JPH0737700Y2 - Hollow fiber type liquid treatment equipment - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial application] The present invention relates to a hollow fiber type liquid treatment device such as a hollow fiber type artificial kidney and a hollow fiber type artificial lung.

[Prior Art] In a hollow fiber type liquid treatment device, as described in, for example, Japanese Patent Publication No. 63-52522, a large number of hollow fibers are loaded in a casing, and the end of the bundle of hollow fibers is the end of the casing. The hollow fiber is supported by a partition wall member of a synthetic polymer material that is filled and solidified in the hollow fiber, and the opening of each hollow fiber is opened to the outer end surface of the partition wall member. Then, a header that surrounds the entire opening of each hollow fiber is attached to the end of the casing, and the header is provided with a port for the first liquid (for example, blood) that communicates with the opening of each hollow fiber, The casing is provided with a port for the second liquid (for example, dialysate) facing the periphery of the hollow fiber bundle.

In the above hollow fiber type liquid treatment apparatus, the operation of supporting the hollow fiber bundle by providing the partition member in the casing prepares a large number of hollow fibers longer than the length of the casing,
The hollow fiber bundle is positioned inside the casing. Then, after pouring the synthetic polymer material (potting material) into the casing from the second liquid port provided in the casing, the casing is rotated with the central axis of the casing being on the radius of rotation, and the potting is performed. The material is concentrated under the action of centrifugal force in the partition wall forming portion at the outer end in the axial direction of the casing, and the partition wall is formed by solidification after a predetermined time has elapsed. After the potting material is solidified, the partition wall has its outer end portion sliced with a sharp blade to expose the open end of the hollow fiber on the surface.

[Problems to be Solved by the Invention] However, in the prior art, when the end of the hollow fiber bundle is supported by filling and solidifying the partition member, a means for reliably holding the hollow fiber bundle during the solidification process of the potting material is provided. Since the hollow fiber bundle does not exist, the hollow fiber bundle is observed to move with the flow of the potting material and the like, resulting in the following problems.

It is difficult to maintain the flow path of the hollow fiber bundle for the first liquid, because some of the openings of each hollow fiber opening on the outer end surface of the partition member open outside the area surrounded by the header.
This means that it is difficult to subject all hollow fibers to liquid treatment.

It is difficult to maintain the flow path of the hollow fiber bundle for the second liquid, because the outer diameter of the hollow fiber bundle located in the cross section including the second liquid port of the casing is disturbed. This makes it difficult to form a uniform second liquid annular flow passage between the casing inner peripheral portion and the hollow fiber bundle outer peripheral portion within the above-mentioned cross section, and the second liquid port and the casing inner space are formed. This means that the second liquid tends to flow unevenly between the first and the second liquids, and it is difficult to provide the entire region of the hollow fiber bundle for effective liquid treatment.

It is an object of the present invention to provide a hollow fiber type liquid treatment apparatus which supports the hollow fiber bundle without disturbing when supporting the end of the hollow fiber bundle by filling and solidifying the partition member, and which has good liquid treatment performance. To do.

[Means for Solving the Problems] In the present invention according to claim 1, a large number of hollow fibers are loaded in a casing, and an end portion of the hollow fiber bundle is supported by a partition member at an end portion of the casing. The opening of each hollow fiber is opened at the outer end surface of the partition member, and a header surrounding the entire opening of each hollow fiber is attached to the end of the casing. A hollow fiber type liquid treatment device, wherein a first liquid port communicating with the hollow fiber bundle is provided, and a second liquid port facing the periphery of the hollow fiber bundle is provided in the casing, wherein the casing has an outer peripheral portion of the hollow fiber bundle. A hollow fiber bundle holder for holding the hollow fiber bundle is provided, the hollow fiber bundle holder includes a first holding portion and a second holding portion, and the first holding portion is a hollow fiber bundle supported by the partition wall member. The outer periphery of the end is held and the second
The holding portion holds the outer peripheral portion of the hollow fiber bundle located in a cross section including the second liquid port of the casing and is disposed in the casing, and the second liquid is provided between the holding portion and the inner peripheral portion of the casing. And a plurality of communication passages that form an annular flow channel for use and connect the annular flow channel to the outer surface of each hollow fiber at a plurality of positions around the outer circumference of the hollow fiber bundle.

The present invention according to claim 2 is characterized in that the hollow fiber bundle holder includes a straightening portion arranged in the casing, and the straightening portion is a partition member of the communication passage forming portion of the second holding portion. A partition wall extends from the opposite side portion and abuts on the inner peripheral portion of the casing to form a partition wall between the region on the opposite side of the partition member of the annular flow passage and the hollow fiber bundle loading region in the casing. It is the one.

[Operation] According to the present invention described in claim 1, the following operation effects are obtained.

When supporting the end portion of the hollow fiber bundle by filling and solidifying the partition member, the hollow fiber bundle is securely held by the hollow fiber bundle holder during the solidification process of the partition member, and the hollow fiber bundle is It does not move and become disturbed as the partition member flows.

The outer peripheral portion of the end portion of the hollow fiber bundle supported by the partition member is the first
As a result of being securely held by the holding portion, all the openings of each hollow fiber that opens to the outer end surface of the partition member are surely and orderly opened within the area surrounded by the header, and the flow path of the hollow fiber bundle for the first liquid is formed. Easy to maintain. Therefore, all hollow fibers can be reliably subjected to liquid treatment.

As a result of the outer peripheral portion of the hollow fiber bundle located in the cross section including the second liquid port of the casing being securely held by the second holding portion, the maintenance of the flow path of the hollow fiber bundle for the second liquid is easy. Therefore, in the cross section, a uniform second liquid annular flow path is reliably formed between the casing inner peripheral portion and the hollow fiber bundle outer peripheral portion, and between the second liquid port and the casing inner space. Second
It is possible to perform effective liquid treatment on the entire area of the hollow fiber bundle without causing a liquid drift.

According to the present invention as set forth in claim 2, there are the following operational effects.

The hollow fiber bundle holder holds the hollow fiber bundle by the above-mentioned first holding portion and second holding portion, and at the same time, by the rectifying portion thereof, the region opposite to the partition member of the annular channel and the hollow fiber in the casing. A partition wall may be formed between the bundle loading area. As a result, the second liquid does not flow in a short circuit between only the region near the second liquid port in the annular flow path and the hollow fiber bundle loading area in the casing, and the second liquid always flows in the annular flow path. It circulates through the entire circumference area and the communication path of the second holding portion facing the entire circumference area. Therefore, between the second liquid port and the casing inner space, the second liquid can be more surely subjected to more effective liquid treatment in the entire region of the hollow fiber bundle without causing uneven flow.

[Embodiment] FIG. 1 is a sectional view showing an artificial kidney according to an embodiment of the present invention, FIG. 2 is an enlarged sectional view of an essential part of FIG. 1, and FIG. 3 is a perspective view showing a hollow fiber bundle holder. Is.

The artificial kidney 10 has a large number of hollow fibers in a cylindrical casing 11.
Partition member 14 of synthetic polymer material loaded with 12 and filled with both ends of hollow fiber bundle 13 at both ends of casing 11 for solidification.
Support by 15.

The opening of each hollow fiber 12 is opened at the outer end surface of the partition members 14 and 15, and the headers 16 and 17 that surround the entire opening of each hollow fiber 12 are provided.
Are adhered to both ends of the casing 11 by adhesion or screwing. Incidentally, 18 and 19 are sealing members such as O-rings.

The header 16 is provided with a blood inflow port 21 communicating with the opening of each hollow fiber 12, and the header 17 is provided with a blood inflow port 22 communicating with the opening of each hollow fiber 12. Further, the casing 11 is provided with a dialysate inflow port 23 facing the periphery of the hollow fiber bundle 13 located near the partition member 15, and a dialysate outflow port facing the periphery of the hollow fiber bundle 13 located near the partition member 14. 24 are provided.

That is, in the artificial kidney 10, downward flow in the figure of blood flowing in from the blood inflow port 21 and flowing out from the blood outflow port 22 and inflow from the dialysate inflow port 23 and outflow from the dialysate outflow port 24. Upflow with the dialysate diagram
A large number of hollow fibers 12 are allowed to mass-transfer to each other through the semipermeable membrane.

Incidentally, in the artificial kidney 10, the casing 11, the header 16,
17 is made of a hard synthetic resin material such as polypropylene or polycarbonate.

The partition members 14 and 15 are made of, for example, a synthetic resin material such as polyurethane or silicone.

The hollow fiber 12 is composed of, for example, regenerated cellulose in the case of artificial kidney, polypropylene in the case of artificial lung,
A semipermeable membrane having an inner diameter of about 200μ and a wall thickness of 9 to 15μ is formed. The hollow fiber bundle 13 is an assembly of, for example, 500 to 15,000 hollow fibers 12.

However, in the artificial kidney 10, the hollow fiber bundle holder 30 is provided on the inner surface of both ends of the casing 11. As shown in FIGS. 2 and 3, each hollow fiber bundle holder 30 is made of, for example, a synthetic resin material such as polycarbonate, AS resin, BS resin, or the like, and has a substantially annular shape. Part 31, second
The holding section 32, the rectifying section 33, and the joining section 34 are provided. In each hollow fiber bundle holder 30, the joint portion 34 is, for example, adhesively fixed to the inner surface of the casing 11.

The first holding portion 31 holds the outer peripheral portion of the end portion of the hollow fiber bundle 13 supported by the partition wall members 14 and 15 and is embedded in the partition wall members 14 and 15.

The second holding portion 33 includes the dialysate ports 23, 24 of the casing 11.
Is disposed in the casing 11 while holding the outer peripheral portion of the hollow fiber bundle 13 located in the cross section including the inner peripheral portion of the casing 11, and the annular flow paths 35 and 36 are formed between the inner peripheral portion and the inner peripheral portion of the casing 11. Further, the second holding portion 32
Is provided with a plurality of elongated hole-like communication passages 37 communicating the annular flow passages 35 and 36 with the outer surface of each hollow fiber 12 at a plurality of positions around the outer circumference of the hollow fiber bundle 13.

The rectifying portion 33 extends in a skirt shape from a portion of the second holding portion 32 that forms the communication passage 37 on the opposite side of the partition members 14 and 15 to reach the joint portion 34. Close to. The rectifying unit 33 forms a partition wall between the region of the annular flow passages 35 and 36 on the opposite side of the partition members 14 and 15 and the region where the hollow fiber bundle 13 is loaded in the casing 11.

In the hollow fiber bundle holder 30 described above, the free end of the first holding portion 31 is located on the outer end surface of the partition members 14 and 15 with an interval of, for example, 0.1 to 20 mm between them. In the state where it does not reach, it is embedded inside the partition members 14 and 15 as described above. However, the closer the free end of the first holding portion 31 is to the outer end surfaces of the partition members 14 and 15, the longer the range for holding the hollow fiber bundle 13, which is preferable.

Further, in the hollow fiber bundle holder 30, the communication passage 37 provided in the second holding portion 32 continuously extends to the intermediate portion of the first holding portion 31, and the synthetic polymer material when the partition members 14 and 15 are formed. Improves fluidity of (potting material).

Further, in the hollow fiber bundle holder 30, the first holding portion 31 that is in contact with the potting material for forming the partition members 14 and 15 has a rough surface, or a groove is formed on the surface to form the first holding portion. It is possible to improve the adhesion strength between 31 and the partition members 14 and 15.

In the artificial kidney 10, the operation of supporting the hollow fiber bundle 13 by providing the partition members 14 and 15 in the casing 11 is to prepare a large number of hollow fibers 12 longer than the length of the casing 11, The bundle 13 is provided with a hollow fiber bundle holder 30 in the casing 11.
Hold and position. Then, after pouring the potting material into the casing 11 from the dialysate ports 23 and 24 provided in the casing 11, the casing 11 is rotated in a state where the central axis of the casing 11 is placed on the rotation radius,
The potting material is concentrated under centrifugal force in the partition wall forming portion at the axially outer end portion of the casing 11, and the partition wall members 14 and 15 are formed by solidification after a lapse of a predetermined time.
The partition members 14 and 15 are, after the potting material is solidified,
The outer end is sliced with a sharp blade to expose the open end of the hollow fiber 11 on the surface.

Next, the operation of the above embodiment will be described.

When supporting the ends of the hollow fiber bundle 13 by filling and solidifying the partition members 14 and 15, the hollow fiber bundle 13 is securely held by the hollow fiber bundle holder 30 during the solidification process of the potting material. The hollow fiber bundle 13 will not move and be disturbed as the potting material flows or the like.

As a result of the outer peripheral portion of the end portion of the hollow fiber bundle 13 supported by the partition members 14 and 15 being reliably held by the first holding portion 31, the openings of the hollow fibers 12 that open to the outer end surfaces of the partition members 14 and 15. All of the parts are surely and orderly opened in the area surrounded by the headers 16 and 17, so that the flow passage of the hollow fiber bundle 13 for blood can be easily maintained. Therefore, all the hollow fibers 12 can be reliably subjected to liquid treatment.

As a result of the outer peripheral portion of the hollow fiber bundle 13 located in the cross section including the dialysate ports 23 and 24 of the casing 11 being securely held by the second holding portion 32, the maintenance of the flow path of the hollow fiber bundle 13 for the dialysate is easy. Is. Therefore, within the above cross section, the casing
11 to form a uniform dialysate annular flow path 35, 36 between the inner peripheral portion and the outer periphery of the hollow fiber bundle 13 reliably, between the dialysing ports 23, 24 and the casing 11 internal space of the dialysate. An effective liquid treatment can be performed in the entire area of the hollow fiber bundle 13 without causing a drift.

The hollow fiber bundle holder 30 holds the hollow fiber bundle 13 by the above-mentioned first holding portion 31 and second holding portion 32, and at the same time, by the rectifying portion 33 thereof, regions of the annular flow passages 35, 36 on the opposite side of the partition member. A partition wall can be formed between the hollow fiber bundle loading area and the casing 11. Thereby, the dialysate is the annular flow path 35,
Only the area near the dialysate port of 36 and the casing
It does not flow in a short-cut manner with the hollow fiber bundle loading area in 11 and always includes the entire peripheral area of the annular flow paths 35, 36 and the communication passage 37 of the second holding portion 32 facing the entire peripheral area. Distribute through. Therefore, the dialysate ports 23 and 24 and the casing
A more effective liquid treatment can be carried out in the entire region of the hollow fiber bundle 13 without causing uneven flow of the dialysate between the inner space and the inner space.

In the implementation of the present invention, the first holding portion and the second holding portion of the hollow fiber bundle holding tool may be configured as separate members.

Further, in the practice of the present invention, when the hollow fiber bundle holder is constructed as an integrated structure of the first holding portion and the second holding portion, the portion directly supported on the casing side is the first holding portion and the second holding portion. Either side of the holding portion may be used, or both sides may be supported together.

[Advantages of the Invention] As described above, according to the present invention, when the end of the hollow fiber bundle is supported by filling and solidifying the partition member, the hollow fiber bundle is supported without disorder, and the hollow fiber having good liquid treatment performance is provided. A mold liquid processing device can be obtained.

[Brief description of drawings]

FIG. 1 is a sectional view showing an artificial kidney according to an embodiment of the present invention, FIG. 2 is an enlarged sectional view of an essential part of FIG. 1, and FIG. 3 is a perspective view showing a hollow fiber bundle holder. 10 …… Artificial kidney, 11 …… Casing, 12 …… Hollow fiber, 13
...... Hollow fiber bundle, 14, 15 ...... Partition member, 16, 17 ...... Header, 21 ...... Blood inflow port, 22 ...... Blood outflow port, 23
...... Dialysate inflow port, 24 ...... Dialysate outflow port, 30 ...
... Hollow fiber bundle holder, 31 ... first holding part, 32 ... second holding part, 33 ... rectifying part, 35,36 ... annular flow path, 37 ... communication path.

Claims (2)

[Scope of utility model registration request] 1. A large number of hollow fibers are loaded in a casing,
An end portion of the hollow fiber bundle is supported by a partition wall member at an end portion of the casing, an opening portion of each hollow fiber is opened to an outer end surface of the partition wall member, and a header surrounding the entire opening portion of each hollow fiber is A first liquid port, which is attached to the end of the casing and is in communication with the opening of each hollow fiber, is provided in the header, and a second liquid port facing the periphery of the hollow fiber bundle is provided in the casing. In the hollow fiber type liquid processing apparatus, a hollow fiber bundle holder for holding an outer peripheral portion of the hollow fiber bundle is provided in the casing, and the hollow fiber bundle holder has a first holding portion and a second holding portion. The first holding portion holds an outer peripheral portion of an end portion of the hollow fiber bundle supported by the partition member, and the second holding portion is positioned in a cross section including the second liquid port of the casing. Is disposed in the casing while holding the outer peripheral portion of the hollow fiber bundle,
A second liquid annular flow path is formed between the inner peripheral portion of the casing and communication passages communicating the annular flow path with the outer surface of each hollow fiber are provided at a plurality of positions around the outer circumference of the hollow fiber bundle. A characteristic hollow fiber type liquid processing device. 2. The hollow fiber bundle holder comprises a straightening portion arranged in the casing, the straightening portion extending from a portion of the second holding portion opposite to the partition member of the communication passage forming portion. 2. The partition wall according to claim 1, wherein the partition wall is formed so as to come into contact with the inner peripheral portion of the casing and to form a partition wall between a region of the annular flow passage opposite to the partition member and the hollow fiber bundle loading region in the casing. Hollow fiber type liquid treatment device.