JPS5495570A - Hydantoin derivative therapeutic agent - Google Patents

Hydantoin derivative therapeutic agent

Info

Publication number: JPS5495570A
Authority: JP; Japan
Prior art keywords: therapeutic agent; hydantoin derivative; derivative therapeutic; hydantoin; agent
Prior art date: 1976-10-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP14592578A

Other languages

Japanese (ja)

Other versions

JPS5940388B2 (en

Inventor

Saajiesu Reinhaado

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Inc

Original Assignee

Pfizer Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-10-18

Filing date

1978-11-25

Publication date

1979-07-28

1977-02-11 Priority claimed from US05/767,803 external-priority patent/US4117230A/en

1978-11-25 Application filed by Pfizer Inc filed Critical Pfizer Inc

1979-07-28 Publication of JPS5495570A publication Critical patent/JPS5495570A/en

1984-09-29 Publication of JPS5940388B2 publication Critical patent/JPS5940388B2/en

Status Expired legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

JP53145925A 1976-10-18 1978-11-25 Hydantoin derivative therapeutic agent Expired JPS5940388B2 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US73306276A	1976-10-18	1976-10-18
US000000733062		1976-10-18
US000000767803		1977-02-11
US05/767,803 US4117230A (en)	1976-10-18	1977-02-11	Hydantoin derivatives as therapeutic agents

Publications (2)

Publication Number	Publication Date
JPS5495570A true JPS5495570A (en)	1979-07-28
JPS5940388B2 JPS5940388B2 (en)	1984-09-29

Family

ID=27112515

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
JP12437177A Granted JPS5353653A (en)	1976-10-18	1977-10-17	Hydantoin derivatives medicines
JP53145925A Expired JPS5940388B2 (en)	1976-10-18	1978-11-25	Hydantoin derivative therapeutic agent
JP53145926A Expired JPS607997B2 (en)	1976-10-18	1978-11-25	Hydantoin derivative therapeutic agent

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
JP12437177A Granted JPS5353653A (en)	1976-10-18	1977-10-17	Hydantoin derivatives medicines

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
JP53145926A Expired JPS607997B2 (en)	1976-10-18	1978-11-25	Hydantoin derivative therapeutic agent

Country Status (29)

Country	Link
JP (3)	JPS5353653A (en)
AR (1)	AR220901A1 (en)
AT (1)	AT356136B (en)
AU (1)	AU504978B2 (en)
BG (1)	BG28847A3 (en)
CA (1)	CA1088945A (en)
CH (1)	CH625511A5 (en)
DD (1)	DD131931A5 (en)
DE (4)	DE2746244C2 (en)
DK (1)	DK150302C (en)
ES (1)	ES463267A1 (en)
FI (1)	FI62307C (en)
FR (1)	FR2367754A1 (en)
GB (1)	GB1566171A (en)
GR (1)	GR70201B (en)
HK (1)	HK53881A (en)
IE (1)	IE45805B1 (en)
IL (1)	IL53094A0 (en)
KE (1)	KE3167A (en)
LU (1)	LU78330A1 (en)
MX (1)	MX4899E (en)
MY (1)	MY8200157A (en)
NL (1)	NL167434C (en)
NO (1)	NO148453C (en)
NZ (1)	NZ185358A (en)
PH (1)	PH15639A (en)
PT (1)	PT67164B (en)
SE (1)	SE437024B (en)
YU (1)	YU40821B (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents
US4127665A (en) *	1978-01-18	1978-11-28	Pfizer Inc.	Thienohydantoin derivatives
US4147797A (en) *	1978-08-11	1979-04-03	Pfizer Inc.	Spiro-furanohydantoin derivatives
US4200642A (en) *	1978-08-21	1980-04-29	Pfizer Inc.	Spiro-oxazolidindiones
US4181728A (en) *	1978-11-16	1980-01-01	Pfizer Inc.	Spiro-polycyclicimidazolidinedione derivatives
US4181729A (en) *	1979-03-21	1980-01-01	Pfizer Inc.	Phenyl or phenoxy substituted spiro-imidazolidinedione derivatives
US4235911A (en) *	1979-06-13	1980-11-25	Pfizer Inc.	Hydantoin derivatives
US4283409A (en) *	1979-10-29	1981-08-11	Pfizer Inc.	Imidazolone derivatives
US4286098A (en) *	1980-03-28	1981-08-25	Pfizer Inc.	Process for the preparation of chiral hydantoins
JPS5745185A (en) *	1980-07-21	1982-03-13	Eisai Co Ltd	Hydantoin derivative and its preparation
DE3262294D1 (en) *	1981-05-13	1985-03-28	Ici Plc	Pharmaceutical compositions containing spiro succinimide derivatives
JPS58213717A (en) *	1982-01-20	1983-12-12	Eisai Co Ltd	Remedy containing hydantoin derivative
JPS59500617A (en) *	1982-04-15	1984-04-12	アルコン・ラボラトリ−ズ・インコ−ポレ−テッド	Hydantoin therapeutic agent
SU1380610A3 (en) *	1982-12-06	1988-03-07	Пфайзер Инк. (Фирма)	Method of producing spiroheteroazolydindiones or pharmaceutically acceptable salts thereof
US4474967A (en) *	1983-04-27	1984-10-02	Pfizer Inc.	8-Deutero and 8-tritio-substituted derivatives of D-4S-6-fluoro-spiro-[chroman-4,4'-imidazolidine]-2',5'-dione
WO1986002647A1 (en) *	1984-10-30	1986-05-09	Pfizer Inc.	Spiro-heteroazolones for treatment of diabetes complications
JPS61200991A (en) *	1985-03-04	1986-09-05	Sanwa Kagaku Kenkyusho:Kk	Novel spiro-3-heteroazolidine compound, production thereof, preventive and remedy for diabetic complication comprising same as active ingredient
US4575507A (en) *	1985-05-29	1986-03-11	Pfizer Inc.	Spiro-imidazolidines as aldose reductase inhibitors and their pharmaceutical use
JPS6357588A (en) *	1986-08-28	1988-03-12	Sanwa Kagaku Kenkyusho Co Ltd	Hydantoin derivative, salt and, production thereof and preventing and treating, agent for diabetic complication
HU204832B (en) *	1987-09-04	1992-02-28	Pfizer	Process for producing spiro-(imidazolidine-4,4'-pyrano/2,3-b/pyridine) derivatives and pharmaceutical compositions comprising same
GB2355264A (en)	1999-09-30	2001-04-18	Merck & Co Inc	Spirohydantoin derivatives useful as alpha 1a adrenoceptor antagonists
WO2003088915A2 (en)	2002-04-18	2003-10-30	University Of Virginia Patent Foundation	Novel sodium channel blockers
FR2955107B1 (en)	2010-01-08	2012-03-02	Servier Lab	NOVEL THIOCHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB818724A (en) *	1956-10-18	1959-08-19	Ici Ltd	Hydantoin derivatives
DE1135915B (en) *	1961-06-29	1962-09-06	Asta Werke Ag Chem Fab	Process for the production of new, anticonvulsant spirohydantoins
US3532744A (en) *	1967-07-28	1970-10-06	American Home Prod	1- and 2-amino substituted indane and tetralene carboxylic acids
US3821383A (en)	1972-07-10	1974-06-28	Ayerst Mckenna & Harrison	Compositions for and a method of treating diabetic complications
DE2449030A1 (en) *	1974-10-11	1976-05-20	Schering Ag	NEW PYRIDINE DERIVATIVES
US4130714A (en) *	1977-05-23	1978-12-19	Pfizer Inc.	Hydantoin therapeutic agents

1977
- 1977-09-30 CA CA287,868A patent/CA1088945A/en not_active Expired
- 1977-10-03 SE SE7711053A patent/SE437024B/en not_active IP Right Cessation
- 1977-10-04 GR GR54503A patent/GR70201B/el unknown
- 1977-10-05 NZ NZ185358A patent/NZ185358A/en unknown
- 1977-10-06 AU AU29431/77A patent/AU504978B2/en not_active Expired
- 1977-10-10 YU YU2442/77A patent/YU40821B/en unknown
- 1977-10-10 IL IL53094A patent/IL53094A0/en not_active IP Right Cessation
- 1977-10-14 DE DE2746244A patent/DE2746244C2/en not_active Expired
- 1977-10-14 PH PH20335A patent/PH15639A/en unknown
- 1977-10-14 FI FI773060A patent/FI62307C/en not_active IP Right Cessation
- 1977-10-14 DE DE2759543A patent/DE2759543C2/en not_active Expired
- 1977-10-14 DE DE2759927A patent/DE2759927C2/en not_active Expired
- 1977-10-14 DE DE2759542A patent/DE2759542C2/de not_active Expired
- 1977-10-15 ES ES463267A patent/ES463267A1/en not_active Expired
- 1977-10-17 IE IE2114/77A patent/IE45805B1/en not_active IP Right Cessation
- 1977-10-17 MX MX776490U patent/MX4899E/en unknown
- 1977-10-17 CH CH1262677A patent/CH625511A5/en not_active IP Right Cessation
- 1977-10-17 LU LU78330A patent/LU78330A1/en unknown
- 1977-10-17 PT PT67164A patent/PT67164B/en unknown
- 1977-10-17 DK DK461377A patent/DK150302C/en not_active IP Right Cessation
- 1977-10-17 GB GB43122/77A patent/GB1566171A/en not_active Expired
- 1977-10-17 NL NL7711358.A patent/NL167434C/en not_active IP Right Cessation
- 1977-10-17 NO NO773548A patent/NO148453C/en unknown
- 1977-10-17 JP JP12437177A patent/JPS5353653A/en active Granted
- 1977-10-17 FR FR7731216A patent/FR2367754A1/en active Granted
- 1977-10-18 BG BG037604A patent/BG28847A3/en unknown
- 1977-10-18 AR AR269623A patent/AR220901A1/en active
- 1977-10-18 AT AT745977A patent/AT356136B/en not_active IP Right Cessation
- 1977-10-18 DD DD7700201582A patent/DD131931A5/en unknown
1978
- 1978-11-25 JP JP53145925A patent/JPS5940388B2/en not_active Expired
- 1978-11-25 JP JP53145926A patent/JPS607997B2/en not_active Expired
1981
- 1981-10-09 KE KE3167A patent/KE3167A/en unknown
- 1981-11-05 HK HK538/81A patent/HK53881A/en unknown
1982
- 1982-12-30 MY MY157/82A patent/MY8200157A/en unknown

Also Published As

Publication number	Publication date
DD131931A5 (en)	1978-08-09
FI773060A (en)	1978-04-19
NZ185358A (en)	1979-06-08
SE437024B (en)	1985-02-04
NL167434B (en)	1981-07-16
FI62307B (en)	1982-08-31
JPS607997B2 (en)	1985-02-28
AR220901A1 (en)	1980-12-15
ATA745977A (en)	1979-09-15
JPS5495575A (en)	1979-07-28
FI62307C (en)	1982-12-10
DK461377A (en)	1978-04-19
HK53881A (en)	1981-11-13
ES463267A1 (en)	1978-07-16
DE2746244C2 (en)	1983-05-19
KE3167A (en)	1981-11-06
BG28847A3 (en)	1980-07-15
MY8200157A (en)	1982-12-31
YU244277A (en)	1982-08-31
DE2746244A1 (en)	1978-04-20
DE2759542C2 (en)	1988-07-07
NO148453B (en)	1983-07-04
NL167434C (en)	1981-12-16
GR70201B (en)	1982-08-31
JPS5940388B2 (en)	1984-09-29
NL7711358A (en)	1978-04-20
DK150302C (en)	1987-09-28
YU40821B (en)	1986-06-30
FR2367754B1 (en)	1982-07-09
JPS5353653A (en)	1978-05-16
PT67164B (en)	1979-03-20
PH15639A (en)	1983-03-11
DE2759543C2 (en)	1987-04-09
CH625511A5 (en)	1981-09-30
LU78330A1 (en)	1979-06-01
CA1088945A (en)	1980-11-04
DE2759927C2 (en)	1986-12-04
NO148453C (en)	1983-10-12
AU2943177A (en)	1979-04-12
IE45805L (en)	1978-04-18
AT356136B (en)	1980-04-10
MX4899E (en)	1982-12-14
DK150302B (en)	1987-02-02
PT67164A (en)	1977-11-01
GB1566171A (en)	1980-04-30
JPS5534132B2 (en)	1980-09-04
AU504978B2 (en)	1979-11-01
IE45805B1 (en)	1982-12-01
FR2367754A1 (en)	1978-05-12
NO773548L (en)	1978-04-19
IL53094A0 (en)	1977-12-30
SE7711053L (en)	1978-04-19

Publication	Publication Date	Title
ZA775907B (en)	1978-05-30	Hydantoin derivatives as therapeutic agents
ZA782919B (en)	1979-06-27	Hydantoin therapeutic agents
JPS5495570A (en)	1979-07-28	Hydantoin derivative therapeutic agent
GB2000136B (en)	1982-01-06	Therapeutic agents
GB2005248B (en)	1982-03-24	Therapeutic agents
ZA782816B (en)	1979-05-30	Therapeutic agents
GB2018134A (en)	1979-10-17	Cerebral therapeutic agent
GB2000138B (en)	1982-03-03	Therapeutic agents
GB2000131B (en)	1982-01-13	Therapeutic agents
ZA767066B (en)	1977-10-26	Fungicidal agents
JPS5369822A (en)	1978-06-21	Pharmaceutical agent
GB2004876B (en)	1982-03-10	Therapeutic agents
AU1655376A (en)	1978-02-09	Fungicidal agents
ZA77776B (en)	1978-06-28	Therapeutic agents
GB2007656B (en)	1982-05-19	Therapeutic agents
ZA786184B (en)	1979-10-31	Therapeutic agents
JPS5248665A (en)	1977-04-18	Hydantoin derivatives
GB2000510B (en)	1982-01-27	Therapeutic agents
JPS5321165A (en)	1978-02-27	Imidazole derivative
JPS52130925A (en)	1977-11-02	Mouthhthrough administrating agent for cattle
JPS5312834A (en)	1978-02-04	Antiiviral agent for animals
DE2967199D1 (en)	1984-10-11	Vegetative stigmata therapeutic agent
GB2010824B (en)	1982-06-16	Therapeutic agents
JPS5379863A (en)	1978-07-14	Imidazole derivative
JPS52118481A (en)	1977-10-04	Therapeutic agents