[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

JPS6440467A - Novel substituted diphenylimidazole derivative - Google Patents

Novel substituted diphenylimidazole derivative

Info

Publication number
JPS6440467A
JPS6440467A JP19611787A JP19611787A JPS6440467A JP S6440467 A JPS6440467 A JP S6440467A JP 19611787 A JP19611787 A JP 19611787A JP 19611787 A JP19611787 A JP 19611787A JP S6440467 A JPS6440467 A JP S6440467A
Authority
JP
Japan
Prior art keywords
formula
diphenylimidazole
derivative
compound
novel substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP19611787A
Other languages
Japanese (ja)
Inventor
Masayoshi Tsuji
Toshitaka Inoue
Koichi Ikesue
Noriyuki Fujimoto
Kanji Noda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hisamitsu Pharmaceutical Co Inc
Original Assignee
Hisamitsu Pharmaceutical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hisamitsu Pharmaceutical Co Inc filed Critical Hisamitsu Pharmaceutical Co Inc
Priority to JP19611787A priority Critical patent/JPS6440467A/en
Publication of JPS6440467A publication Critical patent/JPS6440467A/en
Pending legal-status Critical Current

Links

Landscapes

  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NEW MATERIAL:The substituted diphenylimidazole derivative of formula I (X is H, halogen, lower alkyl or lower alkoxy; m is 0 or 1; n is 1-4; R is heterocyclic group or cyclic amino; when n=2, R is not 2-pyridyl) and its acid addition salt. EXAMPLE:4,5-Diphenyl-2-(2-pyridylmethyl)thio-imidazole. USE:It has antiulcer and anti-inflammatory actions and is useful as a drug. It has low side effect and high safety. PREPARATION:The compound of formula I can be produced according to the reaction formula, by reacting the compound of formula II with the compound of formula III in a solvent (e.g. methanol) at 20-120 deg.C.
JP19611787A 1987-08-04 1987-08-04 Novel substituted diphenylimidazole derivative Pending JPS6440467A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP19611787A JPS6440467A (en) 1987-08-04 1987-08-04 Novel substituted diphenylimidazole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP19611787A JPS6440467A (en) 1987-08-04 1987-08-04 Novel substituted diphenylimidazole derivative

Publications (1)

Publication Number Publication Date
JPS6440467A true JPS6440467A (en) 1989-02-10

Family

ID=16352523

Family Applications (1)

Application Number Title Priority Date Filing Date
JP19611787A Pending JPS6440467A (en) 1987-08-04 1987-08-04 Novel substituted diphenylimidazole derivative

Country Status (1)

Country Link
JP (1) JPS6440467A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009030A1 (en) * 1989-12-12 1991-06-27 Rhone-Poulenc Sante 2-substituted 4,5-diphenyl-imidazoles
JPH04217963A (en) * 1990-04-09 1992-08-07 Meiji Seika Kaisha Ltd Thiazole or imidazole derivative and antiulcer agent
EP0522887A1 (en) * 1991-07-12 1993-01-13 Rhone-Poulenc Rorer Limited Imidazoles as ACAT- and thromboxane TxA2 inhibitors
EP0523941A1 (en) * 1991-07-11 1993-01-20 Rhone-Poulenc Rorer Limited Imidazoles as ACAT inhibitor
WO2002076951A1 (en) * 2001-03-26 2002-10-03 Beiersdorf Ag 2-mercapto-4,5-diarylimidazole derivatives and the use thereof as cyclooxygenase inhibitors
WO2004018458A1 (en) 2002-08-20 2004-03-04 Merckle-Gmbh 2-thio-substituted imidazole derivatives and their use in pharmaceutics
JP2005530799A (en) * 2002-05-17 2005-10-13 メルクル・ゲーエムベーハー 2-thio-substituted imidazole derivatives and their use in pharmacy
US7253191B2 (en) 2001-02-19 2007-08-07 Merckle Gmbh 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54154766A (en) * 1978-05-24 1979-12-06 Schering Ag Novel imidazole derivative*its manufacture and medicine containing said derivative and having antiiinflammatory and antiiallergic activity
JPS62207270A (en) * 1986-03-06 1987-09-11 Yamanouchi Pharmaceut Co Ltd Azole compound substituted with 2-pyridylmethylthio group or 2-pyridylmethylsulfinyl group
JPS6463575A (en) * 1987-07-31 1989-03-09 Chiesi Farma Spa Thiomethyl and sulfinylmethyl derivative having gastric acid secretion control, manufacture and pharmaceutical composition

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54154766A (en) * 1978-05-24 1979-12-06 Schering Ag Novel imidazole derivative*its manufacture and medicine containing said derivative and having antiiinflammatory and antiiallergic activity
JPS62207270A (en) * 1986-03-06 1987-09-11 Yamanouchi Pharmaceut Co Ltd Azole compound substituted with 2-pyridylmethylthio group or 2-pyridylmethylsulfinyl group
JPS6463575A (en) * 1987-07-31 1989-03-09 Chiesi Farma Spa Thiomethyl and sulfinylmethyl derivative having gastric acid secretion control, manufacture and pharmaceutical composition

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991009030A1 (en) * 1989-12-12 1991-06-27 Rhone-Poulenc Sante 2-substituted 4,5-diphenyl-imidazoles
JPH04217963A (en) * 1990-04-09 1992-08-07 Meiji Seika Kaisha Ltd Thiazole or imidazole derivative and antiulcer agent
EP0523941A1 (en) * 1991-07-11 1993-01-20 Rhone-Poulenc Rorer Limited Imidazoles as ACAT inhibitor
WO1993001183A1 (en) * 1991-07-11 1993-01-21 Rhone-Poulenc Rorer Limited Imidazole derivative as acat inhibitor
EP0522887A1 (en) * 1991-07-12 1993-01-13 Rhone-Poulenc Rorer Limited Imidazoles as ACAT- and thromboxane TxA2 inhibitors
WO1993001184A1 (en) * 1991-07-12 1993-01-21 Rhone-Poulenc Rorer Limited Imidazoles inhibitors as acat and thromboxane txa2
US7253191B2 (en) 2001-02-19 2007-08-07 Merckle Gmbh 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry
WO2002076951A1 (en) * 2001-03-26 2002-10-03 Beiersdorf Ag 2-mercapto-4,5-diarylimidazole derivatives and the use thereof as cyclooxygenase inhibitors
US7223781B2 (en) 2001-03-26 2007-05-29 Beiersdorf Ag 2-mercapto-4,5-diarylimidazole derivatives and the use thereof as cyclooxygenase inhibitors
JP2005530799A (en) * 2002-05-17 2005-10-13 メルクル・ゲーエムベーハー 2-thio-substituted imidazole derivatives and their use in pharmacy
WO2004018458A1 (en) 2002-08-20 2004-03-04 Merckle-Gmbh 2-thio-substituted imidazole derivatives and their use in pharmaceutics
US7582660B2 (en) 2002-08-20 2009-09-01 C-A-I-R Biosciences Gmbh 2-thio-substituted imidazole derivatives and their use in pharmaceutics

Similar Documents

Publication Publication Date Title
JPS6440467A (en) Novel substituted diphenylimidazole derivative
JPS646261A (en) 4-thioquinazoline derivative, its production and antiulcer agent containing said derivative as active component
ES454063A1 (en) Novel benzylalcohol derivatives and processes for preparing the same
JPS57179147A (en) Amidine derivative
GB1505020A (en) Substituted 2-phenylimino-thiazolines a process for their preparation and their use as ectoparasiticides
JPS57183768A (en) 4-methyl-5-(o-carboxyphenyl)carbamoylthiazole derivative and its preparation
ES2000406A6 (en) Process for the preparation of oxazinobenzothiazine 6,6-dioxide derivatives.
JPS6413083A (en) Streptonigrin derivative and medicinal composition
JPS57197256A (en) Novel cyclohexanecarboxamide derivative and its preparation
JPS6440468A (en) Novel indenoimidazole derivative
JPS643181A (en) Pyridonecarboxylic acid derivative
JPS54112856A (en) Preparation of thiophene derivative
JPS5754167A (en) Pyroglutamic acid derivative and its preparation
JPS54106498A (en) Carbostyril derivative
JPS54112872A (en) Preparation of dihydropyridine and pyridine derivatives
JPS5527142A (en) Novel 1-phthalazone derivative
JPS5695165A (en) Preparation of substituted benzoic acid amide
JPS55104266A (en) Novel pyridone derivative
JPS54112881A (en) Preparation of 2-mercaptopyrimidine hydrochloride
JPS55151547A (en) Production of guanidinocapronic ester
JPS57131792A (en) Novel 2-oxabicyclo(2.2.2)octan-3-one derivative
JPS6468354A (en) Novel indoleacetic acid derivative
TH11188EX (en) Derivatives of thiazolidine carboxylic acid The knife, which has the agility to fight allergies. Preparation and use of these substances
JPS5551069A (en) Preparation of benzimidazole derivative
JPS5587769A (en) Preparation of pyrroleacetic acid derivative