KR102076179B1 - A cosmetic composition for alleviating skin irritation by vitamin c containing a mixed extract of iris lactea and doellingeria scabra - Google Patents

Abstract

The present invention relates to a cosmetic composition having an effect of alleviating skin irritation caused by vitamin C by containing a mixed extract of Iris lactea and Doellingeria scabra. In particular, the present invention relates to a cosmetic composition for alleviating skin irritation, wherein the cosmetic composition does not damage the skin by alleviating irritation caused when vitamin C touches the skin.

Description

Cosmetic composition for alleviating skin irritation by vitamin C containing mixed extract of iris and smelt smelter

The present invention relates to a cosmetic composition for alleviating skin irritation by vitamin C, and more particularly, to a cosmetic composition for alleviating skin irritation by high concentration of vitamin C, containing a mixed extract of corolla iris and sesame.

Generally, various raw materials are used to make cosmetics, and typically 20 to 50 raw materials are used. These ingredients have been proved to be safe through skin irritation tests, but when applied to the product can cause irritation, itching and allergies to the skin. These irritating reactions do not happen to everyone, but can only happen to certain people.

Depending on the skin sensitivity, various skin irritation may occur due to the use of cosmetics, which may cause irritation such as itching, stinging and burning, and erythema and edema. And the like. Contact dermatitis may be described as irritant contact dermatitis, allergic contact dermatitis, sensory irritation, and phototoxic dermatitis, but it is difficult to clearly distinguish them, and most of them are mixed with each other. Above all, skin irritation must occur in order for skin irritation to occur, and they interact with the epidermis or dermal cells to activate the immune system and cause irritation.

In order to alleviate the skin irritation, various methods such as removing the skin irritants have been mobilized, but indispensable ingredients for preserving, maintaining and maintaining cosmetics are preservatives, surfactants, sunscreens and whitening agents. In many cases, the raw material itself acts as an irritant.

Among them, vitamin C can be a great help for skin care due to its excellent antioxidant activity and anti-pigmentation. However, vitamin C generally starts to oxidize in contact with air, heat and moisture, and cosmetics containing a certain concentration of vitamin C causes skin irritation. Therefore, there is an urgent need for cosmetics that contain vitamin C and minimize skin irritation.

Republic of Korea Patent No. 10-1867308 discloses a cosmetic composition for stimulating the skin irritation and skin irritation containing hydrangea fermentation, Republic of Korea Patent No. 10-1822558 contains an apple extract and alpha hydroxy acid A cosmetic composition for alleviating skin irritation is disclosed.

No studies have been reported to reduce the skin irritation effect of vitamin C in a mixture of irises and sesame.

The inventors of the present invention contain mixed extracts of irises and stalks to prevent irritation of the skin caused by vitamin C together with highly concentrated vitamin C so that good components of vitamin C can be stably absorbed into the skin without causing damage to the skin. It is an object to provide a cosmetic composition.

Therefore, the object of the present invention as described above is achieved by the cosmetic composition for alleviating the skin irritation by vitamin C, including at least one extract of the corkscrew and scent in the cosmetic composition comprising vitamin C.

Preferably, the cosmetic composition is a cosmetic composition for alleviating the skin irritation by preventing the skin damage by the extract to relieve skin irritation caused by vitamin C.

Preferably, the extract is a cosmetic composition for alleviating skin irritation contained 0.1 to 10.0% by weight based on the total weight of the composition.

Preferably, the extract is a cosmetic composition for alleviating the skin irritation containing a corkscrew: sesame in a mixed weight ratio of 1-4: 4-1.

The present invention can alleviate skin irritation caused by vitamin C by reducing the skin irritation caused by stimulated vitamin C.

Unless defined otherwise, all technical terms used in the present invention have the following definitions and conform to the meanings as commonly understood by one of ordinary skill in the related art of the present invention. Also described herein are preferred methods or samples, but similar or equivalent ones are within the scope of the present invention.

The term "about" means 30, 25, 20, 15, 10, 9, 8, 7, 6, 5, by reference quantity, level, value, number, frequency, percentage, dimension, size, amount, weight, or length. By amount, level, value, number, frequency, percentage, dimension, size, amount, weight or length, varying by 4, 3, 2 or 1%.

Throughout this specification, the terms "comprises" and "comprising", unless otherwise indicated in the context, include a given step or component, or group of steps or components, but any other step or component, or It is to be understood that this does not exclude a step or group of components.

The present invention provides a cosmetic composition for alleviating skin irritation caused by vitamin C as a cosmetic composition for alleviating skin irritation, which contains at least one extract of two natural plants.

The two natural plants are Iris lactea and Doellingeria scabra.

Iris lactea is a perennial herb attached to the iris family. It grows in dry places in the mountains. The stem is largely abandoned, gathered and stands upright. The leaves are linear and twisted in thin sword, sharp at the end, 40cm long, about 5mm long, green, and purple at the bottom. The root is short and has a thin and strong brown beard root. Flowers bloom in May-June, with light purple flowers on stalks shorter than leaves and have fragrance. Hyacinth lobe is narrow and long, with 3 external flowers covered with upper half spreading out, and 3 inside are straight and spatula-shaped. Fruits are thin and long, about 6cm long, about 1cm in diameter at the center, and pointed to beak at the end. Seeds are called marine or ryokan.

Doellingeria scabra is a perennial herb attached to Asteraceae. It grows mainly in mountains and fields and is distributed all over Korea. The stem extends straight up to 1.5 meters. The leaves are broad, egg-shaped, pointed and displaced. The leaves running on the lower part of the stem have wings on the petioles. From the summer to autumn, several heads of about 2cm are running in turn. The coronalization in the center is yellow, whereas the periphery of the margin is white. Fruits are formed in November, and hairs on end of seeds are blackish white and 3.5 ~ 4mm long.

In the present invention, the natural plant extract means that it is obtained by extracting from various organs or parts (eg, leaves, flowers, roots, stems and branches) of the plant.

According to the present invention, the natural plant extract may contain 0.001 to 30.0% by weight based on the total weight of the cosmetic composition, more preferably, the natural plant extract contains 0.01 to 20% by weight based on the total weight of the cosmetic composition Can be. More preferably, 0.1 to 10 weight% is contained. When the content of the extract is less than 0.001% by weight does not appear to improve the skin, when the content of more than 30.0% by weight increase of the skin improvement effect to increase the content is insignificant, there is a problem in the safety and stability of the formulation and economic Neither ever

The mixed extract of the present invention is preferably prepared by mixing the weight of the skein iris: sesame seeds 1-4: 4-1, and more preferably, the mixture of Sakura iris: sesame in a weight ratio of 1: 1. desirable.

And the extract of the natural plant of the present invention can be prepared using a conventional solvent, under the conditions of the usual temperature and pressure in accordance with conventional methods known in the art, preferably (a) water, 1-C 4 anhydrous or hydrous lower alcohols (e.g. methanol, ethanol, propanol and butanol), propylene glycol, 1,3-butylene glycol, glycerin, acetone, diethyl ether, ethyl acetate, butyl acetate, dichloromethane, chloroform Extraction is carried out using a solvent extraction method using a solvent selected from the group consisting of hexane and mixtures thereof.

In the present invention, a solvent extraction method using an extraction solvent was used. Preferably obtained using ethanol, 70% (v / v) ethanol or water, most preferably obtained using 70% (v / v) ethanol.

On the other hand, it will be apparent to those skilled in the art that at least one extract selected from the group consisting of the corkscrew and stalk of the present invention can obtain an extract having substantially the same effect using not only the aforementioned extraction solvent but also other extraction solvents. It is.

The components included in the cosmetic composition of the present invention may include, as an active ingredient, ingredients commonly used in cosmetic compositions in addition to the active ingredient, and include, for example, conventional agents such as antioxidants, stabilizers, solubilizers, vitamins, pigments, and perfumes. Adjuvants, and carriers.

Cosmetic compositions of the present invention may be prepared in any formulation conventionally prepared in the art, for example, solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleansing , Oils, powder foundations, emulsion foundations, wax foundations, packs, massage creams and sprays and the like, but is not limited thereto. More specifically, it may be prepared in the form of a flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream or gel, animal oils, vegetable oils, waxes, paraffins, starches, trachants, cellulose derivatives, polyethylene glycols, silicones, bentonites, silicas, talc or zinc oxide may be used as carrier components. Can be. When the formulation of the present invention is a solution or emulsion, a solvent, solubilizer or emulsifier is used as the carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 Fatty acid esters of, 3-butylglycol oil, glycerol aliphatic ester, polyethyleneglycol or sorbitan. When the formulation of the present invention is a suspension, liquid carrier diluents such as water, ethanol or propylene glycol, suspending agents such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, and microcrystals are used as carrier components. Soluble cellulose, aluminum metahydroxy, bentonite, agar or tracant and the like can be used. When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used, in particular in the case of a spray, additionally chlorofluorohydrocarbon, propane Propellant such as butane or dimethyl ether. When the formulation of the present invention is a surfactant-containing cleansing, the carrier component is aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide ether Sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used. When the cosmetic composition of the present invention is a soap, a surfactant-containing cleansing formulation or a surfactant-free cleansing formulation, it may be wiped off, peeled off or washed with water after application to the skin. As a specific example, the soap is liquid soap, powdered soap, solid soap and oil soap, the surfactant-containing cleansing formulation is a cleansing foam, cleansing water, cleansing towel and cleansing pack, the surfactant-free cleansing formulation is a cleansing cream , Cleansing lotion, cleansing water and cleansing gel, but are not limited thereto.

Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, it will be apparent to those skilled in the art that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention. .

Preparation Example 1 Preparation of a Skeleton Iris Extract of the Present Invention

100 g of the outpost portion of the iris is cut into 99% ethanol and extracted by heating at 100 ° C. for 8 hours. The extraction residue is filtered first using cotton swabs, and then secondly using Wattman # 4 filter paper. The precipitate was removed by filtration to give a single extract.

Preparation Example 2 Preparation of Single Extract of Tuna of the Present Invention

100 g of the outcrop of tuna chopped, put into 99% ethanol and extracted by heating at 100 ° C. for 8 hours, filtered first with extraction cotton, and then filtered with Wattman # 4 filter paper. The precipitate was removed to obtain a single extract.

Preparation Example 3-1 Preparation of Mixed Extract of Skewered Iris and Tuna of the Present Invention

After extracting and drying, 100 g of fine irises and 100 g of scallops (weight ratio = 1: 1) were put in 99% ethanol and extracted by heating at 100 ° C. for 8 hours. After filtration, secondary filtration was performed using 'Watman # 4 filter paper' to remove the precipitate to obtain a mixed extract.

Preparation Example 3-2 Preparation of Mixed Extract of Skewered Iris and Tuna of the Present Invention

After extracting and drying, 150 g of fine irises and 50 g of tuna squirt (weight ratio = 3: 1) were added to 99% ethanol and extracted by heating at 100 ° C. for 8 hours. After filtration, secondary filtration was performed using 'Watman # 4 filter paper' to remove the precipitate to obtain a mixed extract.

Preparation Example 3-3 Preparation of Mixed Extract of Skewered Iris and Tuna of the Present Invention

After extracting and drying, 50 g of fine irises and 150 g of scallops (weight ratio = 1: 3) were put into 99% ethanol and extracted by heating at 100 ° C. for 8 hours. After filtration, secondary filtration was performed using 'Watman # 4 filter paper' to remove the precipitate to obtain a mixed extract.

Hereinafter, only the essence formulation is illustrated as a formulation of the present invention, but the formulation including the cosmetic composition of the present invention is not limited thereto, and is prepared by cream, massage cream, lotion, skin lotion, pack, cleansing foam, lipstick, and the like. Can be.

Formulation Examples 1-12 Preparation of Essence Formulation

Essence compositions of Formulation Examples 1 to 12 were prepared according to a conventional method using the components described in Tables 1 to 3 below.

Raw material name Content (% by weight) Formulation Example 1 Formulation Example 2 Formulation Example 3 Formulation Example 4-1 Formulation Example 4-2 Formulation Example 4-3 Comparative Formulation Example 1 Preparation Example 1 1.0 - 0.5 - - - - Preparation Example 2 - 1.0 0.5 - - - - Preparation Example 3-1 - - - 1.0 - - - Preparation Example 3-2 - - - - 1.0 - - Preparation Example 3-3 - - - - - 1.0 - Vitamin c 5 5 5 5 5 5 5 Concentrated glycerin 15.0 15.0 15.0 15 15 15.0 15.0 1.3-butylene glycol 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Allatoin 0.1 0.1 0.1 0.1 0.1 0.1 0.1 ethanol 6.0 6.0 6.0 6.0 6.0 6.0 6.0 Paraoxybenzoic Acid Methyl 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Triethanolamine 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Holyoxyethylene hardened castor oil One One One One One One One Tocopherol Acetate 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Carboxy Vinyl Polymer 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Spices a very small amount a very small amount a very small amount a very small amount a very small amount a very small amount a very small amount Purified water Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount

Raw material name Content (% by weight) Formulation Example 5 Formulation Example 6 Formulation Example 7 Formulation Example 8-1 Formulation Example 8-2 Formulation Example 8-3 Comparative Formulation Example 2 Preparation Example 1 1.0 - 0.5 - - - - Preparation Example 2 - 1.0 0.5 - - - - Preparation Example 3-1 - - - 1.0 - - - Preparation Example 3-2 - - - - 1.0 - - Preparation Example 3-3 - - - - - 1.0 - Vitamin c 10 10 10 10 10 10 10 Concentrated glycerin 15.0 15.0 15.0 15 15 15.0 15.0 1.3-butylene glycol 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Allatoin 0.1 0.1 0.1 0.1 0.1 0.1 0.1 ethanol 6.0 6.0 6.0 6.0 6.0 6.0 6.0 Paraoxybenzoic Acid Methyl 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Triethanolamine 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Holyoxyethylene hardened castor oil One One One One One One One Tocopherol Acetate 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Carboxy Vinyl Polymer 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Spices a very small amount a very small amount a very small amount a very small amount a very small amount a very small amount a very small amount Purified water Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount

Raw material name Content (% by weight) Formulation Example 9 Formulation Example 10 Formulation Example 11 Formulation Example 12-1 Formulation Example 12-2 Formulation Example 12-3 Comparative Formulation Example 3 Preparation Example 1 1.0 - 0.5 - - - - Preparation Example 2 - 1.0 0.5 - - - - Preparation Example 3-1 - - - 1.0 - - - Preparation Example 3-2 - - - - 1.0 - - Preparation Example 3-3 - - - - - 1.0 - Vitamin c 20 20 20 20 20 20 20 Concentrated glycerin 15 15 15 15 15 15 15 1.3-butylene glycol 5.0 5.0 5.0 5.0 5.0 5.0 5.0 Allatoin 0.1 0.1 0.1 0.1 0.1 0.1 0.1 ethanol 6.0 6.0 6.0 6.0 6.0 6.0 6.0 Paraoxybenzoic Acid Methyl 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Triethanolamine 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Holyoxyethylene hardened castor oil One One One One One One One Tocopherol Acetate 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Carboxy Vinyl Polymer 0.15 0.15 0.15 0.15 0.15 0.15 0.15 Spices a very small amount a very small amount a very small amount a very small amount a very small amount a very small amount a very small amount Purified water Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount Remaining amount

[Test Example 1] Evaluation of skin irritation efficacy through patch application test (patch test)

The test subjects were visited three times during the human application test period (before the start of the test, the date of removing the patch, and 24 hours after the removal of the patch) to determine whether the skin was irritated. At the first visit, subjects performed skin patch tests on the subject's back using an IQ chamber (Chemotechnique Diagnostics, Sweden). For each of the 15 subjects, a sample was applied between the shoulder blade and the waistline using the IQ chamber on the back.

The test site was wiped with 70% ethanol and dried, and the test sample prepared according to Table 1, Table 2 and Table 3 was added dropwise to the IQ chamber, and then fixed on the test site. The patch was applied to the skin for 24 hours, and after removing the patch, the test sites were marked with a marking pen, and after 30 minutes, the test sites were observed after 24 hours.

- No response 0 . Dim light erythema 0.5 ± Weak erythema with clear borders One + Pronounced erythema, papules and vesicles 2 ++ Severe erythema, cannon 6 +++ Crust formation 12

The degree of skin irritation in Test Example 1 was expressed according to the evaluation criteria as shown in Table 4 above, and was shown in Table 5 obtained by the following calculation formula.

Skin irritation is determined to be irritant if the irritation rate is 0.0, unstimulated if it is 0.1 to 1.0, light irritant for 1.0 to 1.7, medium irritant for 1.7 to 2.5, and strong irritant for 2.5 or more.

Composition Skin irritation rate Stimulus Formulation Example 1 1.37 Light stimulation Formulation Example 2 1.50 Light stimulation Formulation Example 3 1.07 Light stimulation Formulation Example 4-1 0.80 Unstimulated Formulation Example 4-2 1.06 Light stimulation Formulation Example 4-3 1.03 Light stimulation Formulation Example 5 1.47 Light stimulation Formulation Example 6 1.63 Light stimulation Formulation Example 7 1.33 Light stimulation Formulation Example 8-1 0.87 Unstimulated Formulation Example 8-2 1.43 Light stimulation Formulation Example 8-3 1.40 Light stimulation Formulation Example 9 2.23 Heavy stimulation Formulation Example 10 2.33 Heavy stimulation Formulation Example 11 1.67 Light stimulation Formulation Example 12-1 0.93 Unstimulated Formulation Example 12-2 1.73 Light stimulation Formulation Example 12-3 1.67 Heavy stimulation Comparative Formulation Example 1 1.70 Light stimulation Comparative Formulation Example 2 2.43 Heavy stimulation Comparative Formulation Example 3 2.70 Strong stimulation

Skin irritation relaxation rate in this Test Example 1 is shown in Table 6 calculated by the following formula.

Composition Stimulation Relief (%) Formulation Example 1 19.41 Formulation Example 2 11.76 Formulation Example 3 37.06 Formulation Example 4-1 52.94 Formulation Example 4-2 37.65 Formulation Example 4-3 39.41 Formulation Example 5 39.51 Formulation Example 6 32.92 Formulation Example 7 45.27 Formulation Example 8-1 64.20 Formulation Example 8-2 41.15 Formulation Example 8-3 42.39 Formulation Example 9 17.41 Formulation Example 10 13.70 Formulation Example 11 38.15 Formulation Example 12-1 65.56 Formulation Example 12-2 35.93 Formulation Example 12-3 38.15

As can be seen from Test Example 1 of the present invention, it was confirmed that the composition formulation containing vitamin C or more at a certain concentration (20.0%) causes strong irritation to the skin. Referring to Table 5, the present invention Cosmetics contained in the extract of the skin irritation rate was found to be significantly lower than the cosmetics do not contain. In particular, as can be seen through the skin irritation rate of the cosmetic formulations of Formulation Examples 3, 7, 11, it can be seen that the extract of the present invention increases the irritation-releasing effect as the components of each extract together.

And as can be seen in Table 6 together with Table 5, the cosmetics containing the mixed extract extracted together with a certain ratio of the stalks of the present invention, such as the cosmetic formulation of Formulation Examples 4, 8, 12 has a content ratio of vitamin C It was confirmed that the higher the proportion of the content of vitamin C and the more stimulating effect increases.

In addition, when compared with Formulation Examples 4-1 to 3 and 8-1 to 3 and 12-1 to 3, the mixing weight ratio is the most excellent at the stimulating effect at 4-1, 8-1, 12-1 of 1: 1 It was confirmed.

Claims (4)

A cosmetic composition comprising vitamin C, wherein the cosmetic composition for alleviating skin irritation by vitamin C, comprising one or more extracts of a corolla iris and scent. The cosmetic composition of claim 1, wherein the cosmetic composition prevents the extract from alleviating skin irritation caused by vitamin C to prevent damage to the skin. The cosmetic composition of claim 1 or 2, wherein the extract is contained in an amount of 0.1 to 10.0% by weight based on the total weight of the cosmetic composition. The cosmetic composition according to claim 1, wherein the extract contains a skein iris: sesame in a mixed weight ratio of 1-4: 4-1.