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JPS5799598A - Hapten antigen and its synthetic intermediate - Google Patents

Hapten antigen and its synthetic intermediate

Info

Publication number
JPS5799598A
JPS5799598A JP17466880A JP17466880A JPS5799598A JP S5799598 A JPS5799598 A JP S5799598A JP 17466880 A JP17466880 A JP 17466880A JP 17466880 A JP17466880 A JP 17466880A JP S5799598 A JPS5799598 A JP S5799598A
Authority
JP
Japan
Prior art keywords
methyl
formula
antigen
hapten antigen
methylxanthine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP17466880A
Other languages
Japanese (ja)
Inventor
Keiichi Takamura
Sadao Tanaka
Isao Matsunaga
Hidetaka Shimada
Seiji Hashimoto
Kiyoshige Wakabayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chugai Pharmaceutical Co Ltd
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Priority to JP17466880A priority Critical patent/JPS5799598A/en
Publication of JPS5799598A publication Critical patent/JPS5799598A/en
Pending legal-status Critical Current

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Abstract

NEW MATERIAL:The hapten antigen of formula I (R is immunogenic carrier substance; the terminal carbonyl group in the brackets bonds with amino group which is a part of R; R1 is H or methyl; n is 10W30).
EXAMPLE: The addition product of bovine serum albumin and 1-(3'-carboxypropyl)-3-methyl-xanthine.
USE: For the preparation of a high-titer antiserum having high specificity to theophylline and caffeine.
PROCESS: An intermediate for the snythesis of hapten antigen, 1-(3'-carboxypropyl)-3-methylxanthine which is a novel substance of formula IV (R1 is H or methyl) wherein R is H, is prepared by the alkali hydrolysis of 1-(3'-ethyl-carboxyproyl)-3-methyl-7-pivaloyloxymethylxanthine of formula III which can be derived, e.g. from 3-methylxanthine of formula II. The intermediate is made to react with an immunogenic carrier substance such as bovine serum albumin, etc. to obtain the objective antigen.
COPYRIGHT: (C)1982,JPO&Japio
JP17466880A 1980-12-12 1980-12-12 Hapten antigen and its synthetic intermediate Pending JPS5799598A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP17466880A JPS5799598A (en) 1980-12-12 1980-12-12 Hapten antigen and its synthetic intermediate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP17466880A JPS5799598A (en) 1980-12-12 1980-12-12 Hapten antigen and its synthetic intermediate

Publications (1)

Publication Number Publication Date
JPS5799598A true JPS5799598A (en) 1982-06-21

Family

ID=15982602

Family Applications (1)

Application Number Title Priority Date Filing Date
JP17466880A Pending JPS5799598A (en) 1980-12-12 1980-12-12 Hapten antigen and its synthetic intermediate

Country Status (1)

Country Link
JP (1) JPS5799598A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3620653A1 (en) * 1986-06-20 1987-12-23 Boehringer Mannheim Gmbh METHOD FOR PRODUCING AN IMMUNREACTIVE SUPPORT MATERIAL FOR HETEROGENEOUS IMMUNOLOGICAL ANALYSIS
JPH02426A (en) * 1982-06-30 1990-01-05 E I Du Pont De Nemours & Co Hybridoma cell line
JPH0269196A (en) * 1988-09-02 1990-03-08 Matsushita Electric Ind Co Ltd Antibody, antibody forming cell and production of antibody
CN109517056A (en) * 2018-11-05 2019-03-26 杭州旭科生物技术有限公司 A kind of synthetic method and its application of artificial antigen of theophylline

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53130692A (en) * 1977-04-15 1978-11-14 Syva Co Reagent using in concurrent protein bond analyzing method method of preparing same and using method

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS53130692A (en) * 1977-04-15 1978-11-14 Syva Co Reagent using in concurrent protein bond analyzing method method of preparing same and using method

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02426A (en) * 1982-06-30 1990-01-05 E I Du Pont De Nemours & Co Hybridoma cell line
JPH0471516B2 (en) * 1982-06-30 1992-11-13 Ii Ai Deyuhon De Nimoasu Ando Co
DE3620653A1 (en) * 1986-06-20 1987-12-23 Boehringer Mannheim Gmbh METHOD FOR PRODUCING AN IMMUNREACTIVE SUPPORT MATERIAL FOR HETEROGENEOUS IMMUNOLOGICAL ANALYSIS
JPH0269196A (en) * 1988-09-02 1990-03-08 Matsushita Electric Ind Co Ltd Antibody, antibody forming cell and production of antibody
CN109517056A (en) * 2018-11-05 2019-03-26 杭州旭科生物技术有限公司 A kind of synthetic method and its application of artificial antigen of theophylline
CN109517056B (en) * 2018-11-05 2022-02-11 杭州旭科生物技术有限公司 Synthetic method and application of theophylline artificial antigen

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