KR101460777B1 - Cosmetic composition for improving acne - Google Patents

Abstract

The present invention relates to a cosmetic composition for improving acne. The cosmetic composition for improving acne includes sulfur and dimethysulfone as an active ingredient, and the sulfur and dimethylsulfone are in a weight ratio of 1: 1.

Description

COSMETIC COMPOSITION FOR IMPROVING ACNE <br> <br> <br> Patents - stay tuned to the technology COSMETIC COMPOSITION FOR IMPROVING ACNE

The present invention relates to a cosmetic composition for improving acne. More particularly, the present invention relates to a cosmetic composition for improving acne which contains sulfur and dimethysulfone at a specific weight ratio and has an excellent effect of improving skin troubles such as acne.

Acne is a chronic, intractable, inflammatory skin disease that occurs in the sebaceous glands around the hair follicles and hair follicles. Although the exact cause of such acne is not known, it is known that the increase in sebum secretion due to hormone abnormalities, follicular stenosis, Reactions are known to be the main causes. Therefore, acne is common on face, scalp, neck, chest, back, upper and shoulders where sebaceous glands are concentrated.

Specifically, the cause of acne due to hormone abnormality is that it begins to be secreted in puberty, and when androgen hormone, which normally plays a role in enlarging sebaceous glands, is excessively stimulated and abnormally increased sebum secretion is used as an energy source of bacteria And it is known that it leads to the proliferation of acne bacteria and causes acne. Propionibacterium acnes, which resides in the hair follicle, is a major cause of acne while growing on sebum. It does not cause problems when it is normally present on the skin. However, when the hair follicles become clogged and sebum accumulates in the hair follicles, I grow up quickly. This bacterium breaks down into free fatty acids after eating fat. Such chemical changes break down the pH balance of the skin surface, alkalizing the weakly acidic pH of the healthy skin, which eventually deteriorates the skin's own function and causes a vicious cycle of the skin.

Common methods of treating acne include reducing sebum secretion, softening hair follicles and keratin so that they do not harden, reducing the number of bacteria in hair follicles, and preventing acne from developing into inflammation. For the treatment of acne, medicines in the form of oral or topical agents are used. For example, anticancer drugs such as anticancer drugs such as anticancer drugs, antimetabolites for inhibiting the production of sebum using antihistamines, steroid hormones and nonsteroidal antiinflammatory agents, And erythromycin. Also, there are tretinoin and adrenalin, which are skin regenerating ointment agents, which have a function of peeling the keratin to release the sebum, and benzoyl peroxide, which has a strong antimicrobial agent and few antibacterial and anti-inflammatory action. Retinoid is a vitamin A-derived substance that affects the skin in various ways. Retinoids reduce the production of sebum, normalize the removal and growth of skin cells in the hair follicle, and decrease the propionibacterium acnes to improve all the causes of acne. However, it may cause side effects such as lips and oral mucous membranes to dry out, palatal exfoliation of the palms, or itching of the whole body, and excessive use during pregnancy may cause malformation.

In the field of cosmetics, methods of removing skin exfoliation and inhibiting acne bacterium have been mainly used by adding components such as resorcinol, sulfur, salicylic acid, and benzoyl peroxide. However, when these components are added in excess, skin irritation and easily dry side effects are liable to occur. In the case of resorcinol and salicylic acid, the blending limit is determined, and a component such as benzoyl peroxide is designated as a blending-inhibiting component in Korea .

It is an object of the present invention to provide a cosmetic composition for improving acne which is excellent in antibacterial and anti-inflammatory properties.

Another object of the present invention is to provide a cosmetic composition for improving acne which is excellent in stability and harmless to human body.

It is still another object of the present invention to provide a cosmetic composition for improving acne with excellent feeling in use.

It is still another object of the present invention to provide a cosmetic composition for improving acne without skin irritation.

Still another object of the present invention is to provide a cosmetic composition for improving acne excellent in stability.

One aspect of the present invention relates to a cosmetic composition for improving acne. The cosmetic composition comprises sulfur and dimethysulfone as an active ingredient, and the sulfur and dimethysulfone are in a weight ratio of 1: 1.

The sulfur and dimethysulfone are contained in the cosmetic composition in an amount of 0.5 to 25% by weight.

In one embodiment, the composition further comprises squalane.

The composition may further comprise at least one of a thickener, a moisturizer, a pH adjuster, an emulsifier, a pigment, a flavoring, a preservative and a solvent.

The composition may be in the form of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray .

The composition can be used in a wide variety of applications including oil-in-water (O / W), water-in-oil (W / O), water- O) and water-in-oil-in-water (W / O / W).

The cosmetic composition according to the present invention is excellent in antibacterial and anti-inflammatory properties, has no irritation to the skin, has excellent stability and is harmless to the human body and has excellent feeling of use, and can be particularly useful in the production of cosmetics for improving acne.

Fig. 1 (a) is a photograph before applying the cosmetic composition according to the present invention (Example 2) to the right ball, Fig. 1 (b) This is a picture of the degree of acne improvement after PSI WELL-BEING JANUS.
FIG. 2 (a) is a photograph before applying the cosmetic composition (Example 2) according to the present invention to the forehead, and FIG. 2 (b) is a photograph showing an acne improvement after applying the composition according to the present invention PSI WELL-BEING JANUS.

In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory and are intended to be exemplary, self-explanatory, allowing for equivalent explanations of the present invention.

One aspect of the present invention relates to a cosmetic composition for improving acne. The cosmetic composition includes sulfur and dimethysulfone.

As the sulfur, a conventional one can be used. For example, insoluble powder type sulfur can be used. In the present invention, the sulfur has excellent antimicrobial and anti-inflammatory effects and can impart excellent acne improvement effect.

In one embodiment, the sulfur may be added to the formulation in a form dispersed in a specific phase (an aqueous phase containing a polyol or an oil phase).

As the above-mentioned dimethysulfone, a conventional one can be used. For example, pine, seaweed, and green algae can be used. In the present invention, the dimethylsulfone has excellent antimicrobial and anti-inflammatory properties, and can exert excellent acne improvement effect.

In one embodiment, the dimethysulfone may be included in the formulation by dissolving it in an aqueous phase.

In one embodiment, the sulfur and dimethysulfone may be included in the cosmetic composition at a weight ratio of 1: 1. When the two components are included at the same weight ratio, skin irritation and dryness can be minimized more than the formulations independently comprising sulfur or dimethylsulfone, and when included at a weight ratio outside the scope of the present invention, The synergy effect is reduced, and the antibacterial and anti-inflammatory effect and the acne improvement effect may be lowered.

The sulfur and dimethysulfone may be included in an amount ranging from 0.5 to 25% by weight based on the total weight of the composition. And preferably from 1 to 20% by weight. More preferably 5 to 20% by weight. Within the above range, it is possible to expect the acne improvement effect promoted without skin irritation without inhibiting the feeling of use of the cosmetic composition for improving acne.

The cosmetic composition for improving acne may further comprise squalan (C ₃₀ H ₆₂ ). In the present invention, the squalane can be prepared by a conventional method. For example, squalene, which is an unsaturated hydrocarbon (C ₃₀ H ₅₀ ) contained in deep sea shark liver oil, olive oil, yeast, etc., is saturated with hydrogen in an aqueous solution can be used. When the squalane is contained, the composition provides excellent cell regeneration and cell activating effects while supplying oxygen and nutrients, and the composition can excellently improve the acne of the composition.

In one embodiment, the squalane may be included in an amount ranging from 0.01 to 10% by weight based on the total weight of the composition. Preferably 0.5 to 5% by weight. More preferably 1 to 4% by weight. Within the above range, it is possible to expect the acne improvement effect promoted without skin irritation without inhibiting the feeling of use of the cosmetic composition for improving acne.

The cosmetic composition for acne improvement may further contain components included in a conventional cosmetic composition in addition to the components described above. For example, it may further include one or more ingredients listed in the list of cosmetic ingredients registered in the Food and Drug Administration and ICID (International Cosmetic Ingredient Collection). Specifically, it may further include at least one of an increasing agent, a moisturizing agent, a pH adjusting agent, an emulsifying agent, a pigment, a flavoring agent, an antiseptic agent or a solvent.

The above-mentioned thickener may be any conventional one. For example, carbomer, acrylate, ammonium acryloyldimethyltaurate / Vpicopolymer, acrylate / C10-30 alkyl acrylate crosspolymer, xanthan gum and cellulose gum can be used.

As the moisturizing agent, a conventional one can be used. For example, there may be mentioned butylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, diglycerin, propanediol, 1,2- hexanediol, sodium hyaluronate, urea and trehalose trehalose and the like can be used.

As the pH adjusting agent, a conventional one may be used. For example, organic acids such as citric acid, succinic acid, tartaric acid, lactic acid, malic acid, fumaric acid, maleic acid and glycolic acid, inorganic acids such as hydrochloric acid, sulfuric acid, phosphoric acid and nitric acid, sodium salts, potassium salts or ammonium salts of these acids, Or a mixture of two or more thereof. It may further contain triethanolamine, sodium chloride, sodium hydroxide, potassium hydroxide, and the like.

Conventional emulsifiers may be used. For example, it is possible to use polyoxyethylene sorbitan monolaurate, polyethylene glycol and phage-hydrogenated castor oil, and it is preferable to use twin 20 which is polyoxyethylene sorbitan monolaurate and lipophilic surfactant Pigment-60 Hydrogenated castor oil can be mixed and used.

Organic and inorganic pigments conventionally used may be used as the coloring matter. For example, muscovite, synthetic mica, roughness, kaolin, titanium dioxide, titanium oxide coated mica, aluminum powder, sulfur iron oxide, black iron oxide, barium sulfate and the like can be used.

The fragrance may be any of those commonly used in cosmetic compositions.

The preservative may be any conventional one. For example, benzoic acid, paraoxybenzoic acid ester, a mixture of methylchloroisothiazolinone, phenoxyethanol, Methylparaben, ethylparaben or propylparaben can be used.

The solvent may be any conventional one. For example, purified water, ethanol, cyclomethicone or dimethicone can be used.

The cosmetic composition of the present invention may further include known natural extracts, vitamin derivatives, sequestering agents and the like, which are known to moisturize and soothe skin, in addition to the above-mentioned components.

In addition, the cosmetic composition of the present invention can be prepared into any formulation conventionally produced in the art. For example, they may be formulated as solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations and sprays, But is not limited thereto. More specifically, the present invention relates to a cosmetic composition comprising: a softening lotion, a nutritional lotion, a nutritive cream, a massage cream, an essence, an eye cream, a cleansing cream, a cleansing foam, a cleansing water, a pack, a spray, a powder, a fact, a lip gloss, a lipstick, . &Lt; / RTI &gt; (O / W), water-in-oil (W / O), water-in- W / O) and water-in-oil-in-water (W / O / W)

When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters.

Hereinafter, the configuration and operation of the present invention will be described in more detail with reference to preferred embodiments of the present invention. However, the following examples are provided to aid understanding of the present invention, and the scope of the present invention is not limited to the following examples. The contents not described here are sufficiently technically inferior to those skilled in the art, and a description thereof will be omitted.

Examples and Comparative Examples

Production Example 1. Preparation of sulfur dispersion

A solution containing 4 g of polyol (butylene glycol) and 86 g of purified water was heated to about 70 캜, and 10 g of sulfur powder having a powdery and insoluble properties was added to the warmed solvent, followed by the use of a cavitation mixer And dispersed at 2000 rpm for about 10 minutes to obtain a dispersion.

Manufacturing example  2. Dimethysulfone ( Dimethyl Sulfone ) Preparation of solution

4 g of butylene glycol and 86 g of purified water was heated to about 70 DEG C and 10 g of dimethysulfone having the water-soluble property of powder phase was added to the warmed solvent, followed by the use of a cavitation mixer And dissolved at 2000 rpm for about 10 minutes to obtain a solution.

Test Example 1: Measurement of antibacterial activity

The sulfur dispersions and dimethysulfone dissolution solutions prepared in Preparation Example 1 and Preparation Example 2 were mixed in the proportions shown in Table 1 below to prepare sulfur compounds to prepare Propionibacterium acnes, The antimicrobial activity against Staphylococcus aureus and Staphylococcus epidermidis was measured. At this time, the mixing ratios in Table 1 were set as the ratio of sulfur and dimethylsulfone contained in the sulfuric acid dispersion solution and dimethysulfone dissolution solution.

The antimicrobial activity of the test strain was measured by placing a disc on which a sulfur solution and a dimethylsulfone solution were placed on a solid agar medium coated with the test strains. The antimicrobial activity was measured by comparing the sizes of the transparent rings around the disk using the paper disc method, and the results are shown in Table 1 below.

Mixture ratio of sulfur and dimethyl sulfone P. acnes inhibition S. aureus inhibition S. epidermidis inhibitory activity 1: 1 +++ +++ +++ 1: 2 ++ +++ ++ 1: 3 ++ + + 2: 1 +++ +++ ++ 3: 1 +++ ++ ++ -: Transparency can not be formed, - +: Strain grows after transparency formation, +: Creation of weak transparency ++: Strong transparency formation, +++:

In Table 1, it was confirmed that the best antimicrobial effect was obtained when sulfur and dimethylsulfone dissolving solution were blended at a ratio of 1: 1.

Examples 1 to 4 and Comparative Examples 1 to 7

Using the sulfur dispersion and dimethysulfone solution prepared above, a cosmetic composition for the improvement of acne having a water-in-oil formulation was prepared so as to have the components and composition ratios shown in Table 2 below.

Ingredient / content
(Unit: wt%) Comparative Example Example One 2 3 4 5 6 7 One 2 3 4 sulfur - 10.0 - 5.0 5.0 15.0 10.0 2.5 5.0 10.0 5.0 Dimethysulfone - - 10.0 10.0 15.0 5.0 5.0 2.5 5.0 10.0 5.0 Squalane 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 - Glyceryl stearate, phage-100 stearate 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Cetearyl alcohol 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 1.5 Dipropylene glycol 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Caprylic /
Capric triglyceride 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 1.0 Allantoin 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 1,2-hexanediol 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 2.0 Dimethicone 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Xanthan gum 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Titanium dioxide 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Tocopheryl acetate 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Disodium iodide 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Butylene glycol 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Sodium hyaluronate 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Purified water 82.88 72.88 72.88 67.88 62.88 62.88 67.88 77.88 72.88 62.88 64.88 Sum 100 100 100 100 100 100 100 100 100 100 100

Test Example  2: skin irritation test

In order to evaluate skin irritation tests for Comparative Examples 1 to 7 and Examples 1 to 4, a skin patch test was conducted to evaluate skin irritation. The subjects were selected as persons without skin disease at the test sites of 15 to 30 years old and were performed on 16 persons. The upper part of the information area was wiped with 70% ethanol and dried. Then, 0.1 g of each of Comparative Examples 1 to 7 and Examples 1 to 4 was applied to the upper part of the human body for 24 hours, and the skin reaction was visually observed within 1 hour And 48 hours later. Skin response determinations were made according to the following test criteria. The skin patch test results are shown in Table 3 below.

* Skin reaction test standard

-: no response

±: weak positive reaction (erythema)

+: Positive reaction (erythema)

++: Strong positive reaction (erythema, edema)

Prescription Number of test persons (persons) Judgment result - ± + ++ +++ Example 1 16 16 - - - - Example 2 16 16 - - - - Example 3 16 14 2 - - - Example 4 16 15 One - - - Comparative Example 1 16 14 One One - - Comparative Example 2 16 11 2 3 One - Comparative Example 3 16 12 2 One - - Comparative Example 4 16 12 2 2 - - Comparative Example 5 16 12 3 One - - Comparative Example 6 16 11 One 2 One One Comparative Example 7 16 14 One One - -

Referring to Table 3, Examples 1 to 4 according to the present invention showed less skin irritation than Comparative Examples 1 to 7.

Test Example  3: Evaluation of acne improvement effect

Comparative Examples 1 to 7 and Examples 1 to 4 were evaluated for the effect of improving acne. A group of 20 subjects were selected as the subjects, and foreheads or balls with a high frequency of acne were selected, and the same subjects were allowed to use Comparative Examples 1 to 7 on the left side and Examples 1 to 4 on the right side after evening cleansing three times a week , And the degree of healing of acne was evaluated after 3 weeks. The results are shown in Table 4, Figs. 1 and 2.

division very good satisfied usually Slightly dissatisfied dissatisfaction Example 1 Number of respondents (persons) 9 8 3 0 0 % 45 40 15 0 0 Example 2 Number of respondents (persons) 9 9 2 0 0 % 45 45 10 0 0 Example 3 Number of respondents (persons) 10 3 6 One 0 % 50 15 30 5 0 Example 4 Number of respondents (persons) 8 6 5 One 0 % 40 30 25 5 0 Comparative Example 1 Number of respondents (persons) 0 One 5 8 6 % 0 5 25 40 30 Comparative Example 2 Number of respondents (persons) 0 One 5 5 9 % 0 5 25 25 45 Comparative Example 3 Number of respondents (persons) One 5 2 8 4 % 5 25 10 40 20 Comparative Example 4 Number of respondents (persons) 0 2 6 6 6 % 0 10 30 30 30 Comparative Example 5 Number of respondents (persons) 0 2 4 7 7 % 0 10 20 35 35 Comparative Example 6 Number of respondents (persons) 0 One 6 4 9 % 0 5 30 20 45 Comparative Example 7 Number of respondents (persons) 0 One 3 8 8 % 0 5 15 40 40

Fig. 1 (a) is a photograph before applying the cosmetic composition according to the present invention (Example 2) to the right ball, Fig. 1 (b) This is a picture of the degree of acne improvement after PSI WELL-BEING JANUS.

2 (a) is a photograph before applying the cosmetic composition (Example 2) according to the present invention to the forehead, and Fig. 2 (b) is a photograph after applying the cosmetic composition (Example 2) This is a picture taken by PSI WELL-BEING JANUS for the improvement of acne.

Referring to FIGS. 1 (a) to 1 (b), 2 (a) to 2 (b) and Table 4, when the cosmetic compositions of Examples 1 to 4 were used as compared with Comparative Examples 1 to 7, .

Test Example 4: Evaluation of stability

In order to measure the stability with respect to the degree of separation and discoloration of Comparative Examples 1 to 7 and Examples 1 to 4, the temperature was maintained at 45 占 폚 and 25 占 폚 constantly, in a refrigerator kept constant at 4 占 폚, The cosmetic packs of Comparative Examples 1 to 7 and Examples 1 to 4 were placed in a sample container and stored for 8 weeks. The degree of discoloration and discoloration were measured and the results are shown in Table 5 below. The degree of separation and discoloration of the product was classified into the following six grades and evaluated.

* Separation and discoloration evaluation criteria

0: No change 1: Very little separation (discoloration) 2: Little separation (discoloration)

3: Severely separated (discolored) 4: Severely separated (discolored) 5: Severely separated (discolored)

Evaluation items Degree of separation and discoloration Comparative Example Example One 2 3 4 5 6 7 One 2 3 4 45 ° C 0 2 0 2 2 4 3 0 One 2 One 25 ℃ 0 One 0 0 One One One 0 0 One 0 4 ℃ 0 0 0 0 0 0 0 0 0 0 0 daylight 0 0 0 0 0 0 0 0 0 0 0

Referring to Table 5, Examples 1 to 4 showed less discoloration and separation phenomena than Comparative Examples 1 to 7, indicating excellent stability.

When the results of Test Examples 1 to 4 are summarized, the skin moisturizing, soothing and improving effects of acne are largely deteriorated when the essential ingredients of the present invention are not included or included in the content ranges of the present invention, The feeling of use was also lowered.

Claims (6)

Sulfur, and dimethylsulfone as active ingredients,
Wherein the sulfur and dimethysulfone are in a weight ratio of 1: 1.
The cosmetic composition for improving acne according to claim 1, wherein the sulfur and dimethyl sulfone are contained in the cosmetic composition in an amount of 0.5 to 25% by weight.
The cosmetic composition for acne improvement according to claim 1, wherein the composition further comprises squalane.
The cosmetic composition for improving acne according to claim 1, wherein the composition further comprises at least one selected from the group consisting of a thickener, a moisturizer, a pH adjuster, an emulsifier, a pigment, a flavor, a preservative and a solvent.
The composition of claim 1, wherein the composition is a solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation and spray &Lt; / RTI &gt; wherein the composition has a formulation selected from the group consisting of: &lt; RTI ID = 0.0 &gt;
The composition of claim 1, wherein the composition is selected from the group consisting of Oil-in-Water (O / W), Water-in-Oil (W / O), Water- Wherein the cosmetic composition is an oil (O / W / O) and water-in-oil-in-water (W / O / W) formulation.

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