KR20150051751A - Composition for treating hair or scalp to prevent hair loss - Google Patents

Abstract

The present invention relates to a composition for preventing hair loss and treating a scalp disease, and is effective for preventing hair loss, promoting hair growth, and treating scalp disease by the combined action of herbal medicine extracts such as apricot seeds, ≪ / RTI >
The composition of the present invention is excellent in the effect of alleviating hair loss and improving the symptoms of seborrheic dermatitis, so that it can be widely applied to the treatment of diseases appearing on the scalp. Also, the stickiness and the smell are relatively small, and the user's sense of rejection can be minimized.

Description

TECHNICAL FIELD The present invention relates to a composition for preventing hair loss and for treating a scalp disease.

The present invention relates to a composition for preventing hair loss and treating a scalp disease, and is effective for preventing hair loss, promoting hair growth, and treating scalp disease by the combined action of herbal medicine extracts such as apricot seeds, ≪ / RTI >

The human body has about 100,000 to 150,000 hairs, and each hair grows through anagen, catagen, and telogen, and falls off. It takes 3 to 6 years to complete the circulation cycle after eliminating the circulation through each step. In general, alopecia is a phenomenon in which the number of hair dropping from the scalp per day is suddenly or gently reduced when the number of hair is larger than the number of new hair.

The cause of hair loss is caused by excessive production of dihydrotestosterone in the scalp, resulting in deterioration of hair follicle function, blood circulation disorder, nutritional imbalance, stress caused by chemical substances in scalp, psychological stress, disease, and seborrheic dermatitis And a variety of other scalp disorders such as the function of the scalp is to reduce the function.

Testosterone, one of the male hormones, is converted to dihydrotestosterone by the action of an enzyme called 5α-reductase, which is known to promote alopecia. Therefore, it is known that dihydrodestosterone Products that prevent hair loss have been developed through the effect of inhibiting production. From this point of view, although a therapeutic agent for male pattern baldness has been developed using finasteride, which has been used as a treatment for male prostate, there are side effects such as sexual dysfunction and hepatic dysfunction, and the cause of hair loss in recent years is hair loss caused by genetic factors The ratio decreases, and the rate of hair loss of various acquired factors increases. Therefore, it is difficult to expect the hair loss treatment to be effective by the inhibition of 5α-reductase single enzyme.

In this regard, Korean Patent Publication No. 2008-0031583 discloses a hair growth composition containing green tea, apricot seed, omija, and extract extract. In Korean Patent No. 0929880, And black beans as an active ingredient. However, there are no products that can completely prevent hair loss, and there is a need to continuously study hair loss prevention.

Accordingly, the present inventors have made efforts to provide a composition having the effect of preventing hair loss, promoting hair growth, and improving scalp disease. As a result, it has been found that when the herbal extract of apricot seeds, horseradish, And the therapeutic effect of the scalp disease, thereby completing the present invention.

Accordingly, it is an object of the present invention to provide a composition exhibiting hair loss prevention, hair growth promotion, and scalp disease improving effect.

In order to achieve the above object, the present invention provides a composition for preventing hair loss and treating scalp disease comprising herbal medicine extracts containing apricot seeds, horseradish, mackerel and walnuts, and a fermentation liquid of walnut suture extract.

In a preferred embodiment of the present invention, the composition for preventing hair loss and scalp disease according to the present invention may comprise 1 to 50 parts by weight of the fermentation liquid of the walnut suture extract, based on 100 parts by weight of the herbal medicine extract.

In addition, the herbal medicine extract may contain 30 to 50 parts by weight of horseradish, 50 to 80 parts by weight of papaya, and 1 to 20 parts by weight of walnuts, based on 100 parts by weight of apricot seeds.

In addition, the herbal medicine extract may further contain 30 to 50 parts by weight per 100 parts by weight of apricot seeds.

The herbal medicine extract may further contain 70 to 100 parts by weight of persimmon leaf to 100 parts by weight of apricot seeds.

The composition of the present invention is excellent in the effect of alleviating hair loss and improving the symptoms of seborrheic dermatitis, so that it can be widely applied to the treatment of diseases appearing on the scalp. Also, the stickiness and the smell are relatively small, and the user's sense of rejection can be minimized.

Hereinafter, the present invention will be described in detail. Prior to this, terms and words used in the present specification and claims should not be construed as limited to ordinary or dictionary terms, and the inventor should appropriately interpret the concepts of the terms appropriately It should be interpreted in accordance with the meaning and concept consistent with the technical idea of the present invention based on the principle that it can be defined. Therefore, the constitutions described in the embodiments described herein are merely the most preferred embodiments of the present invention, and are not intended to represent all of the technical ideas of the present invention. Therefore, various equivalents which can be substituted at the time of application It should be understood that variations can be made.

The composition for preventing hair loss and treating scalp disease of the present invention includes herbal medicine extracts including apricot seeds, horseradish, mulberry leaves and walnuts, and fermentation liquid of walnut suture extract.

The apricot seed is a seed of an apricot tree, and the apricot tree It is a deciduous arboreous tree cultivated in various places. It grows about 5m in length and its leaves are alternate, ovate or oval. The bottom of the leaf is round, the tip is sharp and sharp, the edge is sharp, the flower is pink, the flower is bloomed in April, the petal is round, the stamen is large, and the pistil is one. The fruit of apricot is spherical nucleus, and there is chorion, and it ripens in yellow in June. Apricot is also known as a passerine, and it contains unsaturated fatty acids and various skin-friendly ingredients, which are effective in preventing dullness and freckles. Especially, the extract oil of apricot seeds has been used for skin whitening since ancient times, and has antibacterial anti-inflammatory function, which is also effective for oily skin.

The Hassuo is a perennial vine of Chinese origin and is native to the wilderness of Korea and contains as main components anthraquinolide such as cresophorol, emodine, lane, cision, crysopanol, anthrone and the like. It also contains a large number of starches, fats and lecithin, and exists in two forms, emodimin and psicin, free and glycoside, and 2,3,4,5'-tetrahydroxystilbene-2-0-0-beta -D-glucoside and the like.

The hyphae are the leaves of a periwinkle tree, and the periwinkle (Thujaorientalis) is an evergreen tree belonging to the Cupressaceae. The leaves and branches of the periwinkle are sun-dried, and the perilla leaf has been used as a moisturizing agent, a hemostatic agent, or in the treatment of large intestine. It contains juniperic acid, thujone, mayurone, sabinic acid, saponin, alkaloids and vitamins, and it has a function of bleeding and haemostasis. .

On the other hand, walnut is a fruit of walnut tree ( Juglans sinensis ), which is a deciduous tree of the pine tree. Surgical blood is green in meat quality, and the intracranial part is not broken by very hard bone. The nucleus is obovate, yellowish brown, the surface has many wrinkles along the bongline, and there are four inside the nucleus. Seed is composed of two cotyledons, close to spherical shape, very wrinkled, white or pale yellow, and its outer surface is membranous dark brown seed coat. Generally, the nuclei in the nucleus of the walnut fruit are used for edible purposes. In the present invention, the walnut contained in the herbal medicine extract is obtained by extracting an edible nucleus portion in the endosperm as a raw material.

The herbal medicine extract contained in the composition of the present invention comprises as an ingredient an extract of the above-mentioned apricot seeds, horseradish, mackerel, and walnuts, wherein the extract is selected from the group consisting of water, C ₁ to C ₁₀ hydrocarbons, C ₁ to C ₁₀ ketones, C ₁ and ethers of C ₁₀ acids, by extracting with a solvent selected from halogenated hydrocarbons and alcohols of C ₁ to C ₁₀ of the C ₁ to C ₁₀ esters, C ₁ to C ₁₀ a can be obtained. At this time, a mixed extract obtained by mixing all the raw materials of apricot seeds, seaweed, mackerel, and walnut can be used, or the extracts separately extracted can be mixed and used. The extraction solvent may be 2 to 10 times the dry weight of the raw material, and the extraction method may be an extraction method such as hot water extraction, reflux cooling extraction, ultrasonic extraction, and the like, preferably 1 to 5 times Can be extracted.

In addition, the composition for preventing hair loss and treating scalp disease of the present invention comprises a fermentation liquid of a walnut suture extract. Since the extract of walnut scutellum has a problem of being on hand, it is required to include it in the composition of the present invention as a fermentation broth fermented.

The fermentation liquid of the walnut scutellum extract may be prepared by fermenting an extract of a scutellum present in the outermost walnut fruit and then fermenting the extract. The microorganism may be selected from the group consisting of yeast (Saccharomyces), fungi (Aspergillus), lactobacillus

Can be used for fermentation. The fermentation can be carried out at 25 to 50 ° C for about 24 to 120 hours, preferably 48 to 72 hours, but can be appropriately controlled depending on the microorganism used and the condition of the raw materials to be used.

The composition for preventing hair loss and scalp disease according to the present invention preferably contains 1 to 50 parts by weight, more preferably 5 to 30 parts by weight, of 10 to 50 parts by weight of the fermentation liquid of the walnut suture extract, per 100 parts by weight of the herbal medicine extract, Most preferably 20 parts by weight. When the fermented broccoli extract of walnuts is used in an amount less than the above range, improvement of the effect of preventing the hair loss by the fermentation broth is not expected to be greatly expected, and when used in excess of the above range, the content of the herbal medicine extract, The prevention effect is reduced.

In addition, the herbal medicine extract preferably contains 30 to 50 parts by weight of seaweed, 50 to 80 parts by weight of a lateral leaf, and 1 to 20 parts by weight of walnuts, more preferably 35 to 45 parts by weight of seaweed, , 60 to 70 parts by weight of a lateral leaflet, and 5 to 10 parts by weight of walnut. When each ingredient in the herbal medicine extract is included in the above-mentioned limited range, it acts in a balanced manner between each effective ingredient, Lt; / RTI >

In addition, the herbal medicine extract may further include Hansik suk. It is a perennial plant which grows in the wetlands of rice fields and streams in the central and southern parts of Korea. It contains saponin and tannin, gumminess, echulipine (vitamins A), vitamin A, nicotine and coumarin compounds. When the stalk of the hanchukscho is cut off, the juice comes out and becomes oxidized and black color over time. This is because the wedelolactin is oxidized by the oxidation in the air and has been used as a dye for clothes, hair, and hair. It is preferable that 30 to 50 parts by weight, preferably 35 to 45 parts by weight, of the saccharin is included in 100 parts by weight of the apricot seeds.

In addition, the herbal medicine extract may further include persimmon leaves. The persimmon leaf is a leaf of persimmon ( Diospyros Kaki L.) . The persimmon is about 6 to 14 m in height. The crust of the stem is split into a scaly shape, and brown branches are small branches. The persimmon leaves are oval, oval, oval, about 7 to 17 cm long, about 4 to 10 cm wide, with no sawtooth, petiole is 5 to 15 mm long and has hairs. The back of persimmon leaves is green and glossy. The persimmon leaves are effective against adult diseases such as hypertension, arteriosclerosis and heart disease, chronic diseases such as gastric ulcer, duodenal ulcer and diabetes, and vitamin A, C, D and chlorophyll which are known to have cancer preventive effect. In addition, it contains vitamin B1, pantothenic acid, folic acid, and tannin in large amounts. Tannin, a pungent ingredient, has various biological activities, as well as toxin decryption, immune function, and free radical scavenging. The persimmon leaves may contain 70 to 100 parts by weight, preferably 80 to 90 parts by weight, based on 100 parts by weight of apricot.

The composition for preventing hair loss and scalp disease according to the present invention may be prepared in various forms, and may be manufactured into cosmetic formulations of general emulsification and solubilization formulations. Cosmetics of emulsified form include nutrition lotion, cream, essence, etc., and cosmetics of solubilized form have softening longevity. In addition, the composition of the present invention can be prepared in the form of an adjuvant which can be applied topically or systemically, which is conventionally used in the field of dermatology by containing a dermatologically acceptable medium or base in addition to cosmetics. Suitable cosmetic formulations include, for example, solutions, gels, solid or kneaded anhydrous products, emulsions obtained by dispersing the oil phase in water, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes) In the form of a foliar dispersant, in the form of a cream, a skin, a lotion, a powder, an ointment, a spray or a conceal stick. It can also be prepared in the form of a foam or an aerosol composition further containing a compressed propellant.

The composition of the present invention can further comprise at least one of a fatty substance, an organic solvent, a solubilizing agent, a thickening agent and a gelling agent, a softening agent, an antioxidant, a suspending agent, a stabilizer, a foaming agent, a perfume, a surfactant, Any other ingredients commonly used in cosmetics, such as nonionic emulsifiers, fillers, sequestering and chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, , ≪ / RTI > and the like.

Examples of products to which the composition of the present invention can be added include skin lotions, skin softeners, skin toners, astringents, lotions, milk lotions, moisturizing lotions, nutritional lotions, massage creams, nutritional creams, Nourishing essence, pack, soap, shampoo, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, latex, press powder, loose powder and the like.

Hereinafter, the present invention will be described concretely with reference to Examples and Experimental Examples. However, the following Examples and Experimental Examples are merely illustrative of the present invention, and the present invention is not limited to the following Examples and Experimental Examples.

Example 1: Preparation of anti-depilation composition

The extraction solvent was added to 100 g of apricot seeds, 40 g of sucrose, 65 g of western white leaf and 10 g of walnut (nucleus), and the mixture was pulverized for 3 minutes at 2,000 rpm using a mixer. As the extraction solvent, an aqueous solution of 60 wt% ethanol was used. 600 ml of the above extraction solvent was added, and the raw material was pulverized and stirred for 3 days to obtain a first extract.

The primary extract was allowed to stand to separate the raw material of the lower layer, and 400 ml of an extraction solvent was further added thereto, followed by stirring for 3 days to obtain a secondary extract. The raw material was separated and removed with a filter (strainer) obtained through the secondary extraction mixture, and the secondary extract from which the raw material was removed was mixed with the primary extract to obtain a herbal composition.

On the other hand, 20 g of walnut suture was pulverized for 3 minutes at 2,000 rpm using a mixer while adding an extraction solvent. As the extraction solvent, an aqueous solution of 60 wt% ethanol was used. 60 ml of the above extraction solvent was added, and the mixture was pulverized and stirred for 3 days to obtain a first extract. The primary extract was allowed to stand to separate the raw material of the lower layer, and 60 ml of an extraction solvent was further added thereto, followed by stirring for 3 days to obtain a secondary extract. The secondary extract mixture was separated and removed with a coarse filter (strainer), and the secondary extract from which the raw material was removed was mixed with the primary extract to obtain a walnut suture extract.

The extracts of the walnut scutellariae were heated at 120 ° C for 20 minutes to remove germs, and lactic acid bacteria ( Lactobacillus fermentum ) was inoculated and fermented at 40 ° C for 48 hours. Microorganisms were removed by microfiltration to obtain a walnut suture extract fermentation broth.

100 g of the crude herbal composition and 20 g of the fermentation liquid of the walnut scutellum extract were weighed and mixed to prepare a final hair loss preventing composition.

Example 2: Preparation of Anti Hair Loss Composition Containing Antler

In preparing the herbal medicine mixed composition, an anti-hair-loss composition was prepared in the same manner as in Example 1, except that the raw material in which 40 g of persimmon was added.

Example 3: Preparation of anti-depilation composition containing persimmon leaves

In preparing the herbal medicine composition, an anti-depressant composition was prepared in the same manner as in Example 1 except that 80 g of persimmon leaves were further added.

EXPERIMENTAL EXAMPLE 1: Test for confirming hair loss prevention effect

The number of dropouts that were dropped when the hair was wrapped was collected with a collecting tool, and the amount of the drop was measured to observe the change in dropout pattern. The drop-out simulation method is to use the water used for water and rinse in a round tube with a diameter of 30 cm and a height of 20 cm with a gauze on the underside, passing water through the water, Respectively.

The subjects were 2 persons in the control group and 6 persons in the test group, each of 3 men and 3 women.

The compositions of Examples 1 to 3 were sprayed uniformly onto the scalp 5ml each time, and the number of times of daily application was 2 times in the morning and evening. For the first three days, distilled water was applied to the scalp to set the dropout threshold before use, and the extract was applied on the fourth day. The number of days of application of the composition was 50 days, and decidua was measured in units of 10 days.

On the other hand, the control group applied distilled water twice a day instead of the extract.

Table 1 shows the average values of the number of decolorized compounds when the compositions of Examples 1 to 3 were applied.

Control group Example 1 Example 2 Example 3 Before using extract 42 44 43 41 After 10 days 41 40 38 39 After 20 days 41 36 33 35 After 30 days 45 29 27 29 After 40 days 44 27 25 26 After 50 days 42 26 23 23

As shown in Table 1, when the composition for preventing alopecia of the Example was used, the decolorization was remarkably decreased as compared with the control group. In particular, it was confirmed that the decolorization decreased rapidly until 40 days and thereafter decreased gradually.

Experimental Example 2: Experiment to confirm mitigation effect of oscillatory rash

Pseudo-rash is a representative symptom observed in patients with seborrheic dermatitis. The subject was a person with acute rash among the symptoms of seborrheic dermatitis, 2 in the control group and 6 in the test group.

The compositions of Examples 1 to 3 were sprayed uniformly onto the scalp 5ml each time, and the number of times of daily application was 2 times in the morning and evening.

The number of days of application of the composition was 60 days, and peak oscillation was observed every 20 days.

On the other hand, the control group applied distilled water twice a day instead of the extract.

Table 2 below shows the confirmed spherical oscillations when the compositions of Examples 1 to 3 were applied.

Control group Example 1 Example 2 Example 3 Before using extract 10 10 10 10 After 20 days 9 5 4 4 After 40 days 10 4 2 2 60 days later 11 2 One One

As shown in the above Table 2, the compositions of Examples 1 to 3 alleviate the petechial oscillations that occur in the scalp of patients with seborrheic dermatitis, and the petechial oscillations decrease markedly from the early 20th day of use of the composition, It was confirmed that it was steadily eased.

The pseudo-oscillation occurs through excessive production of sebum, bad discharge of sebum, and propagation of harmful microorganisms, and the composition of the present invention can be expected to alleviate it by alleviating it.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed embodiments, but, on the contrary, is intended to cover various modifications and equivalent arrangements included within the spirit and scope of the appended claims. . Accordingly, the true scope of the present invention is to be determined by the following claims.

Claims (5)

Herbal medicine extracts including apricot seeds, daphnia magna, mackerel leaves and walnuts,
A composition for preventing hair loss and treating a scalp disease, which comprises a fermentation liquid of a walnut surgical sphincter extract.
The method according to claim 1,
Wherein the composition comprises 1 to 50 parts by weight of a fermentation liquid of a walnut slice extract according to 100 parts by weight of a crude drug extract.
The method according to claim 1,
Wherein the herbal medicine extract comprises 30 to 50 parts by weight of horseradish, 50 to 80 parts by weight of leaves, and 1 to 20 parts by weight of walnuts in relation to 100 parts by weight of apricot seeds.
The method according to claim 1,
Wherein the herbal medicine extract further comprises 30 to 50 parts by weight per 100 parts by weight of apricot seeds.
The method according to claim 1,
Wherein the herbal medicine extract further comprises 70 to 100 parts by weight of persimmon leaves per 100 parts by weight of apricot seeds.