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IL135648A0 - Novel 3, 6-hemiketals from the class of 9a-azalides - Google Patents

Novel 3, 6-hemiketals from the class of 9a-azalides

Info

Publication number
IL135648A0
IL135648A0 IL13564898A IL13564898A IL135648A0 IL 135648 A0 IL135648 A0 IL 135648A0 IL 13564898 A IL13564898 A IL 13564898A IL 13564898 A IL13564898 A IL 13564898A IL 135648 A0 IL135648 A0 IL 135648A0
Authority
IL
Israel
Prior art keywords
azalides
hemiketals
class
novel
Prior art date
Application number
IL13564898A
Other languages
English (en)
Original Assignee
Pliva Pharm & Chem Works
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HR970551A external-priority patent/HRP970551B1/xx
Priority claimed from HR980497A external-priority patent/HRP980497B1/xx
Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works
Publication of IL135648A0 publication Critical patent/IL135648A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
IL13564898A 1997-10-16 1998-10-13 Novel 3, 6-hemiketals from the class of 9a-azalides IL135648A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HR970551A HRP970551B1 (en) 1997-10-16 1997-10-16 Novel o-methyl azythromycin derivatives
HR980497A HRP980497B1 (en) 1998-09-10 1998-09-10 NOVEL 3,6-HEMIKETALS FROM THE CLASS OF 9a-AZALIDES
PCT/HR1998/000005 WO1999020639A2 (en) 1997-10-16 1998-10-13 NOVEL 3,6-HEMIKETALS FROM THE CLASS OF 9a-AZALIDES

Publications (1)

Publication Number Publication Date
IL135648A0 true IL135648A0 (en) 2001-05-20

Family

ID=26317108

Family Applications (2)

Application Number Title Priority Date Filing Date
IL13564898A IL135648A0 (en) 1997-10-16 1998-10-13 Novel 3, 6-hemiketals from the class of 9a-azalides
IL135648A IL135648A (en) 1997-10-16 2000-04-13 Azithromycin derivatives, their preparation, and pharmaceutical antibacterial compositions containing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL135648A IL135648A (en) 1997-10-16 2000-04-13 Azithromycin derivatives, their preparation, and pharmaceutical antibacterial compositions containing them

Country Status (26)

Country Link
US (1) US6369035B1 (xx)
EP (2) EP1036083B9 (xx)
JP (1) JP2001520234A (xx)
KR (1) KR100554549B1 (xx)
CN (1) CN1281615C (xx)
AR (1) AR018014A1 (xx)
AT (2) ATE348836T1 (xx)
AU (1) AU755315B2 (xx)
BG (1) BG64650B1 (xx)
BR (1) BR9812808A (xx)
CA (1) CA2306963C (xx)
DE (2) DE69824201T2 (xx)
DK (2) DK1036083T5 (xx)
EE (1) EE04681B1 (xx)
ES (2) ES2222610T3 (xx)
HK (1) HK1032785A1 (xx)
HU (1) HUP0004085A3 (xx)
IL (2) IL135648A0 (xx)
NO (1) NO20001871L (xx)
NZ (1) NZ503897A (xx)
PL (1) PL191087B1 (xx)
PT (2) PT1437359E (xx)
RU (1) RU2220148C2 (xx)
SI (2) SI1036083T1 (xx)
SK (1) SK285914B6 (xx)
WO (1) WO1999020639A2 (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0104192A3 (en) * 1998-11-03 2003-12-29 Pfizer Prod Inc Novel macrolide antibiotics
KR100361397B1 (ko) * 2000-03-15 2002-11-23 한미약품공업 주식회사 에리스로마이신 에이 9-오-트로필옥심 유도체를 이용한클라리스로마이신의 제조방법
EP1482957A4 (en) 2002-02-15 2006-07-19 Merckle Gmbh ANTIBIOTIC CONJUGATES
EP1483277A4 (en) 2002-02-15 2007-10-03 Merckle Gmbh CONJUGATES OF BIOLOGICALLY ACTIVE COMPOUNDS, METHODS OF PREPARATION AND USE, AND FORMULATION AND PHARMACEUTICAL APPLICATIONS
US20060099660A1 (en) 2002-02-15 2006-05-11 Synovo Gmbh Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof
HRP20020779A2 (en) 2002-09-27 2005-02-28 Pliva-Istra�iva�ki institut d.o.o. NEW 3-DECLADINOSYL DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICIN A 9a, 11-CYCLIC CARBAMATES
ITMI20022292A1 (it) * 2002-10-29 2004-04-30 Zambon Spa 9a-azalidi ad attivita' antiinfiammatoria.
US7435805B2 (en) 2003-05-30 2008-10-14 Glaxpsmithkline Istrazivacki O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
WO2004106353A1 (en) * 2003-05-30 2004-12-09 Pliva - Istrazivacki Institut D.O.O. Process for selective alkylation of macrolide and azalide derivatives
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
WO2008106204A1 (en) * 2007-02-28 2008-09-04 Rib-X-Pharmaceuticals, Inc. Macrolide compounds and methods of making and using the same
US9145436B2 (en) 2010-10-10 2015-09-29 Michael W. Burnet Anti-inflammatory macrolides
CA2869461A1 (en) * 2012-03-27 2013-10-03 Michael W. BURNET Anti-inflammatory macrolides
JP7184520B2 (ja) * 2018-01-22 2022-12-06 旭化成株式会社 トランス型脂環式カーボネートの製造方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
US4474768A (en) * 1982-07-19 1984-10-02 Pfizer Inc. N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor
RU2066324C1 (ru) * 1987-07-09 1996-09-10 Пфайзер Инк. Кристаллический дигидрат азитромицина и способ его получения
DE3860503D1 (de) * 1987-09-03 1990-10-04 Pliva Pharm & Chem Works 10-dihydro-10-deoxo-11-azaerythronolid-a-verbindungen,verfahren und zwischenprodukte zu ihrer herstellung und ihre verwendung in arzneimitteln und in deren herstellung.
WO1989002271A1 (en) * 1987-09-10 1989-03-23 Pfizer Azithromycin and derivatives as antiprotozoal agents
SI9011409A (en) * 1990-07-18 1995-10-31 Pliva Pharm & Chem Works O-methyl azitromycin derivates, methods and intermediates for their preparation and methods for preparation of pharmaceuticals products which comprise them
FR2691464B1 (fr) * 1992-05-21 1995-06-02 Roussel Uclaf Nouveaux dérivés de la 1-oxa 6-azacyclopentadécane 13,15-dione, leur procédé de préparation et leur application comme médicaments.
WO1999000124A1 (en) * 1997-06-26 1999-01-07 Merck & Co., Inc. 9a-azalides, compositions containing such compounds and methods of treatment

Also Published As

Publication number Publication date
BG64650B1 (bg) 2005-10-31
KR100554549B1 (ko) 2006-03-03
BR9812808A (pt) 2005-04-12
EP1437359A2 (en) 2004-07-14
WO1999020639A2 (en) 1999-04-29
ES2279242T3 (es) 2007-08-16
PT1437359E (pt) 2007-04-30
DE69836697T2 (de) 2007-10-04
BG104445A (en) 2001-02-28
HK1032785A1 (en) 2001-08-03
SK285914B6 (sk) 2007-11-02
KR20010031160A (ko) 2001-04-16
EP1437359A3 (en) 2005-03-30
ATE267835T1 (de) 2004-06-15
NO20001871L (no) 2000-04-17
DK1036083T5 (da) 2005-04-04
CA2306963C (en) 2007-05-01
EP1437359B1 (en) 2006-12-20
DK1036083T3 (da) 2004-09-27
AU755315B2 (en) 2002-12-12
IL135648A (en) 2007-03-08
RU2220148C2 (ru) 2003-12-27
DE69824201D1 (de) 2004-07-01
CN1281615C (zh) 2006-10-25
DK1437359T3 (da) 2007-04-30
EP1036083B9 (en) 2005-01-12
EE200000226A (et) 2001-06-15
SI1437359T1 (sl) 2007-06-30
NZ503897A (en) 2002-10-25
HUP0004085A2 (hu) 2001-04-28
SK5522000A3 (en) 2000-11-07
US6369035B1 (en) 2002-04-09
SI1036083T1 (en) 2004-10-31
NO20001871D0 (no) 2000-04-11
PL340372A1 (en) 2001-01-29
PL191087B1 (pl) 2006-03-31
WO1999020639A3 (en) 1999-07-08
JP2001520234A (ja) 2001-10-30
DE69824201T2 (de) 2005-09-22
HUP0004085A3 (en) 2003-05-28
PT1036083E (pt) 2004-10-29
EE04681B1 (et) 2006-08-15
EP1036083A2 (en) 2000-09-20
DE69836697D1 (de) 2007-02-01
CA2306963A1 (en) 1999-04-29
ATE348836T1 (de) 2007-01-15
AR018014A1 (es) 2001-10-31
CN1280585A (zh) 2001-01-17
AU9362298A (en) 1999-05-10
ES2222610T3 (es) 2005-02-01
EP1036083B1 (en) 2004-05-26

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Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees