KR101512217B1 - Fak의 억제제로서의 피라졸릴아미노피리딘 - Google Patents
Fak의 억제제로서의 피라졸릴아미노피리딘 Download PDFInfo
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- KR101512217B1 KR101512217B1 KR1020117011999A KR20117011999A KR101512217B1 KR 101512217 B1 KR101512217 B1 KR 101512217B1 KR 1020117011999 A KR1020117011999 A KR 1020117011999A KR 20117011999 A KR20117011999 A KR 20117011999A KR 101512217 B1 KR101512217 B1 KR 101512217B1
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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Abstract
Description
Claims (13)
- 제1항에 있어서, 2-[(5-클로로-2-{[3-메틸-1-(1-메틸에틸)-1H-피라졸-5-일]아미노}-4-피리디닐)아미노]-N-(메틸옥시)벤즈아미드인 화합물.
- 제1항에 있어서, 2-[(5-클로로-2-{[3-메틸-1-(1-메틸에틸)-1H-피라졸-5-일]아미노}-4-피리디닐)아미노]-N-(메틸옥시)벤즈아미드 모노히드로클로라이드인 화합물.
- 제1항 내지 제3항 중 어느 한 항의 화합물 및 제약상 허용되는 담체를 포함하는, 암을 치료하거나 암의 중증도를 감소시키기 위한 제약 조성물.
- 제4항에 있어서, 인간에서 암을 치료하거나 암의 중증도를 감소시키기 위한 제약 조성물.
- 제4항에 있어서, 정제 형태인 제약 조성물.
- 제4항에 있어서, 암이 피부, 유방, 뇌, 자궁경부 암종, 고환 암종, 성상 세포, 결장직장, 자궁내막, 식도, 위(gastric), 두경부, 간세포, 후두, 폐, 경구, 난소, 전립선, 갑상선 암종, 육종, 폐, 림프종, 중피종, 위장, 위(stomach), 췌장, 소장, 대장, 신장, 방광 및 요도, 간, 골, 유잉 육종, 악성 림프종, 다발성 골수종, 악성 거세포 종양 척삭종, 뇌, 다형성 교모세포종, 척수, 자궁, 자궁경부, 난소, 편평 세포 암종, 및 혈액암으로부터 선택된 것인 제약 조성물.
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US61/242,432 | 2009-09-15 | ||
PCT/US2009/062163 WO2010062578A1 (en) | 2008-10-27 | 2009-10-27 | Pyrazolylaminopyridines as inhibitors of fak |
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