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JPS5589282A - Ergolene derivative*its manufacture and medical composition containing it and having antihypertensive and antiprolactin activity - Google Patents

Ergolene derivative*its manufacture and medical composition containing it and having antihypertensive and antiprolactin activity

Info

Publication number
JPS5589282A
JPS5589282A JP11436879A JP11436879A JPS5589282A JP S5589282 A JPS5589282 A JP S5589282A JP 11436879 A JP11436879 A JP 11436879A JP 11436879 A JP11436879 A JP 11436879A JP S5589282 A JPS5589282 A JP S5589282A
Authority
JP
Japan
Prior art keywords
group
carbon atoms
methyl
hydrogen
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP11436879A
Other languages
English (en)
Other versions
JPS6221792B2 (ja
Inventor
Mantejiyaani Serujio
Arukaari Jiyuriaana
Maria Karabatsuji Anna
Boshitsushio Jierumaano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Carlo Erba SpA filed Critical Carlo Erba SpA
Publication of JPS5589282A publication Critical patent/JPS5589282A/ja
Publication of JPS6221792B2 publication Critical patent/JPS6221792B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP11436879A 1978-09-08 1979-09-07 Ergolene derivative*its manufacture and medical composition containing it and having antihypertensive and antiprolactin activity Granted JPS5589282A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7836080 1978-09-08

Publications (2)

Publication Number Publication Date
JPS5589282A true JPS5589282A (en) 1980-07-05
JPS6221792B2 JPS6221792B2 (ja) 1987-05-14

Family

ID=10499526

Family Applications (1)

Application Number Title Priority Date Filing Date
JP11436879A Granted JPS5589282A (en) 1978-09-08 1979-09-07 Ergolene derivative*its manufacture and medical composition containing it and having antihypertensive and antiprolactin activity

Country Status (17)

Country Link
US (2) US4252941A (ja)
EP (1) EP0008802B1 (ja)
JP (1) JPS5589282A (ja)
AT (1) ATE1354T1 (ja)
AU (1) AU526764B2 (ja)
CA (1) CA1128502A (ja)
CS (1) CS208135B2 (ja)
DE (1) DE2963371D1 (ja)
DK (1) DK148419C (ja)
FI (1) FI66613C (ja)
GR (1) GR71867B (ja)
HU (1) HU179450B (ja)
IE (1) IE48550B1 (ja)
IL (1) IL58182A (ja)
SU (1) SU906377A3 (ja)
YU (1) YU41347B (ja)
ZA (1) ZA794682B (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713457A (en) * 1985-02-21 1987-12-15 Maruko Seiyaku Co., Ltd. Ergoline derivatives and acid addition salts thereof
JPH04106090U (ja) * 1991-02-27 1992-09-11 河西工業株式会社 エンジンルーム用インシユレータ

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU526764B2 (en) * 1978-09-08 1983-01-27 Farmitalia Carlo Erba S.P.A. Ergoline derivatives
DE3020895A1 (de) * 1979-06-12 1980-12-18 Sandoz Ag Ergopeptinderivate, verfahren zu deren herstellung sowie diese ergopeptinderivate enthaltende pharmazeutischen zusammensetzungen
GB2120242A (en) * 1982-04-30 1983-11-30 Erba Farmitalia Ergoline derivatives
GB8318790D0 (en) * 1983-07-12 1983-08-10 Erba Farmitalia Anorexigenic ergot derivatives
GB8501078D0 (en) * 1985-01-16 1985-02-20 Erba Farmitalia Piperazin-1-yl-ergo-line derivatives
US4801712A (en) * 1985-06-24 1989-01-31 Eli Lilly And Company 2-Alkyl(or phenyl)thio-6-n-alkylergolines are dopamine D-1 antagonists without D-2 agonist activity
US4704396A (en) * 1985-12-20 1987-11-03 Eli Lilly And Company Phenacyl esters of 1-substituted-6-(substituted and unsubstituted) dihydrolysergic acids useful as 5HT receptor antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR206772A1 (es) * 1972-07-21 1976-08-23 Lilly Co Eli Procedimiento para preparar una nueva d-2-halo-6-metil-8-ciano(carboxamido)metil ergolina
CS177530B1 (en) * 1974-07-19 1977-07-29 Miroslav Semonsky New nbeta-substituted derivatives of b-beta-aminoethyl-ergoline-i their salts and methods for the production thereof
CH605936A5 (en) * 1974-07-19 1978-10-13 Sandoz Ag 8-Alpha-(Amino-or cyanomethyl)-ergoline derivs
US3985752A (en) * 1974-12-06 1976-10-12 Eli Lilly And Company 6-Methyl-8-(substituted) methylergolines
GB1513322A (en) * 1976-01-09 1978-06-07 Farmaceutici Italia Heterocyclic ergoline derivatives
GB1555751A (en) * 1977-02-02 1979-11-14 Farmaceutici Italia Ergoline deritatives
AU526764B2 (en) * 1978-09-08 1983-01-27 Farmitalia Carlo Erba S.P.A. Ergoline derivatives

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713457A (en) * 1985-02-21 1987-12-15 Maruko Seiyaku Co., Ltd. Ergoline derivatives and acid addition salts thereof
JPH04106090U (ja) * 1991-02-27 1992-09-11 河西工業株式会社 エンジンルーム用インシユレータ

Also Published As

Publication number Publication date
AU526764B2 (en) 1983-01-27
AU5045579A (en) 1980-03-13
ATE1354T1 (de) 1982-08-15
FI66613C (fi) 1984-11-12
IE48550B1 (en) 1985-03-06
FI66613B (fi) 1984-07-31
JPS6221792B2 (ja) 1987-05-14
SU906377A3 (ru) 1982-02-15
EP0008802A1 (en) 1980-03-19
FI792776A (fi) 1980-03-09
IE791705L (en) 1980-03-08
ZA794682B (en) 1980-11-26
DK148419B (da) 1985-07-01
DK148419C (da) 1985-12-09
HU179450B (en) 1982-10-28
CS208135B2 (en) 1981-08-31
GR71867B (ja) 1983-07-07
DK375279A (da) 1980-03-09
US4252941A (en) 1981-02-24
DE2963371D1 (en) 1982-09-09
CA1128502A (en) 1982-07-27
IL58182A (en) 1983-07-31
US4321381A (en) 1982-03-23
EP0008802B1 (en) 1982-07-21
YU217479A (en) 1983-02-28
YU41347B (en) 1987-02-28

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