JPS5495575A - Hydantoin derivative therapeutic medicine - Google Patents

Hydantoin derivative therapeutic medicine

Info

Publication number: JPS5495575A
Authority: JP; Japan
Prior art keywords: therapeutic medicine; hydantoin derivative; derivative therapeutic; hydantoin; medicine
Prior art date: 1976-10-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP14592678A

Other languages

Japanese (ja)

Other versions

JPS607997B2 (en

Inventor

Saajiesu Reinhaado

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Inc

Original Assignee

Pfizer Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-10-18

Filing date

1978-11-25

Publication date

1979-07-28

1977-02-11 Priority claimed from US05/767,803 external-priority patent/US4117230A/en

1978-11-25 Application filed by Pfizer Inc filed Critical Pfizer Inc

1979-07-28 Publication of JPS5495575A publication Critical patent/JPS5495575A/en

1985-02-28 Publication of JPS607997B2 publication Critical patent/JPS607997B2/en

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

JP53145926A 1976-10-18 1978-11-25 Hydantoin derivative therapeutic agent Expired JPS607997B2 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US73306276A	1976-10-18	1976-10-18
US733062		1976-10-18
US767803		1977-02-11
US05/767,803 US4117230A (en)	1976-10-18	1977-02-11	Hydantoin derivatives as therapeutic agents

Publications (2)

Publication Number	Publication Date
JPS5495575A true JPS5495575A (en)	1979-07-28
JPS607997B2 JPS607997B2 (en)	1985-02-28

Family

ID=27112515

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
JP12437177A Granted JPS5353653A (en)	1976-10-18	1977-10-17	Hydantoin derivatives medicines
JP53145925A Expired JPS5940388B2 (en)	1976-10-18	1978-11-25	Hydantoin derivative therapeutic agent
JP53145926A Expired JPS607997B2 (en)	1976-10-18	1978-11-25	Hydantoin derivative therapeutic agent

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
JP12437177A Granted JPS5353653A (en)	1976-10-18	1977-10-17	Hydantoin derivatives medicines
JP53145925A Expired JPS5940388B2 (en)	1976-10-18	1978-11-25	Hydantoin derivative therapeutic agent

Country Status (29)

Country	Link
JP (3)	JPS5353653A (en)
AR (1)	AR220901A1 (en)
AT (1)	AT356136B (en)
AU (1)	AU504978B2 (en)
BG (1)	BG28847A3 (en)
CA (1)	CA1088945A (en)
CH (1)	CH625511A5 (en)
DD (1)	DD131931A5 (en)
DE (4)	DE2746244C2 (en)
DK (1)	DK150302C (en)
ES (1)	ES463267A1 (en)
FI (1)	FI62307C (en)
FR (1)	FR2367754A1 (en)
GB (1)	GB1566171A (en)
GR (1)	GR70201B (en)
HK (1)	HK53881A (en)
IE (1)	IE45805B1 (en)
IL (1)	IL53094A0 (en)
KE (1)	KE3167A (en)
LU (1)	LU78330A1 (en)
MX (1)	MX4899E (en)
MY (1)	MY8200157A (en)
NL (1)	NL167434C (en)
NO (1)	NO148453C (en)
NZ (1)	NZ185358A (en)
PH (1)	PH15639A (en)
PT (1)	PT67164B (en)
SE (1)	SE437024B (en)
YU (1)	YU40821B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents
US4127665A (en) *	1978-01-18	1978-11-28	Pfizer Inc.	Thienohydantoin derivatives
US4147797A (en) *	1978-08-11	1979-04-03	Pfizer Inc.	Spiro-furanohydantoin derivatives
US4200642A (en) *	1978-08-21	1980-04-29	Pfizer Inc.	Spiro-oxazolidindiones
US4181728A (en) *	1978-11-16	1980-01-01	Pfizer Inc.	Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) *	1979-03-21	1980-01-01	Pfizer Inc.	Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4235911A (en) *	1979-06-13	1980-11-25	Pfizer Inc.	Hydantoin derivatives
US4283409A (en) *	1979-10-29	1981-08-11	Pfizer Inc.	Imidazolone derivatives
US4286098A (en) *	1980-03-28	1981-08-25	Pfizer Inc.	Process for the preparation of chiral hydantoins
JPS5745185A (en) *	1980-07-21	1982-03-13	Eisai Co Ltd	Hydantoin derivative and its preparation
DE3262294D1 (en) *	1981-05-13	1985-03-28	Ici Plc	Pharmaceutical compositions containing spiro succinimide derivatives
JPS58213717A (en) *	1982-01-20	1983-12-12	Eisai Co Ltd	Remedy containing hydantoin derivative
JPS59500617A (en) *	1982-04-15	1984-04-12	アルコン・ラボラトリ−ズ・インコ−ポレ−テッド	Hydantoin therapeutic agent
SU1380610A3 (en) *	1982-12-06	1988-03-07	Пфайзер Инк. (Фирма)	Method of producing spiroheteroazolydindiones or pharmaceutically acceptable salts thereof
US4474967A (en) *	1983-04-27	1984-10-02	Pfizer Inc.	8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
WO1986002647A1 (en) *	1984-10-30	1986-05-09	Pfizer Inc.	Spiro-heteroazolones for treatment of diabetes complications
JPS61200991A (en) *	1985-03-04	1986-09-05	Sanwa Kagaku Kenkyusho:Kk	Novel spiro-3-heteroazolidine compound, production thereof, preventive and remedy for diabetic complication comprising same as active ingredient
US4575507A (en) *	1985-05-29	1986-03-11	Pfizer Inc.	Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
JPS6357588A (en) *	1986-08-28	1988-03-12	Sanwa Kagaku Kenkyusho Co Ltd	Hydantoin derivative, salt and, production thereof and preventing and treating, agent for diabetic complication
HU204832B (en) *	1987-09-04	1992-02-28	Pfizer	Process for producing spiro-(imidazolidine-4,4'-pyrano/2,3-b/pyridine) derivatives and pharmaceutical compositions comprising same
GB2355264A (en)	1999-09-30	2001-04-18	Merck & Co Inc	Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
WO2003088915A2 (en)	2002-04-18	2003-10-30	University Of Virginia Patent Foundation	Novel sodium channel blockers
FR2955107B1 (en)	2010-01-08	2012-03-02	Servier Lab	NOVEL THIOCHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB818724A (en) *	1956-10-18	1959-08-19	Ici Ltd	Hydantoin derivatives
DE1135915B (en) *	1961-06-29	1962-09-06	Asta Werke Ag Chem Fab	Process for the production of new, anticonvulsant spirohydantoins
US3532744A (en) *	1967-07-28	1970-10-06	American Home Prod	1- and 2-amino substituted indane and tetralene carboxylic acids
US3821383A (en)	1972-07-10	1974-06-28	Ayerst Mckenna & Harrison	Compositions for and a method of treating diabetic complications
DE2449030A1 (en) *	1974-10-11	1976-05-20	Schering Ag	NEW PYRIDINE DERIVATIVES
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents

1977
- 1977-09-30 CA CA287,868A patent/CA1088945A/en not_active Expired
- 1977-10-03 SE SE7711053A patent/SE437024B/en not_active IP Right Cessation
- 1977-10-04 GR GR54503A patent/GR70201B/el unknown
- 1977-10-05 NZ NZ185358A patent/NZ185358A/en unknown
- 1977-10-06 AU AU29431/77A patent/AU504978B2/en not_active Expired
- 1977-10-10 YU YU2442/77A patent/YU40821B/en unknown
- 1977-10-10 IL IL53094A patent/IL53094A0/en not_active IP Right Cessation
- 1977-10-14 DE DE2746244A patent/DE2746244C2/en not_active Expired
- 1977-10-14 PH PH20335A patent/PH15639A/en unknown
- 1977-10-14 FI FI773060A patent/FI62307C/en not_active IP Right Cessation
- 1977-10-14 DE DE2759543A patent/DE2759543C2/en not_active Expired
- 1977-10-14 DE DE2759927A patent/DE2759927C2/en not_active Expired
- 1977-10-14 DE DE2759542A patent/DE2759542C2/de not_active Expired
- 1977-10-15 ES ES463267A patent/ES463267A1/en not_active Expired
- 1977-10-17 IE IE2114/77A patent/IE45805B1/en not_active IP Right Cessation
- 1977-10-17 MX MX776490U patent/MX4899E/en unknown
- 1977-10-17 CH CH1262677A patent/CH625511A5/en not_active IP Right Cessation
- 1977-10-17 LU LU78330A patent/LU78330A1/en unknown
- 1977-10-17 PT PT67164A patent/PT67164B/en unknown
- 1977-10-17 DK DK461377A patent/DK150302C/en not_active IP Right Cessation
- 1977-10-17 GB GB43122/77A patent/GB1566171A/en not_active Expired
- 1977-10-17 NL NL7711358.A patent/NL167434C/en not_active IP Right Cessation
- 1977-10-17 NO NO773548A patent/NO148453C/en unknown
- 1977-10-17 JP JP12437177A patent/JPS5353653A/en active Granted
- 1977-10-17 FR FR7731216A patent/FR2367754A1/en active Granted
- 1977-10-18 BG BG037604A patent/BG28847A3/en unknown
- 1977-10-18 AR AR269623A patent/AR220901A1/en active
- 1977-10-18 AT AT745977A patent/AT356136B/en not_active IP Right Cessation
- 1977-10-18 DD DD7700201582A patent/DD131931A5/en unknown
1978
- 1978-11-25 JP JP53145925A patent/JPS5940388B2/en not_active Expired
- 1978-11-25 JP JP53145926A patent/JPS607997B2/en not_active Expired
1981
- 1981-10-09 KE KE3167A patent/KE3167A/en unknown
- 1981-11-05 HK HK538/81A patent/HK53881A/en unknown
1982
- 1982-12-30 MY MY157/82A patent/MY8200157A/en unknown

Also Published As

Publication number	Publication date
DD131931A5 (en)	1978-08-09
FI773060A (en)	1978-04-19
NZ185358A (en)	1979-06-08
SE437024B (en)	1985-02-04
NL167434B (en)	1981-07-16
FI62307B (en)	1982-08-31
JPS607997B2 (en)	1985-02-28
AR220901A1 (en)	1980-12-15
ATA745977A (en)	1979-09-15
FI62307C (en)	1982-12-10
DK461377A (en)	1978-04-19
HK53881A (en)	1981-11-13
ES463267A1 (en)	1978-07-16
DE2746244C2 (en)	1983-05-19
KE3167A (en)	1981-11-06
BG28847A3 (en)	1980-07-15
MY8200157A (en)	1982-12-31
YU244277A (en)	1982-08-31
DE2746244A1 (en)	1978-04-20
DE2759542C2 (en)	1988-07-07
NO148453B (en)	1983-07-04
NL167434C (en)	1981-12-16
GR70201B (en)	1982-08-31
JPS5940388B2 (en)	1984-09-29
NL7711358A (en)	1978-04-20
DK150302C (en)	1987-09-28
YU40821B (en)	1986-06-30
FR2367754B1 (en)	1982-07-09
JPS5353653A (en)	1978-05-16
PT67164B (en)	1979-03-20
PH15639A (en)	1983-03-11
DE2759543C2 (en)	1987-04-09
CH625511A5 (en)	1981-09-30
LU78330A1 (en)	1979-06-01
CA1088945A (en)	1980-11-04
DE2759927C2 (en)	1986-12-04
NO148453C (en)	1983-10-12
AU2943177A (en)	1979-04-12
IE45805L (en)	1978-04-18
AT356136B (en)	1980-04-10
MX4899E (en)	1982-12-14
DK150302B (en)	1987-02-02
PT67164A (en)	1977-11-01
GB1566171A (en)	1980-04-30
JPS5534132B2 (en)	1980-09-04
JPS5495570A (en)	1979-07-28
AU504978B2 (en)	1979-11-01
IE45805B1 (en)	1982-12-01
FR2367754A1 (en)	1978-05-12
NO773548L (en)	1978-04-19
IL53094A0 (en)	1977-12-30
SE7711053L (en)	1978-04-19

Publication	Publication Date	Title
ZA775907B (en)	1978-05-30	Hydantoin derivatives as therapeutic agents
JPS5495575A (en)	1979-07-28	Hydantoin derivative therapeutic medicine
ZA782919B (en)	1979-06-27	Hydantoin therapeutic agents
JPS52146991A (en)	1977-12-07	Therapeutic chair
GB2013084B (en)	1982-07-28	Ophthalmic drug dosage
JPS52128357A (en)	1977-10-27	Antiitumor drug
JPS52146992A (en)	1977-12-07	Therapeutic chair
JPS5463099A (en)	1979-05-21	Medicine
ZA77776B (en)	1978-06-28	Therapeutic agents
JPS54141797A (en)	1979-11-05	Therapeutic drug
PH14956A (en)	1982-02-05	Trans-broparestrol based therapeutic
JPS5376584A (en)	1978-07-07	Medical capsule
JPS5334385A (en)	1978-03-30	Medical capsule
GB1538000A (en)	1979-01-10	Medicine for renal diseases
JPS52114010A (en)	1977-09-24	Medicine for nicotinism
JPS52131678A (en)	1977-11-04	Medical capsule
JPS5338620A (en)	1978-04-08	Isomalin antiimold drug
JPS5349880A (en)	1978-05-06	Medical capsule
JPS5347183A (en)	1978-04-27	Medical capsule
JPS5294681A (en)	1977-08-09	Medical capsule
JPS5353183A (en)	1978-05-15	Medical capsule
JPS5573611A (en)	1980-06-03	Medical drug containing hydantoin derivative
JPS52118481A (en)	1977-10-04	Therapeutic agents
JPS5294682A (en)	1977-08-09	Medical capsule
JPS5328986A (en)	1978-03-17	Medical capsule