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JPS5762218A - Ophthalmic solution - Google Patents

Ophthalmic solution

Info

Publication number
JPS5762218A
JPS5762218A JP13743180A JP13743180A JPS5762218A JP S5762218 A JPS5762218 A JP S5762218A JP 13743180 A JP13743180 A JP 13743180A JP 13743180 A JP13743180 A JP 13743180A JP S5762218 A JPS5762218 A JP S5762218A
Authority
JP
Japan
Prior art keywords
ophthalmic solution
chlorobutanol
amino acids
blended
phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP13743180A
Other languages
Japanese (ja)
Inventor
Nobuo Kojima
Setsuo Iwasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lion Corp
Original Assignee
Lion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lion Corp filed Critical Lion Corp
Priority to JP13743180A priority Critical patent/JPS5762218A/en
Publication of JPS5762218A publication Critical patent/JPS5762218A/en
Pending legal-status Critical Current

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  • Medicinal Preparation (AREA)

Abstract

PURPOSE: An ophthalmic solution having improved pH buffering power, preventing the decomposition of chlorobutanol, having low eye irritation, obtained by blending chlorobutanol as a preservative for an ophthalmic solution with an amino acid and citric acid and/or sodium dihydrogen-phosphate.
CONSTITUTION: In an ophthalmic solution containing chlorobutanol, one or more of amino acids selected from amino acids and their salts as a buffering agent are blended with citric acid and/or sodium dihydrogen-phosphate. By the use of the buffering agent, an ophthalmic solution having increased buffering power, improved pH stability and appearance stability blended with safe and nonirritant chlorobutanol can be obtained. ε-Caproic acid is especially preferable as the amino acids, and its amount calculated as anhydrous salt is preferably 0.05W0.1 (wt/vol%) based on the total amount.
COPYRIGHT: (C)1982,JPO&Japio
JP13743180A 1980-10-01 1980-10-01 Ophthalmic solution Pending JPS5762218A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13743180A JPS5762218A (en) 1980-10-01 1980-10-01 Ophthalmic solution

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13743180A JPS5762218A (en) 1980-10-01 1980-10-01 Ophthalmic solution

Publications (1)

Publication Number Publication Date
JPS5762218A true JPS5762218A (en) 1982-04-15

Family

ID=15198458

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13743180A Pending JPS5762218A (en) 1980-10-01 1980-10-01 Ophthalmic solution

Country Status (1)

Country Link
JP (1) JPS5762218A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0723302B1 (en) * 1989-08-03 1995-03-15
JP2003183157A (en) * 2001-12-19 2003-07-03 Lion Corp Ophthalmologic composition
JP2004256519A (en) * 2003-02-07 2004-09-16 Senju Pharmaceut Co Ltd Chlorobutanol-containing artificial tear liquid
JPWO2005025539A1 (en) * 2003-09-10 2007-11-08 千寿製薬株式会社 Ophthalmic composition for contact lenses
JP2016028077A (en) * 2010-12-28 2016-02-25 ロート製薬株式会社 Aqueous ophthalmic composition

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0723302B1 (en) * 1989-08-03 1995-03-15
JP2003183157A (en) * 2001-12-19 2003-07-03 Lion Corp Ophthalmologic composition
JP2004256519A (en) * 2003-02-07 2004-09-16 Senju Pharmaceut Co Ltd Chlorobutanol-containing artificial tear liquid
JPWO2005025539A1 (en) * 2003-09-10 2007-11-08 千寿製薬株式会社 Ophthalmic composition for contact lenses
JP5123484B2 (en) * 2003-09-10 2013-01-23 千寿製薬株式会社 Ophthalmic composition for contact lenses
JP2016028077A (en) * 2010-12-28 2016-02-25 ロート製薬株式会社 Aqueous ophthalmic composition

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