KR20190026433A - Composition comprising eutectic mixture of extract of centella asiatica - Google Patents

Abstract

The present invention relates to a composition containing an eutectic mixture of a titrated extract of centella asiatica (TECA). The eutectic mixture includes TECA, butter, a surfactant, a higher alcohol, and a higher fatty acid. According to the present invention, there can be provided a composition of various formulations containing the TECA without a precipitation phenomenon.

Description

A composition comprising a eutectic mixture of Centella asiatica extract (Centella asiatica)

The present invention relates to a composition comprising a Centella asiatica extract.

Centella asiatica is also called centella, centipedes, or tiger herb, and is known as Titrated Extract of Cetella asiatica : TECA) has been used for various purposes in the field of medicine.

Centella asiatica is also called centella, centipedium or tiger herb, and Titrated Extract of Cetella asiatica (TECA) is used for various purposes in the field of medicine.

The centenarius extract contains asiaticoside, madecassic acid and asiatic acid as main ingredients and exhibits skin wounds and chronic ulcer treatment activity. Asian ticosides and acidic acid are involved in the production and secretion of collagen and are known to be effective in regenerating damaged skin and improving the elasticity of the dermis. Recently, there is a growing demand for functional cosmetics as well as pharmaceuticals.

Centella asiatica extracts are generally of high viscosity type and are made into ointment formulations to enhance adhesion to the skin. However, since the main components of the centilla extract are poorly soluble, their solubility in purified water is very low. Therefore, in order to increase the solubility of Centella asiatica extract, it is dissolved in strong polar ethanol and added during the production. However, in the finished formulation, the solubility of Centella asiatica extract decreases and precipitates frequently. To overcome this problem, excessive use of the thickening agent, or keeping the pH of the product at 5.0 or less, or excessive amount of ethanol is added, however, this method is limited to a specific formulation and thus it is difficult to apply it to the manufacture of various formulations.

Therefore, a method of stably maintaining the solubility of TECA in various formulations is required.

A eutectic mixture of Centella asiatica extract is provided.

One aspect provides a eutectic mixture comprising centilla extract, butter, surfactants, higher alcohols and higher fatty acids.

A "eutectic mixture" means a mixture of two or more different components, or a mixture having a constant melting point, i.e., a process (eutectic solution), as if it were a solid compound composed of one component. The eutectic mixture appears to be uniform on the surface as it has a constant melting point, but in reality it may be mixed with a number of finely different crystals.

The eutectic mixture may comprise 2 to 8%, 3 to 7%, 4 to 6%, or about 5% (w / w) of the centilla extract. The centaur extracts were obtained from Titrated Extract ofCetella asiatica: TECA). TECA may contain about 40% of asiaticoside, about 40% of madecassic acid, and about 20% of asiatic acid. The centilla extract may be obtained by diluting TECA with a suitable solvent such as water or ethanol. The centilla extract may be commercially available as a raw material for a pharmaceutical composition or a cosmetic composition. The Kunchuk extract can be easily prepared by an ordinary technician according to the standard of pharmaceuticals of the Food and Drug Administration and the known extract preparation method.

The eutectic mixture may comprise 20 to 60%, 25 to 55%, 30 to 50%, 35 to 45%, or about 40% (w / w) of the butter. The butter may comprise vegetable butter. The vegetable butter may comprise shea butter, cacao butter, mango seed butter, cooassa seed butter, or palm seed butter, or mixtures thereof.

The eutectic mixture may comprise 10 to 40%, 15 to 35%, 20 to 30%, or about 25% (w / w) of the surfactant. The surfactant may comprise glyceryl stearate, phage-40 stearate, phage-100 stearate, polysorbate 60, or glyceryl stearate S, or mixtures thereof.

The eutectic mixture may comprise 5 to 25%, 10 to 20%, or about 15% (w / w) of the higher alcohol. The higher alcohols may include cetyl alcohol, stearyl alcohol, behenyl alcohol, batyl alcohol, or mixtures thereof.

The eutectic mixture may comprise 5 to 25%, 10 to 20%, or about 15% (w / w) of the higher fatty acid. The higher fatty acids may include stearic acid, isostearic acid, myristic acid, or palmitic acid, or mixtures thereof.

Another aspect provides a cosmetic composition comprising the eutectic mixture.

The cosmetic composition of the present invention may be used in cosmetics (skin lotion), skin softener, skin toner, astringent, lotion, milk lotion, moisturizing lotion, nutrition lotion, massage cream, nutritional cream, moisturizer cream, hand cream, foundation, essence, Such as a soap, a cleansing foam, a cleansing lotion, a cleansing cream, a body lotion, a body cleanser, a suspension, a gel, a powder, a paste, a mask pack or a sheet or an aerosol composition. Compositions of such formulations may be prepared according to methods conventional in the art.

The cosmetic composition may contain, in addition to the above-described components, a preservative, a stabilizer, a surfactant, a thickener, a solubilizer, a moisturizer, an emollient, an ultraviolet absorber, an antiseptic, a bactericide, an emulsifier, an antioxidant, a pH adjuster, Or additives commonly used in the art such as, The amount of the additional ingredient such as the preservative may be easily selected by a person skilled in the art within a range not to impair the purpose and effect of the present invention. The amount of the additional ingredient is 0.001 to 30% (w / w) To about 10% (w / w).

Another aspect provides an external composition for skin comprising the eutectic mixture.

The composition for external application for skin may be prepared in any formulations conventionally produced in the art and includes, for example, emulsions, creams, lotions, packs, foundation, lotions, essences, hair cosmetics and the like. Specifically, the present invention relates to a skin lotion, a skin softener, a skin toner, an astringent, a lotion, a milk lotion, a moisturizing lotion, a nutrition lotion, a massage cream, a nutritive cream, a moisturizing cream, a hand cream, a foundation, Foams, cleansing lotions, cleansing creams, body lotions and body cleansers.

The cosmetic composition or the composition for external application for skin may be an aqueous type (O / W) formulation.

The water phase of the composition may comprise 1.0 to 20% (w / w) of a moisturizer, and 0.01 to 5.0% (w / w) of an increasing agent. The moisturizing agent may include glycerin, 1,3-butylene glycol, propylene glycol, pentylene glycol, or a mixture thereof for the purpose of preventing freezing of the continuous phase at a low temperature and helping moisturizing effect. The thickener may be selected from the group consisting of carbomer, guar gum, carrageenan, xanthan gum, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, polyacrylate-13, polyacrylamide, sodium acrylate / sodium acrylate Hydroxyethyl methacrylate / sodium acryloyldimethyltaurate copolymer, or a mixture thereof. The term " copolymer "

The oily portion of the composition may comprise 1.0 to 30.0% (w / w) of emollient oil, 0.1 to 10.0% (w / w) of emulsifier, and 0.1 to 10.0% (w / w) of wax. The emollient oil may include various ester oils, macadamia oil, jojoba oil, various vegetable oils including castor oil, squalane, mineral oil, isohexadecane, silicone oil or a mixture thereof. The emulsifier may be selected from the group consisting of Cetyl Phosphite / Phosphite-10/1 dimethicone, Phage-10 Dimethicone, Stearase-21 and Stearase-2, Polyglyceryl-2 dipolyhydroxystearate, Polyglyceryl- Polyglyceryl-3 methylglucose distearate, glyceryl stearate, phage-40 stearate, phage-100 stearate, polysorbate 60, glyceryl stearate esglyceryl stearate, Or mixtures thereof. The wax may comprise beads wax, candelilla wax, carnauba wax, multi-wax, paraffin wax, microcrystalline wax, ceresin wax or mixtures thereof.

Since the composition contains Centella asiatica extract, it can be used for improving or treating skin damages such as skin moisturization, skin soothing, skin protection, wrinkle improvement, and the like.

In another aspect, there is provided a method for preparing a mixture comprising a centilla extract, butter, a surfactant, a higher alcohol and a higher fatty acid, heating the mixture at 65 to 80 캜, and stirring to obtain a mixture; Cooling the mixture to 45 to 60 DEG C while stirring at 20 to 40 rpm, and further stirring at 4000 to 8000 rpm to obtain a mixture; And cooling the mixture to room temperature while stirring at 20 to 40 rpm.

The cooling may be carried out using a cooling bath or the like maintained at a temperature of 0 ° C to 20 ° C, and cooling may be performed until the mixture reaches a desired temperature regardless of time. The cooling may be accompanied by an appropriate level of agitation of 20 to 40 rpm.

Stirring of the mixture after cooling may be carried out using a mixer of 4000 to 8000 rpm and may be carried out until the mixture is sufficiently mixed, such as 1 minute to 30 minutes, 2 minutes to 20 minutes, or 3 minutes to 10 minutes have.

Eutrophic mixtures comprising centella ash extract, butter, surfactants, higher alcohols and higher fatty acids can provide a wide variety of formulations containing it without precipitation.

Figs. 1A, 1B and 1C are photographs showing the appearance of an O / W cosmetic composition comprising Comparative Example 5, Comparative Example 6 and Example 18, respectively.
Figures 2a, 2b and 2c are microscope images showing the precipitation phenomenon of the O / W cosmetic composition comprising Comparative Example 5, Comparative Example 6 and Example 18, respectively.

Hereinafter, the present invention will be described in more detail with reference to examples. However, these examples are for illustrative purposes only, and the scope of the present invention is not limited to these examples.

One. Butter , Surfactants, higher alcohols and higher fatty acids Eutectic  Preparation of mixture

Butylers, surfactants, higher alcohols and higher fatty acids were added to TECA to prepare eutectic compounds. Specifically, a eutectic mixture containing TECA was produced according to the following steps (a) to (c) using various butter, surfactant, higher alcohol and higher fatty acid with the composition shown in Tables 1-4 below Respectively. The composition of each component in Table 1-4 depends on the weight%.

(a) Each component was mixed and heated (70 ~ 75 ° C) and homogeneously mixed using an ultra homomixer (PRIMIX, Homomix marker II 2.5).

(b) The mixture obtained in (a) was cooled (50-55 ° C) while stirring at 25 rpm in a cooling bath maintained at 10 ° C, and then homogeneously mixed at 6,000 rpm for 5 minutes using an ultra homomixer.

(c) The mixture obtained in (b) was cooled (30 캜) while stirring at 25 rpm in a cooling bath maintained at 10 캜 to obtain a eutectic mixture.

Preparation of Eutectic Mixtures by Butter Exchange ingredient Comparative Example 1 Example 1 Example 2 Example 3 Example 4 Example 5 TECA 5.0 5.0 5.0 5.0 5.0 5.0 Sheer butter ㅡ 40.0 ㅡ ㅡ ㅡ ㅡ Cacao butter ㅡ ㅡ 40.0 ㅡ ㅡ ㅡ Mango seed butter ㅡ ㅡ ㅡ 40.0 ㅡ ㅡ Copoic acid seed butter ㅡ ㅡ ㅡ ㅡ 40.0 ㅡ Palm seed butter ㅡ ㅡ ㅡ ㅡ ㅡ 40.0 Glyceryl stearate 10.0 10.0 10.0 10.0 10.0 10.0 FAGE -100 stearate 15.0 15.0 15.0 15.0 15.0 15.0 Cetearyl alcohol 15.0 15.0 15.0 15.0 15.0 15.0 Stearic acid 15.0 15.0 15.0 15.0 15.0 15.0

As a result of the preparation, a composition in the form of a pale yellow opaque wax was obtained in Examples 1-5, while in Comparative Example 1, each TECA was precipitated and a separated composition was obtained.

Preparation of Eutectic Mixtures by Surfactant Replacement ingredient Comparative Example 2 Example 6 Example 7 Example 8 Example 9 TECA 5.0 5.0 5.0 5.0 5.0 Sheer butter 40.0 40.0 40.0 40.0 40.0 Glyceryl stearate ㅡ 10.0 ㅡ ㅡ ㅡ FAGE -100 stearate ㅡ 15.0 10.0 ㅡ ㅡ FAGE-40 stearate ㅡ ㅡ 15.0 10.0 Polysorbate 60 ㅡ ㅡ ㅡ 15.0 10.0 Glyceryl stearate S ㅡ ㅡ ㅡ ㅡ 15.0 Cetearyl alcohol 15.0 15.0 15.0 15.0 15.0 Stearic acid 15.0 15.0 15.0 15.0 15.0

As a result of the preparation, in Example 6-9, a composition in the form of a pale yellow opaque wax was obtained, while in Comparative Example 2, a composition in which TECA was precipitated was obtained.

Manufacture of eutectic mixtures by replacement of higher alcohols and higher fatty acids ingredient Comparative Example 3 Example 10 Example 11 Example 12 Example 13 TECA 5.0 5.0 5.0 5.0 5.0 Sheer butter 40.0 40.0 40.0 40.0 40.0 Glyceryl stearate 10.0 10.0 10.0 10.0 10.0 FAGE -100 stearate 15.0 15.0 15.0 15.0 15.0 Cetearyl alcohol ㅡ 15.0 ㅡ ㅡ ㅡ Stearyl alcohol ㅡ ㅡ 15.0 ㅡ ㅡ Behenyl alcohol ㅡ ㅡ ㅡ 15.0 ㅡ Butyl alcohol ㅡ ㅡ ㅡ ㅡ 15.0 Stearic acid 15.0 15.0 15.0 15.0 15.0

As a result of the preparation, a composition in the form of a pale yellow opaque wax was obtained in Examples 10-13, while in Comparative Example 3, a composition in which TECA was precipitated was obtained.

Preparation of Eutectic Mixtures by High Fatty Acid Exchange ingredient Comparative Example 4 Example 14 Example 15 Example 16 Example 17 TECA 5.0 5.0 5.0 5.0 5.0 Sheer butter 40.0 40.0 40.0 40.0 40.0 Glyceryl stearate 10.0 10.0 10.0 10.0 10.0 FAGE -100 stearate 15.0 15.0 15.0 15.0 15.0 Cetearyl alcohol 15.0 15.0 ㅡ ㅡ ㅡ Stearic acid ㅡ 15.0 ㅡ ㅡ ㅡ Isostearic acid 15.0 ㅡ ㅡ Myristic acid 15.0 ㅡ Palmitic acid 15.0

As a result of the preparation, a composition in the form of a pale yellow opaque wax was obtained in Examples 14-17, while in Comparative Example 4, a composition in which TECA was precipitated was obtained.

2. Manufacture of O / W emulsion

The O / W skin external application was prepared by applying a TECA eutectic mixture with the composition shown in Table 5 below. The preparation method thereof is shown in (a) to (e) below.

Manufacture of O / W skin external application using TECA eutectic mixture Comparative Example 5 Comparative Example 6 Example 18 Water phase Purified water To 100 To 100 To 100 EDTA-2Na 0.02 0.02 0.02 glycerin, 5.00 5.00 5.00 1.3 Butylene glycol, 5.00 5.00 5.00 Propylene glycol, 5.00 5.00 5.00 Pentyleneglycol 1.50 1.50 1.50 Xanthan gum 0.01 0.01 0.01 Carbomer 0.20 0.20 0.20 Triethanolamine 0.20 0.20 0.20 Meteor show Squalane 4.00 4.00 4.00 Isohexadecane 3.00 3.00 3.00 silicon 3.00 3.00 3.00 Hydrogenated poly (C6-14 olefin) 3.00 3.00 3.00 Caprylic / capric triglyceride 2.00 2.00 2.00 Carnauba wax 0.40 0.40 0.40 Three tilipies / piperazine-10/1 dimethicone 0.40 0.40 0.40 Phage-30 dipolyhydroxystearate 0.40 0.40 0.40 Polyglyceryl-3 polylynicollate 0.40 0.40 0.40 Polyglyceryl-2 dipolyhydroxystearate 0.40 0.40 0.40 TECA 1.00 ㅡ ㅡ Sheer butter 8.00 ㅡ ㅡ Glyceryl stearate 2.00 ㅡ ㅡ FAGE -100 stearate 3.00 ㅡ ㅡ Cetearyl alcohol 3.00 ㅡ ㅡ Stearic acid 3.00 ㅡ ㅡ The eutectic mixtures (Comparative Examples 1 to 4) ㅡ 20.00 ㅡ The eutectic mixture (Examples 1-17) 20.00 antiseptic Phenoxyethanol 0.20 0.20 0.20 Spices Spices Suitable amount Suitable amount Suitable amount

(a) The aqueous phase components of Table 5 were mixed and heated (70-75 占 폚) and mixed uniformly to obtain a mixture.

(b) The oily phase components of Table 5 were mixed and heated (70 to 75 ° C) and then mixed uniformly to obtain a mixture.

(C) The mixture of (b) was added to the mixture of (a) and uniformly mixed.

(d) The mixture obtained in (c) was cooled (at 45 캜), and preservatives and perfumes were added thereto and mixed uniformly.

(e) The mixture obtained in (d) was cooled to 30 占 폚.

FIGS. 1A, 1B, and 1C are photographs showing the appearance of an O / W cosmetic composition comprising Comparative Example 5, Comparative Example 6, and Example 18, FIGS. 2A, 2B, and 2C are photographs of Comparative Example 5, 6 and Example 18 show that the O / W cosmetic composition exhibited the precipitation phenomenon. As a result of the preparation, Comparative Example 5 was prepared by adding a simple mixture of TECA, butter, surfactant, higher alcohol and higher fatty acid to the oil phase, and precipitation occurred in about one week and it was confirmed that TECA did not dissolve .

 Comparative Example 6 was prepared by adding any one of Comparative Examples 1-4 to an oil phase, and precipitation of TECA was observed at 4 ° C, 25 ° C, 37 ° C and 45 ° C within 4 weeks.

Example 18 was prepared by adding any one of the eutectic mixtures prepared in Examples 1 to 17 to the oil phase, and observation was made that there was no precipitation at 4 DEG C, 25 DEG C, 37 DEG C and 45 DEG C for 8 weeks.

Claims (9)

Eutectic mixture comprising centilla extract, butter, surfactant, higher alcohol and higher fatty acid. 2. The eutectic mixture according to claim 1, wherein the centilla extract is a Titrated Extract of Cetella asiatica (TECA). The method of claim 1,
2 to 8% (w / w) centipede extract;
30 to 50% (w / w) of butter;
15 to 35% (w / w) of a surfactant;
5 to 25% (w / w) higher alcohol; And
And 5 to 25% (w / w) of a higher fatty acid. 2. The eutectic mixture according to claim 1, wherein the butter comprises at least one of shea butter, cacao butter, mango seed butter, copoic acid butter, or palm seed butter. The eutectic mixture according to claim 1, wherein the surfactant comprises at least one of glyceryl stearate, phage-40 stearate, phage-100 stearate, polysorbate 60, or glyceryl stearate S. The eutectic mixture according to claim 1, wherein the higher alcohol comprises at least one of cetyl alcohol, stearyl alcohol, behenyl alcohol, or butyl alcohol. The eutectic mixture according to claim 1, wherein the higher fatty acid comprises at least one of stearic acid, isostearic acid, myristic acid, or palmitic acid. The composition for external application for skin comprising the eutectic mixture of claim 1. (a) mixing the centilla extract, butter, surfactant, higher alcohol and higher fatty acid, heating to 65 to 80 캜, and stirring to obtain a mixture;
(b) cooling the mixture obtained in step (a) to 45 to 60 占 폚 while stirring at 20 to 40 rpm, and further stirring at 4000 to 8000 rpm to obtain a mixture;
(c) cooling the mixture obtained in step (b) to room temperature while stirring at 20 to 40 rpm.

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