KR100554549B1 - 9ａ-아잘리드류로부터 유래한 신규한 3,6-헤미케탈 - Google Patents

9ａ-아잘리드류로부터 유래한 신규한 3,6-헤미케탈 Download PDF

Info

Publication number: KR100554549B1
Authority: KR; South Korea
Prior art keywords: methyl; same; group; represent; compound
Prior art date: 1997-10-16

Application number

KR1020007004079A

Other languages

English (en)

Korean (ko)

Other versions

KR20010031160A (ko

Inventor

코브레헬가브리젤라

라자레브스키고르자나

빈코비크밀라덴

Original Assignee

플리바 파마세우츠카 인두스트리야, 디오닉코, 드러스트보

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-16

Filing date

1998-10-13

Publication date

2006-03-03

1997-10-16 Priority claimed from HR970551A external-priority patent/HRP970551B1/xx

1998-09-10 Priority claimed from HR980497A external-priority patent/HRP980497B1/xx

1998-10-13 Application filed by 플리바 파마세우츠카 인두스트리야, 디오닉코, 드러스트보 filed Critical 플리바 파마세우츠카 인두스트리야, 디오닉코, 드러스트보

2001-04-16 Publication of KR20010031160A publication Critical patent/KR20010031160A/ko

2006-03-03 Application granted granted Critical

2006-03-03 Publication of KR100554549B1 publication Critical patent/KR100554549B1/ko

Links

0 CC[C@]([C@@](C)(*)[C@](*)[C@@](C)N(C)C[C@](C)C[C@@](C)(*)[C@@]([C@@](C)[C@@](C)(*)[C@@]1C)O[C@](*[C@](*C)CC2N(C)*)[C@@]2(C)O)OC1=O Chemical compound CC[C@]([C@@](C)(*)[C@](*)[C@@](C)N(C)C[C@](C)C[C@@](C)(*)[C@@]([C@@](C)[C@@](C)(*)[C@@]1C)O[C@](*[C@](*C)CC2N(C)*)[C@@]2(C)O)OC1=O 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

KR1020007004079A 1997-10-16 1998-10-13 9ａ-아잘리드류로부터 유래한 신규한 3,6-헤미케탈 KR100554549B1 (ko)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
HRP970551A		1997-10-16
HR970551A HRP970551B1 (en)	1997-10-16	1997-10-16	Novel o-methyl azythromycin derivatives
HRP980497A		1998-09-10
HR980497A HRP980497B1 (en)	1998-09-10	1998-09-10	NOVEL 3,6-HEMIKETALS FROM THE CLASS OF 9a-AZALIDES
PCT/HR1998/000005 WO1999020639A2 (en)	1997-10-16	1998-10-13	NOVEL 3,6-HEMIKETALS FROM THE CLASS OF 9a-AZALIDES

Publications (2)

Publication Number	Publication Date
KR20010031160A KR20010031160A (ko)	2001-04-16
KR100554549B1 true KR100554549B1 (ko)	2006-03-03

Family

ID=26317108

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
KR1020007004079A KR100554549B1 (ko)	1997-10-16	1998-10-13	9ａ-아잘리드류로부터 유래한 신규한 3,6-헤미케탈

Country Status (26)

Country	Link
US (1)	US6369035B1 (hu)
EP (2)	EP1036083B9 (hu)
JP (1)	JP2001520234A (hu)
KR (1)	KR100554549B1 (hu)
CN (1)	CN1281615C (hu)
AR (1)	AR018014A1 (hu)
AT (2)	ATE348836T1 (hu)
AU (1)	AU755315B2 (hu)
BG (1)	BG64650B1 (hu)
BR (1)	BR9812808A (hu)
CA (1)	CA2306963C (hu)
DE (2)	DE69824201T2 (hu)
DK (2)	DK1036083T5 (hu)
EE (1)	EE04681B1 (hu)
ES (2)	ES2222610T3 (hu)
HK (1)	HK1032785A1 (hu)
HU (1)	HUP0004085A3 (hu)
IL (2)	IL135648A0 (hu)
NO (1)	NO20001871L (hu)
NZ (1)	NZ503897A (hu)
PL (1)	PL191087B1 (hu)
PT (2)	PT1437359E (hu)
RU (1)	RU2220148C2 (hu)
SI (2)	SI1036083T1 (hu)
SK (1)	SK285914B6 (hu)
WO (1)	WO1999020639A2 (hu)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP0104192A3 (en) *	1998-11-03	2003-12-29	Pfizer Prod Inc	Novel macrolide antibiotics
KR100361397B1 (ko) *	2000-03-15	2002-11-23	한미약품공업 주식회사	에리스로마이신 에이 9-오-트로필옥심 유도체를 이용한클라리스로마이신의 제조방법
EP1482957A4 (en)	2002-02-15	2006-07-19	Merckle Gmbh	ANTIBIOTIC CONJUGATES
EP1483277A4 (en)	2002-02-15	2007-10-03	Merckle Gmbh	CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS OF PREPARATION AND USE, AND FORMULATION AND PHARMACEUTICAL APPLICATIONS
US20060099660A1 (en)	2002-02-15	2006-05-11	Synovo Gmbh	Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
HRP20020779A2 (en)	2002-09-27	2005-02-28	Pliva-Istra�iva�ki institut d.o.o.	NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
ITMI20022292A1 (it) *	2002-10-29	2004-04-30	Zambon Spa	9a-azalidi ad attivita' antiinfiammatoria.
US7435805B2 (en)	2003-05-30	2008-10-14	Glaxpsmithkline Istrazivacki	O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2004106353A1 (en) *	2003-05-30	2004-12-09	Pliva - Istrazivacki Institut D.O.O.	Process for selective alkylation of macrolide and azalide derivatives
US7276487B2 (en)	2003-09-23	2007-10-02	Enanta Pharmaceuticals, Inc.	9a, 11-3C-bicyclic 9a-azalide derivatives
US7468428B2 (en) *	2004-03-17	2008-12-23	App Pharmaceuticals, Llc	Lyophilized azithromycin formulation
US20060116336A1 (en) *	2004-03-17	2006-06-01	American Pharmaceutical Partners, Inc.	Lyophilized azithromycin formulation
US7402568B2 (en)	2004-09-29	2008-07-22	Enanta Pharmaceuticals, Inc.	Bicyclic 9a-azalide derivatives
US7271155B2 (en)	2005-01-07	2007-09-18	Enanta Pharmaceuticals, Inc.	9A, 11-2C-bicyclic 9a-azalide derivatives
WO2008106204A1 (en) *	2007-02-28	2008-09-04	Rib-X-Pharmaceuticals, Inc.	Macrolide compounds and methods of making and using the same
US9145436B2 (en)	2010-10-10	2015-09-29	Michael W. Burnet	Anti-inflammatory macrolides
CA2869461A1 (en) *	2012-03-27	2013-10-03	Michael W. BURNET	Anti-inflammatory macrolides
JP7184520B2 (ja) *	2018-01-22	2022-12-06	旭化成株式会社	トランス型脂環式カーボネートの製造方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5250518A (en) *	1990-07-18	1993-10-05	Pliva Farmaceutska, Kemijska, Prehrambena I Kozmeticka	O-methyl derivatives of azithromycin A

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
YU43006B (en) *	1981-03-06	1989-02-28	Pliva Pharm & Chem Works	Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) *	1982-07-19	1984-10-02	Pfizer Inc.	N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
RU2066324C1 (ru) *	1987-07-09	1996-09-10	Пфайзер Инк.	Кристаллический дигидрат азитромицина и способ его получения
DE3860503D1 (de) *	1987-09-03	1990-10-04	Pliva Pharm & Chem Works	10-dihydro-10-deoxo-11-azaerythronolid-a-verbindungen,verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung in arzneimitteln und in deren herstellung.
WO1989002271A1 (en) *	1987-09-10	1989-03-23	Pfizer	Azithromycin and derivatives as antiprotozoal agents
FR2691464B1 (fr) *	1992-05-21	1995-06-02	Roussel Uclaf	Nouveaux dérivés de la 1-oxa 6-azacyclopentadécane 13,15-dione, leur procédé de préparation et leur application comme médicaments.
WO1999000124A1 (en) *	1997-06-26	1999-01-07	Merck & Co., Inc.	9a-azalides, compositions containing such compounds and methods of treatment

1998
- 1998-10-13 NZ NZ503897A patent/NZ503897A/xx unknown
- 1998-10-13 RU RU2000111996/04A patent/RU2220148C2/ru not_active IP Right Cessation
- 1998-10-13 BR BR9812808-6A patent/BR9812808A/pt not_active Application Discontinuation
- 1998-10-13 ES ES98946627T patent/ES2222610T3/es not_active Expired - Lifetime
- 1998-10-13 US US09/529,642 patent/US6369035B1/en not_active Expired - Fee Related
- 1998-10-13 KR KR1020007004079A patent/KR100554549B1/ko not_active IP Right Cessation
- 1998-10-13 PL PL340372A patent/PL191087B1/pl unknown
- 1998-10-13 EE EEP200000226A patent/EE04681B1/xx not_active IP Right Cessation
- 1998-10-13 DE DE69824201T patent/DE69824201T2/de not_active Expired - Fee Related
- 1998-10-13 PT PT04004844T patent/PT1437359E/pt unknown
- 1998-10-13 AT AT04004844T patent/ATE348836T1/de not_active IP Right Cessation
- 1998-10-13 WO PCT/HR1998/000005 patent/WO1999020639A2/en not_active Application Discontinuation
- 1998-10-13 CA CA002306963A patent/CA2306963C/en not_active Expired - Fee Related
- 1998-10-13 SK SK552-2000A patent/SK285914B6/sk unknown
- 1998-10-13 DK DK98946627T patent/DK1036083T5/da active
- 1998-10-13 AT AT98946627T patent/ATE267835T1/de not_active IP Right Cessation
- 1998-10-13 SI SI9830675T patent/SI1036083T1/xx unknown
- 1998-10-13 EP EP98946627A patent/EP1036083B9/en not_active Expired - Lifetime
- 1998-10-13 ES ES04004844T patent/ES2279242T3/es not_active Expired - Lifetime
- 1998-10-13 HU HU0004085A patent/HUP0004085A3/hu unknown
- 1998-10-13 EP EP04004844A patent/EP1437359B1/en not_active Expired - Lifetime
- 1998-10-13 IL IL13564898A patent/IL135648A0/xx not_active IP Right Cessation
- 1998-10-13 JP JP2000516980A patent/JP2001520234A/ja active Pending
- 1998-10-13 DE DE69836697T patent/DE69836697T2/de not_active Expired - Fee Related
- 1998-10-13 AU AU93622/98A patent/AU755315B2/en not_active Ceased
- 1998-10-13 PT PT98946627T patent/PT1036083E/pt unknown
- 1998-10-13 DK DK04004844T patent/DK1437359T3/da active
- 1998-10-13 CN CNB988116243A patent/CN1281615C/zh not_active Expired - Fee Related
- 1998-10-13 SI SI9830878T patent/SI1437359T1/sl unknown
- 1998-10-16 AR ARP980105155A patent/AR018014A1/es active IP Right Grant
2000
- 2000-04-11 NO NO20001871A patent/NO20001871L/no not_active Application Discontinuation
- 2000-04-13 IL IL135648A patent/IL135648A/en unknown
- 2000-05-16 BG BG104445A patent/BG64650B1/bg unknown
2001
- 2001-05-22 HK HK01103498A patent/HK1032785A1/xx not_active IP Right Cessation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5250518A (en) *	1990-07-18	1993-10-05	Pliva Farmaceutska, Kemijska, Prehrambena I Kozmeticka	O-methyl derivatives of azithromycin A

Also Published As

Publication number	Publication date
BG64650B1 (bg)	2005-10-31
BR9812808A (pt)	2005-04-12
EP1437359A2 (en)	2004-07-14
WO1999020639A2 (en)	1999-04-29
ES2279242T3 (es)	2007-08-16
PT1437359E (pt)	2007-04-30
DE69836697T2 (de)	2007-10-04
BG104445A (en)	2001-02-28
HK1032785A1 (en)	2001-08-03
SK285914B6 (sk)	2007-11-02
KR20010031160A (ko)	2001-04-16
EP1437359A3 (en)	2005-03-30
ATE267835T1 (de)	2004-06-15
NO20001871L (no)	2000-04-17
DK1036083T5 (da)	2005-04-04
IL135648A0 (en)	2001-05-20
CA2306963C (en)	2007-05-01
EP1437359B1 (en)	2006-12-20
DK1036083T3 (da)	2004-09-27
AU755315B2 (en)	2002-12-12
IL135648A (en)	2007-03-08
RU2220148C2 (ru)	2003-12-27
DE69824201D1 (de)	2004-07-01
CN1281615C (zh)	2006-10-25
DK1437359T3 (da)	2007-04-30
EP1036083B9 (en)	2005-01-12
EE200000226A (et)	2001-06-15
SI1437359T1 (sl)	2007-06-30
NZ503897A (en)	2002-10-25
HUP0004085A2 (hu)	2001-04-28
SK5522000A3 (en)	2000-11-07
US6369035B1 (en)	2002-04-09
SI1036083T1 (en)	2004-10-31
NO20001871D0 (no)	2000-04-11
PL340372A1 (en)	2001-01-29
PL191087B1 (pl)	2006-03-31
WO1999020639A3 (en)	1999-07-08
JP2001520234A (ja)	2001-10-30
DE69824201T2 (de)	2005-09-22
HUP0004085A3 (en)	2003-05-28
PT1036083E (pt)	2004-10-29
EE04681B1 (et)	2006-08-15
EP1036083A2 (en)	2000-09-20
DE69836697D1 (de)	2007-02-01
CA2306963A1 (en)	1999-04-29
ATE348836T1 (de)	2007-01-15
AR018014A1 (es)	2001-10-31
CN1280585A (zh)	2001-01-17
AU9362298A (en)	1999-05-10
ES2222610T3 (es)	2005-02-01
EP1036083B1 (en)	2004-05-26

Publication	Publication Date	Title
KR100554549B1 (ko)	2006-03-03	9ａ-아잘리드류로부터 유래한 신규한 3,6-헤미케탈
RU2045533C1 (ru)	1995-10-10	О-метильные производные азитромицина а, обладающие антибактериальной активностью, азитромицины в качестве промежуточных соединений для получения о-метильных производных азитромицина а и способ получения о-метильных производных азитромицина а
CA2327775C (en)	2007-08-07	15-membered lactams ketolides with antibacterial activity
JP3056035B2 (ja)	2000-06-26	９−デオキソ−９ａ−アザ−１１−デオキシ−９ａ−ホモエリスロマイシンＡ９ａ，１１−環式カルバメート
EP1181298B1 (en)	2006-07-19	Novel 8a- and 9a-15-membered lactams
EP0262905A2 (en)	1988-04-06	Modifications of 3-0-demethyl-mycinose in macrocin and lactenocin
CZ20001319A3 (cs)	2000-09-13	Nové 3,6-hemiketaly ze třídy 9a-azalidů
HRP980497A2 (en)	2000-12-31	NOVEL 3,6-HEMIKETALS FROM THE CLASS OF 9a-AZALIDES
MXPA00003644A (en)	2001-07-09	NOVEL 3,6-HEMIKETALS FROM THE CLASS OF 9a-AZALIDES
HRP970551A2 (en)	2000-12-31	Novel o-methyl azythromycin derivatives
CZ20003704A3 (cs)	2001-01-17	15-členné laktamové ketolidy s antibakteriální účinností
MXPA00009875A (es)	2001-11-21	Cetolidos de lactamas de 15 miembros con actividad antibacteriana

Legal Events

Date	Code	Title
2003-09-20	A201	Request for examination
2005-05-27	E902	Notification of reason for refusal
2005-11-24	E701	Decision to grant or registration of patent right
2006-02-16	GRNT	Written decision to grant
2009-02-17	LAPS	Lapse due to unpaid annual fee