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JPS5657718A - Preparation of s-sulfonated immunoglobulin containing large amount of monomer - Google Patents

Preparation of s-sulfonated immunoglobulin containing large amount of monomer

Info

Publication number
JPS5657718A
JPS5657718A JP13278679A JP13278679A JPS5657718A JP S5657718 A JPS5657718 A JP S5657718A JP 13278679 A JP13278679 A JP 13278679A JP 13278679 A JP13278679 A JP 13278679A JP S5657718 A JPS5657718 A JP S5657718A
Authority
JP
Japan
Prior art keywords
basic
organic compound
immunoglobulin
sulfonated
large amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13278679A
Other languages
Japanese (ja)
Other versions
JPS6155895B2 (en
Inventor
Shoji Ono
Yuji Fukumoto
Tsunemasa Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemo Sero Therapeutic Research Institute Kaketsuken
Teijin Ltd
Original Assignee
Chemo Sero Therapeutic Research Institute Kaketsuken
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeutic Research Institute Kaketsuken, Teijin Ltd filed Critical Chemo Sero Therapeutic Research Institute Kaketsuken
Priority to JP13278679A priority Critical patent/JPS5657718A/en
Priority to US06/182,053 priority patent/US4360457A/en
Priority to CA000359215A priority patent/CA1153695A/en
Priority to AT80303004T priority patent/ATE6740T1/en
Priority to EP80303004A priority patent/EP0025321B1/en
Priority to DE8080303004T priority patent/DE3067150D1/en
Publication of JPS5657718A publication Critical patent/JPS5657718A/en
Publication of JPS6155895B2 publication Critical patent/JPS6155895B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PURPOSE: To prepare an S-sulfonated immunoglobulin containing little aggregate and administrable extremely safely by intravenous injection, by the S-sulfonation of immunoglobulin in the presence of a basic N-containing organic compound having a dissociation index of within a specific range.
CONSTITUTION: An immunoglobulin solution containing a large amount of aggregate (e.g. obtained by Cohn's ethanol fractionation) is mixed with 10W600wt%, pref. 20W400wt%, based on globulin, of a basic N-containing organic compound having a dissociation index of ≤7, and S-sulfonated with an oxidizing agent having low reactivity with sulfite ion and a compound which generates sulfite ions in water, at pH 5.0W9.0 and 10W45°C. The basic N-containing organic compound is e.g. a basic amino acid such as arginine, a neutral amino acid amide derivative such as leucinamide, an amine derivative of glucose such as D-glucosamine, etc.
COPYRIGHT: (C)1981,JPO&Japio
JP13278679A 1979-08-30 1979-10-17 Preparation of s-sulfonated immunoglobulin containing large amount of monomer Granted JPS5657718A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP13278679A JPS5657718A (en) 1979-10-17 1979-10-17 Preparation of s-sulfonated immunoglobulin containing large amount of monomer
US06/182,053 US4360457A (en) 1979-08-30 1980-08-28 S-Sulfonated immunoglobulin composition having a high monomer content and a process for production thereof
CA000359215A CA1153695A (en) 1979-08-30 1980-08-28 S-sulfonated immunoglobulin composition having a high monomer content and a process for production thereof
AT80303004T ATE6740T1 (en) 1979-08-30 1980-08-29 COMPOSITION CONTAINING AN S-SULFONATED IMMUNOGLOBULIN AND ANAGAGING PREVENTION OR AGAGING DISSOCIATION AGENT AND METHODS FOR PREPARING COMPOSITIONS CONTAINING A HIGH PROPORTION OF MONOMERIC S-SULFONATED IMMUNOGLOBULINS.
EP80303004A EP0025321B1 (en) 1979-08-30 1980-08-29 Composition containing s-sulfonated immunoglobulin and aggregation preventing or aggregate dissociating agent therefor, and processes for preparing compositions containing high proportions of monomeric s-sulfonated immunoglobulin
DE8080303004T DE3067150D1 (en) 1979-08-30 1980-08-29 Composition containing s-sulfonated immunoglobulin and aggregation preventing or aggregate dissociating agent therefor, and processes for preparing compositions containing high proportions of monomeric s-sulfonated immunoglobulin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13278679A JPS5657718A (en) 1979-10-17 1979-10-17 Preparation of s-sulfonated immunoglobulin containing large amount of monomer

Publications (2)

Publication Number Publication Date
JPS5657718A true JPS5657718A (en) 1981-05-20
JPS6155895B2 JPS6155895B2 (en) 1986-11-29

Family

ID=15089503

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13278679A Granted JPS5657718A (en) 1979-08-30 1979-10-17 Preparation of s-sulfonated immunoglobulin containing large amount of monomer

Country Status (1)

Country Link
JP (1) JPS5657718A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5485489B2 (en) * 2000-08-11 2014-05-07 中外製薬株式会社 Antibody-containing stabilized preparation
JP2014105180A (en) * 2012-11-27 2014-06-09 Hoya Corp Method of monomerization

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5485489B2 (en) * 2000-08-11 2014-05-07 中外製薬株式会社 Antibody-containing stabilized preparation
JP2014105180A (en) * 2012-11-27 2014-06-09 Hoya Corp Method of monomerization

Also Published As

Publication number Publication date
JPS6155895B2 (en) 1986-11-29

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