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KR102330133B1 - 벤즈이미다졸-프롤린 유도체의 용도 - Google Patents

벤즈이미다졸-프롤린 유도체의 용도 Download PDF

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Publication number
KR102330133B1
KR102330133B1 KR1020167017709A KR20167017709A KR102330133B1 KR 102330133 B1 KR102330133 B1 KR 102330133B1 KR 1020167017709 A KR1020167017709 A KR 1020167017709A KR 20167017709 A KR20167017709 A KR 20167017709A KR 102330133 B1 KR102330133 B1 KR 102330133B1
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South Korea
Prior art keywords
methyl
dementia
compound
phenyl
methanone
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KR1020167017709A
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English (en)
Korean (ko)
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KR20160093686A (ko
Inventor
크리슈토프 보쓰
캐서린 로슈
크리슈티네 브로치
마르쿠스 구데
비비아 아이드망
프랑수아 젱끄
티에리 시페르랑
미헬 슈타이너
조디 티 윌리엄스
Original Assignee
이도르시아 파마슈티컬스 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020167017709A 2013-12-04 2014-12-03 벤즈이미다졸-프롤린 유도체의 용도 KR102330133B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IBPCT/IB2013/060630 2013-12-04
IB2013060630 2013-12-04
PCT/IB2014/066548 WO2015083094A1 (en) 2013-12-04 2014-12-03 Use of benzimidazole-proline derivatives

Publications (2)

Publication Number Publication Date
KR20160093686A KR20160093686A (ko) 2016-08-08
KR102330133B1 true KR102330133B1 (ko) 2021-11-23

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Application Number Title Priority Date Filing Date
KR1020167017709A KR102330133B1 (ko) 2013-12-04 2014-12-03 벤즈이미다졸-프롤린 유도체의 용도

Country Status (29)

Country Link
US (1) US9914721B2 (ja)
EP (1) EP3077391B1 (ja)
JP (1) JP6421185B2 (ja)
KR (1) KR102330133B1 (ja)
CN (1) CN105873921B (ja)
AU (1) AU2014358766B2 (ja)
CA (1) CA2930053A1 (ja)
CL (1) CL2016001349A1 (ja)
CY (1) CY1121089T1 (ja)
DK (1) DK3077391T3 (ja)
EA (1) EA029725B1 (ja)
ES (1) ES2696708T3 (ja)
HK (1) HK1225734B (ja)
HR (1) HRP20181710T1 (ja)
HU (1) HUE040555T2 (ja)
IL (1) IL245914B (ja)
LT (1) LT3077391T (ja)
MA (1) MA39165A1 (ja)
MX (1) MX366642B (ja)
MY (1) MY179605A (ja)
PH (1) PH12016500985B1 (ja)
PL (1) PL3077391T3 (ja)
PT (1) PT3077391T (ja)
SA (1) SA516371253B1 (ja)
SI (1) SI3077391T1 (ja)
TR (1) TR201815342T4 (ja)
UA (1) UA116053C2 (ja)
WO (1) WO2015083094A1 (ja)
ZA (1) ZA201604502B (ja)

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UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
NO3077389T3 (ja) 2013-12-03 2018-02-10
CN105873921B (zh) 2013-12-04 2019-03-15 爱杜西亚药品有限公司 苯并咪唑-脯氨酸衍生物的用途
CN106349228B (zh) 2015-07-17 2019-07-09 广东东阳光药业有限公司 取代的喹唑啉酮类化合物及其制备方法和用途
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BR112022020924A2 (pt) 2020-04-19 2023-02-14 Idorsia Pharmaceuticals Ltd Métodos de tratamento de um transtorno do sono, a sonolência diurna em um indivíduo, a insônia, e, daridorexante na forma de sal livre ou farmaceuticamente aceitável
CN116783182A (zh) * 2021-02-02 2023-09-19 南京明德新药研发有限公司 四氢吡咯并环化合物及其应用
WO2023160004A1 (zh) * 2022-02-25 2023-08-31 南京知和医药科技有限公司 具有镇痛活性的稠环化合物及其制备方法与用途

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