KR102074314B1 - Composition for Preventing Hair Loss or Promoting Hair Growth - Google Patents

Abstract

The present invention relates to a composition for preventing hair loss or promoting hair growth. The composition of the present invention is safe for the human body, causes no side effects, and also has excellent effects of preventing hair loos and promoting hair growth. In addition, the composition for preventing hair loss or promoting hair growth of the present invention acts to provide extremely superior effects on promoting the proliferation of dermal papilla cells and increasing hair elasticity.

Description

Composition for preventing hair loss or promoting hair growth {Composition for Preventing Hair Loss or Promoting Hair Growth}

The present invention relates to a composition for preventing hair loss or promoting hair growth. More specifically, the present invention is to provide a composition excellent in the effect of preventing hair loss and promoting hair growth, while being safe for the human body and without side effects.

Hair is an important part of the process of increasing interest in beauty as the times change. Hair is a thin, keratinized structure produced on the surface of the skin. This acts as a cushion against external shocks, protects the human body from external stimuli such as direct sunlight, cold, friction and danger, and functions to discharge heavy metals such as arsenic, mercury, and zinc harmful to the body outside the body. The aspect is also emphasized. However, more and more people are complaining of hair loss due to various causes, including changes in diet and increased internal and external stress. Hair loss is known to be the most important genetic factor, but as mentioned above, social stress increases, environmental pollution, frequent perm and staining, and incorrect scalp management are also emerging as causes of hair loss.

There are about 100,000 to 150,000 human hairs, and each hair has a different growth cycle. The formation of hair follicles in the early stage of development is caused by the action of beta-catenin, whereby placode is formed by the basement epidermal cells (Sarah E. Miller, 2002) and receives a signal from the formed placode. Dermal fibroblasts form dermal condensate. At the same time, the placode grows and infiltrates in the dermis direction and merges with the dermal condensate to form the primary hair germ. Epidermal cells that form hair embryos grow long in the direction of the dermis, forming a hair peg, a long columnar structure made up of multiple layers, while dermal condensate is a spherical papilla. It is formed of. The end of the hair peg becomes thicker and a hair bulb is formed. The hair bulb becomes a form surrounding the papilla, and the hair follicle is completed and the epidermal cells inside the hair follicle differentiate and hair is generated.

The first generated hair goes through the growth period and enters the degenerative and resting periods, and then the cycle of entering the growth period again after the hair is removed. The hair growth cycle consists of three stages: the anagen stage where hair grows most actively (the anagen stage), the catagen stage where hair deterioration begins, and the telogen stage where hair growth stops or enters rest. It is classified as.

In regulating the growth cycle of hair, the activity of outer root sheath cells including the hair follicle cells and hair follicle stem cells constituting the hair follicles, and various cytokines and growth factors produced by these cells play an important role. It is said that. For example, DKK-1 (Dickkopf-1) plays an important role in inhibiting and killing hair follicle growth (J Invest. Dermatol, 2008: 128 (2)). On the other hand, for periodic hair growth, regeneration of hair follicles and activation of stem cells must be performed, which is known to be caused by the generation and activation of Wnt / β-catenin (Nature 2007: 447 (7142)).

In addition, growth factors such as VEGF, IGF-1, and FGF are known to promote the growth phase of hair, and TGFb-1, EGF, etc. are known to induce the regression phase of hair follicles.

In general, alopecia refers to a decrease in the number of abnormal hair loss due to a decrease in the proportion of hair in the growth phase and a large number of hairs in the degenerative or resting period. Hair loss is a normal phenomenon, but a normal person has a lot of hair in a growing state, whereas a person with alopecia usually has a lot of hair in a resting state, and the hair loss is visible. The characteristic of people who exhibit alopecia is the miniaturization of hair. As the hair loss progresses, the period of the growth phase is shortened, the transition to the degenerative phase and the resting phase is promoted, and the volume of the subsequent papilla is smaller, so that the hair follicle becomes smaller and smaller. Therefore, for the treatment of hair loss, it is important to allow the hair follicles in the resting state to go quickly to the growth phase and to increase the shortened growth phase.

In addition, androgenetic alopecia, the alopecia to which the most hair loss patients belong, is also referred to as 'androgenic alopecia', and on average, male alopecia is common among young men in their 20s and 30s. This is because androgenetic alopecia is influenced not only by genetic effects, but also by the action and age of testosterone. As a major cause of hair loss in male pattern alopecia, it is being studied as testosterone, a male hormone, and is variously classified according to the type and progress of alopecia. In male pattern alopecia caused by testosterone, dihydro-testosterone (DHT) generated by the combination of male hormone and the active enzyme 5α-reductase (DHT) acts on the hair follicle to inhibit cell division and to grow hair. It occurs in inhibiting.

The form of hair loss appears differently depending on the distribution of the active enzyme 5α-reductase on the scalp. In the parietal region, where the active enzyme is widely distributed, cell division is slowed due to the effect of DHT, and the hair cycle of the hair is shortened, resulting in hair softening and hair loss, but in the temporal or occipital region, the activity of the active enzyme is relatively weak and also Under the influence of female hormones, hair loss does not appear easily. Currently, hair transplantation and drug therapy are being used as a management method for male pattern hair loss.

As mentioned earlier, the causes of hair loss have been discussed in male hormone action, excessive sebum secretion, poor blood circulation, decreased scalp function due to peroxide or bacteria, genetic factors, aging, and stress. However, until now, the definite cause of hair loss is unknown, and it is known that a very complicated action is intertwined.

For such various and complex hair loss causes, the hair loss prevention products known to date are aimed at promoting blood circulation as an active ingredient, strengthening hair follicle function, moisturizing scalp, preventing dandruff, anti-oxidant effects, prolonging hair growth, and suppressing male hormone action. Although it contains the ingredients to be said, it has not yet had a clear effect in terms of effectiveness, and the problem of side effects may be raised.

Currently, Minoxidil (2,4-diamino-6-piperidinopyrimidine-3-oxide) is the only hair loss treatment agent approved by the U.S. Food and Drug Administration (FDA), but its effectiveness is 38% and 32 to 48 weeks, respectively. It is unsatisfactory at 13% (J Am Acad Dermatol. 2002. 47 (3)) and has the disadvantage that the effect is inferior to the bangs.

Numerous references are cited and cited throughout this specification. The disclosure content of the cited documents is incorporated by reference herein in its entirety and the level of the technical field to which the present invention pertains and the content of the present invention are more clearly described.

Republic of Korea Registered Patent Publication No. 10-1657082

The present inventors improve problems such as side effects and precautions for use of a conventional hair loss treatment agent, and are compositions that can safely act on hair growth or promote hair growth while being safe for the human body without disadvantages such as a weak effect of hair loss prevention / hair growth promotion As a result of diligent efforts to develop, it was found that there is an effect of promoting hair growth on specific compounds, and furthermore, the present invention was completed by clarifying that there is a remarkable synergistic effect when applying this material.

Accordingly, an object of the present invention is to provide a composition for preventing hair loss or promoting hair growth.

Another object of the present invention is to provide a product for hair or scalp comprising the composition for preventing hair loss or promoting hair growth.

Other objects and advantages of the present invention will become more apparent from the following detailed description of the invention, claims and drawings.

One aspect of the present invention is from the group consisting of Raponticin, Rhein, Chrysophanol and Physion-8-Od-glucopyranoside (Physcion-8-Od-glucopyranoside). It is to provide a composition for preventing hair loss or promoting hair growth, comprising at least one selected compound or a salt, hydrate or solvate thereof as an active ingredient.

Lapontisin is a stilbenoid glucoside compound, which is known to have therapeutic potential for diabetes and Alzheimer's disease, and is represented by the following formula.

Lane (Rhein) is a compound of the anthraquinone group, also called kaesinic acid, is known to have antibacterial and antibiotic properties, represented by the following formula.

Chrysophanol is a compound of a natural anthraquinone group isolated from a fungus and is represented by the following formula.

Physion-8-O-d-glucopyranoside (Physcion-8-O-d-glucopyranoside) is a natural anthraquinone derivative represented by the following formula.

The active ingredient of the present invention may include one or more selected from the above compounds, preferably two or more, and when used in combination of two or more, exhibits a synergistic effect in relation to preventing hair loss and promoting hair growth.

In one embodiment, the active ingredient of the present invention may include two or more compounds, wherein the two or more compounds are (i) crispanol and (ii) lapontisin, lane and pyzin-8-8-Od- It may be any combination selected from glucopyranoside.

In another embodiment, the two or more compounds are any combination selected from (i) lapontisin and (ii) anthraquinone derivative compounds (lanes, chrysopanols and pysion-8-Od-glucopyranosides). Can be

In another embodiment, the two or more compounds may be a combination of four compounds of lapontisine and lane, chrysophanol, and pysion-8-O-d-glucopyranoside.

In addition, what is used as an active ingredient in the composition of the present invention may be not only the compound itself, but also a salt, hydrate or solvate thereof.

The salts include mineral acids such as hydrochloride, hydrobromide or hydroiodide, acetate, adipate, alginate, aspartate, benzoate, benzenesulfonate, p-toluenesulfonate, bisulfate, sulfamate, sulfate, Naphthylate, butyrate, citrate, camphorate, camposulfonate, cyclopentanepropionate, digluconate, dodecylsulfate, ethanesulfonate, fumarate, glucoheptanoate, glycerophosphate, hemisulfate, hep Formed with organic acids such as tanoate, hexanoate, 2-hydroxyethanesulfate, lactate, maleate, methanesulfonate, 2-naphthalenesulfonate, nicotinate, oxalate, tosylate or undecanoate Can be.

Hydrate refers to a substance in which water is added to the compound or water enters as a constituent substance of the molecule, and a solvate refers to a higher order compound formed between a molecule or ion of a solute and a molecule or ion of a solvent. The hydrate or solvate may be prepared using the above-described acids.

The composition of the present invention may exhibit an effect of promoting the proliferation of dermal papilla cells and / or increasing the elasticity of the hair by including an effective amount of the one or more compounds, or salts, solvates or hydrates thereof.

The effective amount refers to an amount sufficient to prevent, improve and treat hair loss. This can be appropriately changed according to the severity of the disease, the patient's age, weight, health status, sex, route of administration, and treatment period.

Specifically, in the composition of the present invention, the effective amount may be 0.00001 to 50% by weight. Specifically, the present invention is 0.00001 to 50% by weight of lapontisin, preferably 0.0001 to 0.1% by weight or 0.00001 to 50% by weight of lane, preferably 0.0001 to 0.1% by weight or 0.000001 to 50% by weight of chrysophanol, Preferably, 0.0001 to 0.01% by weight or 0.0001 to 50% by weight of the cycion-8-Od-glucopyranoside, preferably 0.0001 to 0.1% by weight.

 This means that when the constituents of Rhaponticin, Rhein, Chrysophanol and Physion-8-Od-glucopyranoside are less than 0.00001% by weight, hair This is because the effect of promoting growth induction is insignificant and the stability of the formulation is poor at concentrations exceeding 50% by weight.

The composition for preventing hair loss or promoting hair growth of the present invention is preferably used as a method for transdermal administration, such as by directly applying or spraying on the skin.

As used herein, the term "administration" means to introduce the composition of the present invention in any suitable way, the route of administration of the composition of the present invention can be administered through any general route as long as it can reach the target tissue. have. Preferably, it can be administered transdermally, and among them, topical application is most preferable. The number of times the composition of the present invention is applied can be determined according to prescription, need or desire.

The amount of the composition of the present invention can be appropriately adjusted according to the individual difference or formulation such as age, degree of lesions, etc., and is usually used for a week to several months by applying an appropriate amount once to several times a day to the scalp. In the embodiment of the present invention, the composition for the treatment of hair loss was used 5 times a week for 6 months, and as a result, it was confirmed that an excellent hair growth promoting effect was exhibited (Experimental Example 3).

In one aspect of the present invention, the composition may be a pharmaceutical composition for preventing or treating hair loss. In this case, the composition for preventing hair loss or promoting hair growth may include one or more pharmaceutically acceptable carriers, excipients, or diluents, together with an effective amount of one or more compounds, salts, hydrates or solvates thereof.

As used herein, "pharmaceutically acceptable" refers to a composition that is physiologically acceptable and does not cause an allergic or similar reaction, such as gastrointestinal disorder, dizziness, when administered to a human.

Examples of the carrier, excipients and diluents include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methyl cellulose, Polyvinylpyrrolidone, water, methylhydroxybenzoate, propyl hydroxybenzoate, talc, magnesium stearate and mineral oil. In addition, fillers, anti-coagulants, lubricants, wetting agents, fragrances, emulsifiers and preservatives may be further included.

As another aspect of the present invention, the composition may be a quasi-drug composition. In this case, the active ingredient of the present invention may be added as it is or used with other quasi-drug components, and may be suitably used according to conventional methods. These other ingredients may be arbitrarily selected and formulated according to the formulation of the quasi-drug or the purpose of use. For example, thickeners, stabilizers, solubilizers, vitamins, pigments, and conventional auxiliaries such as fragrances, and carriers may be included.

As another aspect of the present invention, the composition may be a cosmetic composition for preventing hair loss, improving or promoting hair growth.

The cosmetic composition of the present invention may be variously formulated in the form of cosmetics known in the art, and additional ingredients may be arbitrarily selected according to the formulation and purpose of use and appropriately formulated. For example, it may include conventional ingredients such as thickeners, surfactants, moisturizers, abrasives, sweeteners, pH adjusting agents, preservatives, binders, wetting agents, foaming agents, stabilizers, solubilizing agents, vitamins, pigments and flavoring agents.

In addition, the present invention provides a product for hair or scalp comprising the composition for preventing hair loss or promoting hair growth. The product according to the present invention comprising the above-mentioned one or more compounds, or a salt, hydrate or solvate thereof as an active ingredient, generally covers products manufactured and marketed for promoting scalp health and hair growth, and applied hair or scalp. There are no restrictions on dragon products.

The product for hair or scalp of the present invention can be formulated in any form that can be applied to skin, but is preferably formulated in the form of an external preparation. For example, a liquid, creamy, pastey, or solid phase may be prepared in a formulation that can be applied to the skin, and a hair growth agent, a scalp clinic, a scalp scaling agent, and a scalp massage agent for promoting hair growth by adding common additives, Scalp Care, Cleanser, Shampoo, Tonic, Hair Conditioner, Hair Lotion, Gel, Pack, Cream, Essence, Powder, Spray, Oil, Soap, Liquid Cleanser, Liquid Hair Repellent, Hair Styling, Hair Color and Firm May be, it may be variously used in the form of aerosol type of these formulations, but is not limited thereto.

When the product of the present invention is liquid, a solvent, solubilizer or emulsifier is used as a carrier component, for example, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1,3- Butyl glycol oil, glycerol aliphatic esters, polyethylene glycol or fatty acid esters of sorbitan and the like can be used.

When the product of the present invention is a paste, cream or gel, animal oil, vegetable oil, wax, paraffin, starch, trakant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide, etc. may be used as a carrier component. You can.

When the product of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component, and in the case of a spray, additionally chlorofluorohydrocarbon, propane / Propellant such as butane or dimethyl ether.

When the product of the present invention is an external preparation, it contains ingredients commonly used in external preparations to apply the active ingredient to the skin, for example, water, surfactant, moisturizer, lower alcohol, chelating agent, fungicide, antioxidant, It may further include one or more additives selected from the group consisting of preservatives, pigments and fragrances.

The composition of the present invention is safe for the human body and has excellent side effects of preventing hair loss and promoting hair growth without side effects. In addition, the composition for preventing hair loss or promoting hair growth of the present invention promotes proliferation of papillary cells and has a very excellent function in increasing hair elasticity.

Hereinafter, the present invention will be described in more detail through examples. These examples are only intended to illustrate the present invention in more detail, and it will be apparent to those skilled in the art that the scope of the present invention is not limited by these examples.

Example

Manufacturing example  1: Hair Loss Treatment Composition 1 (Hair Tonic)

One or more of Rhaponticin, Rhein, Chrysophanol, and Physion-8-Od-glucopyranoside [Table 1] Hair tonic was prepared in the usual manner according to the prescription shown in.

Ingredients Weight ratio (%) Comparative Example 1 Comparative Example 2 Example 1 Example 2 Example 3 Example 4 Example 5 ethanol 55 55 55 55 55 55 55 Castor oil 5 5 5 5 5 5 5 glycerin 3 3 3 3 3 3 3 Active ingredient 0 Minoxidil
2 μg / ml Lapontisin
10 μg / ml lane
10 μg / ml Chrysophanol
10 μg / ml Fijicon-8-Od-gluco-pyranoside
10 μg / ml Lapontisine, lane, chrysophanol, and Fizion-8-Od-glucopyranoside
2.5 µg / ml each Flavoring and coloring Proper Proper Proper Proper Proper Proper Proper Purified water Remaining amount (total 100)

Manufacturing example  2: Composition 2 for the treatment of hair loss ( Hair lotion )

One or more of lapontisin, lane, chrysophanol, and cycion-8-O-d-glucopyranoside were prepared for hair lotion in a conventional manner according to the prescription shown in [Table 2].

Ingredients Weight ratio (%) Cetostearyl alcohol 2 Stearyl triethylammonium chloride 2 Hydroxyethyl cellulose 0.5 Lapontisin, lane, chrysophanol or pysion-8-O-d-glucopyranoside 0.001 Flavoring and coloring Proper Purified water Remaining amount (total 100)

Experimental Example  One: Breast nipples  Cell proliferation promoting effect

Human dermal papilla cells (DPCs) were purchased from Promocel. The DPCs were 5% fetal calf serum (FBS; Gibco, NY, USA), penicillin 100 unit / mL, and streptomycin 100 μg / mL in DMEM (Hyclone Inc, UT, USA) at 37 ° C. and 5% CO2 conditions Cultured underneath. After 3,000 cells / well of cultured DPCs were dispensed into a 96-well plate, the cells were cultured in 0.1% serum conditions for 24 h. Subsequently, DMSO (vehicle) diluted 1: 1000 in serum-free DMEM in cultured cells as a control, 2 μg / ml of minoxidil as a positive control, and lapontisin, lane, chrysophanol, and pyzion-8- Od-glucopyranoside was treated with 10 µg / ml each and a sample of a single substance combined as shown in Table 3 for 1 day and incubated. After incubation, the proliferation level of the cells was evaluated using the CCK method. CCK-8 was incubated for 1 hour by treating the culture with 1:10. After 1 hour, the absorbance of each well was measured at 450 nm. All experiments were repeated 3 times and the average of absorbance values was calculated. The results were expressed as a percentage of the treatment group with 100 as the control.

As a result, when DPCs proliferation promoting effect was treated with lapontisin, lane, chrysophanol, and Fizion-8-O-d-glucopyranoside, it exhibited excellent dermal papilla cell proliferation effect (Table 3).

Treatment Treatment concentration Breast papillary cell proliferation capacity (%) Untreated - 100.0 Minoxidil 2 μg / ml 187.2 Lapontisin 10 μg / ml 162.7 lane 10 μg / ml 152.7 Chrysophanol 10 μg / ml 152.0 Fizion-8-O-d-glucopyranoside 10 μg / ml 148.3 Lapontisine and chrysophanol 5 μg / ml each 172.2 Lane and chrysophanol 5 μg / ml each 168.5 Chrysophanol and Fizion-8-O-d-glucopyranoside 5 μg / ml each 160.5 Lapontisin and Lane
And chrysophanol
And Fizion-8-Od-glucopyranoside 2.5 µg / ml each 189.4

Experimental Example  2: Breast nipples  Cell activation signal regulation effect

In general, VEGF, IGF-1, FGF, etc. secreted from the papilla induce hair growth phase, Versican is known as a marker of hair growth, and DKK-1 is known as a degenerative marker of hair. Therefore, the effects of the substances of the present invention, lapontisin, lane, chrysophanol, and pysion-8-O-d-glucopyranoside, were investigated on the growth-promoting and degenerative-inducing signals in papillary cells.

Substances of the materials of the present invention, Lapontisin, Lane, Chrysophanol, and Fizion-8-Od-glucopyranoside after seeding 1 x 10 ⁵ of papillary cells in a cultured 6-well plate in each well 10 μg / ml each, and after processing a sample of a single substance as shown in Table 5, the expression level of VEGF, versican, and DKK-1 was measured using a real-time PCR technique. Taqman ^ⓡ probe (Thermo Fisher) of [Table 4] , Massachusetts, USA), and the results are shown in [Table 5].

gene Taqman ^ⓡ probe analysis ID VEGF Hs00900055_m1 Versican Hs00171642_m1 DKK-1 Hs00183740_m1

As a result, the substances of lapontisin, lane, chrysophanol, and pysion-8-Od-glucopyranoside increased the expression of VEGF, a hair growth-induced growth factor, and Versican, a growth-marker, and a degenerative induction factor of hair. The expression of DKK-1 was reduced (Table 5).

Treatment group / treatment concentration Gene expression level (%) VEGF Versican DKK-1 Untreated 100 100 100 Minoxidil 2 μg / ml 110 134 128 Lapontisin 10 μg / ml 210 130 112 Lane 10 μg / ml 144 154 76 Chrysophanol 10 μg / ml 250 158 123 10 g / ml of Fizion-8-O-d-glucopyranoside 164 175 75 Lapontisin 5 μg / ml
And chrysophanol 5 μg / ml 235 150 111 Lane 5 µg / ml and Chrysophanol 5 µg / ml 250 158 65 Chrysophanol 5 µg / ml and Fizion-8-O-d-glucopyranoside 5 µg / ml 264 192 109 Lapontisin 2.5 μg / ml and Lane 2.5 μg / ml
And chrysophanol 2.5 μg / ml
And 2.5 µg / ml of Fizion-8-Od-glucopyranoside 295 188 61

As described above, it is confirmed that the substances of lapontisin, lane, chrysophanol, and pysion-8-Od-glucopyranoside have excellent hair growth induction and hair loss suppression effects, and prevent hair loss and hair according to the present invention. Growth promoting compositions were prepared in several formulations. The formulation example was specifically described below. However, these formulation examples are only examples of the composition for promoting hair growth of the present invention, and it will be apparent to those skilled in the art that the scope of the composition of the present invention is not limited to these formulations.

Experimental Example  3: Composition of hair growth 1 (hair tonic) Hair growth effect  Confirmation test

The hair loss treatment composition 1 (hair tonic) of the present invention prepared in Preparation Example 1 is divided into 4 groups of 10 men and 40 women, who have significantly fewer hairs than normal, or show hair loss symptoms and have weak hairs. , Comparative Examples 1 and 2 and Examples 1 to 5 were used for hair and scalp for 6 months, 5 times a week. After use, the degree of improvement (very good; +3, better; +2, slightly better; +1, no change; 0, slightly worse; -1, worse; -2, very bad; -3) was assessed by the user after 6 months, and the result was shown in [Table 6].

sample The thickness of the hair Density Resilience Overall Rating Comparative Example 1 -0.5 ± 0.2 0.1 ± 0.2 -0.1 ± 0.2 -0.2.1 ± 0.2 Comparative Example 2 2.1 ± 0.2 2.3 ± 0.1 2.1 ± 0.3 2.1 ± 0.2 Example 1 2.8 ± 0.3 2.7 ± 0.1 2.5 ± 0.4 2.8 ± 0.1 Example 2 2.6 ± 0.1 2.8 ± 0.2 2.4 ± 0.3 2.7 ± 0.2 Example 3 1.9 ± 0.1 2.6 ± 0.3 2.0 ± 0.2 2.3 ± 0.1 Example 4 2.6 ± 0.3 2.1 ± 0.1 2.4 ± 0.1 2.6 ± 0.1 Example 5 2.7 ± 0.3 2.9 ± 0.3 2.7 ± 0.3 2.8 ± 0.3

As can be seen from the results, the present invention shows a high hair loss prevention and hair growth effect in the example using the substance of lapontisin, lane, chrysophanol, and pysion-8-Od-glucopyranoside, and the present invention It has been proven to be very effective.

Claims (12)

At least one compound selected from the group consisting of Rhaponticin, Rhein, Chrysophanol and Physion-8-Od-glucopyranoside, Or a composition for preventing hair loss or promoting hair growth, comprising a salt, hydrate or solvate thereof as an active ingredient. The composition of claim 1, wherein the compound is two or more. According to claim 1, wherein the at least one compound is (i) chrysophanol; And (ii) one or more compounds selected from Rhein, Lapontisin, and Physion-8-O-d-glucopyranoside. ◈ Claim 4 was abandoned when payment of the set registration fee was made.◈ The method of claim 1, wherein the one or more compounds are Laponticin, Rhein, Chrysophanol, and Fizion-8-Od-glucopyranoside (Physcion-8-Od-glucopyranoside). ). ◈ Claim 5 was abandoned when payment of the set registration fee was made.◈ The composition of claim 1, wherein the content of the active ingredient is 0.00001 to 50% by weight. The composition of claim 1, wherein the composition promotes proliferation of breast papilla cells. ◈ Claim 7 was abandoned when payment of the set registration fee was made.◈ The composition of claim 1, wherein the composition increases elasticity of hair. The composition according to any one of claims 1 to 7, wherein the composition is a pharmaceutical composition. The composition according to any one of claims 1 to 7, wherein the composition is a quasi-drug composition. The composition according to any one of claims 1 to 7, wherein the composition is a cosmetic composition. A product for hair or scalp comprising a composition according to claim 1. 12. The method of claim 11, wherein the product for hair or scalp is a hair repellent, scalp clinic, scalp scaling agent, scalp massage agent, scalp care agent, detergent, shampoo, tonic, hair conditioner, hair lotion, gel, pack, cream, essence , Powder, spray, oil, soap, ointment, hair styling agent, hair dye, and product characterized in that it is selected from the group consisting of perm.