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JPS5925599B2 - 新生理活性物質モナコリンｋおよびその製造法 - Google Patents

新生理活性物質モナコリンｋおよびその製造法

Info

Publication number
JPS5925599B2
JPS5925599B2 JP54017856A JP1785679A JPS5925599B2 JP S5925599 B2 JPS5925599 B2 JP S5925599B2 JP 54017856 A JP54017856 A JP 54017856A JP 1785679 A JP1785679 A JP 1785679A JP S5925599 B2 JPS5925599 B2 JP S5925599B2
Authority
JP
Japan
Prior art keywords
monacolin
monascus
substance
methanol
active substance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
JP54017856A
Other languages
English (en)
Japanese (ja)
Other versions
JPS55111790A (en
Inventor
章 遠藤
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP54017856A priority Critical patent/JPS5925599B2/ja
Priority to AU55673/80A priority patent/AU532626B2/en
Priority to KR1019800000654A priority patent/KR830002801B1/ko
Priority to IE321/80A priority patent/IE49743B1/en
Priority to CA345,983A priority patent/CA1129794A/en
Priority to HU80397A priority patent/HU182069B/hu
Priority to DD80219159A priority patent/DD154494A5/de
Priority to DE3006216A priority patent/DE3006216C2/de
Priority to CH136680A priority patent/CH645890A5/de
Priority to DK73080A priority patent/DK149095C/da
Priority to ZA00800962A priority patent/ZA80962B/xx
Priority to GB8005748A priority patent/GB2046737B/en
Priority to PH23668A priority patent/PH15145A/en
Priority to SU802887300A priority patent/SU1158048A3/ru
Priority to BE0/199476A priority patent/BE881825A/fr
Priority to FI800506A priority patent/FI66427C/fi
Priority to PL1980222120A priority patent/PL124304B1/pl
Priority to DE3051175A priority patent/DE3051175C2/de
Priority to NO800451A priority patent/NO153974C/no
Priority to MX808652U priority patent/MX6314E/es
Priority to NL8001041A priority patent/NL191540C/xx
Priority to IT67262/80A priority patent/IT1175260B/it
Priority to AT0092980A priority patent/AT373915B/de
Priority to SE8001339A priority patent/SE453301B/sv
Priority to ES488796A priority patent/ES488796A0/es
Priority to FR8003662A priority patent/FR2449685B1/fr
Priority to NZ192919A priority patent/NZ192919A/en
Publication of JPS55111790A publication Critical patent/JPS55111790A/ja
Priority to SU802977031A priority patent/SU969702A1/ru
Priority to SG67/84A priority patent/SG6784G/en
Publication of JPS5925599B2 publication Critical patent/JPS5925599B2/ja
Priority to DK47085A priority patent/DK165990C/da
Priority to DK021889A priority patent/DK21889D0/da
Priority to MX9203568A priority patent/MX9203568A/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/145—Fungal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/645—Fungi ; Processes using fungi

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Obesity (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP54017856A 1979-02-20 1979-02-20 新生理活性物質モナコリンｋおよびその製造法 Expired JPS5925599B2 (ja)

Priority Applications (32)

Application Number Priority Date Filing Date Title
JP54017856A JPS5925599B2 (ja) 1979-02-20 1979-02-20 新生理活性物質モナコリンｋおよびその製造法
AU55673/80A AU532626B2 (en) 1979-02-20 1980-02-19 Monacolink
KR1019800000654A KR830002801B1 (ko) 1979-02-20 1980-02-19 고(高) 콜레스테롤혈증치료제, 모나콜린 k의 제조방법
IE321/80A IE49743B1 (en) 1979-02-20 1980-02-19 Antihypercholesteraemic agent,monacolin k,and its preparation
CA345,983A CA1129794A (en) 1979-02-20 1980-02-19 Antihypercholesteraemic agent, monacolin k, and its preparation
DE3051175A DE3051175C2 (no) 1979-02-20 1980-02-20
NL8001041A NL191540C (nl) 1979-02-20 1980-02-20 Verbinding met antihypercholesteremische werkzaamheid, alsmede farmaceutisch preparaat dat deze verbinding bevat.
DE3006216A DE3006216C2 (de) 1979-02-20 1980-02-20 Monacolin K, Verfahren zu dessen Herstellung und diese Verbindung enthaltende Arzneimittel
CH136680A CH645890A5 (de) 1979-02-20 1980-02-20 Monacolin k, seine herstellung und dieses enthaltendes antihypercholesterinaemisches mittel.
DK73080A DK149095C (da) 1979-02-20 1980-02-20 Fremgangsmaade til fremstilling af en cholesterolsynteseinhiberende forbindelse kaldet monacolin k
ZA00800962A ZA80962B (en) 1979-02-20 1980-02-20 Antihypercholesteraemic agent,monacolin k,and its preparation
GB8005748A GB2046737B (en) 1979-02-20 1980-02-20 Antihypercholesteraemic agent monacolin k and its preparation
PH23668A PH15145A (en) 1979-02-20 1980-02-20 Antihypercholesteraemic agent,monacolin k.process for the production and compositions containing same
SU802887300A SU1158048A3 (ru) 1979-02-20 1980-02-20 Способ получени монаколина @ ,обладающего антигиперхолестеримическим действием
BE0/199476A BE881825A (fr) 1979-02-20 1980-02-20 Agent antihypercholesterolemique prepare par culture de micro-organismes du genre monascus et son procede de preparation
FI800506A FI66427C (fi) 1979-02-20 1980-02-20 Foerfarande foer framstaellning av en ny som laekemedel anvaendbar foerening monacolin k
PL1980222120A PL124304B1 (en) 1979-02-20 1980-02-20 Process for preparing novel 1-/alpha-methylbutyryloxy/-3,7-dimethyl-8-/2-/2-keto-4-hydroxytetrahydropyran-6-yl/-ethyl/-1,2,3,7-8,8a-hexahydronaphtalene
HU80397A HU182069B (en) 1979-02-20 1980-02-20 Process for preparing monacoline k, a compound with antihypercholesteremic activity
NO800451A NO153974C (no) 1979-02-20 1980-02-20 Fremgangsmaate til fremstilling av forbindelsen monacolin k
MX808652U MX6314E (es) 1979-02-20 1980-02-20 Procedimiento microbiologico para la preparacion de monacolin k
DD80219159A DD154494A5 (de) 1979-02-20 1980-02-20 Verfahren zur herstellung von monacolin k
IT67262/80A IT1175260B (it) 1979-02-20 1980-02-20 Agente anti ipercolesterolemico e procedimento per la sua preparazione
AT0092980A AT373915B (de) 1979-02-20 1980-02-20 Verfahren zum herstellen von neuem monacolin k
SE8001339A SE453301B (sv) 1979-02-20 1980-02-20 Antihyperkolesterolemiskt medel, monakolin k, forfarande for framstellning derav samt farmaceutisk komposition innehallande detsamma
ES488796A ES488796A0 (es) 1979-02-20 1980-02-20 Un procedimiento de preparacion de monacolina k.
FR8003662A FR2449685B1 (fr) 1979-02-20 1980-02-20 Agent antihypercholesterolemique prepare par culture de microorganismes du genre monascus et son procede de preparation
NZ192919A NZ192919A (en) 1979-02-20 1980-02-20 Monacolin k and pharmaceutical compositions
SU802977031A SU969702A1 (ru) 1979-02-20 1980-09-12 Монаколин К, обладающий гипохолестеримическим действием
SG67/84A SG6784G (en) 1979-02-20 1984-01-24 Antihypercholesteraemic agent,monacolin k,and its preparation
DK47085A DK165990C (da) 1979-02-20 1985-02-01 Fremgangsmaade til fremstilling af carboxylsyren af en cholesterolsynteseinhiberende forbindelse kaldet monacolin k eller salte deraf
DK021889A DK21889D0 (da) 1979-02-20 1989-01-18 Anvendelse af monacolin k, den tilsvarende carboxylsyreforbindelse eller salte af carboxylsyren til fremstilling af et laegemiddel til behandling af hypercholesterolaemi
MX9203568A MX9203568A (es) 1979-02-20 1992-06-26 Agente antihipercolesteremico, monacolina k, y su preparacion.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP54017856A JPS5925599B2 (ja) 1979-02-20 1979-02-20 新生理活性物質モナコリンｋおよびその製造法

Publications (2)

Publication Number Publication Date
JPS55111790A JPS55111790A (en) 1980-08-28
JPS5925599B2 true JPS5925599B2 (ja) 1984-06-19

Family

ID=11955290

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54017856A Expired JPS5925599B2 (ja) 1979-02-20 1979-02-20 新生理活性物質モナコリンｋおよびその製造法

Country Status (27)

Country Link
JP (1) JPS5925599B2 (no)
KR (1) KR830002801B1 (no)
AT (1) AT373915B (no)
AU (1) AU532626B2 (no)
BE (1) BE881825A (no)
CA (1) CA1129794A (no)
CH (1) CH645890A5 (no)
DD (1) DD154494A5 (no)
DE (2) DE3051175C2 (no)
DK (2) DK149095C (no)
ES (1) ES488796A0 (no)
FI (1) FI66427C (no)
FR (1) FR2449685B1 (no)
GB (1) GB2046737B (no)
HU (1) HU182069B (no)
IE (1) IE49743B1 (no)
IT (1) IT1175260B (no)
MX (1) MX6314E (no)
NL (1) NL191540C (no)
NO (1) NO153974C (no)
NZ (1) NZ192919A (no)
PH (1) PH15145A (no)
PL (1) PL124304B1 (no)
SE (1) SE453301B (no)
SG (1) SG6784G (no)
SU (2) SU1158048A3 (no)
ZA (1) ZA80962B (no)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
US4231938A (en) * 1979-06-15 1980-11-04 Merck & Co., Inc. Hypocholesteremic fermentation products and process of preparation
JPS5621594A (en) * 1979-07-27 1981-02-28 Sankyo Co Ltd Mb-530b carboxylic acid metal salt and its preparation
PT72394B (en) * 1980-02-04 1982-09-06 Merck & Co Inc Process for preparing dihydro and tetrahydromevinoline hypocholesterolimics
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
JPH0692381B2 (ja) * 1980-03-31 1994-11-16 三共株式会社 Ｍｂ−５３０ａ誘導体
JPS56142236A (en) 1980-04-08 1981-11-06 Sankyo Co Ltd Ml-236a and mb-530a derivative
MX7065E (es) * 1980-06-06 1987-04-10 Sankyo Co Un procedimiento microbiologico para preparar derivados de ml-236b
JPS5835144A (ja) * 1981-08-27 1983-03-01 Sankyo Co Ltd Ｍｂ−５３０ｂ誘導体およびその製造法
US4782084A (en) * 1987-06-29 1988-11-01 Merck & Co., Inc. HMG-COA reductase inhibitors
US4997848A (en) * 1987-10-27 1991-03-05 Sankyo Company, Limited Octahydronaphthalene oxime derivatives for cholesterol synthesis inhibition
CA2062023A1 (en) * 1992-02-10 1993-08-11 Jagroop S. Dahiya Novel fungal strains and use thereof in antibiotic production
JPH07504568A (ja) * 1992-03-04 1995-05-25 藤沢薬品工業株式会社 ＨＭＧ−ＣｏＡレダクターゼ阻害物質としてのテトラリン誘導体
NZ247617A (en) 1992-05-15 1995-07-26 Sankyo Co Octahydronaphthalene oxime derivatives and pharmaceutical compositions
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
US6812007B1 (en) * 1992-11-04 2004-11-02 Keri Vilmos Process for the isolation and purification of mevinolin
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance
US5409820A (en) * 1993-08-06 1995-04-25 Apotex, Inc. Process for the production of lovastatin using Coniothyrium fuckelii
US6046022A (en) 1996-09-30 2000-04-04 Peking University Methods and compositions employing red rice fermentation products
US7238348B2 (en) 1996-09-30 2007-07-03 Beijing Peking University Wbl Corporation Ltd. Method of treatment of osteoporosis with compositions of red rice fermentation products
CA2289553C (en) 1998-03-20 2004-05-18 Biogal Gyogyszergyar Rt. Metabolic controlled fermentation procedure for the manufacture of lovastatin hydroxy acid
SK12012002A3 (sk) 2000-02-24 2003-02-04 Biogal Gyogyszergyar Rt. Spôsob purifikácie fermentačného bujónu
JP2003525935A (ja) 2000-03-03 2003-09-02 ビオガル ジョジセルジャール アール テー． 低下したレベルの二量体不純物を伴うロバスタチン及びシンバスタチンの精製方法
KR20010095780A (ko) * 2000-04-12 2001-11-07 나가오카 마사시 배아 홍국
IN192861B (no) 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
CN1273608C (zh) * 2001-02-09 2006-09-06 荷兰联合利华有限公司 通过发酵制备一种或多种抑制素的方法
KR100379075B1 (en) 2002-03-07 2003-04-08 Jinis Biopharmaceuticals Co Method for producing low cholesterol animal food product and food product therefrom
KR20020093147A (ko) * 2002-05-30 2002-12-13 지니스생명공학 주식회사 성인병 예방 및 치료 보조제
KR100710500B1 (ko) 2005-05-18 2007-04-24 고려대학교 산학협력단 홍국균을 이용한 모나콜린 ｋ 생산방법
SI2373609T1 (sl) 2008-12-19 2013-12-31 Krka, D.D., Novo Mesto Uporaba amfifilnih spojin za kontrolirano kristalizacijo statinov in intermediatov statinov
EP2327682A1 (en) 2009-10-29 2011-06-01 KRKA, D.D., Novo Mesto Use of amphiphilic compounds for controlled crystallization of statins and statin intermediates
RO128803A0 (ro) 2012-10-12 2013-09-30 Ion Gigel Fulga Compoziţie pentru tratamentul sau prevenirea dislipidemiilor
CN110331151A (zh) * 2019-04-11 2019-10-15 北京工商大学 紫色红曲菌mokH基因过表达菌株的构建方法
CN111297938A (zh) * 2020-03-11 2020-06-19 北京康立生医药技术开发有限公司 一种辅助降血脂组合物中洛伐他汀的检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5612114B2 (no) * 1974-06-07 1981-03-18
JPS55150898A (en) * 1979-05-11 1980-11-25 Sankyo Co Ltd Preparation of a new physiologically active substance mb-530b
AU535944B2 (en) * 1979-06-15 1984-04-12 Merck & Co., Inc. Hypocholestermic fermentation products from aspergillus

Also Published As

Publication number Publication date
DK149095C (da) 1986-06-16
DE3006216A1 (de) 1980-09-04
SU1158048A3 (ru) 1985-05-23
NO800451L (no) 1980-08-21
ES8103171A1 (es) 1981-02-16
DK73080A (da) 1980-08-21
DE3051175C2 (no) 1989-12-21
DD154494A5 (de) 1982-03-24
DK21889A (da) 1989-01-18
MX6314E (es) 1985-04-01
NL191540C (nl) 1995-09-04
ATA92980A (de) 1983-07-15
NO153974C (no) 1986-06-25
SE8001339L (sv) 1980-08-21
KR830002801B1 (ko) 1983-12-16
DK21889D0 (da) 1989-01-18
IE800321L (en) 1980-08-20
IT8067262A0 (it) 1980-02-20
GB2046737A (en) 1980-11-19
IE49743B1 (en) 1985-12-11
FI66427B (fi) 1984-06-29
ES488796A0 (es) 1981-02-16
KR830002030A (ko) 1983-05-21
SE453301B (sv) 1988-01-25
GB2046737B (en) 1983-01-12
JPS55111790A (en) 1980-08-28
FI66427C (fi) 1984-10-10
FR2449685A1 (fr) 1980-09-19
NO153974B (no) 1986-03-17
NL8001041A (nl) 1980-08-22
FI800506A (fi) 1980-08-21
SU969702A1 (ru) 1982-10-30
CA1129794A (en) 1982-08-17
DK149095B (da) 1986-01-20
ZA80962B (en) 1981-03-25
FR2449685B1 (fr) 1985-06-28
SG6784G (en) 1985-02-08
PL222120A1 (no) 1980-10-20
BE881825A (fr) 1980-08-20
NZ192919A (en) 1984-07-06
HU182069B (en) 1983-12-28
AU532626B2 (en) 1983-10-06
AU5567380A (en) 1980-08-28
CH645890A5 (de) 1984-10-31
PL124304B1 (en) 1983-01-31
PH15145A (en) 1982-08-24
IT1175260B (it) 1987-07-01
AT373915B (de) 1984-03-12
NL191540B (nl) 1995-05-01
DE3006216C2 (de) 1985-10-31

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