1990-06-19
CA1297096C (en) 1992-03-10
AU2099888A (en) 1989-02-23
DE3853901T2 (de) 1995-10-12
ATE123221T1 (de) 1995-06-15
EP0304019B1 (en) 1995-05-31

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